Return of Alpha Gal

from Radiolab · host WNYC Studios

Several years ago, in 2016, we told a story about Amy Pearl. For as long as she could remember, Amy loved meat in all its glorious cuts and marbled flavors. And then one day, for seemingly no reason, her body wouldn’t tolerate it. No steaks. No brisket. No weenies. It made no sense: why couldn’t she eat something that she had routinely enjoyed for decades? It turned out Amy was not alone. And the answer to her mysterious allergy involved maps, a dancing lone star tick, and a very particular sugar called Alpha Gal. In this update, we discover that our troubles with Alpha Gal go way beyond food. We go to NYU Langone Health hospital to see the second ever transplant of a kidney from a pig into a human, talk to some people at Revivicor, the company that bred the pig in question, and go back to Amy to find out what she thinks about this brave new world. The original episode was reported by Latif Nasser, and produced by Annie McEwen and Matt Kielty. Sound design and scoring from Dylan Keefe, Annie McEwen, and Matt Kielty. Mix by Dylan Keefe with Arianne Wack. The update was reported and produced by Sarah Qari. It was sound designed, scored, and mixed by Jeremy Bloom. LATERAL CUTS: How does a tick bit can cause a red meat allergy? - An episode from our friends over at Science Friday, who had a recent conversation with the researcher who discovered the connection, decades ago. Support Radiolab by becoming a member today at Radiolab.org/donate. Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Episode metadata supplied by the publisher feed · Published Jul 24, 2026

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Tuck your napkin under your chin. We’re about to serve up a tale of love, loss, and lamb chops - with a side of genetic modification.

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Return of Alpha Gal

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