Stroke Volume Index for Pediatric P.A.H. Prognosis 04/05/26

Welcome to Cardiology Today – Recorded April 05, 2026. This episode summarizes 2 key cardiology studies on topics like excitation-contraction coupling and right heart catheterization. Key takeaway: Stroke Volume Index for Pediatric P.A.H. Prognosis. Article Links: Article 1: Long-term genetic Orai1 inhibition modulates excitation-contraction coupling in female adult mouse ventricular cardiomyocytes. (American journal of physiology. Heart and circulatory physiology) Article 2: Clinical Utility of Stroke Volume Index in Children with Idiopathic and Heritable Pulmonary Arterial Hypertension. (Pediatric cardiology) Full episode page: https://podcast.explainheart.com/podcast/stroke-volume-index-for-pediatric-p-a-h-prognosis-04-05-26/ Featured Articles Article 1: Long-term genetic Orai1 inhibition modulates excitation-contraction coupling in female adult mouse ventricular cardiomyocytes. Journal: American journal of physiology. Heart and circulatory physiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41926628 Summary: This study found that long-term genetic inhibition of Orai1, a store-operated calcium channel, modulates excitation-contraction coupling in adult mouse ventricular cardiomyocytes. Using a mouse model expressing a dominant-negative human Orai1R91W mutant, researchers observed elevated intracellular calcium transients and calcium spark amplitudes in female mice compared to wild-type controls. These specific findings demonstrate a sex-specific contribution of Orai1 to cardiac excitation-contraction coupling. This indicates a novel role for Orai1 in cardiac function that varies between sexes. Article 2: Clinical Utility of Stroke Volume Index in Children with Idiopathic and Heritable Pulmonary Arterial Hypertension. Journal: Pediatric cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41925853 Summary: This retrospective study determined the clinical utility of stroke volume index in children with idiopathic and heritable pulmonary arterial hypertension. It assessed the prognostic value of stroke volume index, which was evaluated by right heart catheterization, in 103 pediatric patients. The study found a relationship between stroke volume index and adverse outcomes, specifically lung transplant and cardiac death. These findings establish stroke volume index as a valuable prognostic indicator in this pediatric patient population. Transcript Today’s date is April 05, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Long-term genetic Orai1 inhibition modulates excitation-contraction coupling in female adult mouse ventricular cardiomyocytes. This study found that long-term genetic inhibition of Orai1, a store-operated calcium channel, modulates excitation-contraction coupling in adult mouse ventricular cardiomyocytes. Using a mouse model expressing a dominant-negative human Orai1R91W mutant, researchers observed elevated intracellular calcium transients and calcium spark amplitudes in female mice compared to wild-type controls. These specific findings demonstrate a sex-specific contribution of Orai1 to cardiac excitation-contraction coupling. This indicates a novel role for Orai1 in cardiac function that varies between sexes. Article number two. Clinical Utility of Stroke Volume Index in Children with Idiopathic and Heritable Pulmonary Arterial Hypertension. This retrospective study determined the clinical utility of stroke volume index in children with idiopathic and heritable pulmonary arterial hypertension. It assessed the prognostic value of stroke volume index, which was evaluated by right heart catheterization, in 103 pediatric patients. The study found a relationship between stroke volume index and adverse outcomes, specifically lung transplant and cardiac death. These findings establish stroke volume index as a valuable prognostic indicator in this pediatric patient population. Thank you for listening. Don’t forget to subscribe. Keywords excitation-contraction coupling, right heart catheterization, sex-specific differences, pediatric cardiology, pulmonary arterial hypertension, calcium transients, ventricular cardiomyocytes, Orai1 channel, Stroke volume index, prognostic value. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Stroke Volume Index for Pediatric P.A.H. Prognosis 04/05/26 first appeared on Cardiology Today.