S2Ep9: What’s in the Box: the making of a damn fine vaccine

This episode looks at two papers, one a 2019 paper by Hassett et al. about optimizing Lipid Nanoparticles specifically for intramuscular mRNA vaccines. And a second, Laczko et al., from 2020, that shows what kind of immune responses you can get from nucleoside-modified mRNA-LNP after a single shot in mice. Together, these explain why mRNA vaccines aren’t just ‘RNA magic.’ They’re a delivery story, and an immune-programming story.