Sensitive Skin Syndrome: What's Really Happening to Your Skin

Up to 70% of people say they have sensitive skin — but is it really a diagnosis, or something else entirely? Dr. Patti Farris and Dr. Ted Lain break down the biology dermatologists are still trying to figure out. In this episode of the Science of Skin Podcast, Patti and Ted dig into a 15,000+ person global study on sensitive skin prevalence, and explore the science behind why skin reacts with no visible cause — covering TRPV1 and TRPA1 receptor activity, neuropeptide release (substance P, CGRP), and the connection to rosacea. They also unpack the exposome: how pollution, UV exposure, hormones, menopause, and the skin microbiome all play a role, including a deep dive into aryl hydrocarbon receptor (AHR) activation and inflammation. The episode closes with a new comparative cleanser study using D-Squame tape stripping and colorimetric index of mildness (SIM) testing, showing how Cetaphil Gentle Skin Cleanser performs against other "gentle" cleansers on the market. 🔔 Subscribe for new episodes of the Science of Skin Podcast, bringing you cutting-edge dermatology and skincare science. RESOURCES & LINKS📧 Questions or episode ideas? Email: [email protected]🎟️ Join us in Austin, TX — Science of Skin Summit, Sept 17–20, 2026🎟️ Science of Skin Longevity Summit — Scottsdale, AZ, Feb 2027🌐 Learn more: scienceofskinsummit.com Case Study Link: A Comparative Analysis of 8 Facial Cleansers Using Corneosurfametry Reveals Differentiated Irritation Potential - JDDonline - Journal of Drugs in Dermatology This episode is sponsored by Galderma. Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.See omnystudio.com/listener for privacy information.