Saffron: A spice that outperformed Prozac in head-to-head clinical trials

30mg/day of saffron extract showed comparable efficacy to fluoxetine (Prozac) and imipramine in multiple randomized, double-blind clinical trials for mild-to-moderate depression. A $10,000/kg spice, at 30mg per dose, costs ~$0.30/dose and matched a blockbuster pharmaceutical. The evidence quality is remarkably high relative to the number of studies.Publications of interest:https://pubmed.ncbi.nlm.nih.gov/15707766/https://pubmed.ncbi.nlm.nih.gov/27595298/https://pmc.ncbi.nlm.nih.gov/articles/PMC4643654/