Reversing Age with Science: Ryan Smith on Epigenetics, Peptides, and the Future of Longevity episode artwork

EPISODE · Jul 18, 2025 · 59 MIN

Reversing Age with Science: Ryan Smith on Epigenetics, Peptides, and the Future of Longevity

from Ageless and Timeless Podcast® · host Ageless and Timeless Podcast®

In this powerful return episode, Michele Hughes welcomes back Ryan Smith, founder and Chief Scientific Officer of TruDiagnostic. Formerly the CEO of Tailor Made Compounding, Ryan transitioned his focus from peptides to epigenetic science, becoming a leading force in the field of biological aging. This episode is a deep-dive tutorial on biological age testing, DNA methylation, and how epigenetics can give us control over the aging process.Ryan explains the difference between chronological and biological age, the power of DNA methylation data, and the cutting-edge technology behind TruDiagnostic’s comprehensive testing. Listeners will also learn about telomeres, organ-specific age reports, and the groundbreaking “Rejuvenation Olympics.” Michele shares her own test results and explores how these tools offer insight into one’s aging trajectory and risk factors for chronic disease.Whether you’re new to biohacking or a longevity enthusiast, this episode offers a front-row seat to the future of preventative health.🧬 Topics Covered:Ryan’s journey from medical school dropout to peptide pioneer and scientific directorWhat peptides and peptide bioregulators really areUnderstanding epigenetic clocks and why biological age matters more than chronologicalThe science of DNA methylation and how it measures gene expressionDifferences between traditional DNA tests and epigenetic testingWhy telomere testing is outdated and less predictiveWhat TruDiagnostic’s tests reveal—from organ system age to personalized healthspan insightsData-driven interventions for slowing and reversing agingHow TruDiagnostic’s “TrueHealth” report may soon replace traditional blood testsClinical trials, FDA approval pathways, and the future of aging diagnostics🔗 Learn More & Order a Test:Visit www.trudiagnostic.com and use code AGELESS20 for 20% off.Connect with Ryan Smith on LinkedIn for more insights and research updates.Medical Disclaimer – Ageless and Timeless PodcastAgeless and Timeless (the “Show”), along with its host and guests, shares insights and discussions on health, wellness, and longevity for informational and educational purposes only. The Show does not provide medical advice, diagnoses, treatments, cures, or preventative recommendations for any disease or health condition. The content shared should not be used as a substitute for professional medical advice, diagnosis, or treatment.While we strive to feature reputable sources and knowledgeable guests, neither Ageless and Timeless nor its host or affiliates assume responsibility for errors, omissions, or misinterpretations in the information provided. Listeners are encouraged to use their own discretion and consult with a licensed medical professional before making any health-related decisions. By listening to this podcast, you acknowledge that any actions you take based on the information presented are at your own risk, and Ageless and Timeless, its host, guests, and affiliates are not liable for any direct, indirect, incidental, or consequential damages resulting from the use of this content.

In this powerful return episode, Michele Hughes welcomes back Ryan Smith, founder and Chief Scientific Officer of TruDiagnostic. Formerly the CEO of Tailor Made Compounding, Ryan transitioned his focus from peptides to epigenetic science, becoming a leading force in the field of biological aging. This episode is a deep-dive tutorial on biological age testing, DNA methylation, and how epigenetics can give us control over the aging process.Ryan explains the difference between chronological and biological age, the power of DNA methylation data, and the cutting-edge technology behind TruDiagnostic’s comprehensive testing. Listeners will also learn about telomeres, organ-specific age reports, and the groundbreaking “Rejuvenation Olympics.” Michele shares her own test results and explores how these tools offer insight into one’s aging trajectory and risk factors for chronic disease.Whether you’re new to biohacking or a longevity enthusiast, this episode offers a front-row seat to the future of preventative health.🧬 Topics Covered:Ryan’s journey from medical school dropout to peptide pioneer and scientific directorWhat peptides and peptide bioregulators really areUnderstanding epigenetic clocks and why biological age matters more than chronologicalThe science of DNA methylation and how it measures gene expressionDifferences between traditional DNA tests and epigenetic testingWhy telomere testing is outdated and less predictiveWhat TruDiagnostic’s tests reveal—from organ system age to personalized healthspan insightsData-driven interventions for slowing and reversing agingHow TruDiagnostic’s “TrueHealth” report may soon replace traditional blood testsClinical trials, FDA approval pathways, and the future of aging diagnostics🔗 Learn More & Order a Test:Visit www.trudiagnostic.com and use code AGELESS20 for 20% off.Connect with Ryan Smith on LinkedIn for more insights and research updates.Medical Disclaimer – Ageless and Timeless PodcastAgeless and Timeless (the “Show”), along with its host and guests, shares insights and discussions on health, wellness, and longevity for informational and educational purposes only. The Show does not provide medical advice, diagnoses, treatments, cures, or preventative recommendations for any disease or health condition. The content shared should not be used as a substitute for professional medical advice, diagnosis, or treatment.While we strive to feature reputable sources and knowledgeable guests, neither Ageless and Timeless nor its host or affiliates assume responsibility for errors, omissions, or misinterpretations in the information provided. Listeners are encouraged to use their own discretion and consult with a licensed medical professional before making any health-related decisions. By listening to this podcast, you acknowledge that any actions you take based on the information presented are at your own risk, and Ageless and Timeless, its host, guests, and affiliates are not liable for any direct, indirect, incidental, or consequential damages resulting from the use of this content.

