Reverse T3: Myths, Truths, and Clinical Insights | E46

Your patient's TSH looks perfect, but she still has every hypothyroid symptom in the book. Reverse T3 may offer an important clue, and many practitioners misread it.   In this episode of Functional Medicine for Real-World Impact, host Tracy Harrison breaks down reverse T3 thyroid myths that have split the clinical world into two camps. Conventional medicine often dismisses the marker as meaningless. Functional medicine often treats it as a villain to eliminate. Tracy thinks the truth sits closer to the middle, and she explains why.   She starts with the physiology most practitioners skip, how individual tissues make their own local decisions about T4-to-T3 conversion based on what they believe the body needs right now.   From there she debunks five specific myths, including why elevated reverse T3 is not automatically bad and what it may reveal about inflammation, stress, medication dosing, or recent illness.   Tracy also explains why chasing a single lab number and forcing it into the normal range can backfire on your patient.   The episode wraps with her recommended approach to functional medicine thyroid panel testing, including which antibody tests get skipped too often and how to interpret elevated reverse T3 within the larger clinical picture.   If you order thyroid labs for patients, this conversation changes how you read them.   Episode Breakdown: 00:00 Reverse T3 Myths That Divide Conventional and Functional Medicine 02:20 Thyroid Physiology and the HPATG Axis Explained 04:37 How Cells Convert T4 to T3 and Deactivate It 07:02 Myth 1 Is High rT3 Always Bad 09:21 What Elevated rT3 Signals About Medication, Inflammation, and Illness 11:46 Myth 2 Does rT3 Cause Hypothyroid Symptoms 14:07 Myth 3 Is rT3 a Reliable Stress Marker 16:28 D1, D2, and D3 Deiodinase Function Explained 18:56 Myth 4 Does rT3 Block Thyroid Hormone Receptors 21:21 Building a Full Thyroid Panel Beyond TSH 23:43 Checking rT3 With TPO and TG Thyroid Antibodies 25:57 Everyday Causes of Elevated rT3 Like Fasting and Calorie Restriction 28:19 Shifting From Protocol Thinking to Systems Optimization   SAFM Links: Take SAFM’s 10 CME course - The Essential Gut Deep Dive Get weekly Clinical Tips in your inbox  Learn more about SAFM’s practitioner training Subscribe to our YouTube channel Access quick clinical tips on Facebook  Podcast production and show notes provided by HiveCast.fm