S15 Ep42: Long-Term Epcoritamab Data Show Durable Responses and Confirmed Safety in LBCL: With Tycel Phillips, MD

In today’s episode, our discussion features Tycel Phillips, MD. Dr Phillips is an associate professor in the Department of Hematology and Hematopoietic Cell Transplantation in the Division of Lymphoma at City of Hope in Duarte, California.In our exclusive interview, Dr Phillips discussed updated efficacy and safety data from the phase 2 EPCORE NHL-1 trial (NCT03625037) investigating epcoritamab-bysp (Epkinly) monotherapy in patients with relapsed/refractory large B-cell lymphoma (LBCL). He noted that the data, which were presented at the 2025 ASH Annual Meeting, showed that several patients remained in response beyond 4 years, and that no new major safety signals were reported. Overall, he highlighted that the trial findings continue to support the use of epcoritamab as a third-line, potentially curative option for patients with LBCL. He also spotlighted the promise of synergistic polatuzumab vedotin-piiq (Polivy)–based combinations in the management of non-Hodgkin lymphoma.