SGLT-2 Inhibitors Pharmacology

On this episode, I discuss the mechanism of action of the SGLT-2 Inhibitors and how they lower blood sugar. These drugs are classically used for diabetes and eliminate blood sugar through the urine. One of the potential side effects is that these drugs can increase the risk of genital infections and urinary tract infections. There is a boxed warning on canagliflozin for its potential to increase the risk of amputation. These drugs also have a mild diuretic type effect and can potentially cause hypotension. Enjoy the show and be sure to sign up to follow the podcast and get your FREE 31 Page Pharmacology Study Guide! If you find the show helpful, please leave us a kind rating and review wherever you are listening! Cheers! Eric Christianson, PharmD, BCGP, BCPS