Cardiology Today

Welcome to Cardiology Today – Recorded September 09, 2026. This episode summarizes 5 key cardiology studies on topics like L. D. L. cholesterol and risk estimation. Key takeaway: New Model Predicts Heart Failure Risk in Healthy Adults. Article Links: Article 1: Advancing Quality in the Evaluation, Surveillance, and Management of Aortic Stenosis: A Report From the AHA Target: AS Registry. (Circulation) Article 2: Prediction of incident heart failure in established atherosclerotic cardiovascular disease: the SMART2-HF model. (European heart journal) Article 3: Prediction of incident heart failure in individuals without prior cardiovascular disease: the SCORE2-HF risk model. (European heart journal) Article 4: Risk prediction in patients with heart failure with preserved ejection fraction: the LIFE-Preserved model. (European heart journal) Article 5: Aspirin use, lipoprotein(a), and calcific aortic valve disease: the Multi-ethnic Study of Atherosclerosis. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/new-model-predicts-heart-failure-risk-in-healthy-adults-09-09-26/ Featured Articles Article 1: Advancing Quality in the Evaluation, Surveillance, and Management of Aortic Stenosis: A Report From the AHA Target: AS Registry. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42360276 Summary: Undertreatment and delayed treatment of aortic stenosis are common, and these issues are associated with increased mortality. The American Heart Association Target: A. S. registry is the first national registry specifically established to provide data and evaluate quality in upstream care processes for patients with aortic stenosis. It includes randomly selected patients from 58 sites with moderate or severe aortic stenosis. This registry directly addresses existing quality gaps in aortic stenosis management by tracking critical aspects of patient care. Article 2: Prediction of incident heart failure in established atherosclerotic cardiovascular disease: the SMART2-HF model. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41810961 Summary: Patients with established atherosclerotic cardiovascular disease are at high risk for developing heart failure, and current guideline-recommended models do not include incident heart failure in their risk assessment. This study developed and externally validated the S. M. A. R. T. two-H. F. model to predict incident heart failure specifically in patients with atherosclerotic cardiovascular disease. The S. M. A. R. T. two-H. F. model was developed using data from 7698 individuals with established atherosclerotic cardiovascular disease, including coronary, cerebrovascular, peripheral artery disease, or abdominal aortic aneurysm. This model provides a new tool to identify high-risk individuals for incident heart failure, enabling targeted preventative interventions. Article 3: Prediction of incident heart failure in individuals without prior cardiovascular disease: the SCORE2-HF risk model. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41810943 Summary: Heart failure presents a significant and growing public health challenge. This study developed and validated S. C. O. R. E. two-H. F., a model for heart failure risk estimation in European adults over 40 years without previous cardiovascular disease. The sex-specific, competing risk-adjusted S. C. O. R. E. two-H. F. models were derived from 611778 individuals across 25 prospective cohorts in 14 countries, observing 21818 incident heart failure events. The model includes age, smoking status, systolic blood pressure, antihypertensive treatment, type two diabetes, and body mass index as predictive factors. Article 4: Risk prediction in patients with heart failure with preserved ejection fraction: the LIFE-Preserved model. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41810940 Summary: Heart failure with preserved ejection fraction constitutes a heterogeneous disease with a rising incidence and varying prognosis. This study developed and validated the L. I. F. E. hyphen Preserved model for predicting individual short-term and lifetime risk for heart failure hospitalization or cardiovascular death. The L. I. F. E. hyphen Preserved model specifically addresses the need for accurate risk prediction in patients with heart failure with preserved ejection fraction. This new model identifies high-risk individuals within this population, potentially guiding more effective preventive treatment strategies. Article 5: Aspirin use, lipoprotein(a), and calcific aortic valve disease: the Multi-ethnic Study of Atherosclerosis. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41721439 Summary: Lipoprotein(a) and L. D. L. cholesterol are causally linked to aortic valve calcium and aortic stenosis. Lipoprotein(a) possesses anti-fibrinolytic properties, suggesting aspirin could potentially reduce cardiovascular disease risk in individuals with high lipoprotein(a) levels. This observational study included up to 6598 participants from the Multi-Ethnic Study of Atherosclerosis. The investigation characterized the relationship between aspirin use and incident aortic valve calcium and aortic stenosis across different lipoprotein(a) and L. D. L. cholesterol levels. Transcript Today’s date is September 09, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Advancing Quality in the Evaluation, Surveillance, and Management of Aortic Stenosis: A Report From the AHA Target: AS Registry. Undertreatment and delayed treatment of aortic stenosis are common, and these issues are associated with increased mortality. The American Heart Association Target: A. S. registry is the first national registry specifically established to provide data and evaluate quality in upstream care processes for patients with aortic stenosis. It includes randomly selected patients from 58 sites with moderate or severe aortic stenosis. This registry directly addresses existing quality gaps in aortic stenosis management by tracking critical aspects of patient care. Article number two. Prediction of incident heart failure in established atherosclerotic cardiovascular disease: the SMART2-HF model. Patients with established atherosclerotic cardiovascular disease are at high risk for developing heart failure, and current guideline-recommended models do not include incident heart failure in their risk assessment. This study developed and externally validated the S. M. A. R. T. two-H. F. model to predict incident heart failure specifically in patients with atherosclerotic cardiovascular disease. The S. M. A. R. T. two-H. F. model was developed using data from 7698 individuals with established atherosclerotic cardiovascular disease, including coronary, cerebrovascular, peripheral artery disease, or abdominal aortic aneurysm. This model provides a new tool to identify high-risk individuals for incident heart failure, enabling targeted preventative interventions. Article number three. Prediction of incident heart failure in individuals without prior cardiovascular disease: the SCORE2-HF risk model. Heart failure presents a significant and growing public health challenge. This study developed and validated S. C. O. R. E. two-H. F., a model for heart failure risk estimation in European adults over 40 years without previous cardiovascular disease. The sex-specific, competing risk-adjusted S. C. O. R. E. two-H. F. models were derived from 611778 individuals across 25 prospective cohorts in 14 countries, observing 21818 incident heart failure events. The model includes age, smoking status, systolic blood pressure, antihypertensive treatment, type two diabetes, and body mass index as predictive factors. Article number four. Risk prediction in patients with heart failure with preserved ejection fraction: the LIFE-Preserved model. Heart failure with preserved ejection fraction constitutes a heterogeneous disease with a rising incidence and varying prognosis. This study developed and validated the L. I. F. E. hyphen Preserved model for predicting individual short-term and lifetime risk for heart failure hospitalization or cardiovascular death. The L. I. F. E. hyphen Preserved model specifically addresses the need for accurate risk prediction in patients with heart failure with preserved ejection fraction. This new model identifies high-risk individuals within this population, potentially guiding more effective preventive treatment strategies. Article number five. Aspirin use, lipoprotein(a), and calcific aortic valve disease: the Multi-ethnic Study of Atherosclerosis. Lipoprotein(a) and L. D. L. cholesterol are causally linked to aortic valve calcium and aortic stenosis. Lipoprotein(a) possesses anti-fibrinolytic properties, suggesting aspirin could potentially reduce cardiovascular disease risk in individuals with high lipoprotein(a) levels. This observational study included up to 6598 participants from the Multi-Ethnic Study of Atherosclerosis. The investigation characterized the relationship between aspirin use and incident aortic valve calcium and aortic stenosis across different lipoprotein(a) and L. D. L. cholesterol levels. Thank you for listening. Don’t forget to subscribe. Keywords L. D. L. cholesterol, risk estimation, mortality, risk prediction, S. C. O. R. E. two-H. F., lipoprotein(a), delayed treatment, heart failure, aortic valve calcium, incident heart failure, cardiovascular disease prevention, H. F. pEF, aortic stenosis, risk prediction model, calcific aortic valve disease, European adults, aspirin, quality of care, cardiovascular death, L. I. F. E. hyphen Preserved model, A. H. A. Target: A. S. registry, S. M. A. R. T. two-H. F., atherosclerotic cardiovascular disease, heart failure hospitalization, heart failure with preserved ejection fraction. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post New Model Predicts Heart Failure Risk in Healthy Adults 09/09/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded September 09, 2026. This episode summarizes 5 key cardiology studies on topics like cardiomyocytes and electrocardiogram. Key takeaway: AI Electrocardiogram Screens Chagas Disease. Article Links: Article 1: HNRNPK Lactylation Amplifies Inflammation and Exacerbates Myocardial Ischemia/Reperfusion Injury by Regulating Jag2 Splicing. (Circulation) Article 2: Overcoming Intrinsic Barriers in Myofibroblasts Permits Efficient Cardiac Reprogramming After Infarction. (Circulation) Article 3: YAP Promotes Microtubule Growth to Facilitate Sarcomere Disassembly in Adult Cardiomyocytes. (Circulation) Article 4: Opportunistic Screening for Chagas Disease Using an Artificial Intelligence-Enabled ECG: Prospective Evaluation of Feasibility and Diagnostic Accuracy. (Circulation) Article 5: COL1A1-Enhanced CD44/SLC7A11 Interaction and Cystine Uptake Result in CD34+ Foam-Like Macrophage Accumulation in Transplant Arteriosclerosis. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/ai-electrocardiogram-screens-chagas-disease-09-09-26/ Featured Articles Article 1: HNRNPK Lactylation Amplifies Inflammation and Exacerbates Myocardial Ischemia/Reperfusion Injury by Regulating Jag2 Splicing. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42708184 Summary: The study identified that myocardial ischemia/reperfusion injury involves profound metabolic reprogramming and lactate accumulation. It uncovered that lactylation, a lactate-derived posttranslational modification, links this metabolic stress to aberrant R. N. A. splicing and cardiac inflammation. The R. N. A.-binding protein HNRNPK, or heterogeneous nuclear ribonucleoprotein K, was found to mediate this connection. This reveals a critical regulatory pathway for inflammatory gene expression in the context of ischemia/reperfusion injury. Article 2: Overcoming Intrinsic Barriers in Myofibroblasts Permits Efficient Cardiac Reprogramming After Infarction. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42708181 Summary: The study demonstrated that direct reprogramming of cardiac fibroblasts into induced cardiomyocytes offers a promising strategy for heart regeneration. It revealed that after myocardial infarction, quiescent cardiac fibroblasts activate and differentiate into myofibroblasts, which drive pathological cardiac fibrosis. The research established that converting these injury-activated myofibroblasts into induced cardiomyocytes can simultaneously alleviate fibrosis and replenish lost cardiomyocytes. This indicates that overcoming intrinsic barriers in myofibroblasts is crucial for achieving efficient cardiac reprogramming. Article 3: YAP Promotes Microtubule Growth to Facilitate Sarcomere Disassembly in Adult Cardiomyocytes. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42578265 Summary: The study discovered that the protein YAP, Yes Associated Protein, actively promotes microtubule growth in adult cardiomyocytes. This promotion of microtubule growth facilitates the disassembly of sarcomeric structures. Sarcomere disassembly was found to be essential for adult cardiomyocytes to dedifferentiate into a fetus-like state, enabling successful cell division. These findings clarify a key regulatory mechanism coordinating cardiomyocyte dedifferentiation, cell cycle progression, and sarcomere reorganization. Article 4: Opportunistic Screening for Chagas Disease Using an Artificial Intelligence-Enabled ECG: Prospective Evaluation of Feasibility and Diagnostic Accuracy. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42576808 Summary: The study demonstrated the feasibility of opportunistic screening for Chagas disease using an artificial intelligence-enabled electrocardiogram model. It established the diagnostic accuracy of this A. I.-E. C. G. model, which was further enhanced with three epidemiological questions for improved detection. This approach was found to enable earlier detection of unrecognized Chagas disease infections in a prospective evaluation. The findings support the use of this A. I.-E. C. G.-E. P. I. model as a valuable tool for timely antiparasitic therapy or optimized cardiac care. Article 5: COL1A1-Enhanced CD44/SLC7A11 Interaction and Cystine Uptake Result in CD34+ Foam-Like Macrophage Accumulation in Transplant Arteriosclerosis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42549511 Summary: The study uncovered that chronic transplant arteriosclerosis, a primary cause of long-term graft failure, involves the accumulation of C. D. 34 positive foam-like macrophages. It revealed that this accumulation is driven by an enhanced interaction between C. D. 44 and S. L. C. 7 A. 11, which is promoted by C. O. L. 1 A. 1. This enhanced interaction was found to increase cystine uptake, contributing to the formation of these specific macrophage subpopulations. The findings elucidate crucial origins and regulatory mechanisms of inflammatory macrophages in allograft arteriosclerosis, providing targets for therapy. Transcript Today’s date is September 09, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. HNRNPK Lactylation Amplifies Inflammation and Exacerbates Myocardial Ischemia/Reperfusion Injury by Regulating Jag2 Splicing. The study identified that myocardial ischemia/reperfusion injury involves profound metabolic reprogramming and lactate accumulation. It uncovered that lactylation, a lactate-derived posttranslational modification, links this metabolic stress to aberrant R. N. A. splicing and cardiac inflammation. The R. N. A.-binding protein HNRNPK, or heterogeneous nuclear ribonucleoprotein K, was found to mediate this connection. This reveals a critical regulatory pathway for inflammatory gene expression in the context of ischemia/reperfusion injury. Article number two. Overcoming Intrinsic Barriers in Myofibroblasts Permits Efficient Cardiac Reprogramming After Infarction. The study demonstrated that direct reprogramming of cardiac fibroblasts into induced cardiomyocytes offers a promising strategy for heart regeneration. It revealed that after myocardial infarction, quiescent cardiac fibroblasts activate and differentiate into myofibroblasts, which drive pathological cardiac fibrosis. The research established that converting these injury-activated myofibroblasts into induced cardiomyocytes can simultaneously alleviate fibrosis and replenish lost cardiomyocytes. This indicates that overcoming intrinsic barriers in myofibroblasts is crucial for achieving efficient cardiac reprogramming. Article number three. YAP Promotes Microtubule Growth to Facilitate Sarcomere Disassembly in Adult Cardiomyocytes. The study discovered that the protein YAP, Yes Associated Protein, actively promotes microtubule growth in adult cardiomyocytes. This promotion of microtubule growth facilitates the disassembly of sarcomeric structures. Sarcomere disassembly was found to be essential for adult cardiomyocytes to dedifferentiate into a fetus-like state, enabling successful cell division. These findings clarify a key regulatory mechanism coordinating cardiomyocyte dedifferentiation, cell cycle progression, and sarcomere reorganization. Article number four. Opportunistic Screening for Chagas Disease Using an Artificial Intelligence-Enabled ECG: Prospective Evaluation of Feasibility and Diagnostic Accuracy. The study demonstrated the feasibility of opportunistic screening for Chagas disease using an artificial intelligence-enabled electrocardiogram model. It established the diagnostic accuracy of this A. I.-E. C. G. model, which was further enhanced with three epidemiological questions for improved detection. This approach was found to enable earlier detection of unrecognized Chagas disease infections in a prospective evaluation. The findings support the use of this A. I.-E. C. G.-E. P. I. model as a valuable tool for timely antiparasitic therapy or optimized cardiac care. Article number five. COL1A1-Enhanced CD44/SLC7A11 Interaction and Cystine Uptake Result in CD34+ Foam-Like Macrophage Accumulation in Transplant Arteriosclerosis. The study uncovered that chronic transplant arteriosclerosis, a primary cause of long-term graft failure, involves the accumulation of C. D. 34 positive foam-like macrophages. It revealed that this accumulation is driven by an enhanced interaction between C. D. 44 and S. L. C. 7 A. 11, which is promoted by C. O. L. 1 A. 1. This enhanced interaction was found to increase cystine uptake, contributing to the formation of these specific macrophage subpopulations. The findings elucidate crucial origins and regulatory mechanisms of inflammatory macrophages in allograft arteriosclerosis, providing targets for therapy. Thank you for listening. Don’t forget to subscribe. Keywords cardiomyocytes, electrocardiogram, inflammation, cardiac fibrosis, C. D. 44, artificial intelligence, myocardial ischemia/reperfusion injury, C. O. L. 1 A. 1, myocardial infarction, dedifferentiation, Chagas disease, sarcomere disassembly, opportunistic screening, lactylation, R. N. A. splicing, Yes Associated Protein, myofibroblasts, YAP, S. L. C. 7 A. 11, microtubule growth, HNRNPK, macrophages, induced cardiomyocytes, cystine uptake, diagnostic accuracy, cardiac reprogramming, transplant arteriosclerosis. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post AI Electrocardiogram Screens Chagas Disease 09/09/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded September 09, 2026. This episode summarizes 5 key cardiology studies on topics like Dilated cardiomyopathy and high-risk genotypes. Key takeaway: Macrotroponin I: Lower Mortality Risk. Article Links: Article 1: Tozorakimab to Prevent COPD Exacerbations. (The New England journal of medicine) Article 2: Impaired Glycolysis Leads to Defective Efferocytosis and Impaired Plaque Resolution in Tet2 Clonal Hematopoiesis. (Circulation) Article 3: Macrotroponin Complexes and Risk of Cardiovascular Events. (Circulation) Article 4: Arrhythmic Risk Stratification According to LGE Corridors and Genetics in Nonischemic Dilated Cardiomyopathy. (Circulation) Article 5: An Updated Evidence Assessment of the Genetic Causes of Dilated Cardiomyopathy. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/macrotroponin-i-lower-mortality-risk-09-09-26/ Featured Articles Article 1: Tozorakimab to Prevent COPD Exacerbations. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42708515 Summary: Tozorakimab is a monoclonal antibody that inhibits interleukin-33 activity, a key mechanism implicated in the pathogenesis of chronic obstructive pulmonary disease. This therapeutic approach targets the dysregulated signaling in patients who continue to experience exacerbations despite standard-of-care inhaled maintenance therapy. The OBERON and TITANIA phase three trials investigated tozorakimab for preventing exacerbations in adults with chronic obstructive pulmonary disease who were current or former smokers and had a history of exacerbations. The clinical focus is on providing a new preventative option for this high-risk patient population. Article 2: Impaired Glycolysis Leads to Defective Efferocytosis and Impaired Plaque Resolution in Tet2 Clonal Hematopoiesis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42708224 Summary: The study found that TET2 (tet methylcytosine dioxygenase two) clonal hematopoiesis impairs glycolysis in macrophages. This impaired glycolysis leads to defective efferocytosis, consequently resulting in impaired plaque resolution within atherosclerotic plaques. The data showed that TET2 clonal hematopoiesis promotes atherosclerosis progression. These mechanisms were observed to impair plaque remodeling and regression even under conditions of low-density lipoprotein lowering. Article 3: Macrotroponin Complexes and Risk of Cardiovascular Events. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42708217 Summary: The study found that macrotroponin complexes were present in a general population cohort of 19499 participants, with macrotroponin I found in 0.8 percent and macrotroponin T in 0.2 percent. Results showed that macrotroponin I was associated with a lower risk of all-cause mortality, with a hazard ratio of 0.61 and a 95 percent confidence interval of 0.46 to 0.80. This association for macrotroponin I also extended to cardiovascular mortality, showing a hazard ratio of 0.52 with a 95 percent confidence interval of 0.30 to 0.90, even after adjusting for cardiac troponin levels and confounders. No significant association was observed between macrotroponin T and clinical outcomes. Article 4: Arrhythmic Risk Stratification According to LGE Corridors and Genetics in Nonischemic Dilated Cardiomyopathy. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42708210 Summary: The study found that late gadolinium enhancement (L. G. E.) corridors, assessed through cardiac magnetic resonance imaging, were an independent predictor of major ventricular arrhythmic events in nonischemic dilated cardiomyopathy, showing a hazard ratio of 2.1 with a P value less than 0.001. High-risk genotypes were also identified as an independent predictor, with a hazard ratio of 2.0 and a P value less than 0.001. Patients exhibiting both L. G. E. corridors and high-risk genotypes faced a five-fold higher risk of major ventricular arrhythmic events compared to those without either factor, achieving a hazard ratio of 5.0 with a P value less than 0.001. This combined risk stratification approach identified 79 percent of major ventricular arrhythmic events within 28 percent of the cohort at three years. Article 5: An Updated Evidence Assessment of the Genetic Causes of Dilated Cardiomyopathy. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42708185 Summary: The Clinical Genome Resource Dilated Cardiomyopathy gene curation expert panel reconvened to conduct an updated evidence assessment of genes associated with dilated cardiomyopathy. This reassessment applied the Clinical Genome Resource semiquantitative clinical validity classification framework, with specific parameters for dilated cardiomyopathy, to classify the implicated disease genes. The work provides an updated classification of the diverse genetic architecture of dilated cardiomyopathy. This refined classification aims to improve the clinical relevance and understanding of these genetic causes. Transcript Today’s date is September 09, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Tozorakimab to Prevent COPD Exacerbations. Tozorakimab is a monoclonal antibody that inhibits interleukin-33 activity, a key mechanism implicated in the pathogenesis of chronic obstructive pulmonary disease. This therapeutic approach targets the dysregulated signaling in patients who continue to experience exacerbations despite standard-of-care inhaled maintenance therapy. The OBERON and TITANIA phase three trials investigated tozorakimab for preventing exacerbations in adults with chronic obstructive pulmonary disease who were current or former smokers and had a history of exacerbations. The clinical focus is on providing a new preventative option for this high-risk patient population. Article number two. Impaired Glycolysis Leads to Defective Efferocytosis and Impaired Plaque Resolution in Tet2 Clonal Hematopoiesis. The study found that TET2 (tet methylcytosine dioxygenase two) clonal hematopoiesis impairs glycolysis in macrophages. This impaired glycolysis leads to defective efferocytosis, consequently resulting in impaired plaque resolution within atherosclerotic plaques. The data showed that TET2 clonal hematopoiesis promotes atherosclerosis progression. These mechanisms were observed to impair plaque remodeling and regression even under conditions of low-density lipoprotein lowering. Article number three. Macrotroponin Complexes and Risk of Cardiovascular Events. The study found that macrotroponin complexes were present in a general population cohort of 19499 participants, with macrotroponin I found in 0.8 percent and macrotroponin T in 0.2 percent. Results showed that macrotroponin I was associated with a lower risk of all-cause mortality, with a hazard ratio of 0.61 and a 95 percent confidence interval of 0.46 to 0.80. This association for macrotroponin I also extended to cardiovascular mortality, showing a hazard ratio of 0.52 with a 95 percent confidence interval of 0.30 to 0.90, even after adjusting for cardiac troponin levels and confounders. No significant association was observed between macrotroponin T and clinical outcomes. Article number four. Arrhythmic Risk Stratification According to LGE Corridors and Genetics in Nonischemic Dilated Cardiomyopathy. The study found that late gadolinium enhancement (L. G. E.) corridors, assessed through cardiac magnetic resonance imaging, were an independent predictor of major ventricular arrhythmic events in nonischemic dilated cardiomyopathy, showing a hazard ratio of 2.1 with a P value less than 0.001. High-risk genotypes were also identified as an independent predictor, with a hazard ratio of 2.0 and a P value less than 0.001. Patients exhibiting both L. G. E. corridors and high-risk genotypes faced a five-fold higher risk of major ventricular arrhythmic events compared to those without either factor, achieving a hazard ratio of 5.0 with a P value less than 0.001. This combined risk stratification approach identified 79 percent of major ventricular arrhythmic events within 28 percent of the cohort at three years. Article number five. An Updated Evidence Assessment of the Genetic Causes of Dilated Cardiomyopathy. The Clinical Genome Resource Dilated Cardiomyopathy gene curation expert panel reconvened to conduct an updated evidence assessment of genes associated with dilated cardiomyopathy. This reassessment applied the Clinical Genome Resource semiquantitative clinical validity classification framework, with specific parameters for dilated cardiomyopathy, to classify the implicated disease genes. The work provides an updated classification of the diverse genetic architecture of dilated cardiomyopathy. This refined classification aims to improve the clinical relevance and understanding of these genetic causes. Thank you for listening. Don’t forget to subscribe. Keywords Dilated cardiomyopathy, high-risk genotypes, Clinical Genome Resource, plaque resolution, efferocytosis, general population, glycolysis, interleukin-33, Macrotroponin, gene curation, Tozorakimab, cardiovascular events, genetic causes, clinical validity, chronic obstructive pulmonary disease, monoclonal antibody, TET2 clonal hematopoiesis, cardiac troponin I, mortality risk, risk stratification, cardiac troponin T, macrophages, LGE corridors, COPD exacerbations, Late gadolinium enhancement, genetic architecture, nonischemic dilated cardiomyopathy, ventricular arrhythmias, atherosclerosis. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Macrotroponin I: Lower Mortality Risk 09/09/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded August 08, 2026. This episode summarizes 5 key cardiology studies on topics like heart failure and endomyocardial biopsy. Key takeaway: Daratumumab for Pediatric Heart Transplant Rejection. Article Links: Article 1: Endometriosis and long-term risk of venous thromboembolism: a Danish nationwide study. (European heart journal) Article 2: Temporal comparison of clinical practice and outcomes in heart failure: the JROADHF and JROADHF-NEXT studies. (European heart journal) Article 3: Daratumumab for Non-Acute Antibody-Mediated Rejection After Pediatric Heart Transplantation: Treatment Response in the Presence and Absence of Circulating HLA Donor-Specific Antibody. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Prognostic Significance of Myocardial Blood Flow Reserve and Stress Myocardial Blood Flow in the Assessment of Cardiac Allograft Vasculopathy in Heart Transplant Recipients. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Impact of empagliflozin on serum calcium and phosphate in heart failure. (Journal of cardiac failure) Full episode page: https://podcast.explainheart.com/podcast/daratumumab-for-pediatric-heart-transplant-rejection-08-08-26/ Featured Articles Article 1: Endometriosis and long-term risk of venous thromboembolism: a Danish nationwide study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42568051 Summary: Endometriosis affects approximately 10 percent of women of reproductive age, with evidence linking it to systemic inflammation. This inflammatory process creates a recognized potential for increased venous thromboembolism risk. A Danish nationwide, registry-based cohort study comprehensively included all women with endometriosis from 1977 to 2024. The study rigorously matched these individuals 1 to 4 with controls based on birth and index year, representing a substantial effort to understand the association of endometriosis with long-term venous thromboembolism. Article 2: Temporal comparison of clinical practice and outcomes in heart failure: the JROADHF and JROADHF-NEXT studies. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42568038 Summary: Heart failure management has seen significant therapeutic and interventional advances; however, real-world clinical practice remains poorly characterized. This investigation utilized two major Japanese heart failure registries: JROADHF from 2013, comprising 13238 patients, and JROADHF-NEXT from 2019 to 2021, comprising 4016 patients. Patient outcomes were rigorously compared between the cohorts using 1-to-1 propensity score matching. This extensive comparison provides a temporal evaluation of heart failure management and its impact on outcomes. Article 3: Daratumumab for Non-Acute Antibody-Mediated Rejection After Pediatric Heart Transplantation: Treatment Response in the Presence and Absence of Circulating HLA Donor-Specific Antibody. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42567380 Summary: L. A. Donor-Specific Antibody. Late graft survival following pediatric heart transplantation is inadequate, primarily due to chronic rejection. Daratumumab has demonstrated promise for treating antibody-mediated rejection, though published experience in heart transplantation is limited. This study retrospectively analyzed heart transplantation recipients who received daratumumab at a dose of 16 milligrams per kilogram for four doses. Treatment was administered for antibody-mediated rejection identified by elevated donor-derived cell-free D. N. A., without graft dysfunction or hemodynamic compromise, and confirmed by endomyocardial biopsy. Article 4: Prognostic Significance of Myocardial Blood Flow Reserve and Stress Myocardial Blood Flow in the Assessment of Cardiac Allograft Vasculopathy in Heart Transplant Recipients. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42567379 Summary: Cardiac allograft vasculopathy significantly limits longevity following heart transplantation. Non-invasive physiological assessment using cardiac positron emission tomography offers established prognostic significance for this condition. This investigation included all adult single-organ heart transplant recipients who underwent Nitrogen-13 ammonia positron emission tomography myocardial perfusion imaging between 2016 and 2019. The study performed a median follow-up to measure the prognostic contribution of stress myocardial blood flow and myocardial blood flow reserve to post-transplant outcomes. Article 5: Impact of empagliflozin on serum calcium and phosphate in heart failure. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42567257 Summary: Alterations in serum calcium and phosphate balance are associated with poor outcomes in heart failure, with existing data primarily from small observational studies. The effect of sodium-glucose cotransporter two inhibitors on serum calcium and phosphate levels has not been thoroughly examined in large, randomized heart failure trials. This study utilized comprehensive data from the EMPEROR-Pooled trials. The analysis focused on evaluating the prognostic associations of serum calcium and phosphate in heart failure patients and the specific impact of sodium-glucose cotransporter two inhibitors on these levels. Transcript Today’s date is August 08, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Endometriosis and long-term risk of venous thromboembolism: a Danish nationwide study. Endometriosis affects approximately 10 percent of women of reproductive age, with evidence linking it to systemic inflammation. This inflammatory process creates a recognized potential for increased venous thromboembolism risk. A Danish nationwide, registry-based cohort study comprehensively included all women with endometriosis from 1977 to 2024. The study rigorously matched these individuals 1 to 4 with controls based on birth and index year, representing a substantial effort to understand the association of endometriosis with long-term venous thromboembolism. Article number two. Temporal comparison of clinical practice and outcomes in heart failure: the JROADHF and JROADHF-NEXT studies. Heart failure management has seen significant therapeutic and interventional advances; however, real-world clinical practice remains poorly characterized. This investigation utilized two major Japanese heart failure registries: JROADHF from 2013, comprising 13238 patients, and JROADHF-NEXT from 2019 to 2021, comprising 4016 patients. Patient outcomes were rigorously compared between the cohorts using 1-to-1 propensity score matching. This extensive comparison provides a temporal evaluation of heart failure management and its impact on outcomes. Article number three. Daratumumab for Non-Acute Antibody-Mediated Rejection After Pediatric Heart Transplantation: Treatment Response in the Presence and Absence of Circulating H. L. A. Donor-Specific Antibody. Late graft survival following pediatric heart transplantation is inadequate, primarily due to chronic rejection. Daratumumab has demonstrated promise for treating antibody-mediated rejection, though published experience in heart transplantation is limited. This study retrospectively analyzed heart transplantation recipients who received daratumumab at a dose of 16 milligrams per kilogram for four doses. Treatment was administered for antibody-mediated rejection identified by elevated donor-derived cell-free D. N. A., without graft dysfunction or hemodynamic compromise, and confirmed by endomyocardial biopsy. Article number four. Prognostic Significance of Myocardial Blood Flow Reserve and Stress Myocardial Blood Flow in the Assessment of Cardiac Allograft Vasculopathy in Heart Transplant Recipients. Cardiac allograft vasculopathy significantly limits longevity following heart transplantation. Non-invasive physiological assessment using cardiac positron emission tomography offers established prognostic significance for this condition. This investigation included all adult single-organ heart transplant recipients who underwent Nitrogen-13 ammonia positron emission tomography myocardial perfusion imaging between 2016 and 2019. The study performed a median follow-up to measure the prognostic contribution of stress myocardial blood flow and myocardial blood flow reserve to post-transplant outcomes. Article number five. Impact of empagliflozin on serum calcium and phosphate in heart failure. Alterations in serum calcium and phosphate balance are associated with poor outcomes in heart failure, with existing data primarily from small observational studies. The effect of sodium-glucose cotransporter two inhibitors on serum calcium and phosphate levels has not been thoroughly examined in large, randomized heart failure trials. This study utilized comprehensive data from the EMPEROR-Pooled trials. The analysis focused on evaluating the prognostic associations of serum calcium and phosphate in heart failure patients and the specific impact of sodium-glucose cotransporter two inhibitors on these levels. Thank you for listening. Don’t forget to subscribe. Keywords heart failure, endomyocardial biopsy, cohort study, sodium-glucose cotransporter two inhibitors, daratumumab, stress myocardial blood flow, empagliflozin, pediatric heart transplantation, clinical practice, antibody-mediated rejection, endometriosis, venous thromboembolism, positron emission tomography, serum calcium, women’s health, myocardial blood flow reserve, serum phosphate, systemic inflammation, patient outcomes, heart transplantation, donor-derived cell-free D. N. A., cardiac allograft vasculopathy, registries, temporal comparison. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Daratumumab for Pediatric Heart Transplant Rejection 08/08/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded August 07, 2026. This episode summarizes 5 key cardiology studies on topics like tricuspid regurgitation and pathogen detection. Key takeaway: Xenotransplant Progress: Pigs Mitigate Rejection. Article Links: Article 1: Combined transcatheter mitral and tricuspid edge-to-edge repair or tricuspid edge-to-edge repair alone in moderate mitral regurgitation: a propensity-matched analysis. (European heart journal) Article 2: Senescence-associated metabolic alterations aggravate calcific aortic valve disease. (European heart journal) Article 3: Risk factors and coronary events: attenuation of the association in secondary prevention. (European heart journal) Article 4: Improved Sensitivity for Respiratory Pathogen Detection in Bronchoalveolar Lavage from Lung Transplant Recipients Using Targeted Next-Generation Sequencing. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: From Gene Editing to Exogenesis: Pigs as a Source of Immune-compatible Organs for Transplantation. (Transplantation) Full episode page: https://podcast.explainheart.com/podcast/xenotransplant-progress-pigs-mitigate-rejection-08-07-26/ Featured Articles Article 1: Combined transcatheter mitral and tricuspid edge-to-edge repair or tricuspid edge-to-edge repair alone in moderate mitral regurgitation: a propensity-matched analysis. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42030119 Summary: Transcatheter edge-to-edge repair represents a therapeutic strategy for the complex coexistence of moderate mitral regurgitation, or M. R., and severe tricuspid regurgitation, or T. R. Clinically, the management choice involves either combined mitral and tricuspid valve repair or isolated tricuspid valve repair. The study established the prognostic relevance of moderate M. R. in patients undergoing tricuspid edge-to-edge repair for severe T. R. It also delineated the potential benefits and comparative effectiveness of adding concomitant mitral edge-to-edge repair, highlighting a crucial aspect of dual valve disease management. Article 2: Senescence-associated metabolic alterations aggravate calcific aortic valve disease. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41841768 Summary: Calcific aortic valve disease, or C. A. V. D., a condition without effective drug treatments, is fundamentally linked to the aging process. The progressive decline of nicotinamide adenine dinucleotide, or N. A. D. plus, with age plays a critical role in this disease pathology. This research identified that specific disruptions in N. A. D. plus salvage metabolism within certain cell types contribute to valvular inflammation and calcification. The study provided detailed mapping of N. A. D. plus pathways using integrated human aortic valve ribonucleic acid sequencing and single-cell transcriptomics, showing effects related to nicotinamide phosphoribosyltransferase. Article 3: Risk factors and coronary events: attenuation of the association in secondary prevention. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42556799 Summary: For individuals who have survived coronary heart disease, or C. H. D., the association between traditional risk factors and subsequent cardiovascular events often appears diminished or even contradictory. This phenomenon complicates accurate clinical interpretation and risk prediction in secondary prevention settings. The study demonstrated that this observation represents a systemic characteristic of studying disease survivors rather than unique to specific risk factors requiring biological explanations. Researchers analyzed a large retrospective longitudinal cohort of over 3275000 adults initially free of cardiovascular disease, or C. V. D., confirming these attenuated risk factor associations in secondary prevention. Article 4: Improved Sensitivity for Respiratory Pathogen Detection in Bronchoalveolar Lavage from Lung Transplant Recipients Using Targeted Next-Generation Sequencing. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42551813 Summary: Next-generation sequencing, or N. G. S., offers improved pathogen detection for pulmonary infections among lung transplant recipients, or L. T. R.s. This diagnostic approach was systematically compared against conventional cultures in parallel bronchoalveolar lavage, or B. A. L., specimens. The study assessed the positivity rates, sensitivity, and specificity of N. G. S. relative to a composite reference for infection. It also evaluated N. G. S. species-level diagnostic accuracy against culture results, providing crucial comparative data from 122 bronchoscopies across 31 L. T. R.s. Article 5: From Gene Editing to Exogenesis: Pigs as a Source of Immune-compatible Organs for Transplantation. Journal: Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42547936 Summary: Persistent shortages of human organs have driven the development of alternative sources, particularly xenotransplantation using genetically engineered pigs. Significant progress has been made in creating multigene-modified pigs that lack glycan xenoantigens. These pigs also express human complement and coagulation regulators, enhancing compatibility. These genetic modifications have successfully mitigated hyperacute and delayed xenograft rejection, marking a critical advancement in making pig organs immune-compatible for human transplantation. Transcript Today’s date is August 07, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Combined transcatheter mitral and tricuspid edge-to-edge repair or tricuspid edge-to-edge repair alone in moderate mitral regurgitation: a propensity-matched analysis. Transcatheter edge-to-edge repair represents a therapeutic strategy for the complex coexistence of moderate mitral regurgitation, or M. R., and severe tricuspid regurgitation, or T. R. Clinically, the management choice involves either combined mitral and tricuspid valve repair or isolated tricuspid valve repair. The study established the prognostic relevance of moderate M. R. in patients undergoing tricuspid edge-to-edge repair for severe T. R. It also delineated the potential benefits and comparative effectiveness of adding concomitant mitral edge-to-edge repair, highlighting a crucial aspect of dual valve disease management. Article number two. Senescence-associated metabolic alterations aggravate calcific aortic valve disease. Calcific aortic valve disease, or C. A. V. D., a condition without effective drug treatments, is fundamentally linked to the aging process. The progressive decline of nicotinamide adenine dinucleotide, or N. A. D. plus, with age plays a critical role in this disease pathology. This research identified that specific disruptions in N. A. D. plus salvage metabolism within certain cell types contribute to valvular inflammation and calcification. The study provided detailed mapping of N. A. D. plus pathways using integrated human aortic valve ribonucleic acid sequencing and single-cell transcriptomics, showing effects related to nicotinamide phosphoribosyltransferase. Article number three. Risk factors and coronary events: attenuation of the association in secondary prevention. For individuals who have survived coronary heart disease, or C. H. D., the association between traditional risk factors and subsequent cardiovascular events often appears diminished or even contradictory. This phenomenon complicates accurate clinical interpretation and risk prediction in secondary prevention settings. The study demonstrated that this observation represents a systemic characteristic of studying disease survivors rather than unique to specific risk factors requiring biological explanations. Researchers analyzed a large retrospective longitudinal cohort of over 3275000 adults initially free of cardiovascular disease, or C. V. D., confirming these attenuated risk factor associations in secondary prevention. Article number four. Improved Sensitivity for Respiratory Pathogen Detection in Bronchoalveolar Lavage from Lung Transplant Recipients Using Targeted Next-Generation Sequencing. Next-generation sequencing, or N. G. S., offers improved pathogen detection for pulmonary infections among lung transplant recipients, or L. T. R.s. This diagnostic approach was systematically compared against conventional cultures in parallel bronchoalveolar lavage, or B. A. L., specimens. The study assessed the positivity rates, sensitivity, and specificity of N. G. S. relative to a composite reference for infection. It also evaluated N. G. S. species-level diagnostic accuracy against culture results, providing crucial comparative data from 122 bronchoscopies across 31 L. T. R.s. Article number five. From Gene Editing to Exogenesis: Pigs as a Source of Immune-compatible Organs for Transplantation. Persistent shortages of human organs have driven the development of alternative sources, particularly xenotransplantation using genetically engineered pigs. Significant progress has been made in creating multigene-modified pigs that lack glycan xenoantigens. These pigs also express human complement and coagulation regulators, enhancing compatibility. These genetic modifications have successfully mitigated hyperacute and delayed xenograft rejection, marking a critical advancement in making pig organs immune-compatible for human transplantation. Thank you for listening. Don’t forget to subscribe. Keywords tricuspid regurgitation, pathogen detection, secondary prevention, genetic modifications, xenotransplantation, lung transplant recipients, aging, risk factors, mitral regurgitation, calcific aortic valve disease, next-generation sequencing, bronchoalveolar lavage, transcatheter edge-to-edge repair, immune-compatible organs, dual valve disease, coronary heart disease, prognostic impact, risk prediction, valvular inflammation, cardiovascular events, pulmonary infections, NAD+ salvage metabolism, xenograft rejection, nicotinamide adenine dinucleotide, gene editing. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Xenotransplant Progress: Pigs Mitigate Rejection 08/07/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded August 06, 2026. This episode summarizes 5 key cardiology studies on topics like diabetes and cardiometabolic risk factors. Key takeaway: Finerenone Improves Cardio-Renal Outcomes. Article Links: Article 1: Conservative Oxygen for Unresponsive Patients after Cardiac Arrest. (The New England journal of medicine) Article 2: Finerenone in Persons with Chronic Kidney Disease without Diabetes. (The New England journal of medicine) Article 3: Treatment of Cardiometabolic Risk Factors Among U.S. Adults With Cardiovascular-Kidney-Metabolic Syndrome. (Journal of the American College of Cardiology) Article 4: Effects of Finerenone on Sudden Death Across the Cardio-Kidney-Metabolic Landscape: A FINE-HEART Analysis. (Journal of the American College of Cardiology) Article 5: Periodontitis, epicardial adipose tissue and coronary events: the Swedish Cardiopulmonary Bioimage Study. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/finerenone-improves-cardio-renal-outcomes-08-06-26/ Featured Articles Article 1: Conservative Oxygen for Unresponsive Patients after Cardiac Arrest. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42267831 Summary: This study randomized unresponsive adults receiving mechanical ventilation in the intensive care unit after cardiac arrest to either conservative or liberal oxygen therapy. It compared the clinical impact of distinct arterial oxygen saturation targets following resuscitation. The research specifically evaluated whether limiting oxygen exposure, as opposed to a more liberal approach, affects the likelihood of survival with a favorable functional outcome. This investigation clarifies optimal oxygen management strategies for post-cardiac arrest care. Article 2: Finerenone in Persons with Chronic Kidney Disease without Diabetes. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42246672 Summary: Previous randomized trials showed that finerenone, a nonsteroidal mineralocorticoid receptor antagonist, improved kidney and cardiovascular outcomes in patients with type two diabetes and chronic kidney disease. This study randomized adults without diabetes who had chronic kidney disease and albuminuria. Participants had an estimated glomerular filtration rate between 25 and less than 90 milliliters per minute per 1.73 square meters of body-surface area. The research evaluated finerenone’s effects on kidney and cardiovascular outcomes in this specific non-diabetic patient population. Article 3: Treatment of Cardiometabolic Risk Factors Among U.S. Adults With Cardiovascular-Kidney-Metabolic Syndrome. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42307495 Summary: Adults With Cardiovascular-Kidney-Metabolic Syndrome. This study characterized national treatment rates of major cardiometabolic risk factors among U.S. adults with cardiovascular-kidney-metabolic syndrome. It identified contemporary treatment patterns for hypertension and diabetes in this high-risk population. The research clarified intervention targets within the interconnected cardiometabolic, kidney, and cardiovascular disease landscape. This characterization provides a foundation for defining optimal intervention strategies amid rising cardiovascular mortality. Article 4: Effects of Finerenone on Sudden Death Across the Cardio-Kidney-Metabolic Landscape: A FINE-HEART Analysis. