Status Epilepticus

What this episode covers

<br /> Status epilepticus can be very stressful in the Pediatric Emergency Department. This episode of PEM Currents: The Pediatric Emergency Medicine Podcast focuses on management, and will guide you through the treatment process, starting with benzodiazepines, followed by a discussion of the recent evidence for second line therapy between fosphenytoin, levetiracetam, and valproate. <br /> <br /> <br /> <br /> <a style="font-size: inherit;" href="http://twitter.com/PEMTweets">Follow me on Twitter @PEMTweets</a><br /> <br /> <br /> <br /> <a style="font-size: inherit;" href="http://facebook.com/PEMTweets">Check out the facebook page</a><br /> <br /> <br /> <br /> <a href="http://PEMBlog.com">Visit PEMBlog.com</a><br /> <br /> <br /> <br /> References<br /> <br /> <br /> <br /> <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30611-5/fulltext">Chamberlain et al. Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial. LANCET, March, 2020</a><br /> <br /> <br /> <br /> <a href="https://www.ncbi.nlm.nih.gov/pubmed/31005386?dopt=Abstract">Dalziel et al. Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial. Lancet, 2019.</a><br /> <br /> <br /> <br /> <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa1905795">Kapur et al. Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus. NEJM, 2019.</a><br /> <br /> <br /> <br /> <a href="https://www.ncbi.nlm.nih.gov/pubmed/31005385?dopt=Abstract">Lyttle et al. Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. Lancet, 2019.</a><br />