Steve Hsu Q&A: Complex trait prediction in Genomics, and Genomic Prediction / Embryo Selection

Steve answers questions about recent progress in AI/ML prediction of complex traits from DNA and applications in embryo selection.Highlights:Overview of recent advances in trait predictionWould cost savings from breast cancer early detection pay for genotyping of all women?How does IVF work? Economics of embryo selectionWhole embryo genotyping increases IVF success rates (pregnancy per transfer) significantlyFuture predictionsSome relevant scientific papers:Preimplantation Genetic Testing for Aneuploidy: New Methods and Higher Pregnancy Rates - https://infoproc.blogspot.com/2022/01/preimplantation-genetic-testing-for.html2021 review article on complex trait prediction - https://arxiv.org/abs/2101.05870Accurate Genomic Prediction of Human Height - https://www.genetics.org/content/210/2/477Genomic Prediction of 16 Complex Disease Risks Including Heart Attack, Diabetes, Breast and Prostate Cancer - https://www.nature.com/articles/s41598-019-51258-xGenetic architecture of complex traits and disease risk predictors - https://www.nature.com/articles/s41598-020-68881-8Sibling validation of polygenic risk scores and complex trait prediction - https://www.nature.com/articles/s41598-020-69927-7Music used with permission from Blade Runner Blues Livestream improvisation by State Azure.Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon.Hsu is a startup founder (SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU.Please send any questions or suggestions to [email protected] or Steve on Twitter @hsu_steve.You can find Steve's writing on his blog Information Processing.ManifoldOne YouTube channel. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models. Mechanize is hiring! https://mechanize.work/b/hsu Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists. For example: Research Engineer, Alignment: Build evals that test for misaligned model behaviors  $500K salary Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve  $300K salary Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.