RSV vs. rhinovirus bronchiolitis: difference in nasal airway microRNA profiles and NFκB signaling

There are approximately 130,000 infants hospitalised each year in the US due to bronchiolitis. The majority of these cases are caused by either rhinovirus or respiratory syncytial virus (RSV). Rhinovirus is associated with increased risks of acute and chronic respiratory outcomes compared with RSV, however the underlying mechanisms remain unclear. In this episode, Kohei Hasegawa from the department of emergency medicine at the Massachusetts General Hospital, discusses his recent experiment aimed at unravelling the underlying mechanisms between the two viruses' different outcomes by comparing the nasal airway microRNA profiles of infants infected with either virus. Related article - https://www.nature.com/pr/journal/vaop/ncurrent/full/pr2017309a.html