SoS 250: Jake Aronoff's incredible journey into aging (of immune cells)

Jake Aronoff is a human biologist studying immune function and aging from an evolutionary and ecological perspective. During his PhD, he studied how stress and social inequality impacts inflammation and immunosenescence in the Philippines and US. He is currently a postdoctoral researcher at ASU studying inflammation and aging with Ben Trumble and the Tsimane Health and Life History Project. These studies focus on the development of chronic inflammation in later life (inflammaging), the links between metabolic and immune function (immunometabolism and meta-inflammation), and the relationship between infections, inflammation, and brain aging. His research also utilizes life history theory and energetic trade-offs to understand complex changes in biological functioning in later life, like the simultaneous occurrence of inflammaging and immunosenescence. ------------------------------ Find the paper discussed in this episode: Aronoff, J. E., Trumble, B. C. (2025). An evolutionary medicine and life history perspective on aging and disease: Trade-offs, hyperfunction, and mismatch, Evolution, Medicine, and Public Health, 13(1), 111–124. https://doi.org/10.1093/emph/eoaf010 Aronoff, J. E., Koning, S. M., Adair, L. S., Lee, N. R., Carba, D. B., Kuzawa, C. W., & McDade, T. W. (2024). Intimate partner violence, depression, and chronic low-grade inflammation among middle-aged women in Cebu, Philippines. American journal of human biology : the official journal of the Human Biology Council, 36(6), e24053. https://doi.org/10.1002/ajhb.24053 ------------------------------ Contact the Sausage of Science Podcast and the Human Biology Association: Facebook: facebook.com/groups/humanbiologyassociation/, Website: humbio.org, Twitter: @HumBioAssoc Chris Lynn, Co-Host Website: cdlynn.people.ua.edu/, E-mail: [email protected], Twitter:@Chris_Ly Anahi Ruderman, SoS Co-Producer, HBA Junior Fellow. E-mail: [email protected].