Return of Alpha Gal

Tuck your napkin under your chin.  We’re about to serve up a tale of love, loss, and lamb chops - with a side of genetic modification. Several years ago we told a story about Amy Pearl. For as long as she could remember, Amy loved meat in all its glorious cuts and marbled flavors. And then one day, for seemingly no reason, her body wouldn’t tolerate it.  No steaks. No brisket. No weenies. It made no sense: why couldn’t she eat something that she had routinely enjoyed for decades?  It turned out Amy was not alone. And the answer to her mysterious allergy involved maps, a dancing lone star tick, and a very particular sugar called Alpha Gal.  In this update, we discover that our troubles with Alpha Gal go way beyond food. We go to NYU Langone Health hospital to see the second ever transplant of a kidney from a pig into a human, talk to some people at Revivicor, the company that bred the pig in question, and go back to Amy to find out what she thinks about this brave new world. The original episode was reported by Latif Nasser, and produced by Annie McEwen and Matt Kielty. Sound design and scoring from Dylan Keefe, Annie McEwen, and Matt Kielty. Mix by Dylan Keefe with Arianne Wack. The update was reported and produced by Sarah Qari. It was sound designed, scored, and mixed by Jeremy Bloom.  Support Radiolab by becoming a member today at Radiolab.org/donate.

Episode 430 of the Radiolab podcast, hosted by WNYC Studios, titled "Return of Alpha Gal" was published on December 10, 2021 and runs 57 minutes.

December 10, 2021 ·57m · Radiolab

Summary

Tuck your napkin under your chin.  We’re about to serve up a tale of love, loss, and lamb chops - with a side of genetic modification. Several years ago we told a story about Amy Pearl. For as long as she could remember, Amy loved meat in all its glorious cuts and marbled flavors. And then one day, for seemingly no reason, her body wouldn’t tolerate it.  No steaks. No brisket. No weenies. It made no sense: why couldn’t she eat something that she had routinely enjoyed for decades?  It turned out Amy was not alone. And the answer to her mysterious allergy involved maps, a dancing lone star tick, and a very particular sugar called Alpha Gal.  In this update, we discover that our troubles with Alpha Gal go way beyond food. We go to NYU Langone Health hospital to see the second ever transplant of a kidney from a pig into a human, talk to some people at Revivicor, the company that bred the pig in question, and go back to Amy to find out what she thinks about this brave new world. The original episode was reported by Latif Nasser, and produced by Annie McEwen and Matt Kielty. Sound design and scoring from Dylan Keefe, Annie McEwen, and Matt Kielty. Mix by Dylan Keefe with Arianne Wack. The update was reported and produced by Sarah Qari. It was sound designed, scored, and mixed by Jeremy Bloom.  Support Radiolab by becoming a member today at Radiolab.org/donate.

Episode Description