NOW PLAYING

Reversing Age with Science: Ryan Smith on Epigenetics, Peptides, and the Future of Longevity

0:00 59:39

No transcript for this episode yet

We transcribe on demand. Request one and we'll notify you when it's ready — usually under 10 minutes.

Big Old Life: Heather Blackbird interviews people on planet earth. Heather Blackbird loves asking questions. This podcast is a learning experience. Join me, Heather Blackbird, as I talk to people about their lives. Frequency of new episodes is a little all over the place and I'm learning as I go. Big Old Life is a small way of talking about the vastness of life, one person at a time. If you are reading this or found this podcast it's probably because someone you know gave you a link to it. :) Explicit Tales Of A Superstar DJ The Insomniac Spun seemingly out of nowhere from her complacent life in the corporate world, turned seemingly overnight from 16-Hour shift work and into the life of a literally starving artist and working musician, The Protagonist navigates her supposed rise to fame and superstardom on a journey through spiritual awakening, coming-of-age, and intimate self-realization--guided by an omnipresent force and equipped with the power of love, magic, and music. {Enter The Multiverse.} [The Festival Project] The Festival Project, Inc.™ is a multidimensional multimedia platform which encompasses exploratory and artistic social personifications and expressions on cosmic theory, spirituality, growth, health & wellness, philosophy and theoretic dynamics in entertainment such as music, design, film, television, radio, dance and festival culture, art, fashion, literature, and science. The Festival Project™ and its subsidiary Non-Profit, The Collective Complex © aims to challenge modern artistic and philosop Explicit Bitcoin Is Dead Trey Carson Welcome to Bitcoin is Dead, the ultimate Bitcoin variety show where host Trey takes you on a journey through the ever-evolving world of Bitcoin. Each episode brings new personalities, fascinating locations, and insightful conversations with politicians, educators, and innovators shaping the future of Bitcoin. Whether you're a seasoned Bitcoiner or just starting your journey, tune in for thought-provoking discussions, unique perspectives, and a deep dive into the ideas and people driving the Bitcoin revolution. Explicit The Sacred +Profane Podcast nephtaragrace The Sacred + Profane Podcast is a provocative conversation dedicated to cementing a better future for all. We specialize in unpacking the nuances of what is considered sacred and profane, particularly focusing on sex, death, and all that pertains to the circle of life. Our aim in focusing on such ”taboo” subject matter is to demystify what is unconscious, bring to light what has been known for centuries as ”the occult,” and empower the rapid transformation that is occurring on the Planet. Explicit

Frequently Asked Questions

How long is this episode of Ageless and Timeless Podcast®?

This episode is 59 minutes long.

When was this Ageless and Timeless Podcast® episode published?

This episode was published on July 18, 2025.

What is this episode about?

In this powerful return episode, Michele Hughes welcomes back Ryan Smith, founder and Chief Scientific Officer of TruDiagnostic. Formerly the CEO of Tailor Made Compounding, Ryan transitioned his focus from peptides to epigenetic science, becoming a...

Is there a transcript available for this episode?

Yes, a full transcript is available for this episode. You can read the complete transcript on the episode page.

Can I download this Ageless and Timeless Podcast® episode?

Yes, you can download this episode by clicking the download button on the episode player, or subscribe to the podcast in your preferred podcast app for automatic downloads.
URL copied to clipboard!