Sinister Six Assemble ! - Amazing Spider-Man Annual #1 (1964)

The team up everyone said could never happen, the Sinister Six have formed to take down Spider-Man once and for all. Their plan; to fight him one at a time.... The Sinister Six decide to tackle Spidey just like it's a Mega Man game. But fret not, because the wackiness continues. See Aunt May go senile and think that Doctor Octopus is a kind gentlemen (with abs of steel!). Spidey wins a fight by holding his breath! And much, much more as Logan, Batch and Marc explore the first Spider-Man annual