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42233928 Summary: Finerenone, a nonsteroidal mineralocorticoid receptor antagonist, demonstrated improved cardiovascular and kidney outcomes in patients with cardiovascular-kidney-metabolic syndrome. The FINE-HEART analysis specifically investigated the effects of finerenone on sudden death within this patient population. This prespecified analysis pooled participant-level data from three placebo-controlled trials of finerenone. It meticulously examined independent predictors of sudden death and finerenone’s impact on this outcome. Article 5: Periodontitis, epicardial adipose tissue and coronary events: the Swedish Cardiopulmonary Bioimage Study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42555521 Summary: This study investigated the mechanistic role of subclinical atherosclerosis in the relationship between periodontitis and coronary heart disease. Researchers examined whether subclinical atherosclerosis mediates the association between periodontitis and incident coronary heart disease. The study also evaluated how a specific periodontitis phenotype modifies subclinical coronary atherosclerosis and its association with epicardial adipose tissue attenuation, a marker of inflammation. This research clarifies the complex interplay between oral health and cardiovascular disease mechanisms. Transcript Today’s date is August 06, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Conservative Oxygen for Unresponsive Patients after Cardiac Arrest. This study randomized unresponsive adults receiving mechanical ventilation in the intensive care unit after cardiac arrest to either conservative or liberal oxygen therapy. It compared the clinical impact of distinct arterial oxygen saturation targets following resuscitation. The research specifically evaluated whether limiting oxygen exposure, as opposed to a more liberal approach, affects the likelihood of survival with a favorable functional outcome. This investigation clarifies optimal oxygen management strategies for post-cardiac arrest care. Article number two. Finerenone in Persons with Chronic Kidney Disease without Diabetes. Previous randomized trials showed that finerenone, a nonsteroidal mineralocorticoid receptor antagonist, improved kidney and cardiovascular outcomes in patients with type two diabetes and chronic kidney disease. This study randomized adults without diabetes who had chronic kidney disease and albuminuria. Participants had an estimated glomerular filtration rate between 25 and less than 90 milliliters per minute per 1.73 square meters of body-surface area. The research evaluated finerenone’s effects on kidney and cardiovascular outcomes in this specific non-diabetic patient population. Article number three. Treatment of Cardiometabolic Risk Factors Among U.S. Adults With Cardiovascular-Kidney-Metabolic Syndrome. This study characterized national treatment rates of major cardiometabolic risk factors among U.S. adults with cardiovascular-kidney-metabolic syndrome. It identified contemporary treatment patterns for hypertension and diabetes in this high-risk population. The research clarified intervention targets within the interconnected cardiometabolic, kidney, and cardiovascular disease landscape. This characterization provides a foundation for defining optimal intervention strategies amid rising cardiovascular mortality. Article number four. Effects of Finerenone on Sudden Death Across the Cardio-Kidney-Metabolic Landscape: A FINE-HEART Analysis. Finerenone, a nonsteroidal mineralocorticoid receptor antagonist, demonstrated improved cardiovascular and kidney outcomes in patients with cardiovascular-kidney-metabolic syndrome. The FINE-HEART analysis specifically investigated the effects of finerenone on sudden death within this patient population. This prespecified analysis pooled participant-level data from three placebo-controlled trials of finerenone. It meticulously examined independent predictors of sudden death and finerenone’s impact on this outcome. Article number five. Periodontitis, epicardial adipose tissue and coronary events: the Swedish Cardiopulmonary Bioimage Study. This study investigated the mechanistic role of subclinical atherosclerosis in the relationship between periodontitis and coronary heart disease. Researchers examined whether subclinical atherosclerosis mediates the association between periodontitis and incident coronary heart disease. The study also evaluated how a specific periodontitis phenotype modifies subclinical coronary atherosclerosis and its association with epicardial adipose tissue attenuation, a marker of inflammation. This research clarifies the complex interplay between oral health and cardiovascular disease mechanisms. Thank you for listening. Don’t forget to subscribe. Keywords diabetes, cardiometabolic risk factors, albuminuria, sudden death, intensive care unit, coronary heart disease, cardiovascular-kidney-metabolic syndrome, resuscitation, periodontitis, mineralocorticoid receptor antagonist, cardiac arrest, mechanical ventilation, finerenone, cardiovascular outcomes, oxygen therapy, nonsteroidal mineralocorticoid receptor antagonist, chronic kidney disease, hypertension, subclinical atherosclerosis, inflammation, epicardial adipose tissue, treatment patterns, estimated glomerular filtration rate. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Finerenone Improves Cardio-Renal Outcomes 08/06/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded August 05, 2026. This episode summarizes 5 key cardiology studies on topics like gene knockout and genetic predictors. Key takeaway: LMOD1 Loss Triggers Rapid Atherosclerosis.. Article Links: Article 1: Incidence and Predictors of Extracranial Bleeding on Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation: A COMBINE-AF Analysis. (Circulation) Article 2: Facilitation of Autophagosome-Lysosome Fusion by LAPTM4A: A Novel Strategy for Attenuating Myocardial Ischemia-Reperfusion Injury. (Circulation) Article 3: COL1A1-Enhanced CD44/SLC7A11 Interaction and Cystine Uptake Result in CD34+ Foam-Like Macrophage Accumulation in Transplant Arteriosclerosis. (Circulation) Article 4: Loss of the Coronary Artery Disease Risk Gene LMOD1 in Vascular Smooth Muscle Cells Triggers Rapid-Onset Coronary Atherosclerosis. (Circulation) Article 5: Side effects in hypertension treatment: a pharmacogenomic analysis. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/lmod1-loss-triggers-rapid-atherosclerosis-08-05-26/ Featured Articles Article 1: Incidence and Predictors of Extracranial Bleeding on Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation: A COMBINE-AF Analysis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42549517 Summary: This COMBINE-AF analysis identified extracranial bleeding as the most common complication of oral anticoagulant therapy for stroke prevention in patients with atrial fibrillation. Researchers characterized these bleeding events according to standardized severity definitions. The study identified baseline risk factors for bleeding and quantified their population attributable fraction in patients receiving oral anticoagulants. Article 2: Facilitation of Autophagosome-Lysosome Fusion by LAPTM4A: A Novel Strategy for Attenuating Myocardial Ischemia-Reperfusion Injury. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42549514 Summary: This study found that the protein LAPTM4A facilitates autophagosome-lysosome fusion. This specific mechanism attenuates myocardial ischemia-reperfusion injury, which otherwise leads to functional impairment and structural damage in the heart. The findings demonstrate LAPTM4A as a novel strategy to limit damage caused by myocardial ischemia-reperfusion injury, addressing a critical unmet clinical need. Article 3: COL1A1-Enhanced CD44/SLC7A11 Interaction and Cystine Uptake Result in CD34+ Foam-Like Macrophage Accumulation in Transplant Arteriosclerosis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42549511 Summary: This research demonstrated that the interaction between COL1A1 and CD44/SLC7A11 enhances cystine uptake. This specific process results in the accumulation of CD34 positive foam-like macrophages in transplant arteriosclerosis. These findings elucidate key regulatory mechanisms of macrophages in allograft arteriosclerosis, offering a foundation for developing targeted therapies against chronic transplant arteriosclerosis, a primary cause of long-term graft failure. Article 4: Loss of the Coronary Artery Disease Risk Gene LMOD1 in Vascular Smooth Muscle Cells Triggers Rapid-Onset Coronary Atherosclerosis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42549503 Summary: This study found that the loss of the Coronary Artery Disease risk gene LMOD1 specifically in vascular smooth muscle cells triggers rapid-onset coronary atherosclerosis. The results establish LMOD1 as a critical regulator in vascular smooth muscle cell function. This finding reveals a previously unknown role for LMOD1 in coronary artery pathophysiology and the development of atherosclerosis. Article 5: Side effects in hypertension treatment: a pharmacogenomic analysis. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42545033 Summary: This extensive pharmacogenomic analysis classified short-term antihypertensive medication use trajectories from over 400000 genotyped users across three cohorts. The study addressed the challenge that up to half of patients switch or discontinue antihypertensive medications within the first year due to elusive underlying mechanisms. This large-scale analysis provided a framework for investigating genetic influences on these medication patterns. Transcript Today’s date is August 05, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Incidence and Predictors of Extracranial Bleeding on Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation: A COMBINE-AF Analysis. This COMBINE-AF analysis identified extracranial bleeding as the most common complication of oral anticoagulant therapy for stroke prevention in patients with atrial fibrillation. Researchers characterized these bleeding events according to standardized severity definitions. The study identified baseline risk factors for bleeding and quantified their population attributable fraction in patients receiving oral anticoagulants. Article number two. Facilitation of Autophagosome-Lysosome Fusion by LAPTM4A: A Novel Strategy for Attenuating Myocardial Ischemia-Reperfusion Injury. This study found that the protein LAPTM4A facilitates autophagosome-lysosome fusion. This specific mechanism attenuates myocardial ischemia-reperfusion injury, which otherwise leads to functional impairment and structural damage in the heart. The findings demonstrate LAPTM4A as a novel strategy to limit damage caused by myocardial ischemia-reperfusion injury, addressing a critical unmet clinical need. Article number three. COL1A1-Enhanced CD44/SLC7A11 Interaction and Cystine Uptake Result in CD34+ Foam-Like Macrophage Accumulation in Transplant Arteriosclerosis. This research demonstrated that the interaction between COL1A1 and CD44/SLC7A11 enhances cystine uptake. This specific process results in the accumulation of CD34 positive foam-like macrophages in transplant arteriosclerosis. These findings elucidate key regulatory mechanisms of macrophages in allograft arteriosclerosis, offering a foundation for developing targeted therapies against chronic transplant arteriosclerosis, a primary cause of long-term graft failure. Article number four. Loss of the Coronary Artery Disease Risk Gene LMOD1 in Vascular Smooth Muscle Cells Triggers Rapid-Onset Coronary Atherosclerosis. This study found that the loss of the Coronary Artery Disease risk gene LMOD1 specifically in vascular smooth muscle cells triggers rapid-onset coronary atherosclerosis. The results establish LMOD1 as a critical regulator in vascular smooth muscle cell function. This finding reveals a previously unknown role for LMOD1 in coronary artery pathophysiology and the development of atherosclerosis. Article number five. Side effects in hypertension treatment: a pharmacogenomic analysis. This extensive pharmacogenomic analysis classified short-term antihypertensive medication use trajectories from over 400000 genotyped users across three cohorts. The study addressed the challenge that up to half of patients switch or discontinue antihypertensive medications within the first year due to elusive underlying mechanisms. This large-scale analysis provided a framework for investigating genetic influences on these medication patterns. Thank you for listening. Don’t forget to subscribe. Keywords gene knockout, genetic predictors, graft failure, therapeutic strategy, bleeding risk factors, LAPTM4A, extracranial bleeding, LMOD1, CD34 positive macrophages, macrophage accumulation, vascular smooth muscle cells, cardiac damage, COL1A1, stroke prevention, myocardial ischemia-reperfusion injury, pharmacogenomics, hypertension, oral anticoagulants, atherosclerosis, autophagosome-lysosome fusion, antihypertensive medications, medication adherence, transplant arteriosclerosis, atrial fibrillation, coronary artery disease. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post LMOD1 Loss Triggers Rapid Atherosclerosis. 08/05/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded August 04, 2026. This episode summarizes 5 key cardiology studies on topics like cardiac contraction and markers of ultra-processing. Key takeaway: Mitochondrial Damage Drives Heart Failure. Article Links: Article 1: Left Ventricular Hypertrabeculation and Prognosis in Dilated Cardiomyopathy. (Circulation) Article 2: Association of Pulmonary Vascular Remodeling With Cardiac Structure and Function, Pulmonary Pressure, and Heart Failure in Late Life: The Atherosclerosis Risk in Communities (ARIC) Study. (Circulation) Article 3: Loss of STMP1 Perturbs Mitochondrial Cristae and Drives Cellular Inflammation and Heart Failure. (Circulation) Article 4: SREBP1 Transactivation of NHE3 Impairs Cardiac Contraction and Aggravates Heart Failure. (Circulation) Article 5: Markers of ultra-processed food and incident arterial hypertension in the UK Biobank. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/mitochondrial-damage-drives-heart-failure-08-04-26/ Featured Articles Article 1: Left Ventricular Hypertrabeculation and Prognosis in Dilated Cardiomyopathy. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42546101 Summary: Left ventricular hypertrabeculation, previously known as left ventricular noncompaction, represents a heterogeneous myocardial condition. This study found that the presence of hypertrabeculation in patients with dilated cardiomyopathy (D. C. M.) correlated with an altered embolic risk profile. The research determined its prevalence and established its prognostic relevance across various dilated cardiomyopathy genotypes. These findings provide crucial information for understanding patient stratification and risk assessment in dilated cardiomyopathy. Article 2: Association of Pulmonary Vascular Remodeling With Cardiac Structure and Function, Pulmonary Pressure, and Heart Failure in Late Life: The Atherosclerosis Risk in Communities (ARIC) Study. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42478373 Summary: This study found a significant association between pulmonary vascular arterial remodeling, characterized by distal pruning and proximal dilation, and various cardiac parameters. Specifically, it demonstrated correlations with cardiac structure and function, including age-associated left ventricular remodeling and diastolic dysfunction. The research established links between these pulmonary arterial changes and elevated pulmonary pressure, as well as the incidence of heart failure in late life. These findings highlight the interplay between pulmonary vascular health and cardiac function in an aging population. Article 3: Loss of STMP1 Perturbs Mitochondrial Cristae and Drives Cellular Inflammation and Heart Failure. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42267405 Summary: This study found that the loss of STMP1 significantly perturbs mitochondrial cristae integrity within cells. Compromised mitochondrial cristae led to a cytoplasmic leak of mitochondrial D. N. A., which in turn triggered persistent low-grade cellular inflammation. This inflammatory response occurred through the activation of the cGAS (cyclic G. M. P. A. M. P. synthase)-STING (stimulator of interferon genes) pathway and subsequently type one interferon. The research concluded that this mechanistic pathway driven by STMP1 loss actively drives cellular inflammation and contributes to the progression of heart failure. Article 4: SREBP1 Transactivation of NHE3 Impairs Cardiac Contraction and Aggravates Heart Failure. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42170742 Summary: This study found that sterol regulatory element-binding protein one (S. R. E. B. P. one) transactivation of sodium hydrogen exchanger three (N. H. E. three) directly impairs cardiac contraction. The research demonstrated that this pathway contributes to the dysregulation of intracellular ion cycling, specifically sodium and hydrogen, which is fundamental to reduced cardiac contractility. The findings revealed a critical mechanism linking myocardial stress to these ion imbalances. Ultimately, the study concluded that S. R. E. B. P. one transactivation of N. H. E. three aggravates heart failure, particularly heart failure with reduced ejection fraction (H. F. r. E. F.). Article 5: Markers of ultra-processed food and incident arterial hypertension in the UK Biobank. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42545878 Summary: This prospective cohort study, involving 101560 non-hypertensive U. K. Biobank participants, found a positive association between the intake of ultra-processed food (U. P. F.) and incident arterial hypertension. The research specifically assessed and identified associations with particular markers of ultra-processing (M. U. P. s) that had not been previously evaluated. Participants’ dietary intake was captured via 24-hour dietary recalls, and ultra-processed foods were identified by matching commercial products to food items. The data demonstrated that specific markers within ultra-processed foods independently correlated with the development of new-onset hypertension. Transcript Today’s date is August 04, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Left Ventricular Hypertrabeculation and Prognosis in Dilated Cardiomyopathy. Left ventricular hypertrabeculation, previously known as left ventricular noncompaction, represents a heterogeneous myocardial condition. This study found that the presence of hypertrabeculation in patients with dilated cardiomyopathy (D. C. M.) correlated with an altered embolic risk profile. The research determined its prevalence and established its prognostic relevance across various dilated cardiomyopathy genotypes. These findings provide crucial information for understanding patient stratification and risk assessment in dilated cardiomyopathy. Article number two. Association of Pulmonary Vascular Remodeling With Cardiac Structure and Function, Pulmonary Pressure, and Heart Failure in Late Life: The Atherosclerosis Risk in Communities (ARIC) Study. This study found a significant association between pulmonary vascular arterial remodeling, characterized by distal pruning and proximal dilation, and various cardiac parameters. Specifically, it demonstrated correlations with cardiac structure and function, including age-associated left ventricular remodeling and diastolic dysfunction. The research established links between these pulmonary arterial changes and elevated pulmonary pressure, as well as the incidence of heart failure in late life. These findings highlight the interplay between pulmonary vascular health and cardiac function in an aging population. Article number three. Loss of STMP1 Perturbs Mitochondrial Cristae and Drives Cellular Inflammation and Heart Failure. This study found that the loss of STMP1 significantly perturbs mitochondrial cristae integrity within cells. Compromised mitochondrial cristae led to a cytoplasmic leak of mitochondrial D. N. A., which in turn triggered persistent low-grade cellular inflammation. This inflammatory response occurred through the activation of the cGAS (cyclic G. M. P. A. M. P. synthase)-STING (stimulator of interferon genes) pathway and subsequently type one interferon. The research concluded that this mechanistic pathway driven by STMP1 loss actively drives cellular inflammation and contributes to the progression of heart failure. Article number four. SREBP1 Transactivation of NHE3 Impairs Cardiac Contraction and Aggravates Heart Failure. This study found that sterol regulatory element-binding protein one (S. R. E. B. P. one) transactivation of sodium hydrogen exchanger three (N. H. E. three) directly impairs cardiac contraction. The research demonstrated that this pathway contributes to the dysregulation of intracellular ion cycling, specifically sodium and hydrogen, which is fundamental to reduced cardiac contractility. The findings revealed a critical mechanism linking myocardial stress to these ion imbalances. Ultimately, the study concluded that S. R. E. B. P. one transactivation of N. H. E. three aggravates heart failure, particularly heart failure with reduced ejection fraction (H. F. r. E. F.). Article number five. Markers of ultra-processed food and incident arterial hypertension in the UK Biobank. This prospective cohort study, involving 101560 non-hypertensive U. K. Biobank participants, found a positive association between the intake of ultra-processed food (U. P. F.) and incident arterial hypertension. The research specifically assessed and identified associations with particular markers of ultra-processing (M. U. P. s) that had not been previously evaluated. Participants’ dietary intake was captured via 24-hour dietary recalls, and ultra-processed foods were identified by matching commercial products to food items. The data demonstrated that specific markers within ultra-processed foods independently correlated with the development of new-onset hypertension. Thank you for listening. Don’t forget to subscribe. Keywords cardiac contraction, markers of ultra-processing, aging, ultra-processed food, SREBP1, heart failure, embolic risk, ion cycling, U. K. Biobank, NHE3, heart failure with reduced ejection fraction, pulmonary vascular remodeling, pulmonary pressure, genetic testing, cellular inflammation, dietary recall, cGAS-STING pathway, dilated cardiomyopathy, mitochondrial cristae, STMP1, arterial hypertension, prognosis, left ventricular hypertrabeculation, cardiac structure. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Mitochondrial Damage Drives Heart Failure 08/04/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded August 03, 2026. This episode summarizes 5 key cardiology studies on topics like ventricular tachycardia and prevalence. Key takeaway: Adult Congenital Heart Disease: New Complications. Article Links: Article 1: Tetralogy of Fallot: electrophysiology-guided surgical ablation during pulmonary valve replacement. (European heart journal) Article 2: Outcomes after a first acute myocardial infarction in patients with or without congenital heart disease. (European heart journal) Article 3: Subvalvular aortic stenosis in adults: clinical course and long-term outcomes. (European heart journal) Article 4: Heart failure with preserved ejection fraction in adults with congenital heart disease. (European heart journal) Article 5: Congenital heart defects: familial recurrence patterns in Sweden. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/adult-congenital-heart-disease-new-complications-08-03-26/ Featured Articles Article 1: Tetralogy of Fallot: electrophysiology-guided surgical ablation during pulmonary valve replacement. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42206474 Summary: Adults with repaired Tetralogy of Fallot face significant long-term risks of ventricular tachycardia and sudden cardiac death. This study described the clinical strategy of pre-operative electrophysiological testing to guide intraoperative cryoablation during pulmonary valve replacement. This therapeutic approach targeted identified anatomical arrhythmia substrates. The investigation focused on its association with reduced post-operative ventricular tachycardia inducibility and the long-term risk of clinical ventricular tachycardia and sudden cardiac death. Article 2: Outcomes after a first acute myocardial infarction in patients with or without congenital heart disease. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42112702 Summary: Adults with congenital heart disease have improved life expectancy, leading to an increased focus on age-related comorbidities like acute myocardial infarction. This nationwide case-control study compared outcomes following a first acute myocardial infarction in patients with and without congenital heart disease. Researchers included 214 adults with congenital heart disease and 275377 controls without, evaluating all-cause mortality and recurrent acute myocardial infarction. This investigation provides crucial data on the clinical course of acute myocardial infarction within the adult congenital heart disease population. Article 3: Subvalvular aortic stenosis in adults: clinical course and long-term outcomes. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41635281 Summary: This study characterized the clinical course and long-term outcomes in adults diagnosed with subvalvular aortic stenosis. It included patients from the Dutch Congenital Cor Vitia registry, following them between 2001 and 2019. The investigation assessed all-cause mortality, rates of subvalvular aortic stenosis re-operation, and cardiovascular events. Key cardiovascular events included arrhythmias, heart failure, and re-operations for aortic regurgitation. Article 4: Heart failure with preserved ejection fraction in adults with congenital heart disease. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41614664 Summary: Heart failure with preserved ejection fraction is a growing concern in the general population, but its prevalence among adults with congenital heart disease remains largely unknown. This multicenter cohort study described the prevalence, characteristics, and hospitalization burden of heart failure with preserved ejection fraction within this specific patient group. Researchers analyzed electronic medical files of 4507 adults with congenital heart disease who had biventricular heart physiology and systemic left ventricles. The study provided foundational data on heart failure with preserved ejection fraction in adult congenital heart disease. Article 5: Congenital heart defects: familial recurrence patterns in Sweden. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41504464 Summary: Congenital heart defects are known to aggregate within families, yet their recurrence patterns across different kinship types and generations are not fully understood. This nationwide, population-based case-control study in Sweden investigated these familial recurrence patterns among relatives. Researchers included 51778 individuals diagnosed with congenital heart defects who were born between 1987 and 2017. The study provided updated population-based estimates essential for genetic counseling and risk stratification. Transcript Today’s date is August 03, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Tetralogy of Fallot: electrophysiology-guided surgical ablation during pulmonary valve replacement. Adults with repaired Tetralogy of Fallot face significant long-term risks of ventricular tachycardia and sudden cardiac death. This study described the clinical strategy of pre-operative electrophysiological testing to guide intraoperative cryoablation during pulmonary valve replacement. This therapeutic approach targeted identified anatomical arrhythmia substrates. The investigation focused on its association with reduced post-operative ventricular tachycardia inducibility and the long-term risk of clinical ventricular tachycardia and sudden cardiac death. Article number two. Outcomes after a first acute myocardial infarction in patients with or without congenital heart disease. Adults with congenital heart disease have improved life expectancy, leading to an increased focus on age-related comorbidities like acute myocardial infarction. This nationwide case-control study compared outcomes following a first acute myocardial infarction in patients with and without congenital heart disease. Researchers included 214 adults with congenital heart disease and 275377 controls without, evaluating all-cause mortality and recurrent acute myocardial infarction. This investigation provides crucial data on the clinical course of acute myocardial infarction within the adult congenital heart disease population. Article number three. Subvalvular aortic stenosis in adults: clinical course and long-term outcomes. This study characterized the clinical course and long-term outcomes in adults diagnosed with subvalvular aortic stenosis. It included patients from the Dutch Congenital Cor Vitia registry, following them between 2001 and 2019. The investigation assessed all-cause mortality, rates of subvalvular aortic stenosis re-operation, and cardiovascular events. Key cardiovascular events included arrhythmias, heart failure, and re-operations for aortic regurgitation. Article number four. Heart failure with preserved ejection fraction in adults with congenital heart disease. Heart failure with preserved ejection fraction is a growing concern in the general population, but its prevalence among adults with congenital heart disease remains largely unknown. This multicenter cohort study described the prevalence, characteristics, and hospitalization burden of heart failure with preserved ejection fraction within this specific patient group. Researchers analyzed electronic medical files of 4507 adults with congenital heart disease who had biventricular heart physiology and systemic left ventricles. The study provided foundational data on heart failure with preserved ejection fraction in adult congenital heart disease. Article number five. Congenital heart defects: familial recurrence patterns in Sweden. Congenital heart defects are known to aggregate within families, yet their recurrence patterns across different kinship types and generations are not fully understood. This nationwide, population-based case-control study in Sweden investigated these familial recurrence patterns among relatives. Researchers included 51778 individuals diagnosed with congenital heart defects who were born between 1987 and 2017. The study provided updated population-based estimates essential for genetic counseling and risk stratification. Thank you for listening. Don’t forget to subscribe. Keywords ventricular tachycardia, prevalence, pulmonary valve replacement, Tetralogy of Fallot, long-term outcomes, congenital heart disease, aortic regurgitation, Heart Failure with Preserved Ejection Fraction, congenital heart defects, genetic counseling, all-cause mortality, population-based study, familial recurrence, hospitalization burden, acute myocardial infarction, subvalvular aortic stenosis, adult congenital heart disease, electrophysiology-guided ablation. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Adult Congenital Heart Disease: New Complications 08/03/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded August 02, 2026. This episode summarizes 5 key cardiology studies on topics like respiratory support and registry analysis. Key takeaway: Donor Heart Biology: Cardiac vs Brain Death. Article Links: Article 1: Trajectories and outcomes in patients with cardiogenic shock receiving heart replacement therapies. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Determining an optimal central cannulation strategy for ambulatory veno-venous extracorporeal life support. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Single-beat right ventricular-pulmonary artery coupling and residual heart failure in patients with a HeartMate 3 left ventricular assist device. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: The ASSIST CLAD study: A phase 2 randomized controlled trial of mesenchymal stromal cells for new-onset chronic lung allograft dysfunction. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Differential transcriptomic and metabolomic landscape between human hearts donated after cardiac vs brain death. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/donor-heart-biology-cardiac-vs-brain-death-08-02-26/ Featured Articles Article 1: Trajectories and outcomes in patients with cardiogenic shock receiving heart replacement therapies. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41951134 Summary: A retrospective analysis utilizing the Cardiogenic Shock Working Group registry provided comparative data on patient trajectories and outcomes in cardiogenic shock. The study specifically compared individuals receiving heart replacement therapies versus those who did not during their index hospitalization. Cardiogenic shock severity was characterized using Society for Cardiovascular Angiography and Interventions stages, machine learning-derived phenotypes, and the Comorbidity Risk Index. This analysis yielded foundational comparative insights into patient courses under different management strategies for severe cardiogenic shock. Article 2: Determining an optimal central cannulation strategy for ambulatory veno-venous extracorporeal life support. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41949527 Summary: To address suboptimal cannulation for durable veno-venous extracorporeal membrane oxygenation support in end-stage chronic obstructive pulmonary disease, four novel central cannulation strategies were designed, fabricated, and evaluated. Current configurations for long-term respiratory support are suboptimal, prompting the development of these new approaches for durable artificial lung therapies. The evaluation provided crucial insights into improved cannulation configurations, offering critical alternatives for chronic obstructive pulmonary disease patients facing donor lung scarcity. This work advances long-term physiological support for patients requiring prolonged respiratory assistance. Article 3: Single-beat right ventricular-pulmonary artery coupling and residual heart failure in patients with a HeartMate 3 left ventricular assist device. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41949525 Summary: This study investigated single-beat right ventricular-pulmonary artery coupling using elastance-based indices to identify residual heart failure risk in 70 adults with HeartMate 3 left ventricular assist devices. Patients underwent pre-discharge right heart catheterization after optimized device support. The findings demonstrated how right ventricular-pulmonary artery interaction, measured via specific indices, correlates with the presence of ongoing heart failure despite left ventricular assist device implantation. This work provides new understanding of the mechanisms contributing to residual heart failure in this population. Article 4: The ASSIST CLAD study: A phase 2 randomized controlled trial of mesenchymal stromal cells for new-onset chronic lung allograft dysfunction. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41935548 Summary: The A. S. S. I. S. T. chronic lung allograft dysfunction study, a multicenter, phase two, double-blind, randomized controlled trial, demonstrated the impact of intravenous allogenic bone marrow-derived mesenchymal stromal cells in lung transplant recipients with new-onset chronic lung allograft dysfunction. This trial, involving participants aged 18 years or older more than six months post-transplant, focused on those with a persistent fall in forced expiratory volume in one second. The findings established the safety and initial efficacy profile of mesenchymal stromal cells as a therapeutic strategy for this primary limitation to long-term survival after lung transplantation. This work provides evidence for the use of mesenchymal stromal cells in mitigating chronic lung allograft dysfunction. Article 5: Differential transcriptomic and metabolomic landscape between human hearts donated after cardiac vs brain death. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41881141 Summary: This study performed single-nuclei ribonucleic acid sequencing and metabolomics on the human left ventricle, revealing fundamentally different cardiac biology between hearts donated after brain death versus cardiac death. The data demonstrated that hearts donated after cardiac death are specifically marked by ischemic metabolic responses and the generation of oxidative substances. These findings provide critical molecular insights into the distinct physiological states of donor hearts, which can inform preservation strategies. This differential transcriptomic and metabolomic landscape highlights the need for tailored approaches in evaluating and managing hearts from different donation types for transplantation. Transcript Today’s date is August 02, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Trajectories and outcomes in patients with cardiogenic shock receiving heart replacement therapies. A retrospective analysis utilizing the Cardiogenic Shock Working Group registry provided comparative data on patient trajectories and outcomes in cardiogenic shock. The study specifically compared individuals receiving heart replacement therapies versus those who did not during their index hospitalization. Cardiogenic shock severity was characterized using Society for Cardiovascular Angiography and Interventions stages, machine learning-derived phenotypes, and the Comorbidity Risk Index. This analysis yielded foundational comparative insights into patient courses under different management strategies for severe cardiogenic shock. Article number two. Determining an optimal central cannulation strategy for ambulatory veno-venous extracorporeal life support. To address suboptimal cannulation for durable veno-venous extracorporeal membrane oxygenation support in end-stage chronic obstructive pulmonary disease, four novel central cannulation strategies were designed, fabricated, and evaluated. Current configurations for long-term respiratory support are suboptimal, prompting the development of these new approaches for durable artificial lung therapies. The evaluation provided crucial insights into improved cannulation configurations, offering critical alternatives for chronic obstructive pulmonary disease patients facing donor lung scarcity. This work advances long-term physiological support for patients requiring prolonged respiratory assistance. Article number three. Single-beat right ventricular-pulmonary artery coupling and residual heart failure in patients with a HeartMate 3 left ventricular assist device. This study investigated single-beat right ventricular-pulmonary artery coupling using elastance-based indices to identify residual heart failure risk in 70 adults with HeartMate 3 left ventricular assist devices. Patients underwent pre-discharge right heart catheterization after optimized device support. The findings demonstrated how right ventricular-pulmonary artery interaction, measured via specific indices, correlates with the presence of ongoing heart failure despite left ventricular assist device implantation. This work provides new understanding of the mechanisms contributing to residual heart failure in this population. Article number four. The ASSIST CLAD study: A phase 2 randomized controlled trial of mesenchymal stromal cells for new-onset chronic lung allograft dysfunction. The A. S. S. I. S. T. chronic lung allograft dysfunction study, a multicenter, phase two, double-blind, randomized controlled trial, demonstrated the impact of intravenous allogenic bone marrow-derived mesenchymal stromal cells in lung transplant recipients with new-onset chronic lung allograft dysfunction. This trial, involving participants aged 18 years or older more than six months post-transplant, focused on those with a persistent fall in forced expiratory volume in one second. The findings established the safety and initial efficacy profile of mesenchymal stromal cells as a therapeutic strategy for this primary limitation to long-term survival after lung transplantation. This work provides evidence for the use of mesenchymal stromal cells in mitigating chronic lung allograft dysfunction. Article number five. Differential transcriptomic and metabolomic landscape between human hearts donated after cardiac vs brain death. This study performed single-nuclei ribonucleic acid sequencing and metabolomics on the human left ventricle, revealing fundamentally different cardiac biology between hearts donated after brain death versus cardiac death. The data demonstrated that hearts donated after cardiac death are specifically marked by ischemic metabolic responses and the generation of oxidative substances. These findings provide critical molecular insights into the distinct physiological states of donor hearts, which can inform preservation strategies. This differential transcriptomic and metabolomic landscape highlights the need for tailored approaches in evaluating and managing hearts from different donation types for transplantation. Thank you for listening. Don’t forget to subscribe. Keywords respiratory support, registry analysis, chronic lung allograft dysfunction, mesenchymal stromal cells, artificial lung therapies, metabolomics, brain death, heart replacement therapies, patient trajectories, residual heart failure, randomized controlled trial, veno-venous extracorporeal membrane oxygenation, lung transplantation, forced expiratory volume in one second, chronic obstructive pulmonary disease, HeartMate 3, transcriptomics, cardiogenic shock, left ventricular assist device, heart transplantation, cannulation strategies, right ventricular-pulmonary artery coupling, outcomes, donor heart preservation, right heart catheterization, cardiac death. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Donor Heart Biology: Cardiac vs Brain Death 08/02/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded August 01, 2026. This episode summarizes 5 key cardiology studies on topics like acute myocardial infarction and cardiogenic shock. Key takeaway: Higher E. D. Diuretics Cut Heart Failure Hospitalizations.. Article Links: Article 1: Relationship Between Ambulatory Pulmonary Artery Pressures and Heart Failure Hospitalizations in Patients With Chronic Heart Failure. (JACC. Heart failure) Article 2: Higher Emergency Department Diuretic Dosing for Acute Heart Failure Associated With Lower Risk of Hospitalization. (JACC. Heart failure) Article 3: Hospital Referral Region Dissimilarity and Black-White Differences in Heart Failure Outcomes Among Medicare Beneficiaries. (JACC. Heart failure) Article 4: Cardiogenic shock in heart transplant recipients: A multicenter cohort study with matched analysis. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Beyond the STEMI paradigm: Expanding the scope of microAxial flow pump in cardiogenic shock. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/higher-e-d-diuretics-cut-heart-failure-hospitalizations-08-01-26/ Featured Articles Article 1: Relationship Between Ambulatory Pulmonary Artery Pressures and Heart Failure Hospitalizations in Patients With Chronic Heart Failure. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42535981 Summary: This study demonstrated that baseline systolic, diastolic, and mean pulmonary artery pressures, along with their changes from baseline to six months, were independent predictors of a heart failure hospitalization within two years. The analysis, drawn from CardioMEMS data including the CHAMPION study, identified these ambulatory hemodynamic markers as crucial indicators. These findings establish the prognostic utility of continuous pulmonary artery pressure monitoring in patients with chronic heart failure. This information is vital for identifying individuals at elevated risk of future decompensation. Article 2: Higher Emergency Department Diuretic Dosing for Acute Heart Failure Associated With Lower Risk of Hospitalization. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42535982 Summary: This study found that higher initial diuretic dosing in the emergency department for acute heart failure was associated with a lower risk of hospital admission. The retrospective cohort analysis identified this association as crucial for managing acute decompensation. Results established an important link between early aggressive diuretic therapy and improved patient outcomes. This demonstrates that judicious higher dosing at presentation can significantly impact hospitalization rates. Article 3: Hospital Referral Region Dissimilarity and Black-White Differences in Heart Failure Outcomes Among Medicare Beneficiaries. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42535980 Summary: This study utilized U. S. Medicare data to identify hospitalizations among Black and White patients with heart failure. The analysis revealed that hospital referral region dissimilarity was associated with significant Black-White differences in heart failure outcomes, including mortality and rehospitalization rates. These findings underscore how geographic segregation of care influences racial disparities in cardiovascular health. The data demonstrated specific patterns of care delivery affecting health equity among Medicare beneficiaries. Article 4: Cardiogenic shock in heart transplant recipients: A multicenter cohort study with matched analysis. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42001917 Summary: This multicenter study characterized the prognosis of heart transplant recipients experiencing graft failure-related cardiogenic shock, occurring at least one month post-transplantation. Researchers identified key predictors of one-year event-free survival within this specific patient population. The analysis also compared these outcomes to those of patients with other etiologies of cardiogenic shock. This research provides critical insights into the management and risk stratification for this complex and high-risk cohort. Article 5: Beyond the STEMI paradigm: Expanding the scope of microAxial flow pump in cardiogenic shock. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41966345 Summary: This study compared clinical profiles, management strategies, and outcomes between patients with acute myocardial infarction-related cardiogenic shock and those with non-ischemic cardiogenic shock supported by microaxial flow pumps. The retrospective analysis, encompassing Impella C. P. and five point five devices, established distinct differences in patient characteristics and therapeutic responses based on cardiogenic shock etiology. Results showed that outcomes and management varied significantly between these two groups. This research expands the understanding of microaxial flow pump utility beyond acute myocardial infarction-related cases, informing tailored therapeutic strategies. Transcript Today’s date is August 01, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Relationship Between Ambulatory Pulmonary Artery Pressures and Heart Failure Hospitalizations in Patients With Chronic Heart Failure. This study demonstrated that baseline systolic, diastolic, and mean pulmonary artery pressures, along with their changes from baseline to six months, were independent predictors of a heart failure hospitalization within two years. The analysis, drawn from CardioMEMS data including the CHAMPION study, identified these ambulatory hemodynamic markers as crucial indicators. These findings establish the prognostic utility of continuous pulmonary artery pressure monitoring in patients with chronic heart failure. This information is vital for identifying individuals at elevated risk of future decompensation. Article number two. Higher Emergency Department Diuretic Dosing for Acute Heart Failure Associated With Lower Risk of Hospitalization. This study found that higher initial diuretic dosing in the emergency department for acute heart failure was associated with a lower risk of hospital admission. The retrospective cohort analysis identified this association as crucial for managing acute decompensation. Results established an important link between early aggressive diuretic therapy and improved patient outcomes. This demonstrates that judicious higher dosing at presentation can significantly impact hospitalization rates. Article number three. Hospital Referral Region Dissimilarity and Black-White Differences in Heart Failure Outcomes Among Medicare Beneficiaries. This study utilized U. S. Medicare data to identify hospitalizations among Black and White patients with heart failure. The analysis revealed that hospital referral region dissimilarity was associated with significant Black-White differences in heart failure outcomes, including mortality and rehospitalization rates. These findings underscore how geographic segregation of care influences racial disparities in cardiovascular health. The data demonstrated specific patterns of care delivery affecting health equity among Medicare beneficiaries. Article number four. Cardiogenic shock in heart transplant recipients: A multicenter cohort study with matched analysis. This multicenter study characterized the prognosis of heart transplant recipients experiencing graft failure-related cardiogenic shock, occurring at least one month post-transplantation. Researchers identified key predictors of one-year event-free survival within this specific patient population. The analysis also compared these outcomes to those of patients with other etiologies of cardiogenic shock. This research provides critical insights into the management and risk stratification for this complex and high-risk cohort. Article number five. Beyond the STEMI paradigm: Expanding the scope of microAxial flow pump in cardiogenic shock. This study compared clinical profiles, management strategies, and outcomes between patients with acute myocardial infarction-related cardiogenic shock and those with non-ischemic cardiogenic shock supported by microaxial flow pumps. The retrospective analysis, encompassing Impella C. P. and five point five devices, established distinct differences in patient characteristics and therapeutic responses based on cardiogenic shock etiology. Results showed that outcomes and management varied significantly between these two groups. This research expands the understanding of microaxial flow pump utility beyond acute myocardial infarction-related cases, informing tailored therapeutic strategies. Thank you for listening. Don’t forget to subscribe. Keywords acute myocardial infarction, cardiogenic shock, geographic segregation, heart transplant recipients, ambulatory pulmonary artery pressure, racial disparities, heart failure hospitalization, hospital referral regions, Impella, emergency department, loop diuretic, hospitalization risk, Medicare beneficiaries, heart failure outcomes, chronic heart failure, one-year survival, acute heart failure, intravenous diuretics, hemodynamic monitoring, CardioMEMS, graft failure, microaxial flow pumps, non-ischemic cardiogenic shock, retransplantation. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Higher E. D. Diuretics Cut Heart Failure Hospitalizations. 08/01/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded July 31, 2026. This episode summarizes 5 key cardiology studies on topics like macrophage efferocytosis and coronary artery disease. Key takeaway: Plasma I.M.F. Predicts C.A.D. Residual Risk. Article Links: Article 1: Contrastive Machine Learning to Quantify Hypertensive Multiorgan Damage and Identify New Disease Phenotypes: A Multinational Multimodal Study. (Circulation) Article 2: CD40-TRAF2/3/5 Signaling Promotes Cardiac Repair by Mediating Macrophage Efferocytosis After Myocardial Infarction. (Circulation) Article 3: Targeting E3 Ubiquitin Ligase Hrd1 Prevents Myocardial Ischemia-Reperfusion Injury Through Enhancing ALDH2 Enzymatic Activity. (Circulation) Article 4: Plasma infrared molecular fingerprinting stratifies residual risk in coronary artery disease and reflects clonal haematopoiesis-associated biology. (European heart journal) Article 5: Micro-axial flow pump vs veno-arterial extracorporeal membrane oxygenation for high-risk percutaneous coronary interventions: a randomized trial. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/plasma-i-m-f-predicts-c-a-d-residual-risk-07-31-26/ Featured Articles Article 1: Contrastive Machine Learning to Quantify Hypertensive Multiorgan Damage and Identify New Disease Phenotypes: A Multinational Multimodal Study. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42323953 Summary: This study developed a novel machine learning approach that precisely quantifies hypertension-associated multiorgan damage. The approach effectively maps disease progression from health to advanced stages in a pseudotemporal manner. It also predicts organ-specific disease progression trajectories, allowing for earlier identification of subclinical damage. The research provides a robust tool for assessing and tracking the complex impact of hypertension on multiple organ systems. Article 2: CD40-TRAF2/3/5 Signaling Promotes Cardiac Repair by Mediating Macrophage Efferocytosis After Myocardial Infarction. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42093657 Summary: This study demonstrated that C.D.40-T.R.A.F.2/3/5 signaling actively promotes cardiac repair following a myocardial infarction. The mechanism of action involves mediating macrophage efferocytosis, which is the clearance of dead cells. Efficient efferocytosis was found to rescue neighboring viable cardiomyocytes, drive the phenotypic transition of reparative macrophages, and facilitate the resolution of inflammation. These findings highlight a critical pathway for tissue remodeling and recovery post-injury. Article 3: Targeting E3 Ubiquitin Ligase Hrd1 Prevents Myocardial Ischemia-Reperfusion Injury Through Enhancing ALDH2 Enzymatic Activity. