Rewriting the Clinical Trial Paradigm | $500m Paradigm Health Co-Founder Jonathan Hirsch

Today we speak with Jonathan, co-founder of Paradigm Health, a startup which has raised over $350m+ to is build the infrastructure behind clinical trials in order to make them quicker and more accessible.Jonathan walks us through his path from a UChicago neuroscience lab to dropping out of Stanford to launch CyApps, one of the earliest precision medicine companies. We dig into why US trial capacity is fundamentally broken — why oncology needs three times the current bandwidth, why studies are moving to China, and why providers (not patients) are the real recruitment bottleneck. Jonathan breaks down Paradigm's playbook across trial design, site selection, LLM-native patient matching, and real-time data collection, and how they "hacked" the cold start problem through aggressive fundraising and acquisitions like Flatiron's clinical research unit. We close on what keeps him up at night: the risk of the US losing its edge in clinical innovation, and the AI wave he believes can help us win it back.