S.2, Ep. 2 | Biological Age vs. Chronological Age: Are You Aging Faster Than You Should?

Explore the cutting-edge science of aging, including biological age testing, Yamanaka factors, and hormesis, and learn how to apply these insights to extend health span.Key TopicsBiological age vs chronological ageEpigenetic clocks and DNA methylationYamanaka factors and cellular reprogrammingHormesis and controlled stressProactive longevity strategiesChapters00:00 Understanding Biological vs. Chronological Age05:05 The Importance of Biological Age Testing18:11 Exploring Yamanaka Factors23:15 The Concept of Hormesis28:06 Strategies for Longevity and Health Optimization Resources/LinksDunedinPACE DNA methylation biomarkerDunedinPACE showed strong reliability and associations with morbidity, disability, and mortality.https://pmc.ncbi.nlm.nih.gov/articles/PMC8853656/?utm_source=chatgpt.comDunedinPACE overview from Duke’s Moffitt & Caspi LabDescribes DunedinPACE as a “speedometer” for pace of aging.https://moffittcaspi.trinity.duke.edu/dunedinpace?utm_source=chatgpt.comCritical review: Do we actually need aging clocks?Useful for adding balance and discussing limitations of biological age testing.https://www.nature.com/articles/s41514-025-00312-2?utm_source=chatgpt.comPartial reprogramming / Yamanaka Factors reviewDiscusses promise and complexity of reprogramming-induced rejuvenation.https://www.nature.com/articles/s41467-024-46020-5?utm_source=chatgpt.comGene therapy-mediated partial reprogramming reviewCovers OSK/OSKM partial reprogramming and age-related functional restoration in preclinical models.https://pmc.ncbi.nlm.nih.gov/articles/PMC10909732/?utm_source=chatgpt.comCold water therapy and hormesis reviewDiscusses cold exposure as a possible mild stressor and hormetic adaptation, with caution about evidence gaps.https://pmc.ncbi.nlm.nih.gov/articles/PMC11872954/?utm_source=chatgpt.comSauna and hormesis overviewUseful for discussing heat exposure as a controlled stressor that may support protective adaptation.https://www.foundmyfitness.com/topics/sauna?utm_source=chatgpt.com Guest LinksFacebook - www.Facebook.com/ thelongevitygamepodcast Instagram - www.instagram.com/thelongevitygamepodcastWebsite - https://nextleveltrt.comFor Contact, Sponsorship, Press, Support:*Have a question or concern about a topic or particular [email protected]*Interested in being a guest on the show? [email protected]*Interested in supporting/sponsoring the [email protected]