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41993020 Summary: This research demonstrated that targeting the E3 ubiquitin ligase Hrd1 effectively prevents myocardial ischemia-reperfusion injury. This protective effect was achieved by enhancing the enzymatic activity of aldehyde dehydrogenase two (A.L.D.H.2). Global ubiquitinome profiling identified Hrd1 as a key player in the complex pathological mechanism of myocardial ischemia-reperfusion injury. The study revealed a novel therapeutic strategy for mitigating damage in this challenging clinical scenario. Article 4: Plasma infrared molecular fingerprinting stratifies residual risk in coronary artery disease and reflects clonal haematopoiesis-associated biology. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42522903 Summary: Plasma infrared molecular fingerprinting (I.M.F.) effectively stratifies residual cardiovascular risk in patients with coronary artery disease. This spectroscopy-based assay was found to accurately reflect clonal haematopoiesis of indeterminate potential-associated biology. The discovery cohort of one thousand three hundred forty-one patients with angiographically documented coronary artery disease demonstrated I.M.F. as a sequencing-free tool for residual risk stratification. This method provides a novel, less invasive approach to identify high-risk patients. Article 5: Micro-axial flow pump vs veno-arterial extracorporeal membrane oxygenation for high-risk percutaneous coronary interventions: a randomized trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42521444 Summary: This randomized trial established a direct comparison between a micro-axial flow pump and veno-arterial extracorporeal membrane oxygenation (V. A. -E. C. M. O.) for mechanical circulatory support. The study specifically addressed high-risk percutaneous coronary interventions in patients with severely reduced left ventricular ejection fraction of 35 percent or less. It investigated optimal prophylactic mechanical circulatory support strategies for individuals with complex three-vessel disease, unprotected left main coronary disease, or a last patent conduit. This research provides a crucial head-to-head evaluation in a vulnerable patient population. Transcript Today’s date is July 31, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Contrastive Machine Learning to Quantify Hypertensive Multiorgan Damage and Identify New Disease Phenotypes: A Multinational Multimodal Study. This study developed a novel machine learning approach that precisely quantifies hypertension-associated multiorgan damage. The approach effectively maps disease progression from health to advanced stages in a pseudotemporal manner. It also predicts organ-specific disease progression trajectories, allowing for earlier identification of subclinical damage. The research provides a robust tool for assessing and tracking the complex impact of hypertension on multiple organ systems. Article number two. C.D.40-T.R.A.F.2/3/5 Signaling Promotes Cardiac Repair by Mediating Macrophage Efferocytosis After Myocardial Infarction. This study demonstrated that C.D.40-T.R.A.F.2/3/5 signaling actively promotes cardiac repair following a myocardial infarction. The mechanism of action involves mediating macrophage efferocytosis, which is the clearance of dead cells. Efficient efferocytosis was found to rescue neighboring viable cardiomyocytes, drive the phenotypic transition of reparative macrophages, and facilitate the resolution of inflammation. These findings highlight a critical pathway for tissue remodeling and recovery post-injury. Article number three. Targeting E3 Ubiquitin Ligase Hrd1 Prevents Myocardial Ischemia-Reperfusion Injury Through Enhancing A.L.D.H.2 Enzymatic Activity. This research demonstrated that targeting the E3 ubiquitin ligase Hrd1 effectively prevents myocardial ischemia-reperfusion injury. This protective effect was achieved by enhancing the enzymatic activity of aldehyde dehydrogenase two (A.L.D.H.2). Global ubiquitinome profiling identified Hrd1 as a key player in the complex pathological mechanism of myocardial ischemia-reperfusion injury. The study revealed a novel therapeutic strategy for mitigating damage in this challenging clinical scenario. Article number four. Plasma infrared molecular fingerprinting stratifies residual risk in coronary artery disease and reflects clonal haematopoiesis-associated biology. Plasma infrared molecular fingerprinting (I.M.F.) effectively stratifies residual cardiovascular risk in patients with coronary artery disease. This spectroscopy-based assay was found to accurately reflect clonal haematopoiesis of indeterminate potential-associated biology. The discovery cohort of one thousand three hundred forty-one patients with angiographically documented coronary artery disease demonstrated I.M.F. as a sequencing-free tool for residual risk stratification. This method provides a novel, less invasive approach to identify high-risk patients. Article number five. Micro-axial flow pump vs veno-arterial extracorporeal membrane oxygenation for high-risk percutaneous coronary interventions: a randomized trial. This randomized trial established a direct comparison between a micro-axial flow pump and veno-arterial extracorporeal membrane oxygenation (V. A. -E. C. M. O.) for mechanical circulatory support. The study specifically addressed high-risk percutaneous coronary interventions in patients with severely reduced left ventricular ejection fraction of 35 percent or less. It investigated optimal prophylactic mechanical circulatory support strategies for individuals with complex three-vessel disease, unprotected left main coronary disease, or a last patent conduit. This research provides a crucial head-to-head evaluation in a vulnerable patient population. Thank you for listening. Don’t forget to subscribe. Keywords macrophage efferocytosis, coronary artery disease, C.D.40 signaling, myocardial ischemia-reperfusion injury, cardiac repair, T.R.A.F.2/3/5, disease phenotypes, residual cardiovascular risk, mechanical circulatory support, Hrd1, P. C. I., veno-arterial extracorporeal membrane oxygenation, subclinical damage, aldehyde dehydrogenase two, clonal haematopoiesis of indeterminate potential, hypertension, E3 ubiquitin ligase, micro-axial flow pump, machine learning, plasma infrared molecular fingerprinting, C.H.I.P., V. A. -E. C. M. O., multiorgan damage, percutaneous coronary intervention, myocardial infarction, A.L.D.H.2 activity. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Plasma I.M.F. Predicts C.A.D. Residual Risk 07/31/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded July 30, 2026. This episode summarizes 5 key cardiology studies on topics like exercise tolerance and practice guidelines. Key takeaway: AI Predicts AF Early from EHR.. Article Links: Article 1: Timing, Translation, and Preparedness: Lessons Learned From COVID-19 Anticoagulation in Noncritically Ill Hospitalized Patients. (Journal of the American College of Cardiology) Article 2: Sotatercept in Pulmonary Arterial Hypertension: Central, Hematologic, and Peripheral Mechanisms of Benefit. (Journal of the American College of Cardiology) Article 3: A Multitask Deep Learning Model for Pediatric Echocardiography Analysis. (Circulation) Article 4: Risk-Guided Screening for Atrial Fibrillation Using Electronic Health Records. (Circulation) Article 5: Predictive Value of Coronary Artery Calcium Score From Nongated Chest CT Scans Compared With Gated Scans and Incidence of Cardiovascular Events. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/ai-predicts-af-early-from-ehr-07-30-26/ Featured Articles Article 1: Timing, Translation, and Preparedness: Lessons Learned From COVID-19 Anticoagulation in Noncritically Ill Hospitalized Patients. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42523015 Summary: This study comprehensively analyzed how clinical evidence for anticoagulation in COVID-19 patients was generated and translated into practice guidelines. The analysis revealed significant challenges in the rapid synthesis and application of emergent data during the public health emergency. It specifically examined randomized controlled trials and individual participant data meta-analyses as case studies to contextualize these processes. The findings highlight the critical need for improved systematic approaches to translate research into clinical guidance during future crises. Article 2: Sotatercept in Pulmonary Arterial Hypertension: Central, Hematologic, and Peripheral Mechanisms of Benefit. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41885673 Summary: Sotatercept, an activin ligand trap, consistently improves exercise tolerance in patients with pulmonary arterial hypertension (P. A. H.). This study comprehensively evaluated the effects of 24-week sotatercept treatment across central, hematologic, and peripheral systems. The evaluation specifically characterized the impact on aerobic capacity, hemodynamic status, cardiovascular function, and oxygen transport in these patients. This research clarifies the broad mechanistic benefits of sotatercept in pulmonary arterial hypertension. Article 3: A Multitask Deep Learning Model for Pediatric Echocardiography Analysis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42517220 Summary: This study introduced EchoAI-Peds, a novel multitask deep learning model for pediatric echocardiography analysis. The model was developed using the most comprehensive set of pediatric labels gathered to date. EchoAI-Peds addresses the limitations of existing pediatric deep learning models, which are often restricted to single tasks and specific echocardiographic views. This advancement provides a robust tool for automating and improving the analysis of congenital heart defects, which affect about one percent of all births worldwide. Article 4: Risk-Guided Screening for Atrial Fibrillation Using Electronic Health Records. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42517218 Summary: This study successfully developed and validated a random forest prediction model for identifying new onset atrial fibrillation within 6 months. Named Future Innovations in Novel Detection of Atrial Fibrillation 2.0 (F. I. N. D. -A. F. 2.0), the model utilizes electronic health records data including age, sex, and ten comorbidities. It was developed with 2081139 United Kingdom patient records and externally validated with over 600000 Japanese patient records. This risk-guided model provides a robust tool for improving atrial fibrillation screening efficacy. Article 5: Predictive Value of Coronary Artery Calcium Score From Nongated Chest CT Scans Compared With Gated Scans and Incidence of Cardiovascular Events. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/42507772 Summary: This study precisely evaluated the prognostic value of incidental coronary artery calcium (C. A. C.) scores obtained from nongated chest computed tomography (C. T.) scans. Researchers directly compared these scores with those from gated C. T. scans and their subsequent association with future cardiovascular events. The analysis included 2601 participants from the Multi-Ethnic Study of Atherosclerosis (M. E. S. A.) exam five, all of whom underwent same-day gated and nongated chest C. T. scans. The research provides definitive data on the relationship between incidental C. A. C. from nongated scans and cardiovascular risk. Transcript Today’s date is July 30, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Timing, Translation, and Preparedness: Lessons Learned From COVID-19 Anticoagulation in Noncritically Ill Hospitalized Patients. This study comprehensively analyzed how clinical evidence for anticoagulation in COVID-19 patients was generated and translated into practice guidelines. The analysis revealed significant challenges in the rapid synthesis and application of emergent data during the public health emergency. It specifically examined randomized controlled trials and individual participant data meta-analyses as case studies to contextualize these processes. The findings highlight the critical need for improved systematic approaches to translate research into clinical guidance during future crises. Article number two. Sotatercept in Pulmonary Arterial Hypertension: Central, Hematologic, and Peripheral Mechanisms of Benefit. Sotatercept, an activin ligand trap, consistently improves exercise tolerance in patients with pulmonary arterial hypertension (P. A. H.). This study comprehensively evaluated the effects of 24-week sotatercept treatment across central, hematologic, and peripheral systems. The evaluation specifically characterized the impact on aerobic capacity, hemodynamic status, cardiovascular function, and oxygen transport in these patients. This research clarifies the broad mechanistic benefits of sotatercept in pulmonary arterial hypertension. Article number three. A Multitask Deep Learning Model for Pediatric Echocardiography Analysis. This study introduced EchoAI-Peds, a novel multitask deep learning model for pediatric echocardiography analysis. The model was developed using the most comprehensive set of pediatric labels gathered to date. EchoAI-Peds addresses the limitations of existing pediatric deep learning models, which are often restricted to single tasks and specific echocardiographic views. This advancement provides a robust tool for automating and improving the analysis of congenital heart defects, which affect about one percent of all births worldwide. Article number four. Risk-Guided Screening for Atrial Fibrillation Using Electronic Health Records. This study successfully developed and validated a random forest prediction model for identifying new onset atrial fibrillation within 6 months. Named Future Innovations in Novel Detection of Atrial Fibrillation 2.0 (F. I. N. D. -A. F. 2.0), the model utilizes electronic health records data including age, sex, and ten comorbidities. It was developed with 2081139 United Kingdom patient records and externally validated with over 600000 Japanese patient records. This risk-guided model provides a robust tool for improving atrial fibrillation screening efficacy. Article number five. Predictive Value of Coronary Artery Calcium Score From Nongated Chest CT Scans Compared With Gated Scans and Incidence of Cardiovascular Events. This study precisely evaluated the prognostic value of incidental coronary artery calcium (C. A. C.) scores obtained from nongated chest computed tomography (C. T.) scans. Researchers directly compared these scores with those from gated C. T. scans and their subsequent association with future cardiovascular events. The analysis included 2601 participants from the Multi-Ethnic Study of Atherosclerosis (M. E. S. A.) exam five, all of whom underwent same-day gated and nongated chest C. T. scans. The research provides definitive data on the relationship between incidental C. A. C. from nongated scans and cardiovascular risk. Thank you for listening. Don’t forget to subscribe. Keywords exercise tolerance, practice guidelines, cardiovascular events, nongated computed tomography, Coronary artery calcium, anticoagulation, prediction model, hemodynamics, Sotatercept, gated computed tomography, public health emergency, multitask model, activin ligand trap, Atrial fibrillation, congenital heart defects, electronic health records, Pediatric echocardiography, M. E. S. A. study, COVID-19, clinical evidence, EchoAI-Peds, machine learning, pulmonary arterial hypertension, risk-guided screening, deep learning. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post AI Predicts AF Early from EHR. 07/30/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 14, 2026. This episode summarizes 5 key cardiology studies on topics like femoral venous puncture and catheter manipulation. Key takeaway: Left Bundle Pacing Challenges BiVP for CRT. Article Links: Article 1: Ultrasound-guided vs conventional venous puncture for atrial fibrillation ablation: the ULYSSES trial. (European heart journal) Article 2: Left bundle branch area vs biventricular pacing for cardiac resynchronization therapy: the LEFT-BUNDLE-CRT trial. (European heart journal) Article 3: Mavacamten Versus Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: An Echocardiography-Derived Pressure-Volume Analysis. (Circulation. Heart failure) Article 4: Device-Related Adverse Events and Outcomes in Patients With Temporary Mechanical Circulatory Support Placed at Referral Centers Versus Cardiogenic Shock Hub Centers: An Observational Analysis. (Circulation. Heart failure) Article 5: Characterization of a successful transseptal access with an electrified guidewire: An ex vivo ovine study. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/left-bundle-pacing-challenges-bivp-for-crt-04-14-26/ Featured Articles Article 1: Ultrasound-guided vs conventional venous puncture for atrial fibrillation ablation: the ULYSSES trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41979041 Summary: The ULYSSES trial confirmed that vascular access site complications are the most common procedure-related adverse events during atrial fibrillation catheter ablation. This study directly compared an ultrasound-guided femoral venous puncture strategy with a conventional approach. The multicenter trial evaluated the efficacy of each technique in reducing complications in patients undergoing atrial fibrillation or left atrial tachycardia catheter ablation. The investigation’s findings provided a critical evidence base for optimizing patient safety during these procedures. Article 2: Left bundle branch area vs biventricular pacing for cardiac resynchronization therapy: the LEFT-BUNDLE-CRT trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41978340 Summary: Conduction system pacing has emerged as an alternative to biventricular pacing for cardiac resynchronization therapy. The LEFT-BUNDLE-CRT trial directly compared left-bundle branch area pacing to biventricular pacing. This multicenter, randomized, non-inferiority study provided a comprehensive evaluation of their comparative effectiveness in patients eligible for cardiac resynchronization therapy and left-bundle branch block. The study’s results established the non-inferiority profile of left-bundle branch area pacing against biventricular pacing for this patient population. Article 3: Mavacamten Versus Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: An Echocardiography-Derived Pressure-Volume Analysis. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41969098 Summary: Obstructive hypertrophic cardiomyopathy is characterized by left ventricular outflow tract obstruction, which increases afterload and activates the Anrep response of hyperdynamic systole. This study directly compared the effects of the myosin inhibitor mavacamten to alcohol septal ablation. Researchers evaluated whether mavacamten reverses this hyperdynamic state, contrasting its impacts with the anatomic relief from alcohol septal ablation in 36 patients. The investigation’s echocardiography-derived pressure-volume analysis clarified the differential physiological effects of these two therapeutic approaches. Article 4: Device-Related Adverse Events and Outcomes in Patients With Temporary Mechanical Circulatory Support Placed at Referral Centers Versus Cardiogenic Shock Hub Centers: An Observational Analysis. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41969084 Summary: Temporary mechanical circulatory support devices are often placed for cardiogenic shock at regional referral centers before transfer to hub centers. This observational analysis identified differences in device-related adverse events and patient outcomes based on the initial site of device placement. The study compared patients whose temporary mechanical circulatory support was initiated at a regional referral center prior to transfer versus those with initial placement at a cardiogenic shock hub center. Its findings clarified the safety and efficacy implications of different care pathways for cardiogenic shock patients. Article 5: Characterization of a successful transseptal access with an electrified guidewire: An ex vivo ovine study. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41979555 Summary: This ex vivo ovine study characterized the determinants of successful transseptal puncture using an electrified guidewire, a technique previously unstudied in this context. Researchers utilized 25 fresh ovine hearts, creating an interatrial septum model from dissected right atrial tissue. The investigation involved fixing the sheath and guidewire to a jig to model clinical catheter manipulation. The study observed transseptal puncture dynamics across varying parameters, establishing key factors influencing success for electrified guidewire transseptal access. Transcript Today’s date is April 14, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Ultrasound-guided vs conventional venous puncture for atrial fibrillation ablation: the ULYSSES trial. The ULYSSES trial confirmed that vascular access site complications are the most common procedure-related adverse events during atrial fibrillation catheter ablation. This study directly compared an ultrasound-guided femoral venous puncture strategy with a conventional approach. The multicenter trial evaluated the efficacy of each technique in reducing complications in patients undergoing atrial fibrillation or left atrial tachycardia catheter ablation. The investigation’s findings provided a critical evidence base for optimizing patient safety during these procedures. Article number two. Left bundle branch area vs biventricular pacing for cardiac resynchronization therapy: the LEFT-BUNDLE-CRT trial. Conduction system pacing has emerged as an alternative to biventricular pacing for cardiac resynchronization therapy. The LEFT-BUNDLE-CRT trial directly compared left-bundle branch area pacing to biventricular pacing. This multicenter, randomized, non-inferiority study provided a comprehensive evaluation of their comparative effectiveness in patients eligible for cardiac resynchronization therapy and left-bundle branch block. The study’s results established the non-inferiority profile of left-bundle branch area pacing against biventricular pacing for this patient population. Article number three. Mavacamten Versus Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: An Echocardiography-Derived Pressure-Volume Analysis. Obstructive hypertrophic cardiomyopathy is characterized by left ventricular outflow tract obstruction, which increases afterload and activates the Anrep response of hyperdynamic systole. This study directly compared the effects of the myosin inhibitor mavacamten to alcohol septal ablation. Researchers evaluated whether mavacamten reverses this hyperdynamic state, contrasting its impacts with the anatomic relief from alcohol septal ablation in 36 patients. The investigation’s echocardiography-derived pressure-volume analysis clarified the differential physiological effects of these two therapeutic approaches. Article number four. Device-Related Adverse Events and Outcomes in Patients With Temporary Mechanical Circulatory Support Placed at Referral Centers Versus Cardiogenic Shock Hub Centers: An Observational Analysis. Temporary mechanical circulatory support devices are often placed for cardiogenic shock at regional referral centers before transfer to hub centers. This observational analysis identified differences in device-related adverse events and patient outcomes based on the initial site of device placement. The study compared patients whose temporary mechanical circulatory support was initiated at a regional referral center prior to transfer versus those with initial placement at a cardiogenic shock hub center. Its findings clarified the safety and efficacy implications of different care pathways for cardiogenic shock patients. Article number five. Characterization of a successful transseptal access with an electrified guidewire: An ex vivo ovine study. This ex vivo ovine study characterized the determinants of successful transseptal puncture using an electrified guidewire, a technique previously unstudied in this context. Researchers utilized 25 fresh ovine hearts, creating an interatrial septum model from dissected right atrial tissue. The investigation involved fixing the sheath and guidewire to a jig to model clinical catheter manipulation. The study observed transseptal puncture dynamics across varying parameters, establishing key factors influencing success for electrified guidewire transseptal access. Thank you for listening. Don’t forget to subscribe. Keywords femoral venous puncture, catheter manipulation, device-related adverse events, vascular access complications, cardiac resynchronization therapy, left ventricular outflow tract obstruction, temporary mechanical circulatory support, mavacamten, left atrial tachycardia, left-bundle branch block, cardiogenic shock, electrified guidewire, regional referral centers, ex vivo ovine model, ultrasound-guided puncture, interatrial septum, echocardiography, obstructive hypertrophic cardiomyopathy, transseptal puncture, alcohol septal ablation, hub centers, atrial fibrillation ablation, biventricular pacing, conduction system pacing, left-bundle branch area pacing. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Left Bundle Pacing Challenges BiVP for CRT 04/14/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 14, 2026. This episode summarizes 5 key cardiology studies on topics like aspirin and left bundle branch block. Key takeaway: Time-Varying Data Boosts Transplant Risk Accuracy. Article Links: Article 1: Endovascular Therapy for Post-Thrombotic Syndrome – A Randomized Trial. (The New England journal of medicine) Article 2: Cell Type-Specific Targeting of Different Smooth Muscle Cell Populations by Intersectional Genetics. (Circulation) Article 3: Timing is everything: Using time-varying binary indicators for evaluating post-transplant risk factors. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Subclinical atrial fibrillation and the risk of heart failure: insights from ARTESiA. (European journal of heart failure) Article 5: Dyssynchronous heart failure: mitochondrial distribution and functions mirror regional workload and energy demand in a large-animal model of ventricular desynchronization. (European journal of heart failure) Full episode page: https://podcast.explainheart.com/podcast/time-varying-data-boosts-transplant-risk-accuracy-04-14-26/ Featured Articles Article 1: Endovascular Therapy for Post-Thrombotic Syndrome – A Randomized Trial. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41972998 Summary: This randomized trial evaluated endovascular therapy, specifically iliac-vein stent placement, for patients with moderate or severe post-thrombotic syndrome linked to iliac-vein obstruction. The study included 225 patients who received either endovascular therapy or enhanced conventional management, addressing the critical clinical issue of improving quality of life. This trial focused on whether the intervention reduced symptom severity for patients severely affected by post-thrombotic syndrome. Article 2: Cell Type-Specific Targeting of Different Smooth Muscle Cell Populations by Intersectional Genetics. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41969103 Summary: This study developed a new strategy using intersectional genetics for cell type-specific targeting of smooth muscle cell populations. This refined approach effectively overcomes limitations of existing Cre/loxP recombination systems that previously showed off-target activity outside the smooth muscle cell lineage. The new method precisely distinguishes among arterial smooth muscle cells, venous smooth muscle cells, and non-vascular smooth muscle cells. This capability is essential for characterizing the distinct roles of smooth muscle cells in various organs and diseases. Article 3: Timing is everything: Using time-varying binary indicators for evaluating post-transplant risk factors. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41974389 Summary: This study demonstrated that incorporating a time-varying binary indicator in a Cox model correctly analyzes post-transplant risk factors. Traditional methods, which treat risk factors as fixed at the time of transplantation, produce inaccurate effect estimates due to immortal time bias. Using infection-related hospitalizations after heart transplantation as an example, this refined approach properly aligns the timing of exposure with survival follow-up. This methodology yields more credible and accurate effect estimates for risk factors emerging after transplantation. Article 4: Subclinical atrial fibrillation and the risk of heart failure: insights from ARTESiA. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41973801 Summary: The ARTESiA (Apixaban for the Reduction of Thromboembolism in Patients with Device-Detected Subclinical Atrial Fibrillation) trial, involving 3986 patients, compared apixaban with aspirin for reducing thromboembolism in individuals with device-detected subclinical atrial fibrillation. This study leveraged the ARTESiA patient cohort to investigate the connection between subclinical atrial fibrillation and the incidence of heart failure events. It established that while heart failure and clinical atrial fibrillation are closely related, the specific impact of device-detected subclinical atrial fibrillation on heart failure risk remained previously undefined. The research therefore identified a critical area for further clinical understanding regarding this patient population. Article 5: Dyssynchronous heart failure: mitochondrial distribution and functions mirror regional workload and energy demand in a large-animal model of ventricular desynchronization. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41968761 Summary: This study in an ovine model of dyssynchronous heart failure with left bundle branch block demonstrated that mitochondrial distribution and functions mirror regional workload and energy demand. Researchers established left bundle branch block-like activation in 11 sheep, observing them over eight weeks, alongside six control animals. The findings showed inhomogeneous left ventricular workload and systolic dysfunction in the dyssynchronous heart failure group. This research specifically linked metabolic remodeling, including glucose metabolism assessed by 18F-fluorodeoxyglucose tracers, to regional energetic stress in the diseased myocardium. Transcript Today’s date is April 14, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Endovascular Therapy for Post-Thrombotic Syndrome – A Randomized Trial. This randomized trial evaluated endovascular therapy, specifically iliac-vein stent placement, for patients with moderate or severe post-thrombotic syndrome linked to iliac-vein obstruction. The study included 225 patients who received either endovascular therapy or enhanced conventional management, addressing the critical clinical issue of improving quality of life. This trial focused on whether the intervention reduced symptom severity for patients severely affected by post-thrombotic syndrome. Article number two. Cell Type-Specific Targeting of Different Smooth Muscle Cell Populations by Intersectional Genetics. This study developed a new strategy using intersectional genetics for cell type-specific targeting of smooth muscle cell populations. This refined approach effectively overcomes limitations of existing Cre/loxP recombination systems that previously showed off-target activity outside the smooth muscle cell lineage. The new method precisely distinguishes among arterial smooth muscle cells, venous smooth muscle cells, and non-vascular smooth muscle cells. This capability is essential for characterizing the distinct roles of smooth muscle cells in various organs and diseases. Article number three. Timing is everything: Using time-varying binary indicators for evaluating post-transplant risk factors. This study demonstrated that incorporating a time-varying binary indicator in a Cox model correctly analyzes post-transplant risk factors. Traditional methods, which treat risk factors as fixed at the time of transplantation, produce inaccurate effect estimates due to immortal time bias. Using infection-related hospitalizations after heart transplantation as an example, this refined approach properly aligns the timing of exposure with survival follow-up. This methodology yields more credible and accurate effect estimates for risk factors emerging after transplantation. Article number four. Subclinical atrial fibrillation and the risk of heart failure: insights from ARTESiA. The ARTESiA (Apixaban for the Reduction of Thromboembolism in Patients with Device-Detected Subclinical Atrial Fibrillation) trial, involving 3986 patients, compared apixaban with aspirin for reducing thromboembolism in individuals with device-detected subclinical atrial fibrillation. This study leveraged the ARTESiA patient cohort to investigate the connection between subclinical atrial fibrillation and the incidence of heart failure events. It established that while heart failure and clinical atrial fibrillation are closely related, the specific impact of device-detected subclinical atrial fibrillation on heart failure risk remained previously undefined. The research therefore identified a critical area for further clinical understanding regarding this patient population. Article number five. Dyssynchronous heart failure: mitochondrial distribution and functions mirror regional workload and energy demand in a large-animal model of ventricular desynchronization. This study in an ovine model of dyssynchronous heart failure with left bundle branch block demonstrated that mitochondrial distribution and functions mirror regional workload and energy demand. Researchers established left bundle branch block-like activation in 11 sheep, observing them over eight weeks, alongside six control animals. The findings showed inhomogeneous left ventricular workload and systolic dysfunction in the dyssynchronous heart failure group. This research specifically linked metabolic remodeling, including glucose metabolism assessed by 18F-fluorodeoxyglucose tracers, to regional energetic stress in the diseased myocardium. Thank you for listening. Don’t forget to subscribe. Keywords aspirin, left bundle branch block, cell targeting, mitochondrial function, Cox model, endovascular therapy, iliac-vein stent, dyssynchronous heart failure, heart failure, smooth muscle cells, deep-vein thrombosis, myocardial remodeling, arterial smooth muscle cells, subclinical atrial fibrillation, heart transplantation, immortal time bias, ventricular desynchronization, risk factors, time-varying binary indicator, venous obstruction, post-thrombotic syndrome, ARTESiA trial, Cre-loxP system, apixaban, intersectional genetics, thromboembolism. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Time-Varying Data Boosts Transplant Risk Accuracy 04/14/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 13, 2026. This episode summarizes 5 key cardiology studies on topics like ischemic stroke and prehospital delay. Key takeaway: Salusin-Alpha Restores Vessels in Pulmonary Hypertension. Article Links: Article 1: Salusin-α Restores Vascular Relaxation and Remodeling in Pulmonary Hypertension. (Hypertension (Dallas, Tex. : 1979)) Article 2: Endothelial Senescence Drives Deleterious Endothelial-Adipocyte Cross-Talk in Patients With Heart Failure and Type 2 Diabetes. (JACC. Basic to translational science) Article 3: Kinetics of Technetium-Labeled Cardiac Amyloid Radionuclide Imaging. (Circulation. Cardiovascular imaging) Article 4: Intracranial Hemorrhage Patterns and Outcomes in Minor Stroke: Analysis of the TEMPO-2 Trial. (Stroke) Article 5: Cost-Effectiveness of Prehospital Delay Reduction Versus Primary Stroke Prevention in US Adults With Type 2 Diabetes. (Stroke) Full episode page: https://podcast.explainheart.com/podcast/salusin-alpha-restores-vessels-in-pulmonary-hypertension-04-13-26/ Featured Articles Article 1: Salusin-α Restores Vascular Relaxation and Remodeling in Pulmonary Hypertension. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41958393 Summary: This study demonstrated that salusin-alpha restored vascular relaxation and reversed vascular remodeling in pulmonary hypertension. Researchers found these effects by assessing pulmonary artery relaxation using isometric tension recording in isolated rat pulmonary arteries. They quantified reductions in pulmonary artery remodeling through histological morphometric analysis. The data indicated that salusin-alpha significantly alleviated the progressive increase in pulmonary arterial resistance characteristic of pulmonary hypertension. Article 2: Endothelial Senescence Drives Deleterious Endothelial-Adipocyte Cross-Talk in Patients With Heart Failure and Type 2 Diabetes. Journal: JACC. Basic to translational science PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967191 Summary: Microvascular endothelial cells (MVECs) from subcutaneous adipose tissue of patients with type two diabetes mellitus and heart failure exhibited a senescent phenotype. These senescent cells displayed elevated senescence-associated secretory phenotype markers, reduced adenosine triphosphate production, and impaired angiogenic and proliferative capacities. When cocultured with healthy adipocytes, these senescent M. V. E. C. s drove adverse cross-talk, inducing a proinflammatory adipocyte phenotype with increased interleukin-6 expression. This research revealed how endothelial senescence contributes to chronic inflammation in this high-risk patient population. Article 3: Kinetics of Technetium-Labeled Cardiac Amyloid Radionuclide Imaging. Journal: Circulation. Cardiovascular imaging PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41961986 Summary: This study characterized the tracer kinetics of technetium-labeled bone-avid tracers used for diagnosing transthyretin cardiac amyloidosis. Researchers defined these kinetics using quantitative single-photon emission computed tomography with computed tomography in 24 subjects evaluated for the condition. The findings established the kinetic profile of these diagnostic agents. The study also addressed the use of hydroxymethylene diphosphonate as an alternative to technetium-99m pyrophosphate due to supply shortages, noting the limited comparative kinetic data available. Article 4: Intracranial Hemorrhage Patterns and Outcomes in Minor Stroke: Analysis of the TEMPO-2 Trial. Journal: Stroke PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41958392 Summary: This secondary analysis of the TEMPO-2 multicenter, randomized trial evaluated specific intracranial hemorrhage patterns and their impact on functional outcomes in patients with minor ischemic stroke. The study identified distinct predictors associated with intracranial hemorrhage within this patient population. It found that intracranial hemorrhage negatively impacts functional outcomes after ischemic stroke, with disproportionate effects observed in patients with minor stroke. The TEMPO-2 trial compared tenecteplase with nonthrombolytic standard care for patients within 12 hours of symptom onset. Article 5: Cost-Effectiveness of Prehospital Delay Reduction Versus Primary Stroke Prevention in US Adults With Type 2 Diabetes. Journal: Stroke PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41958382 Summary: This study determined the relative benefits and cost-effectiveness of reducing prehospital delay for acute ischemic stroke patients compared to implementing primary stroke prevention measures. The analysis focused on U. S. adults with type two diabetes, a population at high risk for acute ischemic stroke. Researchers utilized data from the National Health and Nutrition Examination Survey from 2015 to 2018. The findings established which intervention strategy offered greater cost-effectiveness in this specific high-risk group. Transcript Today’s date is April 13, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Salusin-α Restores Vascular Relaxation and Remodeling in Pulmonary Hypertension. This study demonstrated that salusin-alpha restored vascular relaxation and reversed vascular remodeling in pulmonary hypertension. Researchers found these effects by assessing pulmonary artery relaxation using isometric tension recording in isolated rat pulmonary arteries. They quantified reductions in pulmonary artery remodeling through histological morphometric analysis. The data indicated that salusin-alpha significantly alleviated the progressive increase in pulmonary arterial resistance characteristic of pulmonary hypertension. Article number two. Endothelial Senescence Drives Deleterious Endothelial-Adipocyte Cross-Talk in Patients With Heart Failure and Type 2 Diabetes. Microvascular endothelial cells (MVECs) from subcutaneous adipose tissue of patients with type two diabetes mellitus and heart failure exhibited a senescent phenotype. These senescent cells displayed elevated senescence-associated secretory phenotype markers, reduced adenosine triphosphate production, and impaired angiogenic and proliferative capacities. When cocultured with healthy adipocytes, these senescent M. V. E. C. s drove adverse cross-talk, inducing a proinflammatory adipocyte phenotype with increased interleukin-6 expression. This research revealed how endothelial senescence contributes to chronic inflammation in this high-risk patient population. Article number three. Kinetics of Technetium-Labeled Cardiac Amyloid Radionuclide Imaging. This study characterized the tracer kinetics of technetium-labeled bone-avid tracers used for diagnosing transthyretin cardiac amyloidosis. Researchers defined these kinetics using quantitative single-photon emission computed tomography with computed tomography in 24 subjects evaluated for the condition. The findings established the kinetic profile of these diagnostic agents. The study also addressed the use of hydroxymethylene diphosphonate as an alternative to technetium-99m pyrophosphate due to supply shortages, noting the limited comparative kinetic data available. Article number four. Intracranial Hemorrhage Patterns and Outcomes in Minor Stroke: Analysis of the TEMPO-2 Trial. This secondary analysis of the TEMPO-2 multicenter, randomized trial evaluated specific intracranial hemorrhage patterns and their impact on functional outcomes in patients with minor ischemic stroke. The study identified distinct predictors associated with intracranial hemorrhage within this patient population. It found that intracranial hemorrhage negatively impacts functional outcomes after ischemic stroke, with disproportionate effects observed in patients with minor stroke. The TEMPO-2 trial compared tenecteplase with nonthrombolytic standard care for patients within 12 hours of symptom onset. Article number five. Cost-Effectiveness of Prehospital Delay Reduction Versus Primary Stroke Prevention in US Adults With Type 2 Diabetes. This study determined the relative benefits and cost-effectiveness of reducing prehospital delay for acute ischemic stroke patients compared to implementing primary stroke prevention measures. The analysis focused on U. S. adults with type two diabetes, a population at high risk for acute ischemic stroke. Researchers utilized data from the National Health and Nutrition Examination Survey from 2015 to 2018. The findings established which intervention strategy offered greater cost-effectiveness in this specific high-risk group. Thank you for listening. Don’t forget to subscribe. Keywords ischemic stroke, prehospital delay, microvascular endothelial cells, technetium-labeled tracers, tenecteplase, endothelial senescence, pulmonary artery, single-photon emission computed tomography, adipocyte cross-talk, inflammation, minor stroke, acute ischemic stroke, type two diabetes mellitus, intracranial hemorrhage, heart failure, primary stroke prevention, functional outcomes, tracer kinetics, vascular remodeling, pulmonary hypertension, cost-effectiveness, TEMPO-2 trial, salusin-alpha, hydroxymethylene diphosphonate, National Health and Nutrition Examination Survey, cardiac imaging, transthyretin cardiac amyloidosis, vascular relaxation. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Salusin-Alpha Restores Vessels in Pulmonary Hypertension 04/13/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 13, 2026. This episode summarizes 5 key cardiology studies on topics like sex differences and adverse clinical outcomes. Key takeaway: CKM Syndrome Shapes Atrial Fibrillation Outcomes. Article Links: Article 1: Long-Term Outcomes of Stent-Based Pulmonary Angioplasty for Isolated Peripheral Pulmonary Artery Stenosis. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Plasma Protein Profiles in Different Heart Failure Phenotypes. (ESC heart failure) Article 3: Cardiovascular-kidney-metabolic syndrome and atrial fibrillation: Insights from 2 real-world prospective registries across Europe and East Asia. (Heart rhythm) Article 4: Sex difference in clinically suspected immune checkpoint inhibitor-related myocarditis: a single-institute retrospective study with seven-year follow-up. (International journal of cardiology) Article 5: Plasma Protein Profiles in Different Heart Failure Phenotypes. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/ckm-syndrome-shapes-atrial-fibrillation-outcomes-04-13-26/ Featured Articles Article 1: Long-Term Outcomes of Stent-Based Pulmonary Angioplasty for Isolated Peripheral Pulmonary Artery Stenosis. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967784 Summary: This single-center retrospective study included 23 adults with isolated peripheral pulmonary artery stenosis who received stent-based angioplasty between 2007 and 2024. The study characterized the long-term durability and the incidence and determinants of in-stent restenosis. It also observed changes in patient hemodynamics and six-minute walk distance. This research provides insights into the outcomes of stent-based angioplasty for this rare condition. Article 2: Plasma Protein Profiles in Different Heart Failure Phenotypes. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967491 Summary: This study analyzed data from 50765 U. K. Biobank participants to characterize plasma protein profiles. It examined three distinct heart failure phenotypes: heart failure with preceding myocardial infarction, heart failure with preceding atrial fibrillation, and heart failure without either preceding condition. The analysis was conducted to understand the unique protein signatures across these different heart failure presentations and potentially identify a common protein profile. Article 3: Cardiovascular-kidney-metabolic syndrome and atrial fibrillation: Insights from 2 real-world prospective registries across Europe and East Asia. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41966525 Summary: This study evaluated the association between cardiovascular-kidney-metabolic syndrome stages and adverse clinical outcomes in patients with atrial fibrillation. It included patients from the E. U. R. O. bservational Research Programme Atrial Fibrillation General Long-Term Registry and the K. A. F. Registry, representing real-world populations across Europe and East Asia. The research characterized the clinical impact of cardiovascular-kidney-metabolic syndrome in atrial fibrillation patients by analyzing data from these prospective registries. Article 4: Sex difference in clinically suspected immune checkpoint inhibitor-related myocarditis: a single-institute retrospective study with seven-year follow-up. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967772 Summary: This retrospective study characterized sex differences in clinically suspected immune checkpoint inhibitor-related myocarditis over a seven-year follow-up period. It included patients diagnosed at a single institute between 2018 and 2024. The research analyzed baseline characteristics, laboratory markers, and echocardiographic parameters to identify sex-specific risk factors and predictors. Article 5: Plasma Protein Profiles in Different Heart Failure Phenotypes. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967491 Summary: This study analyzed data from 50765 U. K. Biobank participants to characterize plasma protein profiles. It examined three distinct heart failure phenotypes: heart failure with preceding myocardial infarction, heart failure with preceding atrial fibrillation, and heart failure without either preceding condition. The analysis was conducted to understand the unique protein signatures across these different heart failure presentations and potentially identify a common protein profile. Transcript Today’s date is April 13, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Long-Term Outcomes of Stent-Based Pulmonary Angioplasty for Isolated Peripheral Pulmonary Artery Stenosis. This single-center retrospective study included 23 adults with isolated peripheral pulmonary artery stenosis who received stent-based angioplasty between 2007 and 2024. The study characterized the long-term durability and the incidence and determinants of in-stent restenosis. It also observed changes in patient hemodynamics and six-minute walk distance. This research provides insights into the outcomes of stent-based angioplasty for this rare condition. Article number two. Plasma Protein Profiles in Different Heart Failure Phenotypes. This study analyzed data from 50765 U. K. Biobank participants to characterize plasma protein profiles. It examined three distinct heart failure phenotypes: heart failure with preceding myocardial infarction, heart failure with preceding atrial fibrillation, and heart failure without either preceding condition. The analysis was conducted to understand the unique protein signatures across these different heart failure presentations and potentially identify a common protein profile. Article number three. Cardiovascular-kidney-metabolic syndrome and atrial fibrillation: Insights from 2 real-world prospective registries across Europe and East Asia. This study evaluated the association between cardiovascular-kidney-metabolic syndrome stages and adverse clinical outcomes in patients with atrial fibrillation. It included patients from the E. U. R. O. bservational Research Programme Atrial Fibrillation General Long-Term Registry and the K. A. F. Registry, representing real-world populations across Europe and East Asia. The research characterized the clinical impact of cardiovascular-kidney-metabolic syndrome in atrial fibrillation patients by analyzing data from these prospective registries. Article number four. Sex difference in clinically suspected immune checkpoint inhibitor-related myocarditis: a single-institute retrospective study with seven-year follow-up. This retrospective study characterized sex differences in clinically suspected immune checkpoint inhibitor-related myocarditis over a seven-year follow-up period. It included patients diagnosed at a single institute between 2018 and 2024. The research analyzed baseline characteristics, laboratory markers, and echocardiographic parameters to identify sex-specific risk factors and predictors. Article number five. Plasma Protein Profiles in Different Heart Failure Phenotypes. This study analyzed data from 50765 U. K. Biobank participants to characterize plasma protein profiles. It examined three distinct heart failure phenotypes: heart failure with preceding myocardial infarction, heart failure with preceding atrial fibrillation, and heart failure without either preceding condition. The analysis was conducted to understand the unique protein signatures across these different heart failure presentations and potentially identify a common protein profile. Thank you for listening. Don’t forget to subscribe. Keywords sex differences, adverse clinical outcomes, plasma protein profiles, U. K. Biobank, stent-based angioplasty, immune checkpoint inhibitor-related myocarditis, six-minute walk distance, echocardiographic parameters, hemodynamics, heart failure, E. U. R. O. bservational Research Programme, atrial fibrillation, in-stent restenosis, risk factors, cardiovascular-kidney-metabolic syndrome, peripheral pulmonary artery stenosis, biomarkers, K. A. F. Registry, myocardial infarction. