Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the July 2026 Emergency Medicine Practice article, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Diagnosis and Management in the Emergency Department.0:17 – Intro & sponsor promo1:09 – Episode introduction4:03 – Definitions: SJS vs. TEN vs. "overlap" by body surface area6:12 – Pathophysiology9:52 – Incidence and rarity of the disease10:53 – Differential diagnosis & clinical presentation clues12:08 – Prehospital care & fluid resuscitation considerations13:47 – ED history-taking: medications, infections, rash progression14:47 – Physical exam findings16:46 – Diagnostic studies18:12 – Scoring systems: SCORTEN and ABCD-1020:50 – Treatment goals23:57 – Wound care principles24:43 – Mechanical ventilation risk factors26:02 – Other possible therapies27:50 – Specialty consults & special populations29:06 – Ophthalmologic treatment31:17 – HIV patients and elevated risk31:55 – Emerging therapies & AI-based diagnostic tools32:57 – Five key clinical takeaways34:37 – Closing remarks & sponsor sign-offSubscribers, take the CME test here.Emergency Medicine Residents, get your free subscription by writing [email protected]