Signal Maps

This release contains only the music track from Base by Base Episode 301. Song title: Signal MapsOriginal Base by Base episode: 301: Biobank Mendelian randomization prioritizes 6,447 genes and nominates ANXA2 for dyslipidemiaOriginal episode link: https://basebybase.com/episodes/biobank-mendelian-randomization-targets Article metadata:Article title: Leveraging large-scale biobanks for therapeutic target discoveryJournal: Human Genetics and Genomics Advances, 7 (2026) 100556. doi:10.1016/j.xhgg.2025.100556DOI: 10.1016/j.xhgg.2025.100556Reference: Ferolito BR, Dashti H, Giambartolomei C, Peloso GM, Golden DJ, Gravel-Pucillo K, Rasooly D, Horimoto ARV R, Matty R, Gaziano L, Liu Y, Smit IA, Zdrazil B, Tsepilov Y, Costa L, Kosik N, Huffman JE, Tartaglia GG, Bini G, Proietti G, Ioannidis H, Karim MA, Hunter F, Hemani G, Butterworth AS, Di Angelantonio E, Langenberg C, Ghoussaini M, Leach AR, Liao KP, Damrauer S, Selva LE, Whitbourne S, Tsao PS, Moser J, Gaunt T, Cai T, Whittaker JC, Million Veteran Program, Casas JP, Muralidhar S, Gaziano JM, Cho K, Pereira AC. Leveraging large-scale biobanks for therapeutic target discovery. Human Genetics and Genomics Advances. 7 (2026) 100556. https://doi.org/10.1016/j.xhgg.2025.100556. Lyrics:Verse 1Late nights, bright screens, the pipeline humsWe stitch the traces where the molecules come69,669 gene-trait links like constellationsOver two thousand phenotypes fold into our map Pre-ChorusColocalization sharpens aim while it denies some lightInstruments argue, but patterns start to writeOur ranking climbs — precision-recall AUC 0.79 ChorusMap the genes, light the way, turn the noise to signs6,447 voices rising from the data linesNominate a target, ANXA2 for lipids in sightWe map the genes, we bring them into light Verse 2Blood signals whisper, pleiotropy blurs the trailHarmonize the phenotypes, mend what might derailMachine ranks the edges, a shortlist for the braveRepurposing and new paths waiting to be paved BridgeA pipeline of discovery, charts that glow and swellWe balance specificity and sensitivity's spellFrom network loops to a prioritized designThe future waits where signal meets the sign Final ChorusMap the genes, light the way, turn the noise to signs6,447 names rising from the data linesPrecision climbing steady, reach the clearer heightWe map the genes — and push the dark into light