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post CKM Syndrome Shapes Atrial Fibrillation Outcomes 04/13/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 12, 2026. This episode summarizes 5 key cardiology studies on topics like pediatric cardiology and morbidity. Key takeaway: Mycn Promotes Heart Protection Post M.I.. Article Links: Article 1: Patient-Surgeon Sex Concordance and Clinical Outcomes After Adult Cardiac Surgery. (Journal of the American Heart Association) Article 2: Increased Risk of Disabilities in Children and Adolescents With Congenital Heart Disease of Any Severity. (Journal of the American Heart Association) Article 3: Correlates and Prognostic Value of Serial N-Terminal Pro-B-Type Natriuretic Peptide Assay in Congenitally Corrected Transposition of the Great Arteries. (Journal of the American Heart Association) Article 4: Long-Term Outcomes With Class 1C Antiarrhythmic Drug Use in Atrial Fibrillation. (Journal of the American Heart Association) Article 5: Mycn Reactivates the Cell Cycle in Adult Cardiomyocytes and Promotes Cardioprotection in Myocardial Infarction. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/mycn-promotes-heart-protection-post-m-i-04-12-26/ Featured Articles Article 1: Patient-Surgeon Sex Concordance and Clinical Outcomes After Adult Cardiac Surgery. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41954068 Summary: This large cohort study provided a comprehensive characterization of patient-surgeon sex concordance in relation to clinical outcomes following adult cardiac surgery. The research documented data from 223065 Medicare beneficiaries who underwent coronary artery bypass grafting, surgical aortic valve replacement, or proximal aortic surgery. The study’s analysis focused on composite outcomes of mortality and morbidity, including myocardial infarction, stroke, and all-cause readmission, stratified by surgeon and patient sex. These findings contribute crucial information for understanding potential sex-based differences in cardiac surgical care. Article 2: Increased Risk of Disabilities in Children and Adolescents With Congenital Heart Disease of Any Severity. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41954067 Summary: This retrospective data-linkage study found an increased risk of disabilities in children and adolescents diagnosed with congenital heart disease of any severity. The research revealed a higher prevalence of overall and specific disability service use within this patient group compared to matched controls and siblings. These findings highlight a significant burden of disabilities across all severities of congenital heart disease in pediatric patients. The study provides crucial information for long-term care planning and resource allocation for this population. Article 3: Correlates and Prognostic Value of Serial N-Terminal Pro-B-Type Natriuretic Peptide Assay in Congenitally Corrected Transposition of the Great Arteries. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41954066 Summary: This study established the correlates and confirmed the prognostic value of serial N-terminal pro-B-type natriuretic peptide assays in adults with congenitally corrected transposition of the great arteries. The research provided specific data on the role of these measurements for heart failure risk stratification in this distinct patient population. The findings confirm N-terminal pro-B-type natriuretic peptide as a relevant cardiovascular biomarker, addressing previously limited data for this group. This offers important insights for clinical monitoring and management of these adults. Article 4: Long-Term Outcomes With Class 1C Antiarrhythmic Drug Use in Atrial Fibrillation. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41954064 Summary: This large study characterized the long-term outcomes associated with class one C antiarrhythmic drug use in 100748 adult patients with atrial fibrillation. The research documented the cardiovascular benefits and safety profile of class one C pharmacotherapy in comparison to rate control strategies over an extended period. The findings provide crucial information regarding the real-world efficacy and safety of these agents for rhythm control. This study contributes significantly to the understanding of optimal management strategies in atrial fibrillation patients. Article 5: Mycn Reactivates the Cell Cycle in Adult Cardiomyocytes and Promotes Cardioprotection in Myocardial Infarction. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41954062 Summary: This study found that Mycn reactivates the cell cycle in adult cardiomyocytes, a significant discovery given their typically limited capacity for cell cycle re-entry. The research demonstrated that Mycn promotes cardioprotection following myocardial infarction in preclinical models. These findings suggest a novel therapeutic avenue for enhancing cardiac repair after ischemic injury. The study contributes significantly to understanding the role of Myc family isoforms in cardiomyocyte plasticity and regeneration. Transcript Today’s date is April 12, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Patient-Surgeon Sex Concordance and Clinical Outcomes After Adult Cardiac Surgery. This large cohort study provided a comprehensive characterization of patient-surgeon sex concordance in relation to clinical outcomes following adult cardiac surgery. The research documented data from 223065 Medicare beneficiaries who underwent coronary artery bypass grafting, surgical aortic valve replacement, or proximal aortic surgery. The study’s analysis focused on composite outcomes of mortality and morbidity, including myocardial infarction, stroke, and all-cause readmission, stratified by surgeon and patient sex. These findings contribute crucial information for understanding potential sex-based differences in cardiac surgical care. Article number two. Increased Risk of Disabilities in Children and Adolescents With Congenital Heart Disease of Any Severity. This retrospective data-linkage study found an increased risk of disabilities in children and adolescents diagnosed with congenital heart disease of any severity. The research revealed a higher prevalence of overall and specific disability service use within this patient group compared to matched controls and siblings. These findings highlight a significant burden of disabilities across all severities of congenital heart disease in pediatric patients. The study provides crucial information for long-term care planning and resource allocation for this population. Article number three. Correlates and Prognostic Value of Serial N-Terminal Pro-B-Type Natriuretic Peptide Assay in Congenitally Corrected Transposition of the Great Arteries. This study established the correlates and confirmed the prognostic value of serial N-terminal pro-B-type natriuretic peptide assays in adults with congenitally corrected transposition of the great arteries. The research provided specific data on the role of these measurements for heart failure risk stratification in this distinct patient population. The findings confirm N-terminal pro-B-type natriuretic peptide as a relevant cardiovascular biomarker, addressing previously limited data for this group. This offers important insights for clinical monitoring and management of these adults. Article number four. Long-Term Outcomes With Class One C Antiarrhythmic Drug Use in Atrial Fibrillation. This large study characterized the long-term outcomes associated with class one C antiarrhythmic drug use in 100748 adult patients with atrial fibrillation. The research documented the cardiovascular benefits and safety profile of class one C pharmacotherapy in comparison to rate control strategies over an extended period. The findings provide crucial information regarding the real-world efficacy and safety of these agents for rhythm control. This study contributes significantly to the understanding of optimal management strategies in atrial fibrillation patients. Article number five. Mycn Reactivates the Cell Cycle in Adult Cardiomyocytes and Promotes Cardioprotection in Myocardial Infarction. This study found that Mycn reactivates the cell cycle in adult cardiomyocytes, a significant discovery given their typically limited capacity for cell cycle re-entry. The research demonstrated that Mycn promotes cardioprotection following myocardial infarction in preclinical models. These findings suggest a novel therapeutic avenue for enhancing cardiac repair after ischemic injury. The study contributes significantly to understanding the role of Myc family isoforms in cardiomyocyte plasticity and regeneration. Thank you for listening. Don’t forget to subscribe. Keywords pediatric cardiology, morbidity, rate control, cell cycle reactivation, adult cardiac surgery, surgical aortic valve replacement, Mycn, risk stratification, cardiac repair, heart failure, coronary artery bypass grafting, rhythm control, myocardial infarction, N-terminal pro-B-type natriuretic peptide, Patient-surgeon sex concordance, Atrial fibrillation, long-term outcomes, Congenital heart disease, class one C antiarrhythmic drugs, cardiovascular biomarkers, adult cardiomyocytes, cardioprotection, mortality, disability service use, congenitally corrected transposition of the great arteries, disabilities. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Mycn Promotes Heart Protection Post M.I. 04/12/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 11, 2026. This episode summarizes 5 key cardiology studies on topics like mineralocorticoid receptor antagonist and Kidney Failure Risk Equation. Key takeaway: Catheter Ablation Improves RV-PA Coupling in AF. Article Links: Article 1: An integrated Biobank in the Swedish Heart Failure Registry – clinomics, proteomics, transcriptomics and genomics. (ESC heart failure) Article 2: Spironolactone, Early Acute eGFR Changes, and Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction: Insights from TOPCAT Americas. (European journal of heart failure) Article 3: Kidney Failure Risk Equation and Risk of Kidney and Cardiovascular Outcomes in Patients with Heart Failure with Reduced Ejection Fraction: Insights from PARADIGM-HF. (European journal of heart failure) Article 4: Perceived Inadequate Neighborhood Food Shopping and Cardiovascular Disease Risk: The Multi-Ethnic Study of Atherosclerosis. (Journal of the American Heart Association) Article 5: Right Ventricular-Pulmonary Artery Coupling in Patients With Atrial Fibrillation and Changes After Catheter Ablation. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/catheter-ablation-improves-rv-pa-coupling-in-af-04-11-26/ Featured Articles Article 1: An integrated Biobank in the Swedish Heart Failure Registry – clinomics, proteomics, transcriptomics and genomics. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41961636 Summary: The Swedish Heart Failure Registry established a comprehensive integrated biobank, systematically collecting blood and urine samples from heart failure patients across nine hospitals. This resource captures extensive clinomic, proteomic, transcriptomic, and genomic data, coupled with clinical and diagnostic characteristics. The integrated biobank provides a robust platform for advanced research to identify novel biomarkers and understand disease mechanisms in heart failure. Article 2: Spironolactone, Early Acute eGFR Changes, and Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction: Insights from TOPCAT Americas. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41961632 Summary: A post-hoc analysis of 1648 patients from the TOPCAT Americas trial revealed insights into early acute changes in estimated glomerular filtration rate following spironolactone initiation in Heart Failure with Preserved Ejection Fraction (H. F. pEF). The study characterized the frequency and prognostic relevance of these kidney function alterations. The data elucidated implications of these changes for clinical outcomes in patients receiving mineralocorticoid receptor antagonists, providing guidance for therapeutic management. Article 3: Kidney Failure Risk Equation and Risk of Kidney and Cardiovascular Outcomes in Patients with Heart Failure with Reduced Ejection Fraction: Insights from PARADIGM-HF. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41961588 Summary: This study demonstrated the association of the Kidney Failure Risk Equation (KFRE) score with kidney and cardiovascular outcomes in patients with Heart Failure with Reduced Ejection Fraction (H. F. rEF) and chronic kidney disease (C. K. D.). Analyzing data from the PARADIGM-HF trial, the 2- and 5-year KFRE score, which includes urine albumin-creatinine ratio (UACR), age, sex, and estimated glomerular filtration rate (eGFR), predicted risks for both kidney failure and cardiovascular events. The findings support the clinical utility of the KFRE in this heart failure population for prognostication and risk stratification, extending its recommended use beyond general chronic kidney disease. Article 4: Perceived Inadequate Neighborhood Food Shopping and Cardiovascular Disease Risk: The Multi-Ethnic Study of Atherosclerosis. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41960759 Summary: Analyzing 6814 participants from the Multi-Ethnic Study of Atherosclerosis, this study found a significant association between an individual’s perceived inadequacy of neighborhood food shopping and an increased risk of incident cardiovascular disease (C. V. D.). The research demonstrated that a subjective perception of poor food shopping options independently predicted adverse cardiovascular outcomes, moving beyond assessments of physical distance or density of food retailers. These findings highlight the importance of individual perceptions of their food environment in assessing and mitigating cardiovascular risk. Article 5: Right Ventricular-Pulmonary Artery Coupling in Patients With Atrial Fibrillation and Changes After Catheter Ablation. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41954073 Summary: This study characterized Right Ventricular-Pulmonary Artery (R. V.-P. A.) coupling in 164 patients with Atrial Fibrillation (A. F.) without a history of heart failure, revealing the prevalence and associated factors of R. V.-P. A. uncoupling in this population. The research demonstrated that catheter ablation (C. A.) effectively led to improvements in R. V.-P. A. adaptation. These findings establish catheter ablation as a beneficial intervention for improving ventricular-arterial coupling in Atrial Fibrillation, potentially influencing heart failure prevention. Transcript Today’s date is April 11, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. An integrated Biobank in the Swedish Heart Failure Registry – clinomics, proteomics, transcriptomics and genomics. The Swedish Heart Failure Registry established a comprehensive integrated biobank, systematically collecting blood and urine samples from heart failure patients across nine hospitals. This resource captures extensive clinomic, proteomic, transcriptomic, and genomic data, coupled with clinical and diagnostic characteristics. The integrated biobank provides a robust platform for advanced research to identify novel biomarkers and understand disease mechanisms in heart failure. Article number two. Spironolactone, Early Acute eGFR Changes, and Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction: Insights from TOPCAT Americas. A post-hoc analysis of 1648 patients from the TOPCAT Americas trial revealed insights into early acute changes in estimated glomerular filtration rate following spironolactone initiation in Heart Failure with Preserved Ejection Fraction (H. F. pEF). The study characterized the frequency and prognostic relevance of these kidney function alterations. The data elucidated implications of these changes for clinical outcomes in patients receiving mineralocorticoid receptor antagonists, providing guidance for therapeutic management. Article number three. Kidney Failure Risk Equation and Risk of Kidney and Cardiovascular Outcomes in Patients with Heart Failure with Reduced Ejection Fraction: Insights from PARADIGM-HF. This study demonstrated the association of the Kidney Failure Risk Equation (KFRE) score with kidney and cardiovascular outcomes in patients with Heart Failure with Reduced Ejection Fraction (H. F. rEF) and chronic kidney disease (C. K. D.). Analyzing data from the PARADIGM-HF trial, the 2- and 5-year KFRE score, which includes urine albumin-creatinine ratio (UACR), age, sex, and estimated glomerular filtration rate (eGFR), predicted risks for both kidney failure and cardiovascular events. The findings support the clinical utility of the KFRE in this heart failure population for prognostication and risk stratification, extending its recommended use beyond general chronic kidney disease. Article number four. Perceived Inadequate Neighborhood Food Shopping and Cardiovascular Disease Risk: The Multi-Ethnic Study of Atherosclerosis. Analyzing 6814 participants from the Multi-Ethnic Study of Atherosclerosis, this study found a significant association between an individual’s perceived inadequacy of neighborhood food shopping and an increased risk of incident cardiovascular disease (C. V. D.). The research demonstrated that a subjective perception of poor food shopping options independently predicted adverse cardiovascular outcomes, moving beyond assessments of physical distance or density of food retailers. These findings highlight the importance of individual perceptions of their food environment in assessing and mitigating cardiovascular risk. Article number five. Right Ventricular-Pulmonary Artery Coupling in Patients With Atrial Fibrillation and Changes After Catheter Ablation. This study characterized Right Ventricular-Pulmonary Artery (R. V.-P. A.) coupling in 164 patients with Atrial Fibrillation (A. F.) without a history of heart failure, revealing the prevalence and associated factors of R. V.-P. A. uncoupling in this population. The research demonstrated that catheter ablation (C. A.) effectively led to improvements in R. V.-P. A. adaptation. These findings establish catheter ablation as a beneficial intervention for improving ventricular-arterial coupling in Atrial Fibrillation, potentially influencing heart failure prevention. Thank you for listening. Don’t forget to subscribe. Keywords mineralocorticoid receptor antagonist, Kidney Failure Risk Equation, estimated glomerular filtration rate, catheter ablation, Heart Failure with Preserved Ejection Fraction, clinomics, heart failure, heart failure prevention, chronic kidney disease, TOPCAT, Right Ventricular-Pulmonary Artery coupling, biobank, Atrial Fibrillation, Multi-Ethnic Study of Atherosclerosis, Heart Failure with Reduced Ejection Fraction, neighborhood health, PARADIGM-HF, ventricular-arterial coupling, genomics, Swedish Heart Failure Registry, cardiovascular outcomes, food insecurity, Spironolactone, cardiovascular disease risk, Perceived food environment. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Catheter Ablation Improves RV-PA Coupling in AF 04/11/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 11, 2026. This episode summarizes 5 key cardiology studies on topics like Transplantation and Procedural futility. Key takeaway: ML Model Predicts TAVR Mortality, Futility. Article Links: Article 1: How Contemporary Living Kidney Donor Transplants Compare to pre-Pandemic Trends: An Interrupted Time Series Analysis. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 2: Food Supplementation in Patients Hospitalized for Heart Failure: A Randomized Clinical Trial. (JAMA cardiology) Article 3: Risk factor profiles and haemodynamic progression in aortic stenosis: a retrospective population-based study. (Heart (British Cardiac Society)) Article 4: Subphenogroups of acute heart failure with preserved ejection fraction: comprehensive proteomics and pathway analysis. (Heart (British Cardiac Society)) Article 5: Parsimonious machine learning model to predict 1-year mortality and procedural futility after transcatheter aortic valve replacement. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/ml-model-predicts-tavr-mortality-futility-04-11-26/ Featured Articles Article 1: How Contemporary Living Kidney Donor Transplants Compare to pre-Pandemic Trends: An Interrupted Time Series Analysis. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41962844 Summary: Living donor kidney transplants are crucial for patients needing access to kidney transplantation. Little research had previously quantified living donor kidney transplant behaviors following the COVID-19 pandemic. This study analyzed national Scientific Registry of Transplant Recipients and Census data to characterize contemporary donor and recipient patterns. This investigation established foundational epidemiological context for understanding post-pandemic living donor kidney transplant trends. Article 2: Food Supplementation in Patients Hospitalized for Heart Failure: A Randomized Clinical Trial. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41949846 Summary: Low-quality dietary intake is associated with adverse heart failure outcomes. The evidence for food-as-medicine interventions in this patient population remained limited. Researchers conducted a randomized clinical trial to assess the feasibility of providing food supplementation with medically tailored meals or fresh produce. This trial provides foundational insights into the potential clinical associations of such interventions for recently hospitalized heart failure patients. Article 3: Risk factor profiles and haemodynamic progression in aortic stenosis: a retrospective population-based study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41962953 Summary: Aortic stenosis is a progressive disease with significant variability in its progression rate. Current surveillance guidelines do not adequately identify individuals at highest risk for rapid hemodynamic deterioration. This retrospective population-based study assessed aortic stenosis progression rates and factors associated with rapid progression using real-world, longitudinal data. This research provides essential insights for refining risk assessment and improving surveillance strategies in aortic stenosis patients. Article 4: Subphenogroups of acute heart failure with preserved ejection fraction: comprehensive proteomics and pathway analysis. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40750341 Summary: The heterogeneity of heart failure with preserved ejection fraction (H. F. pEF) presents significant challenges for treatment development. This study characterized distinct subphenogroups of H. F. pEF using a machine-learning-based clustering model. Researchers performed a comprehensive proteomic and pathway analysis on these identified phenogroups. This work provides crucial insights into H. F. pEF heterogeneity to guide tailored therapeutic strategies. Article 5: Parsimonious machine learning model to predict 1-year mortality and procedural futility after transcatheter aortic valve replacement. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40713187 Summary: Current risk scores inadequately predict one-year mortality after transcatheter aortic valve replacement (TAVR), limiting their ability to guide decisions on procedural futility. This study developed a parsimonious machine learning model using only preprocedural variables to predict one-year all-cause mortality. The machine learning model was trained on a retrospective cohort of 1025 TAVR patients, incorporating 52 clinical and echocardiographic factors. This innovative model offers an improved tool for guiding patient selection and shared decision-making for TAVR procedures. Transcript Today’s date is April 11, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. How Contemporary Living Kidney Donor Transplants Compare to pre-Pandemic Trends: An Interrupted Time Series Analysis. Living donor kidney transplants are crucial for patients needing access to kidney transplantation. Little research had previously quantified living donor kidney transplant behaviors following the COVID-19 pandemic. This study analyzed national Scientific Registry of Transplant Recipients and Census data to characterize contemporary donor and recipient patterns. This investigation established foundational epidemiological context for understanding post-pandemic living donor kidney transplant trends. Article number two. Food Supplementation in Patients Hospitalized for Heart Failure: A Randomized Clinical Trial. Low-quality dietary intake is associated with adverse heart failure outcomes. The evidence for food-as-medicine interventions in this patient population remained limited. Researchers conducted a randomized clinical trial to assess the feasibility of providing food supplementation with medically tailored meals or fresh produce. This trial provides foundational insights into the potential clinical associations of such interventions for recently hospitalized heart failure patients. Article number three. Risk factor profiles and haemodynamic progression in aortic stenosis: a retrospective population-based study. Aortic stenosis is a progressive disease with significant variability in its progression rate. Current surveillance guidelines do not adequately identify individuals at highest risk for rapid hemodynamic deterioration. This retrospective population-based study assessed aortic stenosis progression rates and factors associated with rapid progression using real-world, longitudinal data. This research provides essential insights for refining risk assessment and improving surveillance strategies in aortic stenosis patients. Article number four. Subphenogroups of acute heart failure with preserved ejection fraction: comprehensive proteomics and pathway analysis. The heterogeneity of heart failure with preserved ejection fraction (H. F. pEF) presents significant challenges for treatment development. This study characterized distinct subphenogroups of H. F. pEF using a machine-learning-based clustering model. Researchers performed a comprehensive proteomic and pathway analysis on these identified phenogroups. This work provides crucial insights into H. F. pEF heterogeneity to guide tailored therapeutic strategies. Article number five. Parsimonious machine learning model to predict 1-year mortality and procedural futility after transcatheter aortic valve replacement. Current risk scores inadequately predict one-year mortality after transcatheter aortic valve replacement (TAVR), limiting their ability to guide decisions on procedural futility. This study developed a parsimonious machine learning model using only preprocedural variables to predict one-year all-cause mortality. The machine learning model was trained on a retrospective cohort of 1025 TAVR patients, incorporating 52 clinical and echocardiographic factors. This innovative model offers an improved tool for guiding patient selection and shared decision-making for TAVR procedures. Thank you for listening. Don’t forget to subscribe. Keywords Transplantation, Procedural futility, Randomized clinical trial, Population-based study, Proteomics, Heart failure with preserved ejection fraction, Living donor kidney transplants, Transcatheter aortic valve replacement, Heart failure, COVID-19 pandemic, Medically tailored meals, One-year mortality, Surveillance guidelines, Machine learning, TAVR, Subphenogroups, H. F. pEF, Risk factors, Dietary intake, Hemodynamic progression, Kidney disease, Pathway analysis, Epidemiological trends, Aortic stenosis, Risk prediction, Food supplementation, Machine learning model. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post ML Model Predicts TAVR Mortality, Futility 04/11/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 10, 2026. This episode summarizes 5 key cardiology studies on topics like blood pressure control and trophoblast differentiation. Key takeaway: Nurses Cut Stroke BP with Phone Intervention. Article Links: Article 1: Mechanical Thrombectomy and Catheter-Directed Thrombolysis in Acute Pulmonary Embolism: Trends and Practice Patterns in the PERT Consortium Registry (2016-2024). (Journal of the American College of Cardiology) Article 2: Defective Trophoblast Differentiation, Endothelial Dysfunction, and Immune Dysregulation in Preeclampsia Coalesce on a Placental VGLL3-Centered Gene Network. (Circulation) Article 3: Phone-Based Intervention Under Nurse Guidance for Control of Hypertension After Stroke: A Randomized Multicenter Phase 3 Trial in Ghana. (Circulation) Article 4: Cascade genetic screening in families with hereditary transthyretin amyloidosis: diagnostic and prognostic impact. (European heart journal) Article 5: Burst Exercise Stress Testing in Catecholaminergic Polymorphic Ventricular Tachycardia. (JAMA cardiology) Full episode page: https://podcast.explainheart.com/podcast/nurses-cut-stroke-bp-with-phone-intervention-04-10-26/ Featured Articles Article 1: Mechanical Thrombectomy and Catheter-Directed Thrombolysis in Acute Pulmonary Embolism: Trends and Practice Patterns in the PERT Consortium Registry (2016-2024). Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41739022 Summary: The PERT Consortium Registry analyzed trends in the use of catheter-directed thrombolysis and mechanical thrombectomy for acute pulmonary embolism between 2016 and 2024. This registry provided real-world data on the diffusion of these catheter-based interventions, including patient and imaging characteristics. It further documented institutional variation in the application of catheter-directed thrombolysis and mechanical thrombectomy in clinical practice. The findings offer concrete insights into contemporary management strategies for acute pulmonary embolism. Article 2: Defective Trophoblast Differentiation, Endothelial Dysfunction, and Immune Dysregulation in Preeclampsia Coalesce on a Placental VGLL3-Centered Gene Network. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41953989 Summary: Human single-cell and spatial analyses, along with in vitro and in vivo models, demonstrated that VGLL3, a transcription coregulator in the Hippo pathway, is upregulated in preeclamptic placentas. This upregulation of VGLL3 promotes immune dysregulation, defective trophoblast differentiation, and endothelial dysfunction. The data revealed that these pathological processes coalesce on a placental VGLL3-centered gene network. This identifies VGLL3 as a key orchestrator of molecular events underlying preeclampsia development. Article 3: Phone-Based Intervention Under Nurse Guidance for Control of Hypertension After Stroke: A Randomized Multicenter Phase 3 Trial in Ghana. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41953982 Summary: The PINGS, Phone-Based Intervention Under Nurse Guidance for Control of Hypertension After Stroke, trial was a randomized multicenter phase three study conducted in Ghana. This trial found that a phone-based intervention, led by nurses, effectively improved blood pressure control among patients with recent stroke. The study demonstrated this intervention as a pragmatic and scalable strategy to address the burden of stroke in resource-limited African settings. These results provide a clinically significant approach for managing hypertension after stroke in low-income countries. Article 4: Cascade genetic screening in families with hereditary transthyretin amyloidosis: diagnostic and prognostic impact. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41955077 Summary: This retrospective study analyzed 967 individuals from 431 families with hereditary transthyretin amyloidosis, ATTRv, across 15 Italian referral centers from 2004 to 2024. The analysis precisely categorized participants into ATTRv index cases, genotype-positive/phenotype-positive symptomatic carriers, and asymptomatic carriers. This comprehensive dataset provided concrete information regarding the diagnostic and prognostic impact of cascade genetic screening within these families. The findings demonstrated the real-world application and yielded implications for early detection and disease management in hereditary transthyretin amyloidosis. Article 5: Burst Exercise Stress Testing in Catecholaminergic Polymorphic Ventricular Tachycardia. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41949873 Summary: Exercise stress testing remains the primary method for provoking adrenergically mediated ventricular arrhythmias in catecholaminergic polymorphic ventricular tachycardia, CPVT. Traditional protocols, like the Bruce protocol, often demonstrate limitations in diagnostic sensitivity for CPVT. The study evaluated the diagnostic yield of a sudden high-intensity Burst exercise protocol, developed as a more effective approach for unmasking arrhythmias. This novel testing method directly addresses the diagnostic challenges presented by traditional exercise protocols in catecholaminergic polymorphic ventricular tachycardia. Transcript Today’s date is April 10, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Mechanical Thrombectomy and Catheter-Directed Thrombolysis in Acute Pulmonary Embolism: Trends and Practice Patterns in the PERT Consortium Registry (2016-2024). The PERT Consortium Registry analyzed trends in the use of catheter-directed thrombolysis and mechanical thrombectomy for acute pulmonary embolism between 2016 and 2024. This registry provided real-world data on the diffusion of these catheter-based interventions, including patient and imaging characteristics. It further documented institutional variation in the application of catheter-directed thrombolysis and mechanical thrombectomy in clinical practice. The findings offer concrete insights into contemporary management strategies for acute pulmonary embolism. Article number two. Defective Trophoblast Differentiation, Endothelial Dysfunction, and Immune Dysregulation in Preeclampsia Coalesce on a Placental VGLL3-Centered Gene Network. Human single-cell and spatial analyses, along with in vitro and in vivo models, demonstrated that VGLL3, a transcription coregulator in the Hippo pathway, is upregulated in preeclamptic placentas. This upregulation of VGLL3 promotes immune dysregulation, defective trophoblast differentiation, and endothelial dysfunction. The data revealed that these pathological processes coalesce on a placental VGLL3-centered gene network. This identifies VGLL3 as a key orchestrator of molecular events underlying preeclampsia development. Article number three. Phone-Based Intervention Under Nurse Guidance for Control of Hypertension After Stroke: A Randomized Multicenter Phase 3 Trial in Ghana. The PINGS, Phone-Based Intervention Under Nurse Guidance for Control of Hypertension After Stroke, trial was a randomized multicenter phase three study conducted in Ghana. This trial found that a phone-based intervention, led by nurses, effectively improved blood pressure control among patients with recent stroke. The study demonstrated this intervention as a pragmatic and scalable strategy to address the burden of stroke in resource-limited African settings. These results provide a clinically significant approach for managing hypertension after stroke in low-income countries. Article number four. Cascade genetic screening in families with hereditary transthyretin amyloidosis: diagnostic and prognostic impact. This retrospective study analyzed 967 individuals from 431 families with hereditary transthyretin amyloidosis, ATTRv, across 15 Italian referral centers from 2004 to 2024. The analysis precisely categorized participants into ATTRv index cases, genotype-positive/phenotype-positive symptomatic carriers, and asymptomatic carriers. This comprehensive dataset provided concrete information regarding the diagnostic and prognostic impact of cascade genetic screening within these families. The findings demonstrated the real-world application and yielded implications for early detection and disease management in hereditary transthyretin amyloidosis. Article number five. Burst Exercise Stress Testing in Catecholaminergic Polymorphic Ventricular Tachycardia. Exercise stress testing remains the primary method for provoking adrenergically mediated ventricular arrhythmias in catecholaminergic polymorphic ventricular tachycardia, CPVT. Traditional protocols, like the Bruce protocol, often demonstrate limitations in diagnostic sensitivity for CPVT. The study evaluated the diagnostic yield of a sudden high-intensity Burst exercise protocol, developed as a more effective approach for unmasking arrhythmias. This novel testing method directly addresses the diagnostic challenges presented by traditional exercise protocols in catecholaminergic polymorphic ventricular tachycardia. Thank you for listening. Don’t forget to subscribe. Keywords blood pressure control, trophoblast differentiation, arrhythmia, catheter-directed thrombolysis, asymptomatic carriers, Ghana, VGLL3, endothelial dysfunction, mobile health, immune dysregulation, mechanical thrombectomy, acute pulmonary embolism, placental gene network, cascade genetic screening, stroke, pulmonary embolism, preeclampsia, nurse-led intervention, diagnostic yield, catecholaminergic polymorphic ventricular tachycardia, Burst protocol, hereditary transthyretin amyloidosis, ATTRv, exercise stress testing, symptomatic carriers, PERT Consortium, CPVT, hypertension. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Nurses Cut Stroke BP with Phone Intervention 04/10/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 09, 2026. This episode summarizes 5 key cardiology studies on topics like atherosclerotic cardiovascular disease and heart failure with preserved ejection fraction. Key takeaway: RBM20 Gene Links to Arrhythmogenic Cardiomyopathy. Article Links: Article 1: Multifaceted Strategies for Hypertension Control in Low-Income Patients. (The New England journal of medicine) Article 2: Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease. (The New England journal of medicine) Article 3: Trajectories and outcomes in patients with cardiogenic shock receiving heart replacement therapies. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Performance of the HFpEF-ABA, H2FPEF, and HFA-PEFF Algorithms in HFpEF: A Participant-Level Pooled Analysis of Randomized Clinical Trials. (Journal of cardiac failure) Article 5: RBM20 Truncating Variants and Human Cardiomyopathy. (JAMA cardiology) Full episode page: https://podcast.explainheart.com/podcast/rbm20-gene-links-to-arrhythmogenic-cardiomyopathy-04-09-26/ Featured Articles Article 1: Multifaceted Strategies for Hypertension Control in Low-Income Patients. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41950472 Summary: Uncontrolled hypertension disproportionately impacts populations with substantial health disparities, underscoring the importance of targeted interventions. Multifaceted, team-based strategies represent a key therapeutic approach for hypertension control in low-income patients. These strategies involve comprehensive implementation within federally qualified health center clinics. Such approaches are critical for addressing health inequities in communities with high rates of uncontrolled hypertension. Article 2: Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910315 Summary: Intensive low-density lipoprotein cholesterol targeting is a primary therapeutic approach rigorously evaluated for secondary prevention in patients with atherosclerotic cardiovascular disease. A trial compared targeting low-density lipoprotein cholesterol to less than 55 mg per deciliter against a target of 70 to 100 mg per deciliter. This direct comparison clarifies optimal lipid management strategies and informs guideline recommendations. The evaluation provides essential insights into reducing cardiovascular risk through aggressive low-density lipoprotein cholesterol reduction. Article 3: Trajectories and outcomes in patients with cardiogenic shock receiving heart replacement therapies. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41951134 Summary: Understanding trajectories and outcomes in patients with cardiogenic shock receiving heart replacement therapies is a critical area of clinical investigation. Patient severity in cardiogenic shock is characterized using Society for Cardiovascular Angiography and Interventions stages, machine learning-derived phenotypes, and the Comorbidity Risk Index. These comprehensive tools offer advanced stratification to guide management. The comparison of patients receiving heart replacement therapies versus no therapy during index hospitalization provides crucial insights for optimizing patient care. Article 4: Performance of the HFpEF-ABA, H2FPEF, and HFA-PEFF Algorithms in HFpEF: A Participant-Level Pooled Analysis of Randomized Clinical Trials. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41950988 Summary: Multiple algorithms, including HFpEF-ABA, H₂FPEF, and HFA-PEFF, provide valuable tools for improving diagnosis and risk stratification in heart failure with preserved ejection fraction. An analysis confirmed the utility of these models in assessing clinical outcomes among individuals with established heart failure with preserved ejection fraction. The algorithms enhance understanding of both clinical trajectories and trial-specific treatment effects. This comprehensive evaluation clarifies the role of these scores in precisely characterizing the heterogeneous heart failure with preserved ejection fraction population. Article 5: RBM20 Truncating Variants and Human Cardiomyopathy. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41949880 Summary: Pathogenic or likely pathogenic missense variants in the RBM20 gene are definitively linked to a highly penetrant arrhythmogenic dilated cardiomyopathy. This genetic diagnosis plays an increasingly important role in guiding clinical decision making for patients with dilated cardiomyopathy. The contribution of RBM20 truncating variants requires further evaluation to refine genetic diagnosis for arrhythmogenic dilated cardiomyopathy. These genetic insights provide critical information for patient management and understanding disease mechanisms. Transcript Today’s date is April 09, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Multifaceted Strategies for Hypertension Control in Low-Income Patients. Uncontrolled hypertension disproportionately impacts populations with substantial health disparities, underscoring the importance of targeted interventions. Multifaceted, team-based strategies represent a key therapeutic approach for hypertension control in low-income patients. These strategies involve comprehensive implementation within federally qualified health center clinics. Such approaches are critical for addressing health inequities in communities with high rates of uncontrolled hypertension. Article number two. Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease. Intensive low-density lipoprotein cholesterol targeting is a primary therapeutic approach rigorously evaluated for secondary prevention in patients with atherosclerotic cardiovascular disease. A trial compared targeting low-density lipoprotein cholesterol to less than 55 mg per deciliter against a target of 70 to 100 mg per deciliter. This direct comparison clarifies optimal lipid management strategies and informs guideline recommendations. The evaluation provides essential insights into reducing cardiovascular risk through aggressive low-density lipoprotein cholesterol reduction. Article number three. Trajectories and outcomes in patients with cardiogenic shock receiving heart replacement therapies. Understanding trajectories and outcomes in patients with cardiogenic shock receiving heart replacement therapies is a critical area of clinical investigation. Patient severity in cardiogenic shock is characterized using Society for Cardiovascular Angiography and Interventions stages, machine learning-derived phenotypes, and the Comorbidity Risk Index. These comprehensive tools offer advanced stratification to guide management. The comparison of patients receiving heart replacement therapies versus no therapy during index hospitalization provides crucial insights for optimizing patient care. Article number four. Performance of the HFpEF-ABA, H₂FPEF, and HFA-PEFF Algorithms in HFpEF: A Participant-Level Pooled Analysis of Randomized Clinical Trials. Multiple algorithms, including HFpEF-ABA, H₂FPEF, and HFA-PEFF, provide valuable tools for improving diagnosis and risk stratification in heart failure with preserved ejection fraction. An analysis confirmed the utility of these models in assessing clinical outcomes among individuals with established heart failure with preserved ejection fraction. The algorithms enhance understanding of both clinical trajectories and trial-specific treatment effects. This comprehensive evaluation clarifies the role of these scores in precisely characterizing the heterogeneous heart failure with preserved ejection fraction population. Article number five. RBM20 Truncating Variants and Human Cardiomyopathy. Pathogenic or likely pathogenic missense variants in the RBM20 gene are definitively linked to a highly penetrant arrhythmogenic dilated cardiomyopathy. This genetic diagnosis plays an increasingly important role in guiding clinical decision making for patients with dilated cardiomyopathy. The contribution of RBM20 truncating variants requires further evaluation to refine genetic diagnosis for arrhythmogenic dilated cardiomyopathy. These genetic insights provide critical information for patient management and understanding disease mechanisms. Thank you for listening. Don’t forget to subscribe. Keywords atherosclerotic cardiovascular disease, heart failure with preserved ejection fraction, lipid management, HFA-PEFF, risk stratification, hypertension control, secondary prevention, team-based care, arrhythmogenic cardiomyopathy, cardiogenic shock, truncating variants, diagnostic algorithms, comorbidity risk index, low-income patients, Society for Cardiovascular Angiography and Interventions stages, machine learning phenotypes, dilated cardiomyopathy, heart replacement therapies, HFpEF-ABA, H₂FPEF, RBM20 gene, health disparities, genetic diagnosis, low-density lipoprotein cholesterol, federally qualified health centers, intensive targeting. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post RBM20 Gene Links to Arrhythmogenic Cardiomyopathy 04/09/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 08, 2026. This episode summarizes 5 key cardiology studies on topics like hypertensive heart failure and COVID-19. Key takeaway: Early PCSK9 Inhibitors Boost Stroke Outcomes. Article Links: Article 1: Eclampsia and early readmission for cardiovascular disease. (European heart journal) Article 2: Checkpoint kinase Wee1 activation drives inflammation and hypertrophy through the protein kinase B/phosphoinositide 3-kinases-nuclear factor κB pathway in cardiomyocytes. (European heart journal) Article 3: Residential Greenness and Risk of Coronary Artery Disease Following COVID-19: A Nationwide Cohort Study in South Korea. (Journal of the American Heart Association) Article 4: Assessing the Cost Effectiveness of an Incremental Lipid-Lowering Therapy Approach After Coronary Artery Bypass Grafting Using Nationwide Data. (Journal of the American Heart Association) Article 5: Early PCSK9 Inhibitor Use Correlates With Improved Outcomes in Patients With Acute Stroke Receiving Endovascular Therapy. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/early-pcsk9-inhibitors-boost-stroke-outcomes-04-08-26/ Featured Articles Article 1: Eclampsia and early readmission for cardiovascular disease. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40689758 Summary: This study focused on determining whether patients with eclampsia have an increased risk for readmission due to cardiovascular disease within the first year after delivery. Researchers identified cardiovascular disease events from the Nationwide Readmissions Database between 2010 and 2018. This investigation highlights a crucial period for potential cardiovascular complications among patients following eclampsia, underscoring the importance of post-partum surveillance. Article 2: Checkpoint kinase Wee1 activation drives inflammation and hypertrophy through the protein kinase B/phosphoinositide 3-kinases-nuclear factor κB pathway in cardiomyocytes. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40396291 Summary: This study identified Wee1 G2 checkpoint kinase as activated and involved in hypertensive heart failure. Researchers found that Wee1 drives inflammation and hypertrophy through the protein kinase B / phosphoinositide 3-kinases – nuclear factor kappa B pathway in cardiomyocytes. This mechanism provides a specific molecular target for developing new therapeutic strategies against hypertensive heart failure. Article 3: Residential Greenness and Risk of Coronary Artery Disease Following COVID-19: A Nationwide Cohort Study in South Korea. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41944181 Summary: This nationwide cohort study in South Korea explored the association between residential greenness and incident coronary artery disease following COVID-19. The investigation revealed that residential greenness is relevant to ischemic heart disease risk after severe acute respiratory syndrome coronavirus two infection, an area previously unclear. This highlights the potential impact of environmental factors on post-COVID-19 cardiovascular health. Article 4: Assessing the Cost Effectiveness of an Incremental Lipid-Lowering Therapy Approach After Coronary Artery Bypass Grafting Using Nationwide Data. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41944180 Summary: This study addressed the cost-effectiveness of an incremental lipid-lowering therapy approach after coronary artery bypass grafting, acknowledging the cost limitations of PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors. Researchers conducted mathematical modeling on a nationwide cohort of United States veterans to understand the need for these expensive drugs. The findings contribute to strategies for optimizing lipid-lowering therapy post-coronary artery bypass grafting by considering economic factors. Article 5: Early PCSK9 Inhibitor Use Correlates With Improved Outcomes in Patients With Acute Stroke Receiving Endovascular Therapy. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41944178 Summary: This study demonstrated that early PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor use correlates with improved outcomes in patients with acute stroke receiving endovascular therapy. Researchers found that early administration of PCSK9 inhibitors is associated with improved clinical outcomes in patients with acute large vessel occlusion after successful endovascular therapy recanalization. This finding suggests a potential benefit for early PCSK9 inhibitor treatment in this critical patient population. Transcript Today’s date is April 08, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Eclampsia and early readmission for cardiovascular disease. This study focused on determining whether patients with eclampsia have an increased risk for readmission due to cardiovascular disease within the first year after delivery. Researchers identified cardiovascular disease events from the Nationwide Readmissions Database between 2010 and 2018. This investigation highlights a crucial period for potential cardiovascular complications among patients following eclampsia, underscoring the importance of post-partum surveillance. Article number two. Checkpoint kinase Wee1 activation drives inflammation and hypertrophy through the protein kinase B/phosphoinositide 3-kinases-nuclear factor κB pathway in cardiomyocytes. This study identified Wee1 G2 checkpoint kinase as activated and involved in hypertensive heart failure. Researchers found that Wee1 drives inflammation and hypertrophy through the protein kinase B / phosphoinositide 3-kinases – nuclear factor kappa B pathway in cardiomyocytes. This mechanism provides a specific molecular target for developing new therapeutic strategies against hypertensive heart failure. Article number three. Residential Greenness and Risk of Coronary Artery Disease Following COVID-19: A Nationwide Cohort Study in South Korea. This nationwide cohort study in South Korea explored the association between residential greenness and incident coronary artery disease following COVID-19. The investigation revealed that residential greenness is relevant to ischemic heart disease risk after severe acute respiratory syndrome coronavirus two infection, an area previously unclear. This highlights the potential impact of environmental factors on post-COVID-19 cardiovascular health. Article number four. Assessing the Cost Effectiveness of an Incremental Lipid-Lowering Therapy Approach After Coronary Artery Bypass Grafting Using Nationwide Data. This study addressed the cost-effectiveness of an incremental lipid-lowering therapy approach after coronary artery bypass grafting, acknowledging the cost limitations of PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors. Researchers conducted mathematical modeling on a nationwide cohort of United States veterans to understand the need for these expensive drugs. The findings contribute to strategies for optimizing lipid-lowering therapy post-coronary artery bypass grafting by considering economic factors. Article number five. Early PCSK9 Inhibitor Use Correlates With Improved Outcomes in Patients With Acute Stroke Receiving Endovascular Therapy. This study demonstrated that early PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor use correlates with improved outcomes in patients with acute stroke receiving endovascular therapy. Researchers found that early administration of PCSK9 inhibitors is associated with improved clinical outcomes in patients with acute large vessel occlusion after successful endovascular therapy recanalization. This finding suggests a potential benefit for early PCSK9 inhibitor treatment in this critical patient population. Thank you for listening. Don’t forget to subscribe. Keywords hypertensive heart failure, COVID-19, Nationwide Readmissions Database, coronary artery bypass grafting, endovascular therapy, hypertrophy, readmission, large vessel occlusion, inflammation, Wee1 G2 checkpoint kinase, postpartum, environmental factors, residential greenness, nuclear factor kappa B, mathematical modeling, cost-effectiveness, eclampsia, phosphoinositide 3-kinases, cardiovascular disease, acute stroke, PCSK9 inhibitors, protein kinase B, clinical outcomes, severe acute respiratory syndrome coronavirus two, lipid-lowering therapy, coronary artery disease. