Silence the Spark

This release contains only the music track from Base by Base Episode 448. Song title: Silence the SparkOriginal Base by Base episode: 448: PrP‑lowering ASOs prolong survival in prion‑infected mice Article metadata:Article title: Antisense oligonucleotides extend survival of prion‑infected miceJournal: JCI InsightDOI: 10.1172/jci.insight.131175Reference: Raymond GJ, Tran Zhao H, Race B, Raymond LD, Williams K, Swayze EE, Graffam S, Le J, Caron T, Stathopoulos J, O’Keefe R, Lubke LDL, Reidenbach AG, Kraus A, Schreiber SL, Mazur C, Cabin DE, Carroll JB, Minikel EV, Kordasiewicz H, Caughey B, Vallabh SM. Antisense oligonucleotides extend survival of prion‑infected mice. JCI Insight. 2019;4(16):e131175. https://doi.org/10.1172/jci.insight.131175. Lyrics:Verse 1Late-night benches, glass and steel,A quiet hunter you can’t feel,One wrong fold makes shadows grow,In fragile circuits moving slow. Pre-ChorusBut on the screen a pattern clears,A simple cut through tangled fears,Turn the message down at the source,And change the ending, change the course. ChorusSilence the spark, slow the storm,Lower the signal, keep the form,If the script won’t shout, the fire won’t start,We buy back time, we guard the heart.Silence the spark, let dawn arrive. Verse 2A measured dose, then wait and see,Threads of warning in chemistry,Not by luck, not by disguise—It’s RNA where the answer lies. BridgeEven when the damage is written in the halls,Even when the night feels heavy on the walls,You can still pull the volume from the pain,Slow the misfold, break the chain. Final ChorusSilence the spark, slow the storm,Lower the signal, keep the form,Less of the maker, less of the mark,Misfolded mountains fade to dark.Silence the spark—let life extend,Hold the line, and bend the end. Chapters (00:00:18) - Silent Spark