Reviving Vancomycin to Fight Superbugs | Science News

Scientists have revived a powerful old antibiotic, vancomycin, by pairing it with a small molecule called pghi-four that blocks a key bacterial enzyme responsible for resistance. This breakthrough, led by Professor John Moses, could make existing drugs effective again against superbugs like drug-resistant E. faecium — without needing to invent new antibiotics. Using a novel chemical method called diversity oriented clicking, they screened over 150 compounds and found pghi-four’s ability to shut down SagA, restoring vancomycin’s power. The strategy offers a promising blueprint for tackling antibiotic resistance by enhancing current drugs, not just creating new ones. Listen in comfort:Get a discount on a Soli Pillow: http://solipillow.com/discount/dnn. Advertise on DNN:[email protected] This is an automated, high-level news summary based on public reporting.Report issues to [email protected]. View sources & latest updates:https://sources.thednn.ai/0839278be97d0053