S1.E10: Hot Tub Flow Time Machine

from Pharm to Table · host LC Campeau, Dani Schultz

For the 10th, and final course of season 1, Dani and LC jump in the hot tub flow time machine with Cecilia Bottecchia and Francois Levesque, co-recipient of the Peter Dunn Green Chemistry Award, and learn how to discover, develop and scale-up a photobromination in flow! But don't let this deceptively simple bromination fool you - this reaction turned out to be a full course meal of challenges! We go into all aspects of the reaction, including: 1) Why they decided to use light vs AIBN to facilitate this reaction; 2) How to design a photoreactor you can use on kilo scale; 3) How to design a robust reaction that can run on >50kg scale; 4) What does hot tub chemistry have to do with a radical bromination reaction.  Read the paper we discussed today here: A Continuous Flow Visible-Light-Induced Benzylic Bromination - Organic Process Research and Development Elucidation of Reaction Mechanisms Using In Situ LED-NMR - Journal of Organic Chemistry Design of a Kilogram Scale, Plug Flow Photoreactor Enabled by High Power LEDs - Organic Process Research and Development Follow Cecilia Bottecchia - @cecibottecchia Follow the Pharm to Table podcast on Twitter - @PharmtoTablePod Visit our website at https://anchor.fm/pharm-to-table

Episode metadata supplied by the publisher feed · Published Jul 1, 2022

What this episode covers

For the 10th, and final course of season 1, Dani and LC jump in the hot tub flow time machine with Cecilia Bottecchia and Francois Levesque, co-recipient of the Peter Dunn Green Chemistry Award, and learn how to discover, develop and scale-up a photobromination in flow! But don't let this deceptively simple bromination fool you - this reaction turned out to be a full course meal of challenges! We go into all aspects of the reaction, including: 1) Why they decided to use light vs AIBN to facilitate this reaction; 2) How to design a photoreactor you can use on kilo scale; 3) How to design a robust reaction that can run on >50kg scale; 4) What does hot tub chemistry have to do with a radical bromination reaction. Read the paper we discussed today here: A Continuous Flow Visible-Light-Induced Benzylic Bromination - Organic Process Research and Development Elucidation of Reaction Mechanisms Using In Situ LED-NMR - Journal of Organic Chemistry Design of a Kilogram Scale, Plug Flow Photoreactor Enabled by High Power LEDs - Organic Process Research and Development Follow Cecilia Bottecchia - @cecibottecchia Follow the Pharm to Table podcast on Twitter - @PharmtoTablePod Visit our website at https://anchor.fm/pharm-to-table

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