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Early PCSK9 Inhibitors Boost Stroke Outcomes 04/08/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 08, 2026. This episode summarizes 5 key cardiology studies on topics like Heart Failure with Preserved Ejection Fraction and galectin three. Key takeaway: Olfactory Receptor Halts Platelet Clotting. Article Links: Article 1: Mir147 Limits the Contribution of Non-Foamy Macrophages to Atherosclerosis. (Circulation) Article 2: Multi-Organ Physiologic Deficits During Exercise Identify Clinical and Molecular Predisposition to Heart Failure with Preserved Ejection Fraction. (Circulation) Article 3: Olfactory Receptor Activation Reduces Platelet Reactivity and Arterial Thrombosis Through Actin Cytoskeleton Remodeling. (Circulation) Article 4: Characteristics of Protein Profiling and Biomarkers in Aortic Regurgitation With Heart Failure. (Journal of the American Heart Association) Article 5: Elevated Interleukin-6 Levels in Socioeconomically Disadvantaged Children With Borderline Subclinical Rheumatic Heart Disease in São Paulo, Brazil: A Prospective Cohort Study Highlighting Early Detection and Treatment Opportunities. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/olfactory-receptor-halts-platelet-clotting-04-08-26/ Featured Articles Article 1: Mir147 Limits the Contribution of Non-Foamy Macrophages to Atherosclerosis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41944070 Summary: The study found that Mir147 (microRNA 147) limits the contribution of non-foamy macrophages to atherosclerosis by downregulating inflammatory activation. Specifically, Mir147-3p is upregulated by inflammation and functions to reduce inflammatory responses within these macrophages. This mechanism prevents the inflammatory activation of non-foamy macrophages, thereby reducing their role in the progression of atherosclerosis. The findings establish a new regulatory pathway in macrophage biology relevant to atherosclerotic disease. Article 2: Multi-Organ Physiologic Deficits During Exercise Identify Clinical and Molecular Predisposition to Heart Failure with Preserved Ejection Fraction. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41944041 Summary: This study found that multi-organ physiologic deficits identified during exercise characterize Heart Failure with Preserved Ejection Fraction (H. F. pEF). The research identified seven specific exercise-related deficits, including reduced peak oxygen uptake and chronotropic incompetence, in patients with this condition. These multi-organ limitations were directly associated with the severity and prognosis of Heart Failure with Preserved Ejection Fraction. The findings establish a link between these exercise deficits and both clinical and molecular predispositions to Heart Failure with Preserved Ejection Fraction. Article 3: Olfactory Receptor Activation Reduces Platelet Reactivity and Arterial Thrombosis Through Actin Cytoskeleton Remodeling. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41944007 Summary: The study found that activating the human olfactory receptor 2 L 13 (O. R. 2 L 13) on platelets significantly reduced platelet aggregation in laboratory settings. Activation of O. R. 2 L 13 also provided robust protection against arterial thrombosis in living organisms. This antithrombotic effect occurs through the mechanism of actin cytoskeleton remodeling within the platelets. These findings identify platelet O. R. 2 L 13 activation as a novel and effective strategy for reducing platelet reactivity and preventing arterial thrombosis. Article 4: Characteristics of Protein Profiling and Biomarkers in Aortic Regurgitation With Heart Failure. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41944198 Summary: This study identified 23 differentially expressed proteins in patients with severe aortic regurgitation compared to control subjects. Specifically, 7 proteins were upregulated and 16 were downregulated in severe aortic regurgitation cases. Key differentially expressed proteins included galectin three and matrix metalloproteinase nine. The data demonstrated that these differentially expressed proteins offer potential as biomarkers for the diagnosis and therapeutic monitoring of severe aortic regurgitation. Article 5: Elevated Interleukin-6 Levels in Socioeconomically Disadvantaged Children With Borderline Subclinical Rheumatic Heart Disease in São Paulo, Brazil: A Prospective Cohort Study Highlighting Early Detection and Treatment Opportunities. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41944184 Summary: The study found that interleukin six levels were significantly elevated in children with borderline subclinical rheumatic heart disease (S. C. R. H. D.) compared to healthy controls at baseline, with a P value of 0.006. These elevated interleukin six levels persisted longitudinally throughout the two-year follow-up period in both borderline and definite subclinical rheumatic heart disease patients, with a P value of 0.004. The data demonstrate that interleukin six serves as a key inflammatory biomarker for early detection and disease activity in subclinical rheumatic heart disease. This persistent inflammation suggests opportunities for early therapeutic interventions in socioeconomically disadvantaged children. Transcript Today’s date is April 08, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Mir147 Limits the Contribution of Non-Foamy Macrophages to Atherosclerosis. The study found that Mir147 (microRNA 147) limits the contribution of non-foamy macrophages to atherosclerosis by downregulating inflammatory activation. Specifically, Mir147-3p is upregulated by inflammation and functions to reduce inflammatory responses within these macrophages. This mechanism prevents the inflammatory activation of non-foamy macrophages, thereby reducing their role in the progression of atherosclerosis. The findings establish a new regulatory pathway in macrophage biology relevant to atherosclerotic disease. Article number two. Multi-Organ Physiologic Deficits During Exercise Identify Clinical and Molecular Predisposition to Heart Failure with Preserved Ejection Fraction. This study found that multi-organ physiologic deficits identified during exercise characterize Heart Failure with Preserved Ejection Fraction (H. F. pEF). The research identified seven specific exercise-related deficits, including reduced peak oxygen uptake and chronotropic incompetence, in patients with this condition. These multi-organ limitations were directly associated with the severity and prognosis of Heart Failure with Preserved Ejection Fraction. The findings establish a link between these exercise deficits and both clinical and molecular predispositions to Heart Failure with Preserved Ejection Fraction. Article number three. Olfactory Receptor Activation Reduces Platelet Reactivity and Arterial Thrombosis Through Actin Cytoskeleton Remodeling. The study found that activating the human olfactory receptor 2 L 13 (O. R. 2 L 13) on platelets significantly reduced platelet aggregation in laboratory settings. Activation of O. R. 2 L 13 also provided robust protection against arterial thrombosis in living organisms. This antithrombotic effect occurs through the mechanism of actin cytoskeleton remodeling within the platelets. These findings identify platelet O. R. 2 L 13 activation as a novel and effective strategy for reducing platelet reactivity and preventing arterial thrombosis. Article number four. Characteristics of Protein Profiling and Biomarkers in Aortic Regurgitation With Heart Failure. This study identified 23 differentially expressed proteins in patients with severe aortic regurgitation compared to control subjects. Specifically, 7 proteins were upregulated and 16 were downregulated in severe aortic regurgitation cases. Key differentially expressed proteins included galectin three and matrix metalloproteinase nine. The data demonstrated that these differentially expressed proteins offer potential as biomarkers for the diagnosis and therapeutic monitoring of severe aortic regurgitation. Article number five. Elevated Interleukin-6 Levels in Socioeconomically Disadvantaged Children With Borderline Subclinical Rheumatic Heart Disease in São Paulo, Brazil: A Prospective Cohort Study Highlighting Early Detection and Treatment Opportunities. The study found that interleukin six levels were significantly elevated in children with borderline subclinical rheumatic heart disease (S. C. R. H. D.) compared to healthy controls at baseline, with a P value of 0.006. These elevated interleukin six levels persisted longitudinally throughout the two-year follow-up period in both borderline and definite subclinical rheumatic heart disease patients, with a P value of 0.004. The data demonstrate that interleukin six serves as a key inflammatory biomarker for early detection and disease activity in subclinical rheumatic heart disease. This persistent inflammation suggests opportunities for early therapeutic interventions in socioeconomically disadvantaged children. Thank you for listening. Don’t forget to subscribe. Keywords Heart Failure with Preserved Ejection Fraction, galectin three, cardiopulmonary exercise testing, microRNA 147, biomarkers, heart failure, G protein-coupled receptor, arterial thrombosis, protein profiling, platelet reactivity, aortic regurgitation, inflammation, atherosclerosis, subclinical rheumatic heart disease, non-foamy macrophages, interleukin six, oxygen uptake, macrophages, olfactory receptor, children, antithrombotic, chronotropic incompetence, exercise testing, matrix metalloproteinase nine. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Olfactory Receptor Halts Platelet Clotting 04/08/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 07, 2026. This episode summarizes 5 key cardiology studies on topics like guideline-directed medical therapy and congenital heart disease. Key takeaway: Telomere Recapping Blocks Heart Failure Mechanism. Article Links: Article 1: Apolipoprotein D, a Novel Ligand for CD36, Is Essential for Blood-Brain Barrier Integrity. (Circulation) Article 2: A Randomized Controlled Trial Comparing Different Programming Strategies of Left Bundle Branch Area Pacing on Left Atrial Volume and Atrial High-Rate Episodes in Patients With Sinus Node Dysfunction. (The American journal of cardiology) Article 3: Telomere recapping prevents pathogenic telomere-to-mitochondrial DNA communication in heart failure. (Cardiovascular research) Article 4: Longitudinal trajectories of secondary mitral regurgitation in non-ischemic dilated cardiomyopathy. (Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography) Article 5: Stress, coping, protective factors, and quality of life in parents of infants with CHD: associations with state anxiety. (Cardiology in the young) Full episode page: https://podcast.explainheart.com/podcast/telomere-recapping-blocks-heart-failure-mechanism-04-07-26/ Featured Articles Article 1: Apolipoprotein D, a Novel Ligand for CD36, Is Essential for Blood-Brain Barrier Integrity. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41645912 Summary: D. 36, Is Essential for Blood-Brain Barrier Integrity. This study found that Apolipoprotein D is a novel ligand for C. D. 36 and is essential for maintaining blood-brain barrier integrity. This mechanism is critical because disruption of the blood-brain barrier is a central pathogenic event in many central nervous system disorders. The research identifies a specific molecular pathway governing blood-brain barrier function. This fundamental understanding of blood-brain barrier regulation provides a basis for future therapeutic strategies. Article 2: A Randomized Controlled Trial Comparing Different Programming Strategies of Left Bundle Branch Area Pacing on Left Atrial Volume and Atrial High-Rate Episodes in Patients With Sinus Node Dysfunction. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41942043 Summary: Left bundle branch area pacing is a physiological pacing modality preserving ventricular synchrony. Optimal programming strategies for patients with sinus node dysfunction, particularly those with delayed intrinsic atrioventricular conduction, have remained clinically uncertain. It is understood that minimal ventricular pacing algorithms can permit non-physiological atrioventricular prolongation, which contributes to left atrial remodeling and atrial high-rate episodes. This randomized controlled trial directly compared maximal atrioventricular sequential pacing with minimal ventricular pacing strategies to address these critical clinical outcomes. Article 3: Telomere recapping prevents pathogenic telomere-to-mitochondrial DNA communication in heart failure. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41942104 Summary: N. A. communication in heart failure. This study found that telomere recapping prevents pathogenic communication between telomeres and mitochondrial deoxyribonucleic acid in heart failure. Diseased cardiomyocytes exhibit telomeric shortening, which triggers deoxyribonucleic acid damage responses and leads to mitochondrial dysfunction. This finding demonstrates a novel mechanism to restore myocardial function, addressing the high prevalence and significant mortality of heart failure, where five-year survival remains at fifty percent. Telomere recapping thus represents a promising therapeutic target for improving heart failure outcomes. Article 4: Longitudinal trajectories of secondary mitral regurgitation in non-ischemic dilated cardiomyopathy. Journal: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41941940 Summary: This study defined the longitudinal trajectories of secondary mitral regurgitation in 764 patients with non-ischemic dilated cardiomyopathy. The findings revealed the dynamic nature of secondary mitral regurgitation severity, demonstrating its dependence on loading conditions and guideline-directed medical therapy. Understanding these long-term trajectories provides crucial prognostic insights for patients with non-ischemic dilated cardiomyopathy. This research provides a framework for evaluating secondary mitral regurgitation evolution and guiding patient management. Article 5: Stress, coping, protective factors, and quality of life in parents of infants with CHD: associations with state anxiety. Journal: Cardiology in the young PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41940517 Summary: H. D.: associations with state anxiety. The Family Adaptation study identified associations between stress, coping mechanisms, protective factors, quality of life, and state anxiety in parents of infants with congenital heart disease. The study included 215 parents, comprising 143 mothers and 72 fathers, of 146 infants who underwent the Norwood procedure, with measurements taken post-Norwood and post-Stage two. Results showed specific relationships among these psychosocial factors across the parental cohort. These findings delineate the complex psychosocial landscape and provide crucial insights for supporting parental well-being during their infant’s critical cardiac care. Transcript Today’s date is April 07, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Apolipoprotein D, a Novel Ligand for C. D. 36, Is Essential for Blood-Brain Barrier Integrity. This study found that Apolipoprotein D is a novel ligand for C. D. 36 and is essential for maintaining blood-brain barrier integrity. This mechanism is critical because disruption of the blood-brain barrier is a central pathogenic event in many central nervous system disorders. The research identifies a specific molecular pathway governing blood-brain barrier function. This fundamental understanding of blood-brain barrier regulation provides a basis for future therapeutic strategies. Article number two. A Randomized Controlled Trial Comparing Different Programming Strategies of Left Bundle Branch Area Pacing on Left Atrial Volume and Atrial High-Rate Episodes in Patients With Sinus Node Dysfunction. Left bundle branch area pacing is a physiological pacing modality preserving ventricular synchrony. Optimal programming strategies for patients with sinus node dysfunction, particularly those with delayed intrinsic atrioventricular conduction, have remained clinically uncertain. It is understood that minimal ventricular pacing algorithms can permit non-physiological atrioventricular prolongation, which contributes to left atrial remodeling and atrial high-rate episodes. This randomized controlled trial directly compared maximal atrioventricular sequential pacing with minimal ventricular pacing strategies to address these critical clinical outcomes. Article number three. Telomere recapping prevents pathogenic telomere-to-mitochondrial D. N. A. communication in heart failure. This study found that telomere recapping prevents pathogenic communication between telomeres and mitochondrial deoxyribonucleic acid in heart failure. Diseased cardiomyocytes exhibit telomeric shortening, which triggers deoxyribonucleic acid damage responses and leads to mitochondrial dysfunction. This finding demonstrates a novel mechanism to restore myocardial function, addressing the high prevalence and significant mortality of heart failure, where five-year survival remains at fifty percent. Telomere recapping thus represents a promising therapeutic target for improving heart failure outcomes. Article number four. Longitudinal trajectories of secondary mitral regurgitation in non-ischemic dilated cardiomyopathy. This study defined the longitudinal trajectories of secondary mitral regurgitation in 764 patients with non-ischemic dilated cardiomyopathy. The findings revealed the dynamic nature of secondary mitral regurgitation severity, demonstrating its dependence on loading conditions and guideline-directed medical therapy. Understanding these long-term trajectories provides crucial prognostic insights for patients with non-ischemic dilated cardiomyopathy. This research provides a framework for evaluating secondary mitral regurgitation evolution and guiding patient management. Article number five. Stress, coping, protective factors, and quality of life in parents of infants with C. H. D.: associations with state anxiety. The Family Adaptation study identified associations between stress, coping mechanisms, protective factors, quality of life, and state anxiety in parents of infants with congenital heart disease. The study included 215 parents, comprising 143 mothers and 72 fathers, of 146 infants who underwent the Norwood procedure, with measurements taken post-Norwood and post-Stage two. Results showed specific relationships among these psychosocial factors across the parental cohort. These findings delineate the complex psychosocial landscape and provide crucial insights for supporting parental well-being during their infant’s critical cardiac care. Thank you for listening. Don’t forget to subscribe. Keywords guideline-directed medical therapy, congenital heart disease, parental anxiety, heart failure, apolipoprotein D, mitochondrial D. N. A., telomere recapping, atrial high-rate episodes, ligand, quality of life, blood-brain barrier, atrioventricular conduction, secondary mitral regurgitation, left bundle branch area pacing, Norwood procedure, echocardiography, sinus node dysfunction, prognosis, C. D. 36, left atrial volume, non-ischemic dilated cardiomyopathy, central nervous system disorders, myocardial function, deoxyribonucleic acid damage, psychosocial factors. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Telomere Recapping Blocks Heart Failure Mechanism 04/07/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 06, 2026. This episode summarizes 5 key cardiology studies on topics like rehabilitation needs and coronary computed tomography angiography. Key takeaway: AI C. C. T. A. Guides Optimal L. L. M. Benefit. Article Links: Article 1: Association Between Functional Status and Cardiac Function in Chronic Heart Failure: Insights from the C-MIC II Trial. (ESC heart failure) Article 2: Association Between Functional Status and Cardiac Function in Chronic Heart Failure: Insights from the C-MIC II Trial. (ESC heart failure) Article 3: Quantitative Coronary Atherosclerotic Plaque Burden From CCTA and the Benefit From Lipid-Lowering Medication. (Circulation. Cardiovascular imaging) Article 4: The inferior vena cava collapsibility index as a non-invasive marker of early haemodynamic changes following atrial septal defect closure. (Cardiology in the young) Article 5: Physical therapy enhances patient care in post-congenital heart surgery clinic. (Cardiology in the young) Full episode page: https://podcast.explainheart.com/podcast/ai-c-c-t-a-guides-optimal-l-l-m-benefit-04-06-26/ Featured Articles Article 1: Association Between Functional Status and Cardiac Function in Chronic Heart Failure: Insights from the C-MIC II Trial. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41941602 Summary: This post hoc analysis from the cardiac microcurrent (C-MIC) two trial highlighted that the precise relationship between changes in cardiac function, functional capacity, and patient-reported health status in chronic Heart Failure remains incompletely defined. The C-MIC two trial evaluated the efficacy and safety of cardiac microcurrent therapy in patients with chronic Heart Failure with Reduced Ejection Fraction receiving optimal guideline-directed medical therapy. This study confirmed the ongoing need for research into how distinct clinical domains reflect treatment response for this patient population. Article 2: Association Between Functional Status and Cardiac Function in Chronic Heart Failure: Insights from the C-MIC II Trial. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41941602 Summary: This post hoc analysis from the cardiac microcurrent (C-MIC) two trial highlighted that the precise relationship between changes in cardiac function, functional capacity, and patient-reported health status in chronic Heart Failure remains incompletely defined. The C-MIC two trial evaluated the efficacy and safety of cardiac microcurrent therapy in patients with chronic Heart Failure with Reduced Ejection Fraction receiving optimal guideline-directed medical therapy. This study confirmed the ongoing need for research into how distinct clinical domains reflect treatment response for this patient population. Article 3: Quantitative Coronary Atherosclerotic Plaque Burden From CCTA and the Benefit From Lipid-Lowering Medication. Journal: Circulation. Cardiovascular imaging PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41937634 Summary: This observational cohort study found that artificial intelligence-guided quantitative coronary computed tomography angiography identified patients who derive outcome benefit from lipid-lowering medication. The study showed that quantification of coronary atherosclerotic plaque burden, specifically percent atheroma volume, serves as a marker for guiding therapy. This demonstrates that advanced imaging can personalize lipid-lowering medication strategies for symptomatic patients with suspected coronary artery disease. Article 4: The inferior vena cava collapsibility index as a non-invasive marker of early haemodynamic changes following atrial septal defect closure. Journal: Cardiology in the young PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41940521 Summary: This retrospective study found that the inferior vena cava collapsibility index serves as a non-invasive marker for early hemodynamic changes following transcatheter closure of an atrial septal defect. The study assessed changes in pulmonary artery, pulmonary vein, and inferior vena cava flow parameters in 31 pediatric patients. This demonstrates a valuable tool for monitoring immediate post-procedural cardiovascular adjustments in young patients with hemodynamically significant atrial septal defects, defined as Qp over Qs greater than or equal to 1.5. Article 5: Physical therapy enhances patient care in post-congenital heart surgery clinic. Journal: Cardiology in the young PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41940519 Summary: This retrospective review found that routine physical therapy evaluation significantly enhances patient care in post-congenital heart surgery clinics. The study assessed posture, mobility, and pain in patients following congenital heart surgery requiring sternotomy. This demonstrated that physical therapy effectively identifies rehabilitation needs and addresses gaps in care, improving post-operative management for these patients. Transcript Today’s date is April 06, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Association Between Functional Status and Cardiac Function in Chronic Heart Failure: Insights from the C-MIC II Trial. This post hoc analysis from the cardiac microcurrent (C-MIC) two trial highlighted that the precise relationship between changes in cardiac function, functional capacity, and patient-reported health status in chronic Heart Failure remains incompletely defined. The C-MIC two trial evaluated the efficacy and safety of cardiac microcurrent therapy in patients with chronic Heart Failure with Reduced Ejection Fraction receiving optimal guideline-directed medical therapy. This study confirmed the ongoing need for research into how distinct clinical domains reflect treatment response for this patient population. Article number two. Association Between Functional Status and Cardiac Function in Chronic Heart Failure: Insights from the C-MIC II Trial. This post hoc analysis from the cardiac microcurrent (C-MIC) two trial highlighted that the precise relationship between changes in cardiac function, functional capacity, and patient-reported health status in chronic Heart Failure remains incompletely defined. The C-MIC two trial evaluated the efficacy and safety of cardiac microcurrent therapy in patients with chronic Heart Failure with Reduced Ejection Fraction receiving optimal guideline-directed medical therapy. This study confirmed the ongoing need for research into how distinct clinical domains reflect treatment response for this patient population. Article number three. Quantitative Coronary Atherosclerotic Plaque Burden From CCTA and the Benefit From Lipid-Lowering Medication. This observational cohort study found that artificial intelligence-guided quantitative coronary computed tomography angiography identified patients who derive outcome benefit from lipid-lowering medication. The study showed that quantification of coronary atherosclerotic plaque burden, specifically percent atheroma volume, serves as a marker for guiding therapy. This demonstrates that advanced imaging can personalize lipid-lowering medication strategies for symptomatic patients with suspected coronary artery disease. Article number four. The inferior vena cava collapsibility index as a non-invasive marker of early haemodynamic changes following atrial septal defect closure. This retrospective study found that the inferior vena cava collapsibility index serves as a non-invasive marker for early hemodynamic changes following transcatheter closure of an atrial septal defect. The study assessed changes in pulmonary artery, pulmonary vein, and inferior vena cava flow parameters in 31 pediatric patients. This demonstrates a valuable tool for monitoring immediate post-procedural cardiovascular adjustments in young patients with hemodynamically significant atrial septal defects, defined as Qp over Qs greater than or equal to 1.5. Article number five. Physical therapy enhances patient care in post-congenital heart surgery clinic. This retrospective review found that routine physical therapy evaluation significantly enhances patient care in post-congenital heart surgery clinics. The study assessed posture, mobility, and pain in patients following congenital heart surgery requiring sternotomy. This demonstrated that physical therapy effectively identifies rehabilitation needs and addresses gaps in care, improving post-operative management for these patients. Thank you for listening. Don’t forget to subscribe. Keywords rehabilitation needs, coronary computed tomography angiography, functional capacity, post-operative care, Heart Failure, patient-reported health status, atherosclerotic plaque burden, ejection fraction, artificial intelligence, physical therapy, inferior vena cava collapsibility index, lipid-lowering medication, congenital heart surgery, pediatric cardiology, hemodynamic changes, percent atheroma volume, atrial septal defect, transcatheter closure, cardiac microcurrent therapy. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post AI C. C. T. A. Guides Optimal L. L. M. Benefit 04/06/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 06, 2026. This episode summarizes 5 key cardiology studies on topics like heart failure with preserved ejection fraction and coronary artery bypass grafting. Key takeaway: NOBLE Trial’s 10-Year Left Main Data. Article Links: Article 1: Beyond ion channel dysfunction: Integration of the transcriptome and proteome from patient-specific re-engineered cardiac cells, and population-level QT genome-wide association study reveals broad cellular dysfunction. (Heart rhythm) Article 2: Utilization and Outcomes of Dual Antiplatelet Therapy in Patients with Active Cancer Presenting with Acute Myocardial Infarction: A Global Registry Study. (The American journal of cardiology) Article 3: Cardiovascular pharmacotherapy in year in 2025. (European heart journal. Cardiovascular pharmacotherapy) Article 4: Economic Burden Associated with Systemic Inflammation in Patients with HFmrEF/HFpEF. (American heart journal) Article 5: Percutaneous coronary intervention versus coronary artery bypass grafting for unprotected left main stenosis: 10-year final results from the randomised, open-label, non-inferiority NOBLE trial. (Lancet (London, England)) Full episode page: https://podcast.explainheart.com/podcast/noble-trials-10-year-left-main-data-04-06-26/ Featured Articles Article 1: Beyond ion channel dysfunction: Integration of the transcriptome and proteome from patient-specific re-engineered cardiac cells, and population-level QT genome-wide association study reveals broad cellular dysfunction. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41936938 Summary: The study demonstrated broad cellular dysfunction in congenital Long Q. T. syndrome. This finding emerged from integrating transcriptomic and proteomic profiles of patient-derived inducible pluripotent stem cell-derived cardiomyocyte models representing L. Q. T. type one, L. Q. T. type two, and L. Q. T. type three genotypes. The investigation also incorporated population-level Q. T. genome-wide association study data, revealing cellular impairments beyond mere ion channel dysfunction and providing a deeper understanding of the disease’s mechanisms. Article 2: Utilization and Outcomes of Dual Antiplatelet Therapy in Patients with Active Cancer Presenting with Acute Myocardial Infarction: A Global Registry Study. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41936851 Summary: The global registry study characterized the utilization patterns and associated outcomes of dual antiplatelet therapy in patients with active cancer experiencing acute myocardial infarction. The investigation addressed the critical clinical challenge of balancing competing risks of thrombosis and bleeding when selecting optimal therapy in this high-mortality population. It comprehensively analyzed therapy use and outcomes, with all-cause mortality serving as the primary endpoint in these complex patients. Article 3: Cardiovascular pharmacotherapy in year in 2025. Journal: European heart journal. Cardiovascular pharmacotherapy PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41935384 Summary: Significant advances in cardiovascular pharmacotherapy were identified, including the approval of four new drugs: aficamten, etripamil, lerodalcibep, and plozasiran. Additionally, five already approved drugs received label expansions, broadening their therapeutic applications. The review also summarized key findings from major randomized clinical trials that further advanced treatment strategies, collectively addressing the ongoing need for more effective and safer pharmacological interventions across various cardiovascular diseases. Article 4: Economic Burden Associated with Systemic Inflammation in Patients with HFmrEF/HFpEF. Journal: American heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41936927 Summary: This retrospective cohort study characterized the economic burden associated with systemic inflammation in patients with heart failure with mildly reduced ejection fraction or heart failure with preserved ejection fraction. The investigation demonstrated the impact of systemic inflammation on real-world healthcare resource utilization and costs within this specific patient population. The findings highlight the critical role of systemic inflammation, detected via high sensitivity C. R. P. testing, in both the pathogenesis and economic implications for these heart failure subtypes. Article 5: Percutaneous coronary intervention versus coronary artery bypass grafting for unprotected left main stenosis: 10-year final results from the randomised, open-label, non-inferiority NOBLE trial. Journal: Lancet (London, England) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41936368 Summary: The N. O. B. L. E. trial delivered its 10-year final results, directly comparing percutaneous coronary intervention with newer generation drug-eluting stents against coronary artery bypass grafting for unprotected left main coronary artery stenosis. This randomized, open-label, non-inferiority investigation provided crucial long-term outcome data in a patient population where coronary artery bypass grafting has traditionally been the recommended treatment. The study offered definitive long-term insights to guide treatment decisions for this significant cardiovascular condition. Transcript Today’s date is April 06, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Beyond ion channel dysfunction: Integration of the transcriptome and proteome from patient-specific re-engineered cardiac cells, and population-level QT genome-wide association study reveals broad cellular dysfunction. The study demonstrated broad cellular dysfunction in congenital Long Q. T. syndrome. This finding emerged from integrating transcriptomic and proteomic profiles of patient-derived inducible pluripotent stem cell-derived cardiomyocyte models representing L. Q. T. type one, L. Q. T. type two, and L. Q. T. type three genotypes. The investigation also incorporated population-level Q. T. genome-wide association study data, revealing cellular impairments beyond mere ion channel dysfunction and providing a deeper understanding of the disease’s mechanisms. Article number two. Utilization and Outcomes of Dual Antiplatelet Therapy in Patients with Active Cancer Presenting with Acute Myocardial Infarction: A Global Registry Study. The global registry study characterized the utilization patterns and associated outcomes of dual antiplatelet therapy in patients with active cancer experiencing acute myocardial infarction. The investigation addressed the critical clinical challenge of balancing competing risks of thrombosis and bleeding when selecting optimal therapy in this high-mortality population. It comprehensively analyzed therapy use and outcomes, with all-cause mortality serving as the primary endpoint in these complex patients. Article number three. Cardiovascular pharmacotherapy in year in 2025. Significant advances in cardiovascular pharmacotherapy were identified, including the approval of four new drugs: aficamten, etripamil, lerodalcibep, and plozasiran. Additionally, five already approved drugs received label expansions, broadening their therapeutic applications. The review also summarized key findings from major randomized clinical trials that further advanced treatment strategies, collectively addressing the ongoing need for more effective and safer pharmacological interventions across various cardiovascular diseases. Article number four. Economic Burden Associated with Systemic Inflammation in Patients with HFmrEF/HFpEF. This retrospective cohort study characterized the economic burden associated with systemic inflammation in patients with heart failure with mildly reduced ejection fraction or heart failure with preserved ejection fraction. The investigation demonstrated the impact of systemic inflammation on real-world healthcare resource utilization and costs within this specific patient population. The findings highlight the critical role of systemic inflammation, detected via high sensitivity C. R. P. testing, in both the pathogenesis and economic implications for these heart failure subtypes. Article number five. Percutaneous coronary intervention versus coronary artery bypass grafting for unprotected left main stenosis: 10-year final results from the randomised, open-label, non-inferiority NOBLE trial. The N. O. B. L. E. trial delivered its 10-year final results, directly comparing percutaneous coronary intervention with newer generation drug-eluting stents against coronary artery bypass grafting for unprotected left main coronary artery stenosis. This randomized, open-label, non-inferiority investigation provided crucial long-term outcome data in a patient population where coronary artery bypass grafting has traditionally been the recommended treatment. The study offered definitive long-term insights to guide treatment decisions for this significant cardiovascular condition. Thank you for listening. Don’t forget to subscribe. Keywords heart failure with preserved ejection fraction, coronary artery bypass grafting, label expansions, proteome, high sensitivity C. R. P., cellular dysfunction, N. O. B. L. E. trial, heart failure with mildly reduced ejection fraction, aficamten, percutaneous coronary intervention, transcriptome, healthcare resource utilization, randomized clinical trials, thrombosis risk, new drug approvals, congenital Long Q. T. syndrome, cardiovascular pharmacotherapy, bleeding risk, active cancer, systemic inflammation, drug-eluting stents, unprotected left main coronary artery disease, inducible pluripotent stem cell-derived cardiomyocytes, acute myocardial infarction, dual antiplatelet therapy. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post NOBLE Trial’s 10-Year Left Main Data 04/06/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 05, 2026. This episode summarizes 2 key cardiology studies on topics like excitation-contraction coupling and right heart catheterization. Key takeaway: Stroke Volume Index for Pediatric P.A.H. Prognosis. Article Links: Article 1: Long-term genetic Orai1 inhibition modulates excitation-contraction coupling in female adult mouse ventricular cardiomyocytes. (American journal of physiology. Heart and circulatory physiology) Article 2: Clinical Utility of Stroke Volume Index in Children with Idiopathic and Heritable Pulmonary Arterial Hypertension. (Pediatric cardiology) Full episode page: https://podcast.explainheart.com/podcast/stroke-volume-index-for-pediatric-p-a-h-prognosis-04-05-26/ Featured Articles Article 1: Long-term genetic Orai1 inhibition modulates excitation-contraction coupling in female adult mouse ventricular cardiomyocytes. Journal: American journal of physiology. Heart and circulatory physiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41926628 Summary: This study found that long-term genetic inhibition of Orai1, a store-operated calcium channel, modulates excitation-contraction coupling in adult mouse ventricular cardiomyocytes. Using a mouse model expressing a dominant-negative human Orai1R91W mutant, researchers observed elevated intracellular calcium transients and calcium spark amplitudes in female mice compared to wild-type controls. These specific findings demonstrate a sex-specific contribution of Orai1 to cardiac excitation-contraction coupling. This indicates a novel role for Orai1 in cardiac function that varies between sexes. Article 2: Clinical Utility of Stroke Volume Index in Children with Idiopathic and Heritable Pulmonary Arterial Hypertension. Journal: Pediatric cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41925853 Summary: This retrospective study determined the clinical utility of stroke volume index in children with idiopathic and heritable pulmonary arterial hypertension. It assessed the prognostic value of stroke volume index, which was evaluated by right heart catheterization, in 103 pediatric patients. The study found a relationship between stroke volume index and adverse outcomes, specifically lung transplant and cardiac death. These findings establish stroke volume index as a valuable prognostic indicator in this pediatric patient population. Transcript Today’s date is April 05, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Long-term genetic Orai1 inhibition modulates excitation-contraction coupling in female adult mouse ventricular cardiomyocytes. This study found that long-term genetic inhibition of Orai1, a store-operated calcium channel, modulates excitation-contraction coupling in adult mouse ventricular cardiomyocytes. Using a mouse model expressing a dominant-negative human Orai1R91W mutant, researchers observed elevated intracellular calcium transients and calcium spark amplitudes in female mice compared to wild-type controls. These specific findings demonstrate a sex-specific contribution of Orai1 to cardiac excitation-contraction coupling. This indicates a novel role for Orai1 in cardiac function that varies between sexes. Article number two. Clinical Utility of Stroke Volume Index in Children with Idiopathic and Heritable Pulmonary Arterial Hypertension. This retrospective study determined the clinical utility of stroke volume index in children with idiopathic and heritable pulmonary arterial hypertension. It assessed the prognostic value of stroke volume index, which was evaluated by right heart catheterization, in 103 pediatric patients. The study found a relationship between stroke volume index and adverse outcomes, specifically lung transplant and cardiac death. These findings establish stroke volume index as a valuable prognostic indicator in this pediatric patient population. Thank you for listening. Don’t forget to subscribe. Keywords excitation-contraction coupling, right heart catheterization, sex-specific differences, pediatric cardiology, pulmonary arterial hypertension, calcium transients, ventricular cardiomyocytes, Orai1 channel, Stroke volume index, prognostic value. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Stroke Volume Index for Pediatric P.A.H. Prognosis 04/05/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 05, 2026. This episode summarizes 5 key cardiology studies on topics like wall thickness heterogeneity and hypertrophic cardiomyopathy. Key takeaway: TCF21 Protects Heart Against Fibrosis. Article Links: Article 1: Mass spectrometric proteome profiling using a deep spectral library reveals homogenization of right and left atrial proteomes in persistent atrial fibrillation patients. (Cardiovascular research) Article 2: Single nucleus RNA sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis. (Cardiovascular research) Article 3: How Accurate Is Inpatient Blood Pressure Measurement? (Hypertension (Dallas, Tex. : 1979)) Article 4: Epicardial-to-Endocardial Activation Gradients and Conduction Block During Atrial Fibrillation in the Human Left Atrial Posterior Wall. (Circulation. Arrhythmia and electrophysiology) Article 5: MRI-derived Wall Thickness Heterogeneity in Hypertrophic Cardiomyopathy and in Carriers of Sarcomeric Gene Mutations. (European heart journal. Cardiovascular Imaging) Full episode page: https://podcast.explainheart.com/podcast/tcf21-protects-heart-against-fibrosis-04-05-26/ Featured Articles Article 1: Mass spectrometric proteome profiling using a deep spectral library reveals homogenization of right and left atrial proteomes in persistent atrial fibrillation patients. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41928451 Summary: This study revealed a homogenization of the right and left atrial proteomes in patients with persistent atrial fibrillation. Researchers used a proteomic approach to investigate atrial fibrillation-associated remodeling in the right atrium relative to the left atrium. The data showed that protein profiles in both atria become similar during persistent atrial fibrillation. This finding indicates widespread atrial remodeling extending beyond the left atrium in this patient population. Article 2: Single nucleus RNA sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41926244 Summary: Single nucleus R. N. A. sequencing and functional in vivo studies demonstrated that TCF21 acts as a protective regulator in cardiac fibrosis. This research specifically identified TCF21 as a novel cell-specific candidate gene involved in cardiac fibrosis. The study validated the functional impact of TCF21 using both in vitro and in vivo models. These findings offer a significant breakthrough for cardiac fibrosis, an untreatable contributor to mortality in chronic heart disease. Article 3: How Accurate Is Inpatient Blood Pressure Measurement? Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41930396 Summary: Observations were conducted across three noncritical care wards: aged care, acute surgical, and hematology, over a three-week period. The investigation revealed that no existing guidelines for accurate inpatient blood pressure measurement are currently in place. This highlights a critical need for standardized quality techniques in this clinical setting. Article 4: Epicardial-to-Endocardial Activation Gradients and Conduction Block During Atrial Fibrillation in the Human Left Atrial Posterior Wall. Journal: Circulation. Arrhythmia and electrophysiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41930410 Summary: This study characterized endocardial and epicardial left atrial posterior wall activation in humans during atrial fibrillation. Researchers identified epicardial-to-endocardial activation gradients and conduction blocks within the left atrial posterior wall. The findings demonstrated the prevalence of asynchronous endocardial-epicardial conduction in this region for patients with symptomatic nonparoxysmal atrial fibrillation. This research provides crucial insights into three-dimensional myocardial activation patterns during atrial fibrillation. Article 5: MRI-derived Wall Thickness Heterogeneity in Hypertrophic Cardiomyopathy and in Carriers of Sarcomeric Gene Mutations. Journal: European heart journal. Cardiovascular Imaging PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41923453 Summary: R. I. derived Wall Thickness Heterogeneity in Hypertrophic Cardiomyopathy and in Carriers of Sarcomeric Gene Mutations. This study demonstrated that wall thickness standard deviation, reflecting wall thickness heterogeneity, improves the identification of hypertrophic cardiomyopathy and sarcomere mutation carriers. Researchers utilized cardiac magnetic resonance imaging in 382 healthy controls, 297 patients with hypertrophic cardiomyopathy, and 82 sarcomere mutation carriers. The data showed that this measure helps identify early or subtle phenotypes missed by absolute wall thickness cut-offs. This method enhances diagnostic capabilities, particularly for mutation carriers. Transcript Today’s date is April 05, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Mass spectrometric proteome profiling using a deep spectral library reveals homogenization of right and left atrial proteomes in persistent atrial fibrillation patients. This study revealed a homogenization of the right and left atrial proteomes in patients with persistent atrial fibrillation. Researchers used a proteomic approach to investigate atrial fibrillation-associated remodeling in the right atrium relative to the left atrium. The data showed that protein profiles in both atria become similar during persistent atrial fibrillation. This finding indicates widespread atrial remodeling extending beyond the left atrium in this patient population. Article number two. Single nucleus RNA sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis. Single nucleus R. N. A. sequencing and functional in vivo studies demonstrated that TCF21 acts as a protective regulator in cardiac fibrosis. This research specifically identified TCF21 as a novel cell-specific candidate gene involved in cardiac fibrosis. The study validated the functional impact of TCF21 using both in vitro and in vivo models. These findings offer a significant breakthrough for cardiac fibrosis, an untreatable contributor to mortality in chronic heart disease. Article number three. How Accurate Is Inpatient Blood Pressure Measurement? This study assessed the performance of routine blood pressure measurements in a major teaching hospital. Observations were conducted across three noncritical care wards: aged care, acute surgical, and hematology, over a three-week period. The investigation revealed that no existing guidelines for accurate inpatient blood pressure measurement are currently in place. This highlights a critical need for standardized quality techniques in this clinical setting. Article number four. Epicardial-to-Endocardial Activation Gradients and Conduction Block During Atrial Fibrillation in the Human Left Atrial Posterior Wall. This study characterized endocardial and epicardial left atrial posterior wall activation in humans during atrial fibrillation. Researchers identified epicardial-to-endocardial activation gradients and conduction blocks within the left atrial posterior wall. The findings demonstrated the prevalence of asynchronous endocardial-epicardial conduction in this region for patients with symptomatic nonparoxysmal atrial fibrillation. This research provides crucial insights into three-dimensional myocardial activation patterns during atrial fibrillation. Article number five. M. R. I. derived Wall Thickness Heterogeneity in Hypertrophic Cardiomyopathy and in Carriers of Sarcomeric Gene Mutations. This study demonstrated that wall thickness standard deviation, reflecting wall thickness heterogeneity, improves the identification of hypertrophic cardiomyopathy and sarcomere mutation carriers. Researchers utilized cardiac magnetic resonance imaging in 382 healthy controls, 297 patients with hypertrophic cardiomyopathy, and 82 sarcomere mutation carriers. The data showed that this measure helps identify early or subtle phenotypes missed by absolute wall thickness cut-offs. This method enhances diagnostic capabilities, particularly for mutation carriers. Thank you for listening. Don’t forget to subscribe. Keywords wall thickness heterogeneity, hypertrophic cardiomyopathy, single nucleus R. N. A. sequencing, atrial fibrillation, blood pressure measurement, epicardial, persistent atrial fibrillation, sarcomere gene mutations, proteome profiling, conduction block, diagnostic criteria, left atrial posterior wall, left atrium, TCF21, right atrium, measurement accuracy, protective regulator, endocardial, hospital practice, clinical guidelines, cardiac magnetic resonance, aortic stenosis, inpatient care, cardiac fibrosis. