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EPISODE · Nov 18, 2025 · 12 MIN

Strategic Fasting to Optimize Brain Health

from The Longevity Podcast: Optimizing HealthSpan & MindSpan · host Dung Trinh

Send us Fan MailWe map the science of strategic fasting to brain performance, linking autophagy, BDNF-driven neurogenesis, and improved insulin sensitivity to sharper focus and slower brain aging. Practical steps make the shift feel achievable without stress.• three pillars of brain resilience: autophagy, neurogenesis, metabolic control• the metabolic switch from glucose to ketones• BDNF’s role in hippocampal growth and learning• synaptic plasticity and mitochondrial efficiency gains• lowering IL6 and TNF alpha to cool neuroinflammation• starter windows like 12:12, then 14:10 or 16:8• smart refeeds to avoid metabolic whiplash• pairing light movement with morning fasts• open questions for preventative neurological careThis podcast is created by Ai for educational and entertainment purposes only and does not constitute professional medical or health advice. Please talk to your healthcare team for medical advice. Never miss an episode—subscribe on your favorite podcast app!

Episode metadata supplied by the publisher feed · Published Nov 18, 2025

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Send us Fan Mail We map the science of strategic fasting to brain performance, linking autophagy, BDNF-driven neurogenesis, and improved insulin sensitivity to sharper focus and slower brain aging. Practical steps make the shift feel achievable without stress. • three pillars of brain resilience: autophagy, neurogenesis, metabolic control • the metabolic switch from glucose to ketones • BDNF’s role in hippocampal growth and learning • synaptic plasticity and mitochondrial efficiency gains • ...

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Strategic Fasting to Optimize Brain Health

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This episode is 12 minutes long.

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This episode was published on November 18, 2025.

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