S2E9: Breakthroughs: Cell and Gene Based Therapies

In this episode, we break down what cell and gene-based therapies are and how they’re shaping the future of IBD treatment. From engineered regulatory T-cells to CRISPR-edited genes, these emerging approaches aim to restore immune balance without the broad side effects of traditional treatments. This is such a breakthrough for IBD patients! Be ready to learn and feel the hope :)Also, follow us on instagram at @ibdiditpodcast and comment more ideas; we would love to hear from you!Here are all the sources- go check it out! “AstraZeneca Enters Agreement with Quell Therapeutics to Develop Autologous Treg Cell Therapies for Autoimmune Diseases.” AstraZeneca, 13 June 2023,⁠ https://www.astrazeneca.com/media-centre/press-releases/2023/astrazeneca-agreement-with-quell-therapeutics.html⁠.Barnes, Emma L., et al. “Emerging Therapies and Gene Editing in the Management of Autoimmune Disease.” Cell Reports Medicine, vol. 4, no. 9, 2023,⁠ https://www.sciencedirect.com/science/article/pii/S2372770523000621⁠.“CRISPR-Cas9 Gene Editing: Revolutionizing Autoimmune Disease Treatment.” Autoimmune Institute,⁠ https://www.autoimmuneinstitute.org/articles/crispr-cas9-gene-editing-revolutionizing-autoimmune-disease-treatment/⁠.“Major Cause of Inflammatory Bowel Disease Discovered.” Francis Crick Institute, 5 June 2024,⁠ https://www.crick.ac.uk/news-and-reports/2024-06-05_major-cause-of-inflammatory-bowel-disease-discovered⁠.“New Research Discovery Could Change Future of IBD Treatment.” HealthCentral,⁠ https://www.healthcentral.com/news/crohns-disease/new-research-discovery-could-change-future-of-ibd-treatment⁠.“OP22 A Phase 1/2 Study of AZD0466 Monotherapy or in Combination with Anti-TNF in Patients with Moderate-to-Severe Ulcerative Colitis.” Journal of Crohn's and Colitis, vol. 19, Supplement_1, 2025, p. i447,⁠ https://academic.oup.com/ecco-jcc/article/19/Supplement_1/i447/7967034⁠.“Quell Therapeutics Achieves Key Milestone in Its CAR-Treg Cell Therapy Program for Inflammatory Bowel Disease.” GlobeNewswire, 10 June 2025,⁠ https://www.globenewswire.com/news-release/2025/06/10/3096491/0/en/Quell-Therapeutics-Achieves-Key-Milestone-in-its-CAR-Treg-Cell-Therapy-Program-for-Inflammatory-Bowel-Disease.html⁠.