S1E28: SOHO Trial — HFNC vs Standard Oxygen in AHRF

from PRISM Rounds: Pulmonary, Critical Care & Sleep Medicine

We break down the 2026 NEJM SOHO trial: high-flow nasal oxygen did not improve 28-day mortality, but it did modestly reduce intubation in acute hypoxemic respiratory failure. We also unpack the NEJM editorial on why mortality may be the wrong endpoint for this kind of ICU support strategy.Trial: https://pubmed.ncbi.nlm.nih.gov/41841715/Editorial: https://pubmed.ncbi.nlm.nih.gov/41841707/Tags#FOAMed #FOAMcc #CriticalCare #ICU #PulmCCM #EmergencyMedicine #RespiratoryFailure #HFNC #HighFlowNasalCannula #AHRF #ARDS #Intubation #MechanicalVentilation #NEJM #JournalClub #MedEd #EvidenceBasedMedicine #EMCrit #RespiratoryCare #AirwayManagement

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This episode was published on March 18, 2026.

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