Saccharomyces boulardii Explained: The Probiotic That Protects Your Gut

***Correction*** - The CNCM I-745 strain of Saccharomyces boulardii is currently only sold by Florastar. This is the most studied strain of Saccharomyces boulardii. I've also tried brands such as Jarrow and Pure, and they've worked well, but the majority of the research supports the CNCM I-745 strain. In the podcast, I mentioned that most of the strains are this CNCM I-745 strain, but that was factually incorrect.  What if a simple yeast, scraped from the peel of tropical fruit during a cholera epidemic, could change the way we protect our microbiome?  In the 1920s, French microbiologist Henri Boulard stumbled upon a probiotic unlike any other. Saccharomyces boulardii isn’t a bacteria, but a hardy yeast that survives heat, stomach acid, and bile. Today, it’s one of the best-studied tools for preventing antibiotic-associated diarrhea, treating traveler’s diarrhea, and protecting gut health when illness strikes.  In this episode of Tribulations, Dr. Ravi Kumar takes you on a journey that weaves history, science, and practical medicine. You’ll discover: The remarkable story of how Boulard’s curiosity led him from alcohol fermentation to a lifesaving probiotic during a cholera outbreak.Why Saccharomyces boulardii acts as a “shepherd” in the gut, preserving balance while pushing back against harmful bacteria.Clinical trial evidence showing its effectiveness against antibiotic-associated diarrhea, traveler’s diarrhea, and recurrent C. difficile infection.Practical dosing strategies for adults and children—when to use it, how long to continue, and important safety caveats.Why a $15 supplement sometimes outperforms prescriptions in protecting your microbiome.It’s a story of serendipity, science, and a forgotten yeast that still holds lessons for modern medicine. For references: drkumardiscovery.com/podcast Stay Connected Podcast signup: drkumardiscovery.com/podcast-signup Instagram: @thedrkumardiscovery Facebook: The Dr Kumar Discovery