S3-E43.2 - Finding the Right Combinations in NASH Therapy

Send us Fan MailNaim opens this conversation with his hope for finding eventual combination therapies that begin to realize a cure for NASH in some patients. In particular, he is encouraged to see so many patients achieve greater than 30% relative fat reduction in such a short study. Louise notes that the ability to show patients “real-world results” quickly will motivate them to maintain therapy and lifestyle modification.The discussion shifts to the inclusion of NITs in these combination therapies, and the need for sound pricing strategies. Naim proposes a 6-month “futility” standard: if the drug does not provide results in 6 months, discontinue. Roger notes the importance of combination therapy in a disease that has so many theoretical target points and pathways within the liver.