RNA Language Models Uncover IRES Structure
from The Dish
Albatross, an RNA language model trained purely on ~50K picornaviral sequences without structural labels, predicts IRES secondary structures with median precision 0.80 versus 0.47 for state-of-the-art thermodynamic/comparative-genomics tools — discovering a novel Type II IRES subclass and showing Type V IRESes outperform the field-standard EMCV IRES ~2-fold across all cell types. Hosted by Theo & Dr. Mara.
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