Stealth Cells: Engineering Immune-Evading Therapies for the Future

"Hello everyone and welcome! Today, we're going to explore groundbreaking research that has the potential to transform allogeneic cell therapies, such as CAR T-cell therapy. These therapies offer great hope, but they face a significant hurdle: rejection by the recipient's immune system. Our focus will be on the work of Maldini et al., published in The Journal of Immunology in 2024, titled "Hypoimmunogenic HLA-E Single Chain Inhibits Alloreactive Immune Responses." These researchers have developed an ingenious solution to make donor cells less visible to the recipient's immune system, potentially leading to more effective treatments. Let's explore how science is working to create 'stealth cells' capable of bypassing immune surveillance, paving the way for safer and more effective therapies." MALDINI, C. R. et al. Hypoimmunogenic HLA-E Single Chain Inhibits Alloreactive Immune Responses. J Immunol, v. 213, n. 12, p. 1799–1810, 2024. Available at: https://doi.org/10.4049/jimmunol.2400491.