S2E6 Wenbiao Gan - The role of sleep in synapse formation and elimination

In this episode, we talk to Professor Wenbiao Gan from the Neuroscience and Physiology and Skirball Institute at New York University School of Medicine.Professor Gan tells us about how he started to become interested in studying sleep and its impact on learning and memory.He talks about intriguing and hands-on ways to assess the formation and elimination of dendritic spines in  the mouse cortex, and how different experimental tasks like running backwards on a treadmill influence spine formation with or without sleep. Some counterintuitive results are presented and Professor Gan also shares his perspective on the synaptic homeostasis hypothesis.In the end, Professor Gan gives some thoughts about the future of sleep research and suggests new methods of improvement in the area.If you would like to find out more, here is a link to Professor Gan's full list of publications:Links to  the studies mentioned in the podcast:REM sleep promotes experience-dependent dendritic spine elimination in the mouse cortexFear extinction reverses dendritic spine formation induced by fear conditioning in the mouse auditory cortexREM sleep selectively prunes and maintains new synapses in development and learningExperience‐dependent plasticity of dendritic spines of layer 2/3 pyramidal neurons in the mouse cortexTwo-photon microscopy as a tool to investigate the therapeutic time window of methylprednisolone in a mouse spinal cord injury modelSleep contributes to dendritic spine formation and elimination in the developing mouse somatosensory cortexGlossary of terms (synaptic) pruning = a natural phase in the development of the nervous system during which connections between neurons that are no longer needed die off dendrites = tree-like extensions of the neuron dendritic spines = extensions of a dendrite that help receive information from other neuronssynaptic homeostasis = the idea that neural synapses cannot keep strengthening forever.  Instead, they must also downscale at some point in order to make space for further strengthening.  Such downscaling can be done in a relative manner that preserves information coded by the synapses in question.  Episode produced by Bianca Strete and Sophie Smith Check out our NaPS website to find out more about the podcast, our research and events. This recording is the property of the Sleep Science Podcast and not for resale.