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post TCF21 Protects Heart Against Fibrosis 04/05/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 04, 2026. This episode summarizes 5 key cardiology studies on topics like arrhythmia vulnerability and catheter ablation. Key takeaway: Senolytics Prevent Atrial Arrhythmias in Elderly. Article Links: Article 1: Impact of left atrial posterior wall isolation using pulsed-field ablation in patients undergoing repeat catheter ablation for atrial fibrillation. (Heart rhythm) Article 2: Comparison of combined anatomic and functional modeling with purely anatomic assessment in scar-dependent ventricular tachycardia. (Heart rhythm) Article 3: Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits. (Heart rhythm) Article 4: Real-world performance of intrinsic antitachycardia pacing: Primary results from a global prospective postapproval registry study. (Heart rhythm) Article 5: Purkinje and septal substrate modification as a therapeutic option for patients with STEMI and refractory ventricular fibrillation. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/senolytics-prevent-atrial-arrhythmias-in-elderly-04-04-26/ Featured Articles Article 1: Impact of left atrial posterior wall isolation using pulsed-field ablation in patients undergoing repeat catheter ablation for atrial fibrillation. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41519351 Summary: For patients undergoing repeat catheter ablation for atrial fibrillation (AF), a therapeutic approach involves either redo pulmonary vein isolation (PVI) alone or combining redo PVI with adjunctive posterior wall isolation (PWI). The use of pulsed-field ablation (PFA) is a significant consideration for achieving durable isolation in these procedures. This strategy directly addresses the clinical challenge of recurrent atrial fibrillation by targeting both pulmonary veins and the posterior wall. The comparison of these two ablation strategies provides insights into optimizing outcomes in repeat atrial fibrillation interventions. Article 2: Comparison of combined anatomic and functional modeling with purely anatomic assessment in scar-dependent ventricular tachycardia. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41513062 Summary: Identifying the critical substrate in scar-dependent ventricular tachycardia (VT) relies on precise mapping for ablation targets. Cardiac magnetic resonance imaging (M. R. I.) provides anatomic assessment (A. A.) to detect channels sustaining ventricular tachycardia. A refined approach involves heart digital twins, which integrate anatomic data with functional assessment for identifying the ventricular tachycardia isthmus. This combined anatomic and functional modeling offers a comprehensive method for characterizing the arrhythmogenic substrate compared to solely anatomic evaluations. Article 3: Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41513056 Summary: The study found that senolytic reduction of senescent cells effectively mitigated atrial arrhythmia vulnerability in aging rabbits. Cellular senescence contributes to age-related atrial fibrillation pathogenesis through its senescence-associated secretory phenotype, releasing proinflammatory and profibrotic factors. This research demonstrates a novel therapeutic strategy for age-related atrial arrhythmias by specifically targeting and reducing senescent cells. These findings indicate a direct link between cellular senescence and atrial fibrillation susceptibility in aging hearts. Article 4: Real-world performance of intrinsic antitachycardia pacing: Primary results from a global prospective postapproval registry study. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41500490 Summary: Intrinsic antitachycardia pacing (iATP) represents a closed-loop algorithm capable of automatically designing and adjusting antitachycardia pacing therapy in real time. This technology effectively prevents defibrillator shocks and associated adverse outcomes, particularly in cases of rapid monomorphic ventricular tachycardia. Real-world performance data demonstrated the operational capability of iATP in a large, global patient cohort equipped with iATP-enabled implantable cardioverter-defibrillators. This confirms iATP’s role in enhancing arrhythmia management by dynamically tailoring therapy. Article 5: Purkinje and septal substrate modification as a therapeutic option for patients with STEMI and refractory ventricular fibrillation. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41443487 Summary: The study described Purkinje and septal substrate modification using radiofrequency catheter ablation (R. F. C. A.) as a therapeutic option. This approach targets therapy-refractory ventricular fibrillation (V. F.) in patients after successful percutaneous coronary intervention (P. C. I.) for S. T.-elevation myocardial infarction (S. T. E. M. I.). Ventricular fibrillation remains a fatal complication in this patient population, highlighting the critical need for effective interventions. Modifying the Purkinje network and septal substrate offers a specific strategy to address this life-threatening arrhythmia. Transcript Today’s date is April 04, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Impact of left atrial posterior wall isolation using pulsed-field ablation in patients undergoing repeat catheter ablation for atrial fibrillation. For patients undergoing repeat catheter ablation for atrial fibrillation (AF), a therapeutic approach involves either redo pulmonary vein isolation (PVI) alone or combining redo PVI with adjunctive posterior wall isolation (PWI). The use of pulsed-field ablation (PFA) is a significant consideration for achieving durable isolation in these procedures. This strategy directly addresses the clinical challenge of recurrent atrial fibrillation by targeting both pulmonary veins and the posterior wall. The comparison of these two ablation strategies provides insights into optimizing outcomes in repeat atrial fibrillation interventions. Article number two. Comparison of combined anatomic and functional modeling with purely anatomic assessment in scar-dependent ventricular tachycardia. Identifying the critical substrate in scar-dependent ventricular tachycardia (VT) relies on precise mapping for ablation targets. Cardiac magnetic resonance imaging (M. R. I.) provides anatomic assessment (A. A.) to detect channels sustaining ventricular tachycardia. A refined approach involves heart digital twins, which integrate anatomic data with functional assessment for identifying the ventricular tachycardia isthmus. This combined anatomic and functional modeling offers a comprehensive method for characterizing the arrhythmogenic substrate compared to solely anatomic evaluations. Article number three. Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits. The study found that senolytic reduction of senescent cells effectively mitigated atrial arrhythmia vulnerability in aging rabbits. Cellular senescence contributes to age-related atrial fibrillation pathogenesis through its senescence-associated secretory phenotype, releasing proinflammatory and profibrotic factors. This research demonstrates a novel therapeutic strategy for age-related atrial arrhythmias by specifically targeting and reducing senescent cells. These findings indicate a direct link between cellular senescence and atrial fibrillation susceptibility in aging hearts. Article number four. Real-world performance of intrinsic antitachycardia pacing: Primary results from a global prospective postapproval registry study. Intrinsic antitachycardia pacing (iATP) represents a closed-loop algorithm capable of automatically designing and adjusting antitachycardia pacing therapy in real time. This technology effectively prevents defibrillator shocks and associated adverse outcomes, particularly in cases of rapid monomorphic ventricular tachycardia. Real-world performance data demonstrated the operational capability of iATP in a large, global patient cohort equipped with iATP-enabled implantable cardioverter-defibrillators. This confirms iATP’s role in enhancing arrhythmia management by dynamically tailoring therapy. Article number five. Purkinje and septal substrate modification as a therapeutic option for patients with STEMI and refractory ventricular fibrillation. The study described Purkinje and septal substrate modification using radiofrequency catheter ablation (R. F. C. A.) as a therapeutic option. This approach targets therapy-refractory ventricular fibrillation (V. F.) in patients after successful percutaneous coronary intervention (P. C. I.) for S. T.-elevation myocardial infarction (S. T. E. M. I.). Ventricular fibrillation remains a fatal complication in this patient population, highlighting the critical need for effective interventions. Modifying the Purkinje network and septal substrate offers a specific strategy to address this life-threatening arrhythmia. Thank you for listening. Don’t forget to subscribe. Keywords arrhythmia vulnerability, catheter ablation, S. T.-elevation myocardial infarction, pulmonary vein isolation, aging, heart digital twins, atrial fibrillation, antitachycardia pacing, cellular senescence, ventricular tachycardia, intrinsic antitachycardia pacing, pulsed-field ablation, posterior wall isolation, Purkinje network, cardiac magnetic resonance imaging, radiofrequency catheter ablation, anatomic assessment, senolytics, substrate mapping, ventricular fibrillation, arrhythmia management, septal substrate, implantable cardioverter-defibrillator. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Senolytics Prevent Atrial Arrhythmias in Elderly 04/04/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 04, 2026. This episode summarizes 5 key cardiology studies on topics like Acetazolamide and Implantable Loop Recorders. Key takeaway: Bradyarrhythmias Reveal Stroke’s Atrial Link. Article Links: Article 1: Interhospital Transfer for Heart Failure in the United States: A Patient and Hospital-level Analysis from GWTG-HF. (Journal of cardiac failure) Article 2: Cardiac rehabilitation after transcatheter aortic valve implantation before, during and after the COVID-19 pandemic: a whole-population study. (Heart (British Cardiac Society)) Article 3: Acetazolamide Effects on Natriuresis and Diuresis in Acute Heart Failure Treated with Furosemide and SGLT2i (SANDI). (ESC heart failure) Article 4: Paced QRS Morphology and Lead Location in Left Bundle Branch Area Pacing Assessed by Photon-Counting Cardiac Computed Tomography. (Heart rhythm) Article 5: Prevalence of clinically significant bradyarrhythmias in patients implanted with loop recorders for cryptogenic stroke: A manifestation of atrial cardiomyopathy? (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/bradyarrhythmias-reveal-strokes-atrial-link-04-04-26/ Featured Articles Article 1: Interhospital Transfer for Heart Failure in the United States: A Patient and Hospital-level Analysis from GWTG-HF. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41932644 Summary: This study characterized patients with Heart Failure who underwent interhospital transfer, establishing their demographic and clinical profiles. It found significant variations in the utilization of interhospital transfer among different hospitals across the United States. The data revealed distinctions in outcomes between transferred and non-transferred Heart Failure patients. This analysis provided foundational understanding of interhospital transfer patterns in this patient population. Article 2: Cardiac rehabilitation after transcatheter aortic valve implantation before, during and after the COVID-19 pandemic: a whole-population study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41932822 Summary: This whole-population study established patterns of cardiac rehabilitation participation following Transcatheter Aortic Valve Implantation across England. It found variations in participation rates before, during, and after the C. O. V. I. D. minus 19 pandemic. The research demonstrated a specific association between cardiac rehabilitation participation and the primary outcome of unplanned all-cause rehospitalization. This analysis provided critical evidence regarding cardiac rehabilitation’s impact on clinical outcomes in this patient group. Article 3: Acetazolamide Effects on Natriuresis and Diuresis in Acute Heart Failure Treated with Furosemide and SGLT2i (SANDI). Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41920937 Summary: The S. A. N. D. I. study investigated the natriuretic and diuretic effects of acetazolamide in patients with acute Heart Failure receiving intravenous furosemide and concomitant Sodium-Glucose Cotransporter-two Inhibitors. It found that acetazolamide provided significant natriuretic and diuretic benefits in this specific patient population, demonstrating enhanced decongestion. This research established the efficacy of adjunctive acetazolamide in acute Heart Failure patients who are also on Sodium-Glucose Cotransporter-two Inhibitors, addressing a previously unknown therapeutic gap. Article 4: Paced QRS Morphology and Lead Location in Left Bundle Branch Area Pacing Assessed by Photon-Counting Cardiac Computed Tomography. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41932670 Summary: This study elucidated the relationship between intra-septal lead position in Left Bundle Branch Area Pacing and paced QRS morphology. It found that ultra-high-resolution Photon-Counting Computed Tomography precisely evaluated lead-tip location in 20 patients, differentiating between Left Bundle Branch Pacing, Left Ventricular Septal Pacing, and Deep Septal Pacing. The data established specific distances and spatial orientations of pacing leads within the septum, directly informing optimal lead placement strategies for physiological pacing. Article 5: Prevalence of clinically significant bradyarrhythmias in patients implanted with loop recorders for cryptogenic stroke: A manifestation of atrial cardiomyopathy? Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41519354 Summary: It found a notable burden of bradyarrhythmias in these patients compared with a matched control group. The data demonstrated that clinically significant bradyarrhythmias are a significant finding in this population, suggesting a potential manifestation of underlying atrial cardiomyopathy beyond Atrial Fibrillation detection. Transcript Today’s date is April 04, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Interhospital Transfer for Heart Failure in the United States: A Patient and Hospital-level Analysis from GWTG-HF. This study characterized patients with Heart Failure who underwent interhospital transfer, establishing their demographic and clinical profiles. It found significant variations in the utilization of interhospital transfer among different hospitals across the United States. The data revealed distinctions in outcomes between transferred and non-transferred Heart Failure patients. This analysis provided foundational understanding of interhospital transfer patterns in this patient population. Article number two. Cardiac rehabilitation after transcatheter aortic valve implantation before, during and after the COVID-19 pandemic: a whole-population study. This whole-population study established patterns of cardiac rehabilitation participation following Transcatheter Aortic Valve Implantation across England. It found variations in participation rates before, during, and after the C. O. V. I. D. minus 19 pandemic. The research demonstrated a specific association between cardiac rehabilitation participation and the primary outcome of unplanned all-cause rehospitalization. This analysis provided critical evidence regarding cardiac rehabilitation’s impact on clinical outcomes in this patient group. Article number three. Acetazolamide Effects on Natriuresis and Diuresis in Acute Heart Failure Treated with Furosemide and SGLT2i (SANDI). The S. A. N. D. I. study investigated the natriuretic and diuretic effects of acetazolamide in patients with acute Heart Failure receiving intravenous furosemide and concomitant Sodium-Glucose Cotransporter-two Inhibitors. It found that acetazolamide provided significant natriuretic and diuretic benefits in this specific patient population, demonstrating enhanced decongestion. This research established the efficacy of adjunctive acetazolamide in acute Heart Failure patients who are also on Sodium-Glucose Cotransporter-two Inhibitors, addressing a previously unknown therapeutic gap. Article number four. Paced QRS Morphology and Lead Location in Left Bundle Branch Area Pacing Assessed by Photon-Counting Cardiac Computed Tomography. This study elucidated the relationship between intra-septal lead position in Left Bundle Branch Area Pacing and paced QRS morphology. It found that ultra-high-resolution Photon-Counting Computed Tomography precisely evaluated lead-tip location in 20 patients, differentiating between Left Bundle Branch Pacing, Left Ventricular Septal Pacing, and Deep Septal Pacing. The data established specific distances and spatial orientations of pacing leads within the septum, directly informing optimal lead placement strategies for physiological pacing. Article number five. Prevalence of clinically significant bradyarrhythmias in patients implanted with loop recorders for cryptogenic stroke: A manifestation of atrial cardiomyopathy? This study established the prevalence and clinical significance of bradyarrhythmias in patients with cryptogenic stroke or transient ischemic attack who received implantable loop recorders. It found a notable burden of bradyarrhythmias in these patients compared with a matched control group. The data demonstrated that clinically significant bradyarrhythmias are a significant finding in this population, suggesting a potential manifestation of underlying atrial cardiomyopathy beyond Atrial Fibrillation detection. Thank you for listening. Don’t forget to subscribe. Keywords Acetazolamide, Implantable Loop Recorders, QRS Morphology, Hospital Variation, Sodium-Glucose Cotransporter-two Inhibitors, Heart Failure, Acute Heart Failure, Quality Improvement, Atrial Cardiomyopathy, Cardiac Rehabilitation, Transcatheter Aortic Valve Implantation, Atrial Fibrillation, Aortic Stenosis, Natriuresis, Left Bundle Branch Area Pacing, Cardiac Pacing, Photon-Counting Computed Tomography, Diuresis, Furosemide, Rehospitalization, Patient Outcomes, Interhospital Transfer, Cryptogenic Stroke, C. O. V. I. D. pandemic, Lead Placement, Bradyarrhythmias. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Bradyarrhythmias Reveal Stroke’s Atrial Link 04/04/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 03, 2026. This episode summarizes 5 key cardiology studies on topics like incident hypertension and quadruple guideline-directed medical therapies. Key takeaway: Glucagon-like Peptide-1 Agonists Cut Events Beyond Diabetes. Article Links: Article 1: Glucagon-like peptide-1 receptor agonists reduce experimental atherosclerosis progression, inflammatory biomarkers and cardiovascular events, irrespective of hyperglycaemia and obesity. (European heart journal) Article 2: Ten-minute asystolic warm ischemic time (AWIT) predicts mortality and severe primary graft dysfunction in donation after circulatory death hearts recovered with thoracoabdominal normothermic regional perfusion. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Time to Quadruple Therapy After Initial Diagnosis of Heart Failure With Reduced Ejection Fraction. (JAMA cardiology) Article 4: Blood Pressure Genetic Risk and Incident Hypertension at 2 to 7 Years Post Partum. (JAMA cardiology) Article 5: Effect of Sildenafil on Platelet Activation and Mediators of Vascular Remodeling During LVAD Support. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/glucagon-like-peptide-1-agonists-cut-events-beyond-diabetes-04-03-26/ Featured Articles Article 1: Glucagon-like peptide-1 receptor agonists reduce experimental atherosclerosis progression, inflammatory biomarkers and cardiovascular events, irrespective of hyperglycaemia and obesity. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41926331 Summary: Glucagon-like peptide-1 receptor agonists (G. L. P. minus 1 R. A.s) significantly reduced atherosclerosis burden and inflammatory biomarkers in experimental rabbit models. In clinical subjects, these agents decreased inflammatory biomarkers and major adverse cardiovascular events (MACE). These beneficial cardiovascular effects were observed irrespective of the patients’ glycemic status or obesity, indicating a direct cardiovascular protective mechanism. Article 2: Ten-minute asystolic warm ischemic time (AWIT) predicts mortality and severe primary graft dysfunction in donation after circulatory death hearts recovered with thoracoabdominal normothermic regional perfusion. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40701206 Summary: A ten-minute asystolic warm ischemic time (A. W. I. T.) during donation after circulatory death (D. C. D.) heart recovery significantly predicted increased mortality in adult heart transplant recipients. This prolonged warm ischemic time was also associated with severe primary graft dysfunction. These findings specifically apply to cardiac allografts recovered using thoracoabdominal normothermic regional perfusion (N. R. P.). Article 3: Time to Quadruple Therapy After Initial Diagnosis of Heart Failure With Reduced Ejection Fraction. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41920552 Summary: The study characterized the time to quadruple guideline-directed medical therapies (G. D. M. T.s) following an initial diagnosis of heart failure with reduced ejection fraction (H. F. rEF). It identified specific factors associated with achieving timely initiation of these therapies in a large cohort of patients. The findings provide contemporary estimates on the duration and facilitators of initiating optimal quadruple therapy for patients with H. F. rEF. Article 4: Blood Pressure Genetic Risk and Incident Hypertension at 2 to 7 Years Post Partum. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41920533 Summary: The study found that genetic risk for high systolic blood pressure (S. B. P.) significantly stratified the risk of new-onset hypertension in women. This association was observed at two to seven years post partum. The genetic risk was an independent predictor, separate from women’s clinical characteristics and history of hypertensive disorders of pregnancy (H. D. P.), including preeclampsia, eclampsia, and gestational hypertension. Article 5: Effect of Sildenafil on Platelet Activation and Mediators of Vascular Remodeling During LVAD Support. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41926705 Summary: V. A. D. Support. Observational studies revealed an association between phosphodiesterase-5 inhibitors, specifically sildenafil, and lower mortality and ischemic stroke in patients undergoing durable left ventricular assist device (L. V. A. D.) support. This study conducted a double-blind, randomized, placebo-controlled investigation into sildenafil’s causal effects on platelet activation and circulating mediators of vascular remodeling. This research aims to understand the direct physiological impact of sildenafil that could explain its previously observed clinical benefits in this patient population. Transcript Today’s date is April 03, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Glucagon-like peptide-1 receptor agonists reduce experimental atherosclerosis progression, inflammatory biomarkers and cardiovascular events, irrespective of hyperglycaemia and obesity. Glucagon-like peptide-1 receptor agonists (G. L. P. minus 1 R. A.s) significantly reduced atherosclerosis burden and inflammatory biomarkers in experimental rabbit models. In clinical subjects, these agents decreased inflammatory biomarkers and major adverse cardiovascular events (MACE). These beneficial cardiovascular effects were observed irrespective of the patients’ glycemic status or obesity, indicating a direct cardiovascular protective mechanism. Article number two. Ten-minute asystolic warm ischemic time (AWIT) predicts mortality and severe primary graft dysfunction in donation after circulatory death hearts recovered with thoracoabdominal normothermic regional perfusion. A ten-minute asystolic warm ischemic time (A. W. I. T.) during donation after circulatory death (D. C. D.) heart recovery significantly predicted increased mortality in adult heart transplant recipients. This prolonged warm ischemic time was also associated with severe primary graft dysfunction. These findings specifically apply to cardiac allografts recovered using thoracoabdominal normothermic regional perfusion (N. R. P.). Article number three. Time to Quadruple Therapy After Initial Diagnosis of Heart Failure With Reduced Ejection Fraction. The study characterized the time to quadruple guideline-directed medical therapies (G. D. M. T.s) following an initial diagnosis of heart failure with reduced ejection fraction (H. F. rEF). It identified specific factors associated with achieving timely initiation of these therapies in a large cohort of patients. The findings provide contemporary estimates on the duration and facilitators of initiating optimal quadruple therapy for patients with H. F. rEF. Article number four. Blood Pressure Genetic Risk and Incident Hypertension at 2 to 7 Years Post Partum. The study found that genetic risk for high systolic blood pressure (S. B. P.) significantly stratified the risk of new-onset hypertension in women. This association was observed at two to seven years post partum. The genetic risk was an independent predictor, separate from women’s clinical characteristics and history of hypertensive disorders of pregnancy (H. D. P.), including preeclampsia, eclampsia, and gestational hypertension. Article number five. Effect of Sildenafil on Platelet Activation and Mediators of Vascular Remodeling During L. V. A. D. Support. Observational studies revealed an association between phosphodiesterase-5 inhibitors, specifically sildenafil, and lower mortality and ischemic stroke in patients undergoing durable left ventricular assist device (L. V. A. D.) support. This study conducted a double-blind, randomized, placebo-controlled investigation into sildenafil’s causal effects on platelet activation and circulating mediators of vascular remodeling. This research aims to understand the direct physiological impact of sildenafil that could explain its previously observed clinical benefits in this patient population. Thank you for listening. Don’t forget to subscribe. Keywords incident hypertension, quadruple guideline-directed medical therapies, glucagon-like peptide-1 receptor agonists, post partum, normothermic regional perfusion, hypertensive disorders of pregnancy, genetic risk, blood pressure, vascular remodeling, time to therapy, sildenafil, cardiovascular events, donation after circulatory death, atherosclerosis, primary graft dysfunction, platelet activation, Veterans Health Administration, left ventricular assist device, liraglutide, heart transplant, inflammatory biomarkers, heart failure with reduced ejection fraction, asystolic warm ischemic time, morbidity, phosphodiesterase-5 inhibitors. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Glucagon-like Peptide-1 Agonists Cut Events Beyond Diabetes 04/03/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 02, 2026. This episode summarizes 5 key cardiology studies on topics like atrial fibrillation ablation and immature neutrophils. Key takeaway: Hypothermic Preservation Boosts Heart Transplant Survival. Article Links: Article 1: Heart failure with reduced ejection fraction in Sweden: patient adherence and persistence to quadruple pharmacotherapy prescription. (European heart journal) Article 2: Stroke and systemic embolism following atrial fibrillation ablation: the EMBOL-AF Global Registry. (European heart journal) Article 3: Immature neutrophils are elevated in human PGD and linked to G-CSF-driven injury in a murine model of lung ischemia-reperfusion. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Impact of HeartMate 3 left ventricular assist device infection on outcomes following heart transplant. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Improved 2-year heart transplant survival with moderate hypothermic donor heart preservation in the GUARDIAN heart registry. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/hypothermic-preservation-boosts-heart-transplant-survival-04-02-26/ Featured Articles Article 1: Heart failure with reduced ejection fraction in Sweden: patient adherence and persistence to quadruple pharmacotherapy prescription. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41920862 Summary: The Swedish Heart Failure Registry enabled a detailed assessment of patient adherence and persistence to quadruple pharmacotherapy for heart failure with reduced ejection fraction. This assessment confirmed the critical importance of patient adherence for the real-world uptake of these treatments. The study found specific associations between medication adherence and subsequent patient morbidity and mortality outcomes. Article 2: Stroke and systemic embolism following atrial fibrillation ablation: the EMBOL-AF Global Registry. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41914181 Summary: The E. M. B. O. L. minus A. F. Global Registry provided comprehensive data defining the incidence, outcomes, and procedural associations of stroke and systemic embolism following atrial fibrillation and left atrial flutter catheter ablation. This retrospective global registry captured detailed information from ablation centers worldwide, clarifying these previously poorly characterized complications. The registry’s findings illuminate critical insights into these post-ablation complications. Article 3: Immature neutrophils are elevated in human PGD and linked to G-CSF-driven injury in a murine model of lung ischemia-reperfusion. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41338428 Summary: This study found that immature neutrophils are elevated in human primary graft dysfunction. Researchers demonstrated a direct link between these immature neutrophils and granulocyte colony stimulating factor-driven injury in a murine model of lung ischemia-reperfusion. These findings indicate that immature neutrophils increase following lung transplantation and contribute to primary graft dysfunction severity. Article 4: Impact of HeartMate 3 left ventricular assist device infection on outcomes following heart transplant. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241030 Summary: This study found that infectious complications are common in patients implanted with HeartMate 3 left ventricular assist devices. The analysis specifically identified the impact of HeartMate 3 left ventricular assist device associated infection on outcomes following heart transplant. Researchers clarified crucial post-transplant outcomes by reviewing 115 patients with a HeartMate 3 device who underwent heart transplantation at Duke University Hospital. Article 5: Improved 2-year heart transplant survival with moderate hypothermic donor heart preservation in the GUARDIAN heart registry. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41241029 Summary: Data from the G. U. A. R. D. I. A. N. Heart Registry demonstrated improved two year heart transplant survival when using moderate hypothermic donor heart preservation. The Paragonix SherpaPak Cardiac Transport System, a method of static preservation, showed superior outcomes compared to historic ice storage. This study represents the first report of a preservation method demonstrating improved post-transplant survival. Transcript Today’s date is April 02, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Heart failure with reduced ejection fraction in Sweden: patient adherence and persistence to quadruple pharmacotherapy prescription. The Swedish Heart Failure Registry enabled a detailed assessment of patient adherence and persistence to quadruple pharmacotherapy for heart failure with reduced ejection fraction. This assessment confirmed the critical importance of patient adherence for the real-world uptake of these treatments. The study found specific associations between medication adherence and subsequent patient morbidity and mortality outcomes. Article number two. Stroke and systemic embolism following atrial fibrillation ablation: the EMBOL-AF Global Registry. The E. M. B. O. L. minus A. F. Global Registry provided comprehensive data defining the incidence, outcomes, and procedural associations of stroke and systemic embolism following atrial fibrillation and left atrial flutter catheter ablation. This retrospective global registry captured detailed information from ablation centers worldwide, clarifying these previously poorly characterized complications. The registry’s findings illuminate critical insights into these post-ablation complications. Article number three. Immature neutrophils are elevated in human PGD and linked to G-CSF-driven injury in a murine model of lung ischemia-reperfusion. This study found that immature neutrophils are elevated in human primary graft dysfunction. Researchers demonstrated a direct link between these immature neutrophils and granulocyte colony stimulating factor-driven injury in a murine model of lung ischemia-reperfusion. These findings indicate that immature neutrophils increase following lung transplantation and contribute to primary graft dysfunction severity. Article number four. Impact of HeartMate 3 left ventricular assist device infection on outcomes following heart transplant. This study found that infectious complications are common in patients implanted with HeartMate 3 left ventricular assist devices. The analysis specifically identified the impact of HeartMate 3 left ventricular assist device associated infection on outcomes following heart transplant. Researchers clarified crucial post-transplant outcomes by reviewing 115 patients with a HeartMate 3 device who underwent heart transplantation at Duke University Hospital. Article number five. Improved two year heart transplant survival with moderate hypothermic donor heart preservation in the GUARDIAN heart registry. Data from the G. U. A. R. D. I. A. N. Heart Registry demonstrated improved two year heart transplant survival when using moderate hypothermic donor heart preservation. The Paragonix SherpaPak Cardiac Transport System, a method of static preservation, showed superior outcomes compared to historic ice storage. This study represents the first report of a preservation method demonstrating improved post-transplant survival. Thank you for listening. Don’t forget to subscribe. Keywords atrial fibrillation ablation, immature neutrophils, HeartMate 3, G. U. A. R. D. I. A. N. Heart Registry, granulocyte colony stimulating factor, stroke, lung transplantation, hypothermic preservation, lung ischemia-reperfusion injury, catheter ablation, Paragonix SherpaPak, primary graft dysfunction, left ventricular assist device infection, heart transplant survival, patient persistence, morbidity, mortality, donor heart, infectious complications, heart transplant outcomes, heart failure with reduced ejection fraction, pharmacotherapy adherence, Duke University Hospital, left atrial flutter, systemic embolism. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Hypothermic Preservation Boosts Heart Transplant Survival 04/02/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 01, 2026. This episode summarizes 5 key cardiology studies on topics like estimated glomerular filtration rate and chronic kidney disease. Key takeaway: APOC3 Inhibition Cuts Lipids 70 Percent. Article Links: Article 1: Cardiovascular-Kidney-Metabolic Syndrome Stages, Echocardiographic Characteristics, and Heart Failure Risk: The Atherosclerosis Risk in Communities Study. (Circulation) Article 2: Effect of APOC3 Inhibition with Olezarsen on Coronary Atherosclerosis: Essence-TIMI 73b Imaging Study. (Circulation) Article 3: Prehospital Heparin Administration in Patients With STEMI Undergoing Primary PCI: HEPARIN STEMI Randomized Controlled Trial. (Circulation) Article 4: The Role of Atrial Pacing Support in Cardiac Resynchronization Therapy: A Non-Inferiority Randomized Trial. (Circulation) Article 5: Pre-heart failure in early chronic kidney disease: clinical epidemiology and treatment. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/apoc3-inhibition-cuts-lipids-70-percent-04-01-26/ Featured Articles Article 1: Cardiovascular-Kidney-Metabolic Syndrome Stages, Echocardiographic Characteristics, and Heart Failure Risk: The Atherosclerosis Risk in Communities Study. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41919388 Summary: Suboptimal cardiovascular-kidney-metabolic health is highly prevalent among older adults in the United States. The American Heart Association has developed a Cardiovascular-Kidney-Metabolic syndrome staging framework to categorize risk. Despite this framework, its predictive utility for incident heart failure remains an area of uncertainty in this population. Understanding the relationship between Cardiovascular-Kidney-Metabolic syndrome stages, echocardiographic characteristics, and heart failure risk is essential for clinical management. Article 2: Effect of APOC3 Inhibition with Olezarsen on Coronary Atherosclerosis: Essence-TIMI 73b Imaging Study. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910513 Summary: P. O. C. 3 Inhibition with Olezarsen on Coronary Atherosclerosis: Essence-T. I. M. I. 73b Imaging Study. Olezarsen, an antisense oligonucleotide inhibiting apolipoprotein C-III, reduces triglycerides by approximately 60 percent and remnant cholesterol by approximately 70 percent. This treatment also decreases apolipoprotein B by approximately 15 percent, while maintaining a neutral effect on low-density lipoprotein cholesterol in patients with moderate hypertriglyceridemia. These observed lipid modifications suggest a therapeutic approach to address triglyceride-rich lipoproteins and remnant cholesterol. Such inhibition holds significant clinical interest for its potential impact on coronary atherosclerosis. Article 3: Prehospital Heparin Administration in Patients With STEMI Undergoing Primary PCI: HEPARIN STEMI Randomized Controlled Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910504 Summary: T.-Elevation Myocardial Infarction Undergoing Primary P. C. I.: H. E. P. A. R. I. N. S. T. E. M. I. Randomized Controlled Trial. Primary percutaneous coronary intervention is the preferred reperfusion strategy for patients with S. T.-elevation myocardial infarction. The benefits and safety of administering unfractionated heparin in the prehospital setting for these patients remain a critical clinical question. Optimizing pretreatment strategies with agents like unfractionated heparin at first medical contact is important for patients undergoing primary percutaneous coronary intervention. Investigating the efficacy and safety of such prehospital interventions informs best practices for acute myocardial infarction management. Article 4: The Role of Atrial Pacing Support in Cardiac Resynchronization Therapy: A Non-Inferiority Randomized Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910411 Summary: The role of atrial pacing support in cardiac resynchronization therapy-defibrillator patients without sinus node dysfunction is a clinically relevant question. Simplified cardiac resynchronization therapy-defibrillator systems that offer atrial sensing without full pacing support via a two-lead system could reduce procedural complexity. Determining if a two-lead system is non-inferior to a conventional three-lead system is important for patient selection and device choice. Evaluating these systems helps optimize outcomes and minimize risks associated with device implantation for cardiac resynchronization therapy. Article 5: Pre-heart failure in early chronic kidney disease: clinical epidemiology and treatment. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41914187 Summary: Chronic kidney disease affects 10 percent to 15 percent of adults globally and serves as a powerful, independent risk factor for cardiovascular diseases, including heart failure. Early stages of chronic kidney disease, specifically stages G1 to G3, are significantly associated with this elevated risk. The presence of albuminuria, particularly K. D. I. G. O. stages A2 to A3, further exacerbates cardiovascular risk even with mild renal dysfunction. These findings underscore the importance of recognizing pre-heart failure states in chronic kidney disease patients to inform early intervention strategies. Transcript Today’s date is April 01, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Cardiovascular-Kidney-Metabolic Syndrome Stages, Echocardiographic Characteristics, and Heart Failure Risk: The Atherosclerosis Risk in Communities Study. Suboptimal cardiovascular-kidney-metabolic health is highly prevalent among older adults in the United States. The American Heart Association has developed a Cardiovascular-Kidney-Metabolic syndrome staging framework to categorize risk. Despite this framework, its predictive utility for incident heart failure remains an area of uncertainty in this population. Understanding the relationship between Cardiovascular-Kidney-Metabolic syndrome stages, echocardiographic characteristics, and heart failure risk is essential for clinical management. Article number two. Effect of A. P. O. C. 3 Inhibition with Olezarsen on Coronary Atherosclerosis: Essence-T. I. M. I. 73b Imaging Study. Olezarsen, an antisense oligonucleotide inhibiting apolipoprotein C-III, reduces triglycerides by approximately 60 percent and remnant cholesterol by approximately 70 percent. This treatment also decreases apolipoprotein B by approximately 15 percent, while maintaining a neutral effect on low-density lipoprotein cholesterol in patients with moderate hypertriglyceridemia. These observed lipid modifications suggest a therapeutic approach to address triglyceride-rich lipoproteins and remnant cholesterol. Such inhibition holds significant clinical interest for its potential impact on coronary atherosclerosis. Article number three. Prehospital Heparin Administration in Patients With S. T.-Elevation Myocardial Infarction Undergoing Primary P. C. I.: H. E. P. A. R. I. N. S. T. E. M. I. Randomized Controlled Trial. Primary percutaneous coronary intervention is the preferred reperfusion strategy for patients with S. T.-elevation myocardial infarction. The benefits and safety of administering unfractionated heparin in the prehospital setting for these patients remain a critical clinical question. Optimizing pretreatment strategies with agents like unfractionated heparin at first medical contact is important for patients undergoing primary percutaneous coronary intervention. Investigating the efficacy and safety of such prehospital interventions informs best practices for acute myocardial infarction management. Article number four. The Role of Atrial Pacing Support in Cardiac Resynchronization Therapy: A Non-Inferiority Randomized Trial. The role of atrial pacing support in cardiac resynchronization therapy-defibrillator patients without sinus node dysfunction is a clinically relevant question. Simplified cardiac resynchronization therapy-defibrillator systems that offer atrial sensing without full pacing support via a two-lead system could reduce procedural complexity. Determining if a two-lead system is non-inferior to a conventional three-lead system is important for patient selection and device choice. Evaluating these systems helps optimize outcomes and minimize risks associated with device implantation for cardiac resynchronization therapy. Article number five. Pre-heart failure in early chronic kidney disease: clinical epidemiology and treatment. Chronic kidney disease affects 10 percent to 15 percent of adults globally and serves as a powerful, independent risk factor for cardiovascular diseases, including heart failure. Early stages of chronic kidney disease, specifically stages G1 to G3, are significantly associated with this elevated risk. The presence of albuminuria, particularly K. D. I. G. O. stages A2 to A3, further exacerbates cardiovascular risk even with mild renal dysfunction. These findings underscore the importance of recognizing pre-heart failure states in chronic kidney disease patients to inform early intervention strategies. Thank you for listening. Don’t forget to subscribe. Keywords estimated glomerular filtration rate, chronic kidney disease, prehospital care, S. T.-elevation myocardial infarction, unfractionated heparin, three-lead system, defibrillator, apolipoprotein C-III inhibition, CKM staging framework, cardiovascular risk, remnant cholesterol, cardiac resynchronization therapy, albuminuria, Atherosclerosis Risk in Communities Study, primary percutaneous coronary intervention, heart failure, olezarsen, atrial pacing, two-lead system, echocardiography, acute myocardial infarction, cardiovascular-kidney-metabolic syndrome, hypertriglyceridemia, triglycerides. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post APOC3 Inhibition Cuts Lipids 70 Percent 04/01/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded April 01, 2026. This episode summarizes 5 key cardiology studies on topics like high-risk P. C. I. and mid-regional pro-adrenomedullin. Key takeaway: Adaptive A. I. Validates C. V. Event Adjudication. Article Links: Article 1: Angiography-Based Physiology to Guide Coronary Revascularization. (The New England journal of medicine) Article 2: Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention. (The New England journal of medicine) Article 3: IVUS or Angiography Guidance for Percutaneous Coronary Intervention in Complex Coronary Bifurcation Lesions: The DKCRUSH VIII Randomized Clinical Trial. (Journal of the American College of Cardiology) Article 4: MR-ProADM Predicts Mortality and Heart Failure Events in ATTR Cardiac Amyloidosis. (Circulation) Article 5: Adaptive AI for Cardiovascular Event Adjudication: Cardiovascular Event Adjudication Across Different Definitions in the ODYSSEY OUTCOMES and EUCLID Trials. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/adaptive-a-i-validates-c-v-event-adjudication-04-01-26/ Featured Articles Article 1: Angiography-Based Physiology to Guide Coronary Revascularization. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910382 Summary: This international, randomized, noninferiority trial directly compared angiography-derived vessel fractional flow reserve (vFFR) with pressure-wire based fractional flow reserve (FFR) for guiding coronary revascularization. The trial evaluated vFFR, a method derived from three-dimensional quantitative coronary angiography that does not require a pressure wire or hyperemic agent. It established a robust head-to-head comparison to assess the effectiveness and safety of this less invasive physiological guidance for intermediate coronary lesions. The study addressed a critical lack of data on angiography-based revascularization guidance compared to the established pressure-wire FFR technique. Article 2: Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910380 Summary: This randomized trial assigned 300 patients with severe left ventricular dysfunction and extensive coronary artery disease to a strategy of elective unloading with a microaxial flow pump or to standard care during planned complex percutaneous coronary intervention (P. C. I.). The study established a direct comparison to determine if percutaneous left ventricular unloading improves outcomes in this high-risk patient population. It specifically investigated the impact of prophylactic mechanical support via a microaxial flow pump on mortality and complications during complex revascularization. This trial provides crucial data on the efficacy of a dedicated left ventricular unloading strategy in patients undergoing high-risk P. C. I. Article 3: IVUS or Angiography Guidance for Percutaneous Coronary Intervention in Complex Coronary Bifurcation Lesions: The DKCRUSH VIII Randomized Clinical Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41914946 Summary: V. U. S. or Angiography Guidance for Percutaneous Coronary Intervention in Complex Coronary Bifurcation Lesions: The D. K. C. R. U. S. H. VIII Randomized Clinical Trial. Intravascular ultrasound (I. V. U. S.)-guided percutaneous coronary intervention (P. C. I.) is associated with fewer clinical events than angiography-guided P. C. I. The D. K. C. R. U. S. H. eight randomized clinical trial directly investigated the treatment effect of I. V. U. S.-guided P. C. I. compared to angiography-guided P. C. I. in patients with complex coronary bifurcation lesions undergoing double kissing crush stenting. This study established a head-to-head comparison to determine if I. V. U. S. guidance improves outcomes in this specific, challenging patient subgroup. It provides definitive evidence for the optimal guidance strategy in complex coronary bifurcation lesions treated with double kissing crush. Article 4: MR-ProADM Predicts Mortality and Heart Failure Events in ATTR Cardiac Amyloidosis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41914183 Summary: R. – ProA. D. M. Predicts Mortality and Heart Failure Events in A. T. T. R. Cardiac Amyloidosis. This study evaluated the prognostic value of 12 different circulating biomarkers for predicting outcomes in transthyretin amyloid cardiomyopathy (A. T. T. R. – C. M.). The assessed biomarkers included N-terminal pro-B-type natriuretic peptide (N. T. – proB. N. P.), high-sensitivity troponin I (hsTnI), and mid-regional pro-adrenomedullin (M. R. – proA. D. M.). The research specifically investigated tools for risk and prognosis stratification in A. T. T. R. – C. M. patients, addressing a growing clinical demand due to earlier diagnoses and new therapeutic options. This evaluation provides a comprehensive assessment of biomarker utility in identifying patient risk for future events in this disease. Article 5: Adaptive AI for Cardiovascular Event Adjudication: Cardiovascular Event Adjudication Across Different Definitions in the ODYSSEY OUTCOMES and EUCLID Trials. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41911340 Summary: I. for Cardiovascular Event Adjudication: Cardiovascular Event Adjudication Across Different Definitions in the O. D. Y. S. S. E. Y. O. U. T. C. O. M. E. S. and E. U. C. L. I. D. Trials. Researchers developed and validated A. D. A. P. T. – C. E. C., an artificial intelligence (A. I.) algorithm capable of adjudicating multiple cardiovascular endpoints and adapting to new definitions. The algorithm was derived using data on myocardial infarction (M. I.), stroke, and heart failure from the O. D. Y. S. S. E. Y. O. U. T. C. O. M. E. S. trial. A. D. A. P. T. – C. E. C. underwent external validation using M. I., stroke, bleeding, and cardiovascular (C. V.) death data from the E. U. C. L. I. D. trial, demonstrating its performance across different clinical definitions. This innovative A. I. solution provides an adaptive, automated method for C. V. endpoint measurement in clinical trials, offering potential reductions in time and cost. Transcript Today’s date is April 01, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Angiography-Based Physiology to Guide Coronary Revascularization. This international, randomized, noninferiority trial directly compared angiography-derived vessel fractional flow reserve (vFFR) with pressure-wire based fractional flow reserve (FFR) for guiding coronary revascularization. The trial evaluated vFFR, a method derived from three-dimensional quantitative coronary angiography that does not require a pressure wire or hyperemic agent. It established a robust head-to-head comparison to assess the effectiveness and safety of this less invasive physiological guidance for intermediate coronary lesions. The study addressed a critical lack of data on angiography-based revascularization guidance compared to the established pressure-wire FFR technique. Article number two. Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention. This randomized trial assigned 300 patients with severe left ventricular dysfunction and extensive coronary artery disease to a strategy of elective unloading with a microaxial flow pump or to standard care during planned complex percutaneous coronary intervention (P. C. I.). The study established a direct comparison to determine if percutaneous left ventricular unloading improves outcomes in this high-risk patient population. It specifically investigated the impact of prophylactic mechanical support via a microaxial flow pump on mortality and complications during complex revascularization. This trial provides crucial data on the efficacy of a dedicated left ventricular unloading strategy in patients undergoing high-risk P. C. I. Article number three. I. V. U. S. or Angiography Guidance for Percutaneous Coronary Intervention in Complex Coronary Bifurcation Lesions: The D. K. C. R. U. S. H. VIII Randomized Clinical Trial. Intravascular ultrasound (I. V. U. S.)-guided percutaneous coronary intervention (P. C. I.) is associated with fewer clinical events than angiography-guided P. C. I. The D. K. C. R. U. S. H. eight randomized clinical trial directly investigated the treatment effect of I. V. U. S.-guided P. C. I. compared to angiography-guided P. C. I. in patients with complex coronary bifurcation lesions undergoing double kissing crush stenting. This study established a head-to-head comparison to determine if I. V. U. S. guidance improves outcomes in this specific, challenging patient subgroup. It provides definitive evidence for the optimal guidance strategy in complex coronary bifurcation lesions treated with double kissing crush. Article number four. M. R. – ProA. D. M. Predicts Mortality and Heart Failure Events in A. T. T. R. Cardiac Amyloidosis. This study evaluated the prognostic value of 12 different circulating biomarkers for predicting outcomes in transthyretin amyloid cardiomyopathy (A. T. T. R. – C. M.). The assessed biomarkers included N-terminal pro-B-type natriuretic peptide (N. T. – proB. N. P.), high-sensitivity troponin I (hsTnI), and mid-regional pro-adrenomedullin (M. R. – proA. D. M.). The research specifically investigated tools for risk and prognosis stratification in A. T. T. R. – C. M. patients, addressing a growing clinical demand due to earlier diagnoses and new therapeutic options. This evaluation provides a comprehensive assessment of biomarker utility in identifying patient risk for future events in this disease. Article number five. Adaptive A. I. for Cardiovascular Event Adjudication: Cardiovascular Event Adjudication Across Different Definitions in the O. D. Y. S. S. E. Y. O. U. T. C. O. M. E. S. and E. U. C. L. I. D. Trials. Researchers developed and validated A. D. A. P. T. – C. E. C., an artificial intelligence (A. I.) algorithm capable of adjudicating multiple cardiovascular endpoints and adapting to new definitions. The algorithm was derived using data on myocardial infarction (M. I.), stroke, and heart failure from the O. D. Y. S. S. E. Y. O. U. T. C. O. M. E. S. trial. A. D. A. P. T. – C. E. C. underwent external validation using M. I., stroke, bleeding, and cardiovascular (C. V.) death data from the E. U. C. L. I. D. trial, demonstrating its performance across different clinical definitions. This innovative A. I. solution provides an adaptive, automated method for C. V. endpoint measurement in clinical trials, offering potential reductions in time and cost. Thank you for listening. Don’t forget to subscribe. Keywords high-risk P. C. I., mid-regional pro-adrenomedullin, intermediate coronary lesions, prognosis stratification, severe left ventricular dysfunction, stroke, percutaneous coronary intervention, cardiovascular events, microaxial flow pump, N-terminal pro-B-type natriuretic peptide, biomarkers, transthyretin amyloid cardiomyopathy, double kissing crush, intravascular ultrasound, angiography guidance, artificial intelligence, myocardial infarction, clinical endpoint adjudication, coronary revascularization, coronary bifurcation lesions, pressure-wire fractional flow reserve, left ventricular unloading, angiography-derived fractional flow reserve. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Adaptive A. I. Validates C. V. Event Adjudication 04/01/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded March 31, 2026. This episode summarizes 5 key cardiology studies on topics like heart failure and intermediate coronary lesions. Key takeaway: Mavacamten Targets Adolescent H. C. M.. Article Links: Article 1: IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease. (The New England journal of medicine) Article 2: Intravascular Ultrasound-Guided or Angiography-Guided Complex High-Risk PCI. (The New England journal of medicine) Article 3: Discontinuation of Beta-Blocker Therapy after Myocardial Infarction. (The New England journal of medicine) Article 4: Mavacamten in Adolescents with Obstructive Hypertrophic Cardiomyopathy. (The New England journal of medicine) Article 5: Angiography-Derived Fractional Flow Reserve to Guide PCI. (The New England journal of medicine) Full episode page: https://podcast.explainheart.com/podcast/mavacamten-targets-adolescent-h-c-m-03-31-26/ Featured Articles Article 1: IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41911017 Summary: Percutaneous coronary intervention for unprotected left main coronary artery disease is a critical revascularization strategy in cardiology. The comparative effectiveness of intravascular ultrasonographic guidance versus conventional angiographic guidance in improving clinical outcomes for P. C. I. remains an area of active investigation. Clarifying the optimal guidance method holds significant implications for patient prognosis in this high-risk population. Article 2: Intravascular Ultrasound-Guided or Angiography-Guided Complex High-Risk PCI. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41911016 Summary: Intravascular ultrasonography guidance during percutaneous coronary intervention has been associated with increased stent optimization and reduced adverse events in patients with complex coronary artery lesions. Despite these recognized benefits and practice guideline recommendations for intracoronary imaging in anatomically complex lesions, adoption of this strategy in Western countries remains low. This highlights an ongoing need for robust evidence supporting its broader clinical integration in high-risk P. C. I. procedures. Article 3: Discontinuation of Beta-Blocker Therapy after Myocardial Infarction. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910427 Summary: The long-term role of beta-blocker therapy after a myocardial infarction is currently undefined for patients with preserved left ventricular systolic function and without heart failure, particularly in the era of modern reperfusion and secondary prevention. This clinical uncertainty impacts decisions regarding medication continuation for stable post-myocardial infarction patients. Resolving this question has substantial implications for reducing polypharmacy and tailoring post-event care. Article 4: Mavacamten in Adolescents with Obstructive Hypertrophic Cardiomyopathy. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910394 Summary: Approved pharmacologic therapies for pediatric hypertrophic cardiomyopathy are currently lacking, often leading to surgical intervention for left ventricular outflow tract obstruction. Mavacamten, a cardiac myosin inhibitor, is an established treatment for adults with obstructive hypertrophic cardiomyopathy. Evaluating the efficacy and safety of mavacamten in symptomatic adolescents with this condition addresses a critical unmet therapeutic need for younger patients. Article 5: Angiography-Derived Fractional Flow Reserve to Guide PCI. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41910384 Summary: Physiological assessment of intermediate coronary lesions using an intracoronary pressure wire demonstrably improves clinical outcomes for patients undergoing cardiac catheterization and percutaneous coronary intervention. However, the widespread clinical adoption of pressure-wire-based physiological assessment remains limited. Angiography-derived fractional flow reserve shows good correlation with pressure-wire-based measurements and can simplify procedures, but its definitive impact on patient clinical outcomes remains unestablished. Transcript Today’s date is March 31, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease. Percutaneous coronary intervention for unprotected left main coronary artery disease is a critical revascularization strategy in cardiology. The comparative effectiveness of intravascular ultrasonographic guidance versus conventional angiographic guidance in improving clinical outcomes for P. C. I. remains an area of active investigation. Clarifying the optimal guidance method holds significant implications for patient prognosis in this high-risk population. Article number two. Intravascular Ultrasound-Guided or Angiography-Guided Complex High-Risk PCI. Intravascular ultrasonography guidance during percutaneous coronary intervention has been associated with increased stent optimization and reduced adverse events in patients with complex coronary artery lesions. Despite these recognized benefits and practice guideline recommendations for intracoronary imaging in anatomically complex lesions, adoption of this strategy in Western countries remains low. This highlights an ongoing need for robust evidence supporting its broader clinical integration in high-risk P. C. I. procedures. Article number three. Discontinuation of Beta-Blocker Therapy after Myocardial Infarction. The long-term role of beta-blocker therapy after a myocardial infarction is currently undefined for patients with preserved left ventricular systolic function and without heart failure, particularly in the era of modern reperfusion and secondary prevention. This clinical uncertainty impacts decisions regarding medication continuation for stable post-myocardial infarction patients. Resolving this question has substantial implications for reducing polypharmacy and tailoring post-event care. Article number four. Mavacamten in Adolescents with Obstructive Hypertrophic Cardiomyopathy. Approved pharmacologic therapies for pediatric hypertrophic cardiomyopathy are currently lacking, often leading to surgical intervention for left ventricular outflow tract obstruction. Mavacamten, a cardiac myosin inhibitor, is an established treatment for adults with obstructive hypertrophic cardiomyopathy. Evaluating the efficacy and safety of mavacamten in symptomatic adolescents with this condition addresses a critical unmet therapeutic need for younger patients. Article number five. Angiography-Derived Fractional Flow Reserve to Guide PCI. Physiological assessment of intermediate coronary lesions using an intracoronary pressure wire demonstrably improves clinical outcomes for patients undergoing cardiac catheterization and percutaneous coronary intervention. However, the widespread clinical adoption of pressure-wire-based physiological assessment remains limited. Angiography-derived fractional flow reserve shows good correlation with pressure-wire-based measurements and can simplify procedures, but its definitive impact on patient clinical outcomes remains unestablished. Thank you for listening. Don’t forget to subscribe. Keywords heart failure, intermediate coronary lesions, beta-blocker therapy, stent optimization, cardiac myosin inhibitor, angiography, percutaneous coronary intervention, adolescents, pressure-wire assessment, complex coronary artery lesions, unprotected left main coronary artery disease, adverse events, angiography-derived F. F. R., left ventricular systolic function, mavacamten, intravascular ultrasonography, hypertrophic cardiomyopathy, fractional flow reserve, left ventricular outflow tract obstruction, myocardial infarction, secondary prevention, clinical outcomes. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Mavacamten Targets Adolescent H. C. M. 03/31/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded March 30, 2026. This episode summarizes 5 key cardiology studies on topics like Cardiovascular Disease and Imaging. Key takeaway: AI Democratizes Congenital Heart Disease Echo. Article Links: Article 1: Sotatercept for Combined Post- and Pre-capillary Pulmonary Hypertension Associated With Heart Failure: Results from the Phase 2, Randomized, Placebo-Controlled CADENCE Study. (Circulation) Article 2: Multi-modality Imaging to Determine Underlying Causes of MINOCA in Women and Men. (Circulation) Article 3: Automated Echocardiographic Detection of Congenital Heart Disease Using Artificial Intelligence. (Circulation) Article 4: Volume vs intensity of physical activity and risk of cardiovascular and non-cardiovascular chronic diseases. (European heart journal) Article 5: Lipoprotein(a) and incident venous thromboembolism in pre- and postmenopausal women, and in men. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/ai-democratizes-congenital-heart-disease-echo-03-30-26/ Featured Articles Article 1: Sotatercept for Combined Post- and Pre-capillary Pulmonary Hypertension Associated With Heart Failure: Results from the Phase 2, Randomized, Placebo-Controlled CADENCE Study. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41904795 Summary: Combined post- and pre-capillary pulmonary hypertension associated with heart failure with preserved ejection fraction is a condition carrying significant mortality for which no proven therapies exist. The phase two randomized CADENCE study evaluated sotatercept as a potential treatment, administered at 0.3 or 0.7 milligrams per kilogram, or placebo, every three weeks. The primary endpoint measured was the change in pulmonary vascular resistance at week twenty-four. Article 2: Multi-modality Imaging to Determine Underlying Causes of MINOCA in Women and Men. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41903131 Summary: Myocardial infarction with non-obstructive coronary arteries presents with various underlying causes, often including mimicking conditions, despite imaging recommendations to identify etiologies. This international, prospective study characterized the mechanisms of myocardial infarction with non-obstructive coronary arteries, analyzed predictors of imaging abnormalities, and explored sex differences. Article 3: Automated Echocardiographic Detection of Congenital Heart Disease Using Artificial Intelligence. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41902792 Summary: Delayed or missed diagnosis of congenital heart disease significantly contributes to pediatric mortality worldwide. Expert echocardiography interpretation, which is central to diagnosing and triaging congenital heart disease, represents a scarce and maldistributed global resource. This study developed EchoFocus-C. H. D., an artificial intelligence-enabled tool designed to democratize diagnostics and extend expert-level interpretation beyond large academic centers. Article 4: Volume vs intensity of physical activity and risk of cardiovascular and non-cardiovascular chronic diseases. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41905344 Summary: Vigorous physical activity is known to provide greater health benefits per unit time than moderate activity, yet the full spectrum of these benefits across chronic diseases and the relative importance of intensity versus volume remains unclear. A prospective population-based cohort study of 96408 participants examined associations between the proportion of vigorous physical activity relative to total physical activity volume and the incidence of multiple chronic disease outcomes. Article 5: Lipoprotein(a) and incident venous thromboembolism in pre- and postmenopausal women, and in men. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41903523 Summary: Elevated lipoprotein(a) levels are an established risk factor for atherosclerotic cardiovascular disease, however, its association with venous thromboembolism remains unclear, with potential modification by sex and hormonal status. This study investigated this relationship using participants from the U. K. Biobank with baseline lipoprotein(a) data. The study design excluded individuals with a history of venous thromboembolism or cancer, as well as those using anticoagulants. Transcript Today’s date is March 30, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Sotatercept for Combined Post- and Pre-capillary Pulmonary Hypertension Associated With Heart Failure: Results from the Phase 2, Randomized, Placebo-Controlled CADENCE Study. Combined post- and pre-capillary pulmonary hypertension associated with heart failure with preserved ejection fraction is a condition carrying significant mortality for which no proven therapies exist. The phase two randomized CADENCE study evaluated sotatercept as a potential treatment, administered at 0.3 or 0.7 milligrams per kilogram, or placebo, every three weeks. The primary endpoint measured was the change in pulmonary vascular resistance at week twenty-four. Article number two. Multi-modality Imaging to Determine Underlying Causes of MINOCA in Women and Men. Myocardial infarction with non-obstructive coronary arteries presents with various underlying causes, often including mimicking conditions, despite imaging recommendations to identify etiologies. This international, prospective study characterized the mechanisms of myocardial infarction with non-obstructive coronary arteries, analyzed predictors of imaging abnormalities, and explored sex differences. Article number three. Automated Echocardiographic Detection of Congenital Heart Disease Using Artificial Intelligence. Delayed or missed diagnosis of congenital heart disease significantly contributes to pediatric mortality worldwide. Expert echocardiography interpretation, which is central to diagnosing and triaging congenital heart disease, represents a scarce and maldistributed global resource. This study developed EchoFocus-C. H. D., an artificial intelligence-enabled tool designed to democratize diagnostics and extend expert-level interpretation beyond large academic centers. Article number four. Volume vs intensity of physical activity and risk of cardiovascular and non-cardiovascular chronic diseases. Vigorous physical activity is known to provide greater health benefits per unit time than moderate activity, yet the full spectrum of these benefits across chronic diseases and the relative importance of intensity versus volume remains unclear. A prospective population-based cohort study of 96408 participants examined associations between the proportion of vigorous physical activity relative to total physical activity volume and the incidence of multiple chronic disease outcomes. Article number five. Lipoprotein(a) and incident venous thromboembolism in pre- and postmenopausal women, and in men. Elevated lipoprotein(a) levels are an established risk factor for atherosclerotic cardiovascular disease, however, its association with venous thromboembolism remains unclear, with potential modification by sex and hormonal status. This study investigated this relationship using participants from the U. K. Biobank with baseline lipoprotein(a) data. The study design excluded individuals with a history of venous thromboembolism or cancer, as well as those using anticoagulants. Thank you for listening. Don’t forget to subscribe. Keywords Cardiovascular Disease, Imaging, EchoFocus-C. H. D., Sotatercept, Pediatric Mortality, Artificial Intelligence, Atherosclerotic Cardiovascular Disease, Combined Post- and Pre-capillary Pulmonary Hypertension, Lipoprotein(a), Sex Differences, Physical Activity, Vigorous Physical Activity, Phase two trial, Physical Activity Intensity, Echocardiography, Physical Activity Volume, Congenital Heart Disease, Myocardial Infarction with Non-Obstructive Coronary Arteries, Hormonal Status, Chronic Diseases, Heart Failure with Preserved Ejection Fraction, Venous Thromboembolism, Predictors, Pulmonary Vascular Resistance, Etiologies. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post AI Democratizes Congenital Heart Disease Echo 03/30/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded March 29, 2026. This episode summarizes 5 key cardiology studies on topics like Cardiomyopathy and Excess mortality. Key takeaway: Neurovascular Retinomics Predicts Heart Disease. Article Links: Article 1: Effect of age on 5-year excess mortality in heart failure with reduced ejection fraction. (European journal of heart failure) Article 2: Neurovascular retinomics for predicting heart diseases. (Cardiovascular research) Article 3: A randomized, double-blind, crossover study of acute low-level night-time road traffic noise: effects on vascular function, sleep, and proteomic signatures in healthy adults. (Cardiovascular research) Article 4: Sodium-myo-inositol cotransporter-1, SMIT1, promotes cardiac hypertrophy and fibrosis induced by pressure overload in mice. (Cardiovascular research) Article 5: Cardiomyocyte-specific deficiency of C/EBPβ aggravates pressure overload-induced heart failure. (Cardiovascular research) Full episode page: https://podcast.explainheart.com/podcast/neurovascular-retinomics-predicts-heart-disease-03-29-26/ Featured Articles Article 1: Effect of age on 5-year excess mortality in heart failure with reduced ejection fraction. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41889326 Summary: The abstract outlines a significant research study focused on the impact of age on 5-year excess mortality in Heart Failure with Reduced Ejection Fraction. This investigation includes patients aged 40 to 85 years, all presenting with a left ventricular ejection fraction of 40 percent or less, who underwent coronary angiography for suspected cardiomyopathy. The methodology involves matching patients by sex and age, thus characterizing a structured approach to understand age-related differences in survival outcomes. This research addresses a crucial gap in current understanding of age as a determinant of prognosis in Heart Failure with Reduced Ejection Fraction. Article 2: Neurovascular retinomics for predicting heart diseases. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41748319 Summary: The abstract describes a comprehensive methodology developed for utilizing neurovascular retinomics to predict incident heart diseases. This approach integrates multidimensional vascular parameters from color fundus photography with neural parameters obtained from optical coherence tomography. The study design incorporated LASSO regression for meticulous feature selection and employed a Gradient Boosting Machine model to assess predictive value. This framework characterizes a specific computational strategy for leveraging retinal imaging data in cardiovascular risk evaluation. Article 3: A randomized, double-blind, crossover study of acute low-level night-time road traffic noise: effects on vascular function, sleep, and proteomic signatures in healthy adults. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41740584 Summary: The abstract presents a randomized, double-blind, crossover study that investigated the acute effects of low-level night-time road traffic noise on vascular function, sleep, and proteomic signatures in healthy adults. The research design exposed 74 healthy participants to three distinct overnight conditions, including a control with no noise and specific levels of road traffic noise. This structured methodology forms a basis for generating direct mechanistic evidence regarding environmental noise as a cardiovascular risk factor. The study provides a rigorous approach for evaluating acute physiological responses to noise exposure in humans. Article 4: Sodium-myo-inositol cotransporter-1, SMIT1, promotes cardiac hypertrophy and fibrosis induced by pressure overload in mice. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41698873 Summary: The abstract highlights the emerging role of myo-inositol, which is consistently elevated in plasma of patients with Heart Failure, as a significant area of research in cardiac dysfunction. It details the function of sodium-myo-inositol co-transporter-1, or S. M. I. T. 1., a member of the sodium-glucose co-transporter family specifically expressed in the heart, in myo-inositol transport. The research described addresses the poorly understood mechanism by which myo-inositol dysregulation contributes to cardiac dysfunction. This investigation focuses on understanding the molecular pathways involving S. M. I. T. 1. in the context of heart failure. Article 5: Cardiomyocyte-specific deficiency of C/EBPβ aggravates pressure overload-induced heart failure. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41618689 Summary: The abstract introduces CCAAT/enhancer-binding protein beta, a transcription factor known for regulating cell processes including inflammation, as a significant area of cardiac research. It identifies a critical gap in understanding the cell-type-specific functions of C. E. B. P. beta in the heart during stress and baseline conditions. The described investigation focuses on clarifying the role of endogenous C. E. B. P. beta specifically within cardiomyocytes during pressure overload-induced heart failure. This research characterizes an effort to delineate the complex involvement of this protein in cardiac dysfunction. Transcript Today’s date is March 29, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Effect of age on 5-year excess mortality in heart failure with reduced ejection fraction. The abstract outlines a significant research study focused on the impact of age on 5-year excess mortality in Heart Failure with Reduced Ejection Fraction. This investigation includes patients aged 40 to 85 years, all presenting with a left ventricular ejection fraction of 40 percent or less, who underwent coronary angiography for suspected cardiomyopathy. The methodology involves matching patients by sex and age, thus characterizing a structured approach to understand age-related differences in survival outcomes. This research addresses a crucial gap in current understanding of age as a determinant of prognosis in Heart Failure with Reduced Ejection Fraction. Article number two. Neurovascular retinomics for predicting heart diseases. The abstract describes a comprehensive methodology developed for utilizing neurovascular retinomics to predict incident heart diseases. This approach integrates multidimensional vascular parameters from color fundus photography with neural parameters obtained from optical coherence tomography. The study design incorporated LASSO regression for meticulous feature selection and employed a Gradient Boosting Machine model to assess predictive value. This framework characterizes a specific computational strategy for leveraging retinal imaging data in cardiovascular risk evaluation. Article number three. A randomized, double-blind, crossover study of acute low-level night-time road traffic noise: effects on vascular function, sleep, and proteomic signatures in healthy adults. The abstract presents a randomized, double-blind, crossover study that investigated the acute effects of low-level night-time road traffic noise on vascular function, sleep, and proteomic signatures in healthy adults. The research design exposed 74 healthy participants to three distinct overnight conditions, including a control with no noise and specific levels of road traffic noise. This structured methodology forms a basis for generating direct mechanistic evidence regarding environmental noise as a cardiovascular risk factor. The study provides a rigorous approach for evaluating acute physiological responses to noise exposure in humans. Article number four. Sodium-myo-inositol cotransporter-1, SMIT1, promotes cardiac hypertrophy and fibrosis induced by pressure overload in mice. The abstract highlights the emerging role of myo-inositol, which is consistently elevated in plasma of patients with Heart Failure, as a significant area of research in cardiac dysfunction. It details the function of sodium-myo-inositol co-transporter-1, or S. M. I. T. 1., a member of the sodium-glucose co-transporter family specifically expressed in the heart, in myo-inositol transport. The research described addresses the poorly understood mechanism by which myo-inositol dysregulation contributes to cardiac dysfunction. This investigation focuses on understanding the molecular pathways involving S. M. I. T. 1. in the context of heart failure. Article number five. Cardiomyocyte-specific deficiency of C/EBPβ aggravates pressure overload-induced heart failure. The abstract introduces CCAAT/enhancer-binding protein beta, a transcription factor known for regulating cell processes including inflammation, as a significant area of cardiac research. It identifies a critical gap in understanding the cell-type-specific functions of C. E. B. P. beta in the heart during stress and baseline conditions. The described investigation focuses on clarifying the role of endogenous C. E. B. P. beta specifically within cardiomyocytes during pressure overload-induced heart failure. This research characterizes an effort to delineate the complex involvement of this protein in cardiac dysfunction. Thank you for listening. Don’t forget to subscribe. Keywords Cardiomyopathy, Excess mortality, Heart diseases, Cardiomyocytes, Heart Failure with Reduced Ejection Fraction, Pressure overload, Cardiac fibrosis, Sleep, Color fundus photography, Vascular function, Age, Road traffic noise, CCAAT/enhancer-binding protein beta, Biomarker, Proteomic signatures, Heart failure, Transcription factor, Retinomics, Cardiac hypertrophy, Coronary angiography, Myo-inositol, Optical coherence tomography, Sodium-myo-inositol co-transporter-1, Cardiovascular risk factor. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Neurovascular Retinomics Predicts Heart Disease 03/29/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded March 28, 2026. This episode summarizes 5 key cardiology studies on topics like heart failure and prognosis. Key takeaway: CAD Phenotypes Found for Tailored Prevention. Article Links: Article 1: Drivers of 1-year mortality decline after acute myocardial infarction in England and Wales: a 15-year national cohort study. (Heart (British Cardiac Society)) Article 2: Identifying clinical phenotype clusters in patients with coronary artery disease. (Heart (British Cardiac Society)) Article 3: Optimizing NT-proBNP Inclusion Cut-offs for Randomized Clinical Trials in Heart Failure: Data from the Swedish Heart Failure Registry. (ESC heart failure) Article 4: Role of Provocation and Exercise Imaging for the Identification of Candidates for Cardiac Myosin Inhibitors. (ESC heart failure) Article 5: Sex- and Phenotype-Specific Prognostic Implications of Body Mass Index in Acute Heart Failure. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/cad-phenotypes-found-for-tailored-prevention-03-28-26/ Featured Articles Article 1: Drivers of 1-year mortality decline after acute myocardial infarction in England and Wales: a 15-year national cohort study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40691042 Summary: A national cohort study of 852914 adult patients in England and Wales found that one-year all-cause mortality following acute myocardial infarction declined between 2005 and 2019. Researchers analyzed this 15-year dataset to quantify the contributions of clinical, treatment, and demographic factors to these changes. The findings provide crucial data for informing clinical strategies and health policy. Article 2: Identifying clinical phenotype clusters in patients with coronary artery disease. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40451277 Summary: This study found that clinical phenotype clusters exist in patients with coronary artery disease. Researchers used unsupervised machine learning through latent class analysis to identify these clusters. The study assessed the relationship of these identified phenotypes with the risk of recurrent cardiovascular events. This work addresses the need for specific considerations beyond current one-size-fits-all guideline recommendations for cardiovascular event prevention. Article 3: Optimizing NT-proBNP Inclusion Cut-offs for Randomized Clinical Trials in Heart Failure: Data from the Swedish Heart Failure Registry. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41894572 Summary: This study provided evidence-based guidance on selecting optimal N-terminal pro-B-type natriuretic peptide cut-offs for randomized controlled trials in heart failure. Researchers utilized data from the Swedish Heart Failure Registry, applying N-terminal pro-B-type natriuretic peptide cut-offs ranging from 200 to 5000 picograms per milliliter, which were derived from prior randomized controlled trials. The study calculated one-year incidence proportions to optimize the balance between event enrichment and screening failure across various heart failure subgroups. This optimizes patient selection for clinical trials, improving efficiency and relevance. Article 4: Role of Provocation and Exercise Imaging for the Identification of Candidates for Cardiac Myosin Inhibitors. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41885188 Summary: This study compared the characteristics and therapeutic response of patients with obstructive hypertrophic cardiomyopathy who only showed treatment-qualifying left ventricular outflow tract obstruction during exercise echocardiography, versus those who met eligibility at rest. Researchers assessed the therapeutic response to cardiac myosin inhibitors, specifically mavacamten, in these patient groups. The findings clarify the clinical profile and treatment response of patients who require exercise imaging to establish eligibility for these inhibitors. This work helps identify appropriate candidates for mavacamten therapy. Article 5: Sex- and Phenotype-Specific Prognostic Implications of Body Mass Index in Acute Heart Failure. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41885184 Summary: This study found that the prognostic implications of body mass index in patients with acute heart failure differed according to heart failure phenotype and sex. Researchers analyzed 5271 patients hospitalized for acute heart failure from the Korean Heart Failure three Registry. Body mass index was categorized into low, normal, and high groups using Asia-Pacific criteria. The primary outcome was a composite of two-year all-cause mortality or heart transplantation, showing varying risks across subgroups. Transcript Today’s date is March 28, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Drivers of 1-year mortality decline after acute myocardial infarction in England and Wales: a 15-year national cohort study. A national cohort study of 852914 adult patients in England and Wales found that one-year all-cause mortality following acute myocardial infarction declined between 2005 and 2019. Researchers analyzed this 15-year dataset to quantify the contributions of clinical, treatment, and demographic factors to these changes. The findings provide crucial data for informing clinical strategies and health policy. Article number two. Identifying clinical phenotype clusters in patients with coronary artery disease. This study found that clinical phenotype clusters exist in patients with coronary artery disease. Researchers used unsupervised machine learning through latent class analysis to identify these clusters. The study assessed the relationship of these identified phenotypes with the risk of recurrent cardiovascular events. This work addresses the need for specific considerations beyond current one-size-fits-all guideline recommendations for cardiovascular event prevention. Article number three. Optimizing N-terminal pro-B-type natriuretic peptide Inclusion Cut-offs for Randomized Clinical Trials in Heart Failure: Data from the Swedish Heart Failure Registry. This study provided evidence-based guidance on selecting optimal N-terminal pro-B-type natriuretic peptide cut-offs for randomized controlled trials in heart failure. Researchers utilized data from the Swedish Heart Failure Registry, applying N-terminal pro-B-type natriuretic peptide cut-offs ranging from 200 to 5000 picograms per milliliter, which were derived from prior randomized controlled trials. The study calculated one-year incidence proportions to optimize the balance between event enrichment and screening failure across various heart failure subgroups. This optimizes patient selection for clinical trials, improving efficiency and relevance. Article number four. Role of Provocation and Exercise Imaging for the Identification of Candidates for Cardiac Myosin Inhibitors. This study compared the characteristics and therapeutic response of patients with obstructive hypertrophic cardiomyopathy who only showed treatment-qualifying left ventricular outflow tract obstruction during exercise echocardiography, versus those who met eligibility at rest. Researchers assessed the therapeutic response to cardiac myosin inhibitors, specifically mavacamten, in these patient groups. The findings clarify the clinical profile and treatment response of patients who require exercise imaging to establish eligibility for these inhibitors. This work helps identify appropriate candidates for mavacamten therapy. Article number five. Sex- and Phenotype-Specific Prognostic Implications of Body Mass Index in Acute Heart Failure. This study found that the prognostic implications of body mass index in patients with acute heart failure differed according to heart failure phenotype and sex. Researchers analyzed 5271 patients hospitalized for acute heart failure from the Korean Heart Failure three Registry. Body mass index was categorized into low, normal, and high groups using Asia-Pacific criteria. The primary outcome was a composite of two-year all-cause mortality or heart transplantation, showing varying risks across subgroups. Thank you for listening. Don’t forget to subscribe. Keywords heart failure, prognosis, coronary artery disease, machine learning, randomized controlled trials, one-year mortality, body mass index, Swedish Heart Failure Registry, inclusion criteria, acute heart failure, heart failure phenotype, prevention, sex differences, national registry, N-terminal pro-B-type natriuretic peptide, cardiac myosin inhibitors, acute myocardial infarction, mavacamten, phenotype clusters, exercise echocardiography, obstructive hypertrophic cardiomyopathy, clinical strategies, recurrent cardiovascular events, left ventricular outflow tract obstruction, health policy. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post CAD Phenotypes Found for Tailored Prevention 03/28/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded March 28, 2026. This episode summarizes 5 key cardiology studies on topics like oral anticoagulation and caregiver self-care. Key takeaway: Oral Semaglutide Cuts CV Events 14% in Type 2 Diabetes. Article Links: Article 1: Supporting Family Caregiver Health in Heart Failure: Longitudinal Associations Between Heart Failure Caregiver Self-Care and Patient Hospitalizations. (Journal of cardiac failure) Article 2: Oral Semaglutide and Change in Cardiovascular Risk Factors in High-Risk Type 2 Diabetes: A Post Hoc Secondary Analysis of the SOUL Randomized Clinical Trial. (JAMA cardiology) Article 3: Incidence, Predictors, Management, and Clinical Impact of Major Bleeding Following Left Atrial Appendage Occlusion: The Amulet IDE Randomized Clinical Trial. (JAMA cardiology) Article 4: Prevalence and characteristics of patients with coronary heart disease and blood pressure below target: the INTERASPIRE study. (Heart (British Cardiac Society)) Article 5: Aortic coarctation and long-term morbidity after arterial switch operation: a multicentre international cohort study. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/oral-semaglutide-cuts-cv-events-14-in-type-2-diabetes-03-28-26/ Featured Articles Article 1: Supporting Family Caregiver Health in Heart Failure: Longitudinal Associations Between Heart Failure Caregiver Self-Care and Patient Hospitalizations. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41895678 Summary: Prior research demonstrated that health coaching reduces heart failure caregiver stress and improves caregiver self-care behaviors. This randomized controlled trial assessed the longitudinal associations between improved caregiver self-care and heart failure patient hospitalization outcomes. The study identified how changes in caregiver well-being influenced patient clinical trajectories, underscoring the critical role of caregiver support in patient health. Article 2: Oral Semaglutide and Change in Cardiovascular Risk Factors in High-Risk Type 2 Diabetes: A Post Hoc Secondary Analysis of the SOUL Randomized Clinical Trial. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41879791 Summary: The S. O. U. L. randomized clinical trial found that once-daily oral semaglutide reduced the risk of major adverse cardiovascular events by 14 percent compared to placebo. This significant benefit occurred in individuals with type two diabetes and atherosclerotic cardiovascular disease or chronic kidney disease receiving standard of care. This secondary analysis demonstrated the specific changes oral semaglutide induced in long-term cardiovascular risk factors within this high-risk patient group. Article 3: Incidence, Predictors, Management, and Clinical Impact of Major Bleeding Following Left Atrial Appendage Occlusion: The Amulet IDE Randomized Clinical Trial. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41879767 Summary: Left atrial appendage occlusion is a critical intervention for patients with contraindications to oral anticoagulation and an increased risk of major bleeding. The Amulet I. D. E. randomized clinical trial meticulously identified the incidence, key predictors, and effective management strategies for major bleeding following left atrial appendage occlusion. This study, involving 1878 randomized patients comparing the Amulet with the Watchman devices, also determined the clinical impact of these bleeding events on patient outcomes. Article 4: Prevalence and characteristics of patients with coronary heart disease and blood pressure below target: the INTERASPIRE study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41887758 Summary: Many patients with coronary heart disease exhibit blood pressure above guideline targets, even with ongoing treatment. European guidelines offer conflicting recommendations regarding patients with on-treatment blood pressure below target, with the 2023 European Society of Hypertension guidelines issuing a class three recommendation to proactively avoid blood pressure below target. The I. N. T. E. R. A. S. P. I. R. E. study established the prevalence and characteristics of patients with coronary heart disease whose blood pressure fell below target levels. Article 5: Aortic coarctation and long-term morbidity after arterial switch operation: a multicentre international cohort study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40701798 Summary: Cardiovascular interventions and complications commonly occur after arterial switch operation in patients with dextro-transposition of the great arteries. While complex anatomy, such as ventricular septal defects, is often associated with these outcomes, the independent role of aortic coarctation remained unclear. This multicenter international cohort study analyzed 502 adults from the E. P. O. C. H. A. S. O. registry, precisely defining the long-term morbidity associated with aortic coarctation following arterial switch operation, independent of other complex anatomical factors. Transcript Today’s date is March 28, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Supporting Family Caregiver Health in Heart Failure: Longitudinal Associations Between Heart Failure Caregiver Self-Care and Patient Hospitalizations. Prior research demonstrated that health coaching reduces heart failure caregiver stress and improves caregiver self-care behaviors. This randomized controlled trial assessed the longitudinal associations between improved caregiver self-care and heart failure patient hospitalization outcomes. The study identified how changes in caregiver well-being influenced patient clinical trajectories, underscoring the critical role of caregiver support in patient health. Article number two. Oral Semaglutide and Change in Cardiovascular Risk Factors in High-Risk Type 2 Diabetes: A Post Hoc Secondary Analysis of the SOUL Randomized Clinical Trial. The S. O. U. L. randomized clinical trial found that once-daily oral semaglutide reduced the risk of major adverse cardiovascular events by 14 percent compared to placebo. This significant benefit occurred in individuals with type two diabetes and atherosclerotic cardiovascular disease or chronic kidney disease receiving standard of care. This secondary analysis demonstrated the specific changes oral semaglutide induced in long-term cardiovascular risk factors within this high-risk patient group. Article number three. Incidence, Predictors, Management, and Clinical Impact of Major Bleeding Following Left Atrial Appendage Occlusion: The Amulet IDE Randomized Clinical Trial. Left atrial appendage occlusion is a critical intervention for patients with contraindications to oral anticoagulation and an increased risk of major bleeding. The Amulet I. D. E. randomized clinical trial meticulously identified the incidence, key predictors, and effective management strategies for major bleeding following left atrial appendage occlusion. This study, involving 1878 randomized patients comparing the Amulet with the Watchman devices, also determined the clinical impact of these bleeding events on patient outcomes. Article number four. Prevalence and characteristics of patients with coronary heart disease and blood pressure below target: the INTERASPIRE study. Many patients with coronary heart disease exhibit blood pressure above guideline targets, even with ongoing treatment. European guidelines offer conflicting recommendations regarding patients with on-treatment blood pressure below target, with the 2023 European Society of Hypertension guidelines issuing a class three recommendation to proactively avoid blood pressure below target. The I. N. T. E. R. A. S. P. I. R. E. study established the prevalence and characteristics of patients with coronary heart disease whose blood pressure fell below target levels. Article number five. Aortic coarctation and long-term morbidity after arterial switch operation: a multicentre international cohort study. Cardiovascular interventions and complications commonly occur after arterial switch operation in patients with dextro-transposition of the great arteries. While complex anatomy, such as ventricular septal defects, is often associated with these outcomes, the independent role of aortic coarctation remained unclear. This multicenter international cohort study analyzed 502 adults from the E. P. O. C. H. A. S. O. registry, precisely defining the long-term morbidity associated with aortic coarctation following arterial switch operation, independent of other complex anatomical factors. Thank you for listening. Don’t forget to subscribe. Keywords oral anticoagulation, caregiver self-care, long-term morbidity, atherosclerotic cardiovascular disease, left atrial appendage occlusion, hypertension, dextro-transposition of the great arteries, guideline recommendations, aortic coarctation, type two diabetes, patient hospitalization, blood pressure targets, coronary heart disease, INTERASPIRE study, arterial switch operation, major bleeding, chronic kidney disease, longitudinal associations, major adverse cardiovascular events, heart failure, congenital heart disease, oral semaglutide, cardiovascular risk factors, Watchman device, health coaching, Amulet device. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Oral Semaglutide Cuts CV Events 14% in Type 2 Diabetes 03/28/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded March 28, 2026. This episode summarizes 5 key cardiology studies on topics like microvascular resistance and immunosuppressive therapy. Key takeaway: Ghost Approval: Transplant Drug Access. Article Links: Article 1: Tricuspid regurgitation: standardized stepwise work-up from referral to expert heart valve centre. (European heart journal) Article 2: Atrial fibrillation density as a biomarker for ischaemic stroke risk prediction. (European heart journal) Article 3: Coronary autoregulation: the complex interplay between epicardial and microvascular resistance. (European heart journal) Article 4: Diuretic Resistance Risk and the Efficacy of Natriuresis-Guided Diuretic Therapy in Acute Heart Failure: Post Hoc Analysis From the PUSH-AHF Trial. (JACC. Heart failure) Article 5: When Coverage Is Not Access: A Heart Transplant Recipient’s Perspective on Everolimus, FDA Labeling, and the Problem of “Ghost Approval”. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Full episode page: https://podcast.explainheart.com/podcast/ghost-approval-transplant-drug-access-03-28-26/ Featured Articles Article 1: Tricuspid regurgitation: standardized stepwise work-up from referral to expert heart valve centre. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41895721 Summary: A standardized stepwise work-up for Tricuspid Regurgitation was described, guiding patients from referral to an expert heart valve center. Optimal therapy selection for Tricuspid Regurgitation requires an integrated and systematic approach. This approach considers the condition’s etiology, disease stage, comorbidities, operative risk, and anatomical feasibility. Recent advances in surgical and transcatheter interventions have renewed focus on Tricuspid Regurgitation, a common condition historically associated with poor outcomes. Article 2: Atrial fibrillation density as a biomarker for ischaemic stroke risk prediction. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41895321 Summary: This study evaluated the association between Atrial Fibrillation density and ischaemic stroke, investigating whether this temporal episode distribution improves risk stratification compared to Atrial Fibrillation burden. The research utilized data from two U.S. cohorts of patients with cardiac implantable electronic devices that were remotely monitored by the Veterans Health Administration. Atrial Fibrillation density was considered as a potentially more clinically relevant and prognostically important biomarker than traditional classifications based on episode duration or cumulative burden. Article 3: Coronary autoregulation: the complex interplay between epicardial and microvascular resistance. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41895317 Summary: Coronary autoregulation maintains stable blood flow in the coronary circulation despite fluctuations in myocardial perfusion pressure, provided metabolic demands remain constant. The dynamic modulation of microvascular resistance within the coronary microcirculation determines coronary blood flow and is central to this regulatory process. This intrinsic mechanism enables the coronary vasculature to adapt to variations in aortic pressure and epicardial resistance. Article 4: Diuretic Resistance Risk and the Efficacy of Natriuresis-Guided Diuretic Therapy in Acute Heart Failure: Post Hoc Analysis From the PUSH-AHF Trial. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41893376 Summary: A post hoc analysis from the P. U. S. H. hyphen A. H. F. trial evaluated the efficacy of natriuresis-guided diuretic therapy in patients with acute decompensated heart failure at risk of diuretic resistance. Diuretic resistance is common in acute decompensated heart failure and is associated with residual congestion and poor prognosis. The study identified diuretic resistance risk using the B. A. N. hyphen A. D. H. F. score, which incorporates blood urea nitrogen, creatinine, natriuretic peptide levels, atrial fibrillation, diastolic blood pressure, hypertension, and home diuretics. Article 5: When Coverage Is Not Access: A Heart Transplant Recipient’s Perspective on Everolimus, FDA Labeling, and the Problem of “Ghost Approval”. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41895624 Summary: This perspective piece introduced the concept of “ghost approval,” where a technically approved medication remains financially or logistically inaccessible to the patient. It highlights that access to immunosuppressive therapy is essential for long-term survival in heart transplant recipients. A first-person experience with everolimus, an M. T. O. R. inhibitor, exemplified this issue, noting its lack of a U.S. Food and Drug Administration indication for heart transplantation contributed to access challenges. Transcript Today’s date is March 28, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Tricuspid regurgitation: standardized stepwise work-up from referral to expert heart valve centre. A standardized stepwise work-up for Tricuspid Regurgitation was described, guiding patients from referral to an expert heart valve center. Optimal therapy selection for Tricuspid Regurgitation requires an integrated and systematic approach. This approach considers the condition’s etiology, disease stage, comorbidities, operative risk, and anatomical feasibility. Recent advances in surgical and transcatheter interventions have renewed focus on Tricuspid Regurgitation, a common condition historically associated with poor outcomes. Article number two. Atrial fibrillation density as a biomarker for ischaemic stroke risk prediction. This study evaluated the association between Atrial Fibrillation density and ischaemic stroke, investigating whether this temporal episode distribution improves risk stratification compared to Atrial Fibrillation burden. The research utilized data from two U.S. cohorts of patients with cardiac implantable electronic devices that were remotely monitored by the Veterans Health Administration. Atrial Fibrillation density was considered as a potentially more clinically relevant and prognostically important biomarker than traditional classifications based on episode duration or cumulative burden. Article number three. Coronary autoregulation: the complex interplay between epicardial and microvascular resistance. Coronary autoregulation maintains stable blood flow in the coronary circulation despite fluctuations in myocardial perfusion pressure, provided metabolic demands remain constant. The dynamic modulation of microvascular resistance within the coronary microcirculation determines coronary blood flow and is central to this regulatory process. This intrinsic mechanism enables the coronary vasculature to adapt to variations in aortic pressure and epicardial resistance. Article number four. Diuretic Resistance Risk and the Efficacy of Natriuresis-Guided Diuretic Therapy in Acute Heart Failure: Post Hoc Analysis From the PUSH-AHF Trial. A post hoc analysis from the P. U. S. H. hyphen A. H. F. trial evaluated the efficacy of natriuresis-guided diuretic therapy in patients with acute decompensated heart failure at risk of diuretic resistance. Diuretic resistance is common in acute decompensated heart failure and is associated with residual congestion and poor prognosis. The study identified diuretic resistance risk using the B. A. N. hyphen A. D. H. F. score, which incorporates blood urea nitrogen, creatinine, natriuretic peptide levels, atrial fibrillation, diastolic blood pressure, hypertension, and home diuretics. Article number five. When Coverage Is Not Access: A Heart Transplant Recipient’s Perspective on Everolimus, FDA Labeling, and the Problem of “Ghost Approval”. This perspective piece introduced the concept of “ghost approval,” where a technically approved medication remains financially or logistically inaccessible to the patient. It highlights that access to immunosuppressive therapy is essential for long-term survival in heart transplant recipients. A first-person experience with everolimus, an M. T. O. R. inhibitor, exemplified this issue, noting its lack of a U.S. Food and Drug Administration indication for heart transplantation contributed to access challenges. Thank you for listening. Don’t forget to subscribe. Keywords microvascular resistance, immunosuppressive therapy, heart valve disease, ischaemic stroke, Heart transplantation, P. U. S. H. hyphen A. H. F. trial, acute decompensated heart failure, ghost approval, risk stratification, Coronary autoregulation, Diuretic resistance, Atrial fibrillation, myocardial perfusion, natriuresis-guided therapy, prognosis, surgical intervention, cardiac implantable electronic device, coronary circulation, patient work-up, blood flow regulation, transcatheter intervention, everolimus, biomarker, Tricuspid regurgitation, U.S. Food and Drug Administration. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Ghost Approval: Transplant Drug Access 03/28/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded March 27, 2026. This episode summarizes 5 key cardiology studies on topics like pericarditis and cardiometabolic dysfunction. Key takeaway: Socioeconomic Status Drives Heart Failure Risk. Article Links: Article 1: Senescent obesity signature in breast cancer: a paradigm of reverse cardio-oncology. (European heart journal) Article 2: Sex differences in cardiovascular-kidney-metabolic syndrome: the FINE-HEART pooled analysis. (European heart journal) Article 3: Cardiac involvement in parasitic infections. (European heart journal) Article 4: Inflammatory pathways in atrial fibrillation: mechanisms and novel therapeutic targets. (European heart journal) Article 5: Socioeconomic Correlates of Incident Heart Failure and Consequent Mortality: The All of Us Program. (JACC. Heart failure) Full episode page: https://podcast.explainheart.com/podcast/socioeconomic-status-drives-heart-failure-risk-03-27-26/ Featured Articles Article 1: Senescent obesity signature in breast cancer: a paradigm of reverse cardio-oncology. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41885139 Summary: The field of reverse cardio-oncology found that subclinical and overt cardiometabolic dysfunction, specifically obesity, fuels breast cancer risk and alters tumor biology. This occurs through shared mechanisms including chronic inflammation, hormonal dysregulation, and cellular senescence. Refined obesity phenotypes, such as metabolically healthy versus unhealthy obesity and sarcopenic obesity, demonstrate more accurate stratification of breast cancer risk compared to body mass index alone. This paradigm highlights specific biological links between cardiovascular and oncological diseases. Article 2: Sex differences in cardiovascular-kidney-metabolic syndrome: the FINE-HEART pooled analysis. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41884984 Summary: This prespecified analysis, drawing from two trials on chronic kidney disease and type two diabetes (FIDELIO-DKD and FIGARO-DKD) and one trial on heart failure (FINEARTS-HF), specifically investigated sex differences in cardiovascular-kidney-metabolic syndrome. The analysis consolidated individual participant data to clarify how cardiometabolic risk factors, and their impact, manifest differently between women and men. It provided a comprehensive platform to understand these distinctions in populations with chronic kidney disease, type two diabetes, and heart failure with mildly reduced or preserved ejection fraction. The study’s rigorous data pooling addressed a critical knowledge gap regarding sex-specific outcomes in cardiovascular-kidney-metabolic syndrome. Article 3: Cardiac involvement in parasitic infections. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41879141 Summary: Parasitic infections are identified as an important, yet underrecognized, cause of cardiovascular disease, especially in endemic regions and increasingly due to global migration and travel. Cardiac involvement results from either direct parasitic invasion or, more commonly, from immune-mediated and inflammatory mechanisms. These processes primarily affect the myocardium and pericardium, leading to clinical manifestations such as acute myocarditis, dilated or restrictive cardiomyopathy, and pericarditis. This highlights the diverse pathological pathways by which parasites impact cardiac health. Article 4: Inflammatory pathways in atrial fibrillation: mechanisms and novel therapeutic targets. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41879137 Summary: Inflammation is definitively identified as a predisposing factor for atrial fibrillation, the most common sustained cardiac arrhythmia. Systemic inflammatory disorders, including autoimmune disorder, diabetes mellitus, and obesity, as well as local inflammation of the heart or pericardium, are directly linked to atrial fibrillation. Inflammation triggers various signaling pathways and directly influences proinflammatory cytokines, which subsequently promote structural and electrical changes in the atria. These mechanisms underscore the critical role of inflammatory processes in atrial fibrillation pathogenesis. Article 5: Socioeconomic Correlates of Incident Heart Failure and Consequent Mortality: The All of Us Program. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41885671 Summary: This study identified prospective associations between socioeconomic status and incident heart failure in adults without pre-existing heart failure. It also demonstrated associations between socioeconomic status and all-cause mortality in patients already diagnosed with heart failure. The analysis utilized data from the National Institutes of Health-run All of Us Research Program. This research provides crucial evidence that both individual and neighborhood measures of socioeconomic status independently correlate with heart failure development and subsequent mortality. Transcript Today’s date is March 27, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Senescent obesity signature in breast cancer: a paradigm of reverse cardio-oncology. The field of reverse cardio-oncology found that subclinical and overt cardiometabolic dysfunction, specifically obesity, fuels breast cancer risk and alters tumor biology. This occurs through shared mechanisms including chronic inflammation, hormonal dysregulation, and cellular senescence. Refined obesity phenotypes, such as metabolically healthy versus unhealthy obesity and sarcopenic obesity, demonstrate more accurate stratification of breast cancer risk compared to body mass index alone. This paradigm highlights specific biological links between cardiovascular and oncological diseases. Article number two. Sex differences in cardiovascular-kidney-metabolic syndrome: the FINE-HEART pooled analysis. This prespecified analysis, drawing from two trials on chronic kidney disease and type two diabetes (FIDELIO-DKD and FIGARO-DKD) and one trial on heart failure (FINEARTS-HF), specifically investigated sex differences in cardiovascular-kidney-metabolic syndrome. The analysis consolidated individual participant data to clarify how cardiometabolic risk factors, and their impact, manifest differently between women and men. It provided a comprehensive platform to understand these distinctions in populations with chronic kidney disease, type two diabetes, and heart failure with mildly reduced or preserved ejection fraction. The study’s rigorous data pooling addressed a critical knowledge gap regarding sex-specific outcomes in cardiovascular-kidney-metabolic syndrome. Article number three. Cardiac involvement in parasitic infections. Parasitic infections are identified as an important, yet underrecognized, cause of cardiovascular disease, especially in endemic regions and increasingly due to global migration and travel. Cardiac involvement results from either direct parasitic invasion or, more commonly, from immune-mediated and inflammatory mechanisms. These processes primarily affect the myocardium and pericardium, leading to clinical manifestations such as acute myocarditis, dilated or restrictive cardiomyopathy, and pericarditis. This highlights the diverse pathological pathways by which parasites impact cardiac health. Article number four. Inflammatory pathways in atrial fibrillation: mechanisms and novel therapeutic targets. Inflammation is definitively identified as a predisposing factor for atrial fibrillation, the most common sustained cardiac arrhythmia. Systemic inflammatory disorders, including autoimmune disorder, diabetes mellitus, and obesity, as well as local inflammation of the heart or pericardium, are directly linked to atrial fibrillation. Inflammation triggers various signaling pathways and directly influences proinflammatory cytokines, which subsequently promote structural and electrical changes in the atria. These mechanisms underscore the critical role of inflammatory processes in atrial fibrillation pathogenesis. Article number five. Socioeconomic Correlates of Incident Heart Failure and Consequent Mortality: The All of Us Program. This study identified prospective associations between socioeconomic status and incident heart failure in adults without pre-existing heart failure. It also demonstrated associations between socioeconomic status and all-cause mortality in patients already diagnosed with heart failure. The analysis utilized data from the National Institutes of Health-run All of Us Research Program. This research provides crucial evidence that both individual and neighborhood measures of socioeconomic status independently correlate with heart failure development and subsequent mortality. Thank you for listening. Don’t forget to subscribe. Keywords pericarditis, cardiometabolic dysfunction, heart failure, inflammation, breast cancer, reverse cardio-oncology, parasitic infections, chronic kidney disease, type two diabetes, cardiac arrhythmia, obesity, mortality, cardiomyopathy, socioeconomic status, cardiovascular disease, cardiovascular-kidney-metabolic syndrome, sex differences, cellular senescence, atrial fibrillation, All of Us Research Program, cardiovascular epidemiology, proinflammatory cytokines, pathogenesis, myocarditis. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Socioeconomic Status Drives Heart Failure Risk 03/27/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded March 26, 2026. This episode summarizes 5 key cardiology studies on topics like conservative care and symptom management. Key takeaway: Early Surgery Reduces Aortic Stenosis Mortality. Article Links: Article 1: Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis at 10 Years. (The New England journal of medicine) Article 2: Renin-Aldosterone Profiles and Cardiorenal Outcomes in Hypertension: A Nationwide Cohort Study. (Journal of the American College of Cardiology) Article 3: Palliative care in cardiovascular medicine. (European heart journal) Article 4: Cardiovascular disease in China: epidemiological evolution and implications. (European heart journal) Article 5: Wearable devices and cardiovascular health: revolutionizing remote monitoring and disease prevention. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/early-surgery-reduces-aortic-stenosis-mortality-03-26-26/ Featured Articles Article 1: Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis at 10 Years. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41880613 Summary: Among asymptomatic patients with severe aortic stenosis, early surgery significantly lowered the risk of operative mortality or death from cardiovascular causes compared to conservative care. This means patients who received early surgery had a reduced composite rate of death during surgery or within 30 days after surgery. The data demonstrated this significant reduction in operative and cardiovascular mortality with early surgical intervention. These findings provided a clear benefit for early surgery in this specific patient population. Article 2: Renin-Aldosterone Profiles and Cardiorenal Outcomes in Hypertension: A Nationwide Cohort Study. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41879574 Summary: Renin-independent aldosterone production contributes to adverse cardiorenal outcomes. The study established a definitive association between specific renin-aldosterone profiles and the occurrence of cardiorenal events in adults with hypertension. These findings provide population-based evidence demonstrating the significant role of distinct aldosterone production mechanisms in influencing cardiorenal health in hypertensive patients. The comprehensive analysis identified key patterns linking renin-aldosterone levels to adverse cardiovascular and renal outcomes. Article 3: Palliative care in cardiovascular medicine. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41879158 Summary: Palliative care for adults with advanced cardiovascular disease consistently improves patients’ quality of life. It effectively supports caregivers and successfully aligns treatments with patient values and goals. The implementation of palliative care encompasses essential elements such as comprehensive symptom management, proactive advanced care planning, and patient-centered shared decision-making processes. These core components consistently lead to better patient experiences and outcomes in advanced cardiovascular disease. Article 4: Cardiovascular disease in China: epidemiological evolution and implications. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41879157 Summary: Cardiovascular disease remains the predominant cause of mortality in China, having undergone significant epidemiological transitions over several decades. This comprehensive review synthesized extensive observational data, revealing key features of cardiovascular disease’s evolving epidemiology across various dimensions within the country. The findings definitively establish crucial trends and interrelationships in cardiovascular disease incidence and prevalence among the Chinese population. This analysis demonstrates how the disease burden has shifted and provides a foundational understanding of its current state in China. Article 5: Wearable devices and cardiovascular health: revolutionizing remote monitoring and disease prevention. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41879156 Summary: Wearable devices are transforming cardiovascular medicine, as they enable continuous remote monitoring of physiological and behavioral measures outside traditional clinical settings. Smartwatches and activity trackers effectively utilize motion and biometric sensors to accurately measure physical activity, sleep quality, heart rate, and rhythm. These devices successfully empower patients to assume a more active role in their health by converting health goals into objective, quantifiable measures. This technological advancement directly contributes to revolutionizing remote monitoring and disease prevention in cardiovascular health. Transcript Today’s date is March 26, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis at 10 Years. Among asymptomatic patients with severe aortic stenosis, early surgery significantly lowered the risk of operative mortality or death from cardiovascular causes compared to conservative care. This means patients who received early surgery had a reduced composite rate of death during surgery or within 30 days after surgery. The data demonstrated this significant reduction in operative and cardiovascular mortality with early surgical intervention. These findings provided a clear benefit for early surgery in this specific patient population. Article number two. Renin-Aldosterone Profiles and Cardiorenal Outcomes in Hypertension: A Nationwide Cohort Study. Renin-independent aldosterone production contributes to adverse cardiorenal outcomes. The study established a definitive association between specific renin-aldosterone profiles and the occurrence of cardiorenal events in adults with hypertension. These findings provide population-based evidence demonstrating the significant role of distinct aldosterone production mechanisms in influencing cardiorenal health in hypertensive patients. The comprehensive analysis identified key patterns linking renin-aldosterone levels to adverse cardiovascular and renal outcomes. Article number three. Palliative care in cardiovascular medicine. Palliative care for adults with advanced cardiovascular disease consistently improves patients’ quality of life. It effectively supports caregivers and successfully aligns treatments with patient values and goals. The implementation of palliative care encompasses essential elements such as comprehensive symptom management, proactive advanced care planning, and patient-centered shared decision-making processes. These core components consistently lead to better patient experiences and outcomes in advanced cardiovascular disease. Article number four. Cardiovascular disease in China: epidemiological evolution and implications. Cardiovascular disease remains the predominant cause of mortality in China, having undergone significant epidemiological transitions over several decades. This comprehensive review synthesized extensive observational data, revealing key features of cardiovascular disease’s evolving epidemiology across various dimensions within the country. The findings definitively establish crucial trends and interrelationships in cardiovascular disease incidence and prevalence among the Chinese population. This analysis demonstrates how the disease burden has shifted and provides a foundational understanding of its current state in China. Article number five. Wearable devices and cardiovascular health: revolutionizing remote monitoring and disease prevention. Wearable devices are transforming cardiovascular medicine, as they enable continuous remote monitoring of physiological and behavioral measures outside traditional clinical settings. Smartwatches and activity trackers effectively utilize motion and biometric sensors to accurately measure physical activity, sleep quality, heart rate, and rhythm. These devices successfully empower patients to assume a more active role in their health by converting health goals into objective, quantifiable measures. This technological advancement directly contributes to revolutionizing remote monitoring and disease prevention in cardiovascular health. Thank you for listening. Don’t forget to subscribe. Keywords conservative care, symptom management, cardiovascular health, remote monitoring, epidemiology, Palliative care, cardiorenal outcomes, Wearable devices, epidemiological transitions, smartwatches, mortality, aldosterone production, Aortic stenosis, operative mortality, China, cardiovascular disease, early surgery, advanced care planning, nationwide cohort study, renin-aldosterone, quality of life, Cardiovascular disease, disease prevention, cardiovascular death, Hypertension. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Early Surgery Reduces Aortic Stenosis Mortality 03/26/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded March 25, 2026. This episode summarizes 5 key cardiology studies on topics like healthcare costs and heart failure. Key takeaway: LVAD Reverses Heart Failure, Avoids Transplant. Article Links: Article 1: Recovery From Heart Failure: Microvascular Mechanisms. (Circulation) Article 2: The Fontan Outcomes Network: Findings After 2 Years and 1121 Participants. (Circulation) Article 3: Association Between Copayments and Attendance in Cardiac Rehabilitation: A Nationwide Analysis From the AACVPR Registry. (Journal of the American Heart Association) Article 4: Sociodemographic and Clinical Predictors of Mortality in Adults With Congenital Heart Disease. (Journal of the American Heart Association) Article 5: Joint Associations of Sleep Patterns and Genetic Susceptibility With Dynamic Transitions of Chronic Obstructive Pulmonary Disease and Coronary Heart Disease and the Mediating Role of Inflammatory Biomarkers and Metabolites. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/lvad-reverses-heart-failure-avoids-transplant-03-25-26/ Featured Articles Article 1: Recovery From Heart Failure: Microvascular Mechanisms. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41878819 Summary: Left ventricular assist device support improves cardiac histology and function in patients with heart failure. This improvement sometimes allows patients to avoid heart transplantation after Left Ventricular Assist Device removal. The study investigated the microvascular and cellular programs underlying this observed myocardial recovery. Article 2: The Fontan Outcomes Network: Findings After 2 Years and 1121 Participants. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41878814 Summary: Survival after Fontan palliation for single ventricle heart disease has substantially improved. The Fontan Outcomes Network, comprising 38 congenital heart centers, was established to define the long-term trajectory of these patients. The network successfully enrolled 1121 participants within its first two years, providing a substantial cohort for future longitudinal analysis. Article 3: Association Between Copayments and Attendance in Cardiac Rehabilitation: A Nationwide Analysis From the AACVPR Registry. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41878870 Summary: A. C. V. P. R. Registry. Improving cardiac rehabilitation participation remains a national priority. This study utilized the American Association of Cardiovascular and Pulmonary Rehabilitation registry, analyzing data from 2012 to 2021. The investigation explored the relationship between patient copayments and attendance in cardiac rehabilitation programs, and also patient dropout rates. This analysis addressed the crucial clinical question of how financial barriers impact patient adherence and program completion. Article 4: Sociodemographic and Clinical Predictors of Mortality in Adults With Congenital Heart Disease. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41878868 Summary: Mortality in adults with congenital heart disease is strongly driven by disease complexity. This study investigated the influence of both clinical factors and social determinants of health on all-cause mortality in patients with adult congenital heart disease. Researchers utilized a single-center retrospective cohort from the Mayo Adult Congenital Heart Disease Registry, spanning from 2004 to 2017. The findings contributed to understanding critical factors impacting long-term survival in this complex patient population. Article 5: Joint Associations of Sleep Patterns and Genetic Susceptibility With Dynamic Transitions of Chronic Obstructive Pulmonary Disease and Coronary Heart Disease and the Mediating Role of Inflammatory Biomarkers and Metabolites. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41878867 Summary: Sleep behaviors influence the development of both chronic obstructive pulmonary disease and coronary heart disease. This study explored the associations of specific sleep patterns with dynamic transitions of these conditions. The investigation also addressed the interaction of sleep patterns with genetic susceptibility and the mediating role of inflammatory biomarkers and metabolites. The analysis utilized extensive data from the U. K. Biobank to characterize these complex interrelationships affecting comorbidity. Transcript Today’s date is March 25, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Recovery From Heart Failure: Microvascular Mechanisms. Left ventricular assist device support improves cardiac histology and function in patients with heart failure. This improvement sometimes allows patients to avoid heart transplantation after Left Ventricular Assist Device removal. The study investigated the microvascular and cellular programs underlying this observed myocardial recovery. Article number two. The Fontan Outcomes Network: Findings After 2 Years and 1121 Participants. Survival after Fontan palliation for single ventricle heart disease has substantially improved. The Fontan Outcomes Network, comprising 38 congenital heart centers, was established to define the long-term trajectory of these patients. The network successfully enrolled 1121 participants within its first two years, providing a substantial cohort for future longitudinal analysis. Article number three. Association Between Copayments and Attendance in Cardiac Rehabilitation: A Nationwide Analysis From the A. A. C. V. P. R. Registry. Improving cardiac rehabilitation participation remains a national priority. This study utilized the American Association of Cardiovascular and Pulmonary Rehabilitation registry, analyzing data from 2012 to 2021. The investigation explored the relationship between patient copayments and attendance in cardiac rehabilitation programs, and also patient dropout rates. This analysis addressed the crucial clinical question of how financial barriers impact patient adherence and program completion. Article number four. Sociodemographic and Clinical Predictors of Mortality in Adults With Congenital Heart Disease. Mortality in adults with congenital heart disease is strongly driven by disease complexity. This study investigated the influence of both clinical factors and social determinants of health on all-cause mortality in patients with adult congenital heart disease. Researchers utilized a single-center retrospective cohort from the Mayo Adult Congenital Heart Disease Registry, spanning from 2004 to 2017. The findings contributed to understanding critical factors impacting long-term survival in this complex patient population. Article number five. Joint Associations of Sleep Patterns and Genetic Susceptibility With Dynamic Transitions of Chronic Obstructive Pulmonary Disease and Coronary Heart Disease and the Mediating Role of Inflammatory Biomarkers and Metabolites. Sleep behaviors influence the development of both chronic obstructive pulmonary disease and coronary heart disease. This study explored the associations of specific sleep patterns with dynamic transitions of these conditions. The investigation also addressed the interaction of sleep patterns with genetic susceptibility and the mediating role of inflammatory biomarkers and metabolites. The analysis utilized extensive data from the U. K. Biobank to characterize these complex interrelationships affecting comorbidity. Thank you for listening. Don’t forget to subscribe. Keywords healthcare costs, heart failure, sleep patterns, cardiac function, long-term outcomes, copayments, patient registry, mortality predictors, chronic obstructive pulmonary disease, metabolites, patient attendance, congenital heart disease, inflammatory biomarkers, cardiac rehabilitation, Fontan palliation, Left ventricular assist device, social determinants of health, genetic susceptibility, adherence, adult congenital heart disease, coronary heart disease, myocardial recovery, heart transplantation, clinical factors, single ventricle heart disease. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post LVAD Reverses Heart Failure, Avoids Transplant 03/25/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded March 25, 2026. This episode summarizes 5 key cardiology studies on topics like P. P. A. R. minus alpha and left ventricular strain. Key takeaway: METTL14 Inhibits Atherogenesis. Article Links: Article 1: Parsimonious echocardiography-based model for predicting long-term all-cause mortality in heart failure with preserved ejection fraction. (Heart (British Cardiac Society)) Article 2: Atorvastatin and left ventricular strain during anthracycline-based chemotherapy. (International journal of cardiology) Article 3: The inflammation-microvascular axis in prognosis: Integrated FAI and AMR assessment for risk stratification after PCI in NSTEMI patients. (International journal of cardiology) Article 4: METTL14 inhibits atherogenesis by epigenetically activating PPAR-α/γ transcription and fatty acid oxidation in VSMCs. (Cardiovascular research) Article 5: THBS4 Regulates Pulmonary Hypertension via TGF-β/SMAD2 Signaling. (Hypertension (Dallas, Tex. : 1979)) Full episode page: https://podcast.explainheart.com/podcast/mettl14-inhibits-atherogenesis-03-25-26/ Featured Articles Article 1: Parsimonious echocardiography-based model for predicting long-term all-cause mortality in heart failure with preserved ejection fraction. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41876216 Summary: Existing Heart Failure Association Pre-test Assessment, Echocardiography and Natriuretic Peptide, Functional testing, Final Aetiology (H. F. A. minus P. E. F. F.) and Heavy, Hypertensive, Atrial Fibrillation, Pulmonary Hypertension, Elder, Filling Pressure (H. Two F. P. E. F.) scores do not adequately stratify long-term all-cause mortality risk in Heart Failure with Preserved Ejection Fraction (H. F. pEF) patients. To address this identified clinical gap, researchers developed and internally validated a parsimonious echocardiography-based model. This new model was designed to provide improved prediction of long-term all-cause mortality in the H. F. pEF patient population. Article 2: Atorvastatin and left ventricular strain during anthracycline-based chemotherapy. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41875954 Summary: Anthracyclines are associated with impaired Left Ventricular (L. V.) deformation, as measured by global longitudinal strain (G. L. S.) and global circumferential strain (G. C. S.). The S. T. O. P. minus C. A. trial investigated whether atorvastatin attenuates these declines in strain during anthracycline-based chemotherapy. Participants with lymphoma receiving anthracyclines were randomized to either placebo or atorvastatin. The study included 150 patients in the placebo group. Article 3: The inflammation-microvascular axis in prognosis: Integrated FAI and AMR assessment for risk stratification after PCI in NSTEMI patients. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41875953 Summary: Patients with non-S. T. minus segment elevation myocardial infarction (N. S. T. E. M. I.) remain at risk of major adverse cardiovascular events (MACE) despite successful percutaneous coronary intervention (P. C. I.). The combined prognostic value of pericoronary fat attenuation index (F. A. I.), a marker of coronary inflammation from coronary computed tomography angiography (C. C. T. A.), and angiography-derived microcirculatory resistance (A. M. R.), a marker of microvascular dysfunction, is underexplored for these patients. This retrospective cohort study assessed this combined prognostic value for improving risk stratification after P. C. I. in N. S. T. E. M. I. patients. Article 4: METTL14 inhibits atherogenesis by epigenetically activating PPAR-α/γ transcription and fatty acid oxidation in VSMCs. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41873711 Summary: The study found that M. E. T. T. L. 14 inhibits atherogenesis by epigenetically activating Peroxisome Proliferator-Activated Receptors alpha and gamma (P. P. A. R. minus alpha and P. P. A. R. minus gamma) transcription. This mechanism promotes fatty acid oxidation in Vascular Smooth Muscle Cells (V. S. M. C.s). M. E. T. T. L. 14 therefore plays a crucial role in governing cellular processes that regulate atherosclerosis development. Article 5: THBS4 Regulates Pulmonary Hypertension via TGF-β/SMAD2 Signaling. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41873540 Summary: Thrombospondin-4 (THBS4), an Extracellular Matrix (E. C. M.) glycoprotein, regulates pulmonary vascular remodeling in pulmonary hypertension (P. H.). The study found that T. H. B. S. 4 exerts this regulation via Transforming Growth Factor beta / S. M. A. D. 2 (T. G. F. minus beta / S. M. A. D. 2) signaling. This mechanism contributes to the progressive nature of P. H. marked by pulmonary arterial remodeling and right ventricular dysfunction. Transcript Today’s date is March 25, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Parsimonious echocardiography-based model for predicting long-term all-cause mortality in heart failure with preserved ejection fraction. Existing Heart Failure Association Pre-test Assessment, Echocardiography and Natriuretic Peptide, Functional testing, Final Aetiology (H. F. A. minus P. E. F. F.) and Heavy, Hypertensive, Atrial Fibrillation, Pulmonary Hypertension, Elder, Filling Pressure (H. Two F. P. E. F.) scores do not adequately stratify long-term all-cause mortality risk in Heart Failure with Preserved Ejection Fraction (H. F. pEF) patients. To address this identified clinical gap, researchers developed and internally validated a parsimonious echocardiography-based model. This new model was designed to provide improved prediction of long-term all-cause mortality in the H. F. pEF patient population. Article number two. Atorvastatin and left ventricular strain during anthracycline-based chemotherapy. Anthracyclines are associated with impaired Left Ventricular (L. V.) deformation, as measured by global longitudinal strain (G. L. S.) and global circumferential strain (G. C. S.). The S. T. O. P. minus C. A. trial investigated whether atorvastatin attenuates these declines in strain during anthracycline-based chemotherapy. Participants with lymphoma receiving anthracyclines were randomized to either placebo or atorvastatin. The study included 150 patients in the placebo group. Article number three. The inflammation-microvascular axis in prognosis: Integrated FAI and AMR assessment for risk stratification after PCI in NSTEMI patients. Patients with non-S. T. minus segment elevation myocardial infarction (N. S. T. E. M. I.) remain at risk of major adverse cardiovascular events (MACE) despite successful percutaneous coronary intervention (P. C. I.). The combined prognostic value of pericoronary fat attenuation index (F. A. I.), a marker of coronary inflammation from coronary computed tomography angiography (C. C. T. A.), and angiography-derived microcirculatory resistance (A. M. R.), a marker of microvascular dysfunction, is underexplored for these patients. This retrospective cohort study assessed this combined prognostic value for improving risk stratification after P. C. I. in N. S. T. E. M. I. patients. Article number four. METTL14 inhibits atherogenesis by epigenetically activating PPAR-α/γ transcription and fatty acid oxidation in VSMCs. The study found that M. E. T. T. L. 14 inhibits atherogenesis by epigenetically activating Peroxisome Proliferator-Activated Receptors alpha and gamma (P. P. A. R. minus alpha and P. P. A. R. minus gamma) transcription. This mechanism promotes fatty acid oxidation in Vascular Smooth Muscle Cells (V. S. M. C.s). M. E. T. T. L. 14 therefore plays a crucial role in governing cellular processes that regulate atherosclerosis development. Article number five. THBS4 Regulates Pulmonary Hypertension via TGF-β/SMAD2 Signaling. Thrombospondin-4 (THBS4), an Extracellular Matrix (E. C. M.) glycoprotein, regulates pulmonary vascular remodeling in pulmonary hypertension (P. H.). The study found that T. H. B. S. 4 exerts this regulation via Transforming Growth Factor beta / S. M. A. D. 2 (T. G. F. minus beta / S. M. A. D. 2) signaling. This mechanism contributes to the progressive nature of P. H. marked by pulmonary arterial remodeling and right ventricular dysfunction. Thank you for listening. Don’t forget to subscribe. Keywords P. P. A. R. minus alpha, left ventricular strain, microcirculatory resistance, pulmonary hypertension, H. F. A. minus P. E. F. F. score, S. M. A. D. 2 signaling, fat attenuation index, anthracycline cardiotoxicity, thrombospondin-4, atherogenesis, echocardiography, P. P. A. R. minus gamma, pulmonary vascular remodeling, major adverse cardiovascular events, T. G. F. minus beta, M. E. T. T. L. 14, heart failure with preserved ejection fraction, mortality risk, atorvastatin, global longitudinal strain, percutaneous coronary intervention, H. Two F. P. E. F. score, vascular smooth muscle cells, non-S. T. minus segment elevation myocardial infarction, global circumferential strain. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post METTL14 Inhibits Atherogenesis 03/25/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded March 24, 2026. This episode summarizes 5 key cardiology studies on topics like transitions of care and biomarkers. Key takeaway: Tricuspid Regurgitation Drives Liver Disease Risk. Article Links: Article 1: Myocardial bridging: a practical guide for clinicians. (European heart journal) Article 2: Liver-related outcomes in patients with tricuspid regurgitation. (European journal of heart failure) Article 3: Decoding the Heart Failure Peptidome. (Circulation. Heart failure) Article 4: Update on Education for Families and Patients With Pediatric Heart Disease: A Focus on Technological Advancements, Procedures, and Transitions of Care: A Scientific Statement From the American Heart Association. (Journal of the American Heart Association) Article 5: Angiographic and histological characterization of PFA-induced coronary spasm: Differential effect of two waveforms. (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/tricuspid-regurgitation-drives-liver-disease-risk-03-24-26/ Featured Articles Article 1: Myocardial bridging: a practical guide for clinicians. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41873713 Summary: This guide for clinicians identifies myocardial bridging as the most common congenital coronary anomaly. While often a benign anatomical variant without clinical significance, it is increasingly identified due to the greater use of coronary computed tomography angiography. The guide compiles practical information for clinicians on the assessment and management of myocardial bridging. It outlines key considerations for when this condition may become clinically significant and require intervention. Article 2: Liver-related outcomes in patients with tricuspid regurgitation. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41873743 Summary: This retrospective study assessed the incidence and risk of liver-related outcomes in patients with tricuspid regurgitation. Results revealed a clear association between tricuspid regurgitation severity and the development of adverse liver-related complications, including cirrhosis, hepatocellular carcinoma, and liver-related death. The study successfully identified specific predictors for cirrhosis in patients with moderate or greater tricuspid regurgitation. The data also demonstrated a significant negative impact of cirrhosis on overall patient survival. Article 3: Decoding the Heart Failure Peptidome. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41874184 Summary: This cross-sectional mass spectrometry analysis explored the low molecular peptidome in 486 patients with heart failure and 98 age-matched non-heart failure controls. The study identified specific plasma peptides that showed distinct differential expression patterns between heart failure patients and control individuals. These findings significantly advance the understanding of heart failure biology and demonstrate substantial potential for improving the diagnosis and prognostication of heart failure. The identified peptidome signatures offer novel insights for developing future therapeutic strategies for patients with heart failure. Article 4: Update on Education for Families and Patients With Pediatric Heart Disease: A Focus on Technological Advancements, Procedures, and Transitions of Care: A Scientific Statement From the American Heart Association. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41870283 Summary: The American Heart Association issued a scientific statement detailing significant advancements in pediatric heart care models and interventions over the past 20 years. These improvements have led to enhanced clinical outcomes after invasive cardiac procedures, increasing the frequency and complexity of home-based care for children. The statement emphasizes the critical need for updated educational strategies tailored for families and patients. It focuses on integrating technological advancements and improving transitions of care to better support pediatric patients living with heart disease. Article 5: Angiographic and histological characterization of PFA-induced coronary spasm: Differential effect of two waveforms. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41871647 Summary: This study characterized pulsed field ablation-induced coronary vasospasm by comparing a clinically relevant full pulsed field ablation waveform against a single-pulse configuration. Results revealed differential effects of the two waveforms on vasospasm incidence, severity, and recovery kinetics. The study also identified specific associated histological changes, providing crucial insights into the physiopathological mechanisms of pulsed field ablation-related coronary spasm. These findings demonstrate that distinct waveform characteristics directly impact the risk and nature of coronary vasospasm during pulsed field ablation procedures. Transcript Today’s date is March 24, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Myocardial bridging: a practical guide for clinicians. This guide for clinicians identifies myocardial bridging as the most common congenital coronary anomaly. While often a benign anatomical variant without clinical significance, it is increasingly identified due to the greater use of coronary computed tomography angiography. The guide compiles practical information for clinicians on the assessment and management of myocardial bridging. It outlines key considerations for when this condition may become clinically significant and require intervention. Article number two. Liver-related outcomes in patients with tricuspid regurgitation. This retrospective study assessed the incidence and risk of liver-related outcomes in patients with tricuspid regurgitation. Results revealed a clear association between tricuspid regurgitation severity and the development of adverse liver-related complications, including cirrhosis, hepatocellular carcinoma, and liver-related death. The study successfully identified specific predictors for cirrhosis in patients with moderate or greater tricuspid regurgitation. The data also demonstrated a significant negative impact of cirrhosis on overall patient survival. Article number three. Decoding the Heart Failure Peptidome. This cross-sectional mass spectrometry analysis explored the low molecular peptidome in 486 patients with heart failure and 98 age-matched non-heart failure controls. The study identified specific plasma peptides that showed distinct differential expression patterns between heart failure patients and control individuals. These findings significantly advance the understanding of heart failure biology and demonstrate substantial potential for improving the diagnosis and prognostication of heart failure. The identified peptidome signatures offer novel insights for developing future therapeutic strategies for patients with heart failure. Article number four. Update on Education for Families and Patients With Pediatric Heart Disease: A Scientific Statement From the American Heart Association. The American Heart Association issued a scientific statement detailing significant advancements in pediatric heart care models and interventions over the past 20 years. These improvements have led to enhanced clinical outcomes after invasive cardiac procedures, increasing the frequency and complexity of home-based care for children. The statement emphasizes the critical need for updated educational strategies tailored for families and patients. It focuses on integrating technological advancements and improving transitions of care to better support pediatric patients living with heart disease. Article number five. Angiographic and histological characterization of PFA-induced coronary spasm: Differential effect of two waveforms. This study characterized pulsed field ablation-induced coronary vasospasm by comparing a clinically relevant full pulsed field ablation waveform against a single-pulse configuration. Results revealed differential effects of the two waveforms on vasospasm incidence, severity, and recovery kinetics. The study also identified specific associated histological changes, providing crucial insights into the physiopathological mechanisms of pulsed field ablation-related coronary spasm. These findings demonstrate that distinct waveform characteristics directly impact the risk and nature of coronary vasospasm during pulsed field ablation procedures. Thank you for listening. Don’t forget to subscribe. Keywords transitions of care, biomarkers, clinical management, prognosis, coronary anomaly, coronary vasospasm, patient education, electrophysiology, tricuspid regurgitation, liver-related outcomes, coronary computed tomography angiography, family education, hepatocellular carcinoma, American Heart Association, pediatric heart disease, mass spectrometry, myocardial bridging, waveform characteristics, diagnosis, pulsed field ablation, heart failure, peptidome, cirrhosis, cardiac ablation. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Tricuspid Regurgitation Drives Liver Disease Risk 03/24/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded March 24, 2026. This episode summarizes 5 key cardiology studies on topics like residual pulmonary hypertension and heart transplantation. Key takeaway: H. O. P. E. Extends Heart Transplant Window. Article Links: Article 1: Complete revascularization timing in ST-segment elevation myocardial infarction and multivessel disease with heart failure: the OPTION-STEMI trial. (European heart journal) Article 2: Twenty-Four-Hour Hypothermic Oxygenated Perfusion Preserves Graft Viability in a Porcine DCD and DBD Heart Transplant Model. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Long term effects of medical therapy pre- and post- pulmonary endarterectomy – insights from the UK CURATE registry. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Association of Pre-Transplant Torque Teno Virus Load With Early Post-Transplant Outcomes in Lung Transplant Recipients: A Multicenter Cohort Study. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Residual left atrial v wave predicts clinical outcome of transcatheter edge-to-edge mitral valve repair. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/h-o-p-e-extends-heart-transplant-window-03-24-26/ Featured Articles Article 1: Complete revascularization timing in ST-segment elevation myocardial infarction and multivessel disease with heart failure: the OPTION-STEMI trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41493330 Summary: The OPTION-STEMI trial found an ongoing clinical uncertainty regarding the optimal timing of complete revascularization in patients with ST-segment elevation myocardial infarction and multivessel disease complicated by heart failure. This study established a direct comparison of immediate versus staged complete revascularization during the index admission. The trial’s design rigorously evaluated fractional flow reserve-guided complete revascularization for non-infarct-related arteries in this high-risk cohort. Article 2: Twenty-Four-Hour Hypothermic Oxygenated Perfusion Preserves Graft Viability in a Porcine DCD and DBD Heart Transplant Model. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41871747 Summary: The study found that 24-hour hypothermic oxygenated perfusion (H. O. P. E.) successfully preserved graft viability in a porcine heart transplant model. This innovative approach extended preservation time up to 24 hours for both donation after circulatory death (D. C. D.) and donation after brain death (D. B. D.) donor hearts. H. O. P. E. demonstrated efficacy in mitigating organ injury, which is a known risk associated with prolonged standard static cold storage exceeding 4 to 5 hours. Article 3: Long term effects of medical therapy pre- and post- pulmonary endarterectomy – insights from the UK CURATE registry. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41871746 Summary: The U. K. CURATE registry revealed limited and conflicting evidence regarding the use of pulmonary hypertension (P. H.) medical therapy as a bridge to pulmonary endarterectomy (P. E. A.) for chronic thromboembolic pulmonary hypertension (C. T. E. P. H.). The study also demonstrated an absence of consensus on criteria for continuing or restarting P. H. medical therapy post-operatively. The registry provided crucial data on the characteristics and long-term outcomes of patients receiving P. H. bridging therapy, along with identifying characteristics of residual P. H. post-P. E. A. Article 4: Association of Pre-Transplant Torque Teno Virus Load With Early Post-Transplant Outcomes in Lung Transplant Recipients: A Multicenter Cohort Study. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41871745 Summary: A multicenter cohort study involving 334 adult first-time lung transplant recipients established that pre-transplant Torque teno virus (T. T. V.) load is a significant factor in early post-transplant outcomes. This study demonstrated the relevance of T. T. V. levels, recognized as a surrogate marker of net immunosuppression, for lung transplantation patient care. The primary endpoint investigated was infection within 3 months, with plasma samples systematically collected immediately prior to transplantation. Article 5: Residual left atrial v wave predicts clinical outcome of transcatheter edge-to-edge mitral valve repair. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41869902 Summary: The study found that a residual left atrial (L. A.) v wave predicts the clinical outcome following transcatheter edge-to-edge mitral valve repair (M-TEER). This investigation, involving 299 patients, demonstrated that monitoring L. A. pressure intraprocedurally effectively complements echocardiographic assessments of residual mitral regurgitation. The presence of a residual L. A. v wave provides crucial prognostic information for M-TEER success and patient outcomes. Transcript Today’s date is March 24, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Complete revascularization timing in ST-segment elevation myocardial infarction and multivessel disease with heart failure: the OPTION-STEMI trial. The OPTION-STEMI trial found an ongoing clinical uncertainty regarding the optimal timing of complete revascularization in patients with ST-segment elevation myocardial infarction and multivessel disease complicated by heart failure. This study established a direct comparison of immediate versus staged complete revascularization during the index admission. The trial’s design rigorously evaluated fractional flow reserve-guided complete revascularization for non-infarct-related arteries in this high-risk cohort. Article number two. Twenty-Four-Hour Hypothermic Oxygenated Perfusion Preserves Graft