Resveratrol: The anti-aging molecule whose anti-aging mechanism might be an artifact

Resveratrol's fame is built on SIRT1 activation (the "longevity gene"). But subsequent research showed the original SIRT1 activation data may have been a fluorescent assay artifact, the fluorophore, not resveratrol, was activating the enzyme. Resveratrol does activate SIRT1, but possibly indirectly via AMPK. The most famous mechanism in longevity nutrition might be partially wrong and it still works.Publications of interest:https://pubmed.ncbi.nlm.nih.gov/19843076/https://pubmed.ncbi.nlm.nih.gov/15684413/https://pmc.ncbi.nlm.nih.gov/articles/PMC6324849/