S01E07 Automated Ventilation vs Human Experts in ACTiVE

Confidence: High (study-specific details reflect only the uploaded JAMA RCT + editorial; no added claims.)Spotify Episode DescriptionA ventilator that adjusts support automatically sounds like the future—but does it improve outcomes patients actually feel? In this PRISM Rounds journal club, two hosts break down the ACTiVE randomized clinical trial comparing closed-loop INTELLiVENT-ASV vs protocolized conventional mechanical ventilation across 7 ICUs in the Netherlands and Switzerland. We walk through the study design (including deferred consent and a very strong “best-practice” control arm), the primary endpoint (ventilator-free days at day 28), key secondary outcomes (including mortality), and what the accompanying editorial argues about case mix, generalizability, and whether we’re ready for “autopilot ventilation.”For education only — not medical advice. Always follow your local protocols and clinical judgment.LinksACTiVE Trial (JAMA): https://doi.org/10.1001/jama.2025.24384Editorial (JAMA): https://doi.org/10.1001/jama.2025.24401ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT04593810Tagscritical care, ICU, mechanical ventilation, ventilator management, closed-loop ventilation, INTELLiVENT-ASV, adaptive support ventilation, weaning, spontaneous breathing trial, ventilator-free days, randomized trial, JAMA, journal club, respiratory therapy, sedation, analgosedation, evidence-based medicine, clinical trials, pulmonary critical care, PRISM Rounds