Same Body, Different Codes

What this episode covers

This release contains only the music track from Base by Base Episode 94. Song title: Same Body, Different CodesOriginal Base by Base episode: 94: Intraindividual epigenetic heterogeneity in advanced prostate cancer Article metadata:Article title: Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancerJournal: Nature CommunicationsDOI: 10.1038/s41467-025-60654-zReference: Mizuno K., Ku S-Y., Venkadakrishnan VB., et al. Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer. Nature Communications (2025). DOI: https://doi.org/10.1038/s41467-025-60654-z Lyrics:Verse 1One patient, many shadows on the scanSame name on the chart, different plansQuiet switches in the methylation lightLineage stories changing overnight Pre-ChorusMarks on the genome, drifting like smokeA surface flag can vanish as a jokeIf we don’t look close, we miss the signRight target, wrong time ChorusSame body, different codesDifferent keys in different roadsRead the silence, read the glowFind the door before it closesSame body, different codesBut we learn where the signal goesMap the marks, then choose the shotHit what’s there, not what we thought Verse 2Across the spread, some patterns still alignBut one site whispers, “I’m not your kind”AR goes dim, ASCL1 takes the stageNew masks turning with the page BridgeDouble-negative, split in twoOne with BMP4 breaking throughOne immune-lit, sharp and wideWe trace the links we can’t denyAnd when the pathway starts to shoutWe dial it down and test it out Final ChorusSame body, different codesDifferent storms in different nodesRead the silence, read the glowBring the therapy where it goesSame body, different codesNow the map is what we holdMethyl marks and open chromatinSay when to strike—so we can win

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