S2E21: Dr. Dale Bredesen - How to Prevent and Reverse Alzheimer's Disease

Dr. Dale Bredesen earned his MD from Duke University Medical Center and served as Chief Resident in Neurology at the University of California, San Francisco (UCSF), before joining Nobel laureate Stanley Prusiner's laboratory at UCSF as an NIH Postdoctoral Fellow. He held faculty positions at UCSF, UCLA, and the University of California, San Diego. Dr. Bredesen also directed the Program on Aging at the Burnham Institute before joining the Buck Institute in 1998 as founding President and CEO.   He's also the author of three books, The End of Alzheimer's, The End of Alzheimer's Program, and The First Survivors of Alzheimer's, and his research explores previously uncharted territory in explaining the physical mechanism behind the erosion of memory seen in Alzheimer's disease, which has opened the door to new treatments.   In this episode, Dr. Bredesen discusses the latest updates in Alzheimer's research, how inflammation, your genes, and your lifestyle play a role in developing Alzheimer's, the importance of undergoing a cognoscopy, and more.   Dr. Bredesen also shares what to do if you test positive for Alzheimer's genes, how to prevent Alzheimer's, ketosis for Alzheimer's treatment and prevention, and other ways you can reduce your risks.   Here's a peek at what's in store in this episode: 03:50 What's going on with the latest shake up in Alzheimer's research? 09:48 The possible root causes of Alzheimer's 11:54 How inflammation plays a role in neurodegenerative diseases  14:41 Is Alzheimer's affected more by your genes or your lifestyle? 16:26 How to tell if you are at risk for developing neurodegenerative diseases like Alzheimer's 17:25 The importance of going for a cognoscopy 19:17 Are more people carrying genes for Alzheimer's now compared to 100 years ago? 23:00 What happens if you do test positive for Alzheimer's genes? 29:26 How your exposure to microorganisms contributes to how you'll fare 33:27 Is there an amount of exposure that is hormetic and offers a benefit or is it all degenerative? 36:07 Using ketosis for Alzheimer's prevention and treatment 38:11 What ketones provide that make them so beneficial for Alzheimer's treatment 41:15 Is there a specific degree of ketosis that needs to be met to reach these therapeutic benefits? 43:48 Reducing inflammation and the role glutathione plays here 45:52 Dr. Bredesen's PreCODE and ReCODE programs 51:31 Is there a point in Alzheimer's treatment where it's too late to reverse the damage? 54:32 The four stages of Alzheimer's and the financial impact of each 57:21 Improving brain fog and cognitive performance 01:00:03 Dr. Bredesen's books and programs   Resources mentioned in this episode: Dr. Dale Bredesen's website Dr. Bredesen's Twitter, Facebook, and Instagram Dr. Bredesen's books, The End of Alzheimer's, The End of Alzheimer's Program, and The First Survivors of Alzheimer's Cognoscopy Dr. Bredesen's PreCODE and ReCODE programs