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S01E30 | Inhaled GM-CSF for PAP — Is This the End of Whole-Lung Lavage? episode artwork

EPISODE · Mar 27, 2026 · 25 MIN

S01E30 | Inhaled GM-CSF for PAP — Is This the End of Whole-Lung Lavage?

from PRISM Rounds: Pulmonary, Critical Care & Sleep Medicine

In this episode of PRISM Rounds, we review the NEJM IMPALA-2 trial evaluating inhaled molgramostim for autoimmune pulmonary alveolar proteinosis (PAP).This phase 3 randomized trial showed improved pulmonary gas transfer (DLCO) and quality of life with inhaled GM-CSF compared to placebo, with a favorable safety profile. We break down the pathophysiology, trial design, and what this means for moving beyond whole-lung lavage in PAP.Article:https://pubmed.ncbi.nlm.nih.gov/40834301/Editorial:https://pubmed.ncbi.nlm.nih.gov/40834306/Tags:#CriticalCare #Pulmonary #ICU #FOAMed #MedEd #MedicalPodcast #PRISMRounds #NEJM #ClinicalTrials #EvidenceBasedMedicine #PAP #PulmonaryAlveolarProteinosis #GMCSF #Molgramostim #RareDisease #RespiratoryMedicine #ICUEducation #MedTwitter #HealthcareEducation #JournalClub

What this episode covers

In this episode of PRISM Rounds, we review the NEJM IMPALA-2 trial evaluating inhaled molgramostim for autoimmune pulmonary alveolar proteinosis (PAP).This phase 3 randomized trial showed improved pulmonary gas transfer (DLCO) and quality of life with inhaled GM-CSF compared to placebo, with a favorable safety profile. We break down the pathophysiology, trial design, and what this means for moving beyond whole-lung lavage in PAP.Article:https://pubmed.ncbi.nlm.nih.gov/40834301/Editorial:https://pubmed.ncbi.nlm.nih.gov/40834306/Tags:#CriticalCare #Pulmonary #ICU #FOAMed #MedEd #MedicalPodcast #PRISMRounds #NEJM #ClinicalTrials #EvidenceBasedMedicine #PAP #PulmonaryAlveolarProteinosis #GMCSF #Molgramostim #RareDisease #RespiratoryMedicine #ICUEducation #MedTwitter #HealthcareEducation #JournalClub

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S01E30 | Inhaled GM-CSF for PAP — Is This the End of Whole-Lung Lavage?

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Frequently Asked Questions

How long is this episode of PRISM Rounds: Pulmonary, Critical Care & Sleep Medicine?

This episode is 25 minutes long.

When was this PRISM Rounds: Pulmonary, Critical Care & Sleep Medicine episode published?

This episode was published on March 27, 2026.

What is this episode about?

In this episode of PRISM Rounds, we review the NEJM IMPALA-2 trial evaluating inhaled molgramostim for autoimmune pulmonary alveolar proteinosis (PAP).This phase 3 randomized trial showed improved pulmonary gas transfer (DLCO) and quality of life...

Can I download this PRISM Rounds: Pulmonary, Critical Care & Sleep Medicine episode?

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