RhAPPcast: Beyond the Joint: Uncontrolled Gout as a Systemic Disease

In this episode of RhAPPcast, the official podcast of Rheumatology Advanced Practice Providers, host Amanda Mixon is joined by RhAPP board member Wendy Simmons to explore uncontrolled gout as a systemic inflammatory disease with effects that extend far beyond acute joint pain. The discussion examines how persistent hyperuricemia can lead to monosodium urate crystal deposition, ongoing inflammation, tophi, bone erosion, cartilage damage, tendon complications, and progressive musculoskeletal impairment. Amanda and Wendy also review the connection between uncontrolled gout and common comorbidities, including cardiovascular disease, chronic kidney disease, hypertension, diabetes, obesity, atrial fibrillation, and heart failure. Listeners will gain practical insights into recognizing silent gout progression, assessing uric acid levels and organ function, identifying patients at risk for long-term systemic complications, and coordinating care across rheumatology, primary care, cardiology, and nephrology. The episode also highlights the importance of regular follow-up, patient education, treat-to-target strategies, and individualized gout management. For more rheumatology podcasts, clinical updates, and educational resources designed for advanced practice providers, visit the RhAPP Content Rheum or access education through the RhAPP ACE mobile app.