S6E20｜从新冠大流行中崛起的 mRNA - What's Next｜科技早知道

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自新冠大流行爆发以来，关于 mRNA 的快速普及和安全争议从未中断。直到今天，仍有不少人好奇，mRNA 为什么会成为解决全球新冠疫情最重要的技术手段。本期节目，「科技早知道」串台「Pfizer Express」，邀请辉瑞的疫苗专家梁家鑫做客，探讨 mRNA 的工作原理和过去三年中的成长轨迹，试图找出未来有哪些全新场景会看到 mRNA 的落地。风险提示：节目内容仅作学术讨论，嘉宾推荐读物及学术分享仅为嘉宾个人观点。本期人物 Nina，辉瑞雇主品牌和校园招聘负责人家鑫，辉瑞医学部医学事务经理刘灿，「科技早知道」监制主要话题 [01:16] mRNA 疫苗安全吗？ [07:18] mRNA 发展中最重要的几个时间节点？ [16:18] 冷链技术是关键？mRNA最大的优势是？ [22:32] mRNA的最新进展？ [36:16] 除了新冠，mRNA 还能解决什么？什么是治疗性疫苗？延伸阅读 Nature 上发表的关于 mRNA 技术发展历史：The tangled history of mRNA vaccines Nature 上发表的关于 mRNA疫苗的综述：mRNA vaccines — a new era in vaccinology mRNA（Messager RNA）：信使 RNA，由DNA转录而来，携带遗传信息，1961 年被首次发现，1984 年科学家 Paul Krieg 和 Douglas Melton 在实验室完成了人工合成 mRNA；1995 年 Drew Weissman 和 Katalin Karikó 发现经过修饰的 mRNA 可以逃逸人体的免疫反应；2019 年 mRNA 疫苗作为一种核酸药物被广泛应用在新冠大流行的预防中。核苷酸（nucleotide）：DNA 和 RNA 的基本组成单位，由含氮碱基、糖（核糖或脱氧核糖）、磷酸基团组成；部分单核苷酸会参与能量代谢过程；mRNA疫苗研发中的一个重要环节就是对 mRNA进行修饰，由尿苷异构化所产生的假尿嘧啶核苷（Pseudouridine，PD）是其中一类修饰。纳米脂质粒（Lipid Nanoparticles）：缩写为 LNPs，一种给药途径；在 mRNA 新冠疫苗开发中，就是通过由脂质构成的纳米颗粒包裹在 mRNA 外面，帮助 mRNA 顺利进入人体细胞，解决 mRNA 递送不稳定的问题。幕后制作监制：刘灿后期：Luke，敬文运营：Yao，Yongxin，Bella，Fiona 设计：饭团关于节目原「硅谷早知道」，全新改版后为「What's Next｜科技早知道」。放眼全球，聚焦科技发展，关注商业格局变化。关于我们声动活泼的宗旨是「用声音碰撞世界」，致力于为人们提供源源不断的思考养料。我们还有这些播客：声东击西、声动早咖啡、反潮流俱乐部、泡腾 VC、商业WHY酱、跳进兔子洞欢迎在即刻、微博等社交媒体上与我们互动，搜索声动活泼即可找到我们期待你给我们写邮件，邮箱地址是：[email protected] 如果你喜欢我们的节目，欢迎打赏支持或把我们的节目推荐给一两位朋友

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How long is this episode of What's Next｜科技早知道?

This episode is 42 minutes long.

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This episode was published on June 29, 2022.

What is this episode about?

自新冠大流行爆发以来，关于 mRNA 的快速普及和安全争议从未中断。直到今天，仍有不少人好奇，mRNA 为什么会成为解决全球新冠疫情最重要的技术手段。本期节目，「科技早知道」串台「Pfizer Express」，邀请辉瑞的疫苗专家梁家鑫做客，探讨 mRNA 的工作原理和过去三年中的成长轨迹，试图找出未来有哪些全新场景会看到 mRNA 的落地。风险提示：节目内容仅作学术讨论，嘉宾推荐读物及学术分享仅为嘉宾个人观点。本期人物 Nina，辉瑞雇主品牌和校园招聘负责人家鑫，辉瑞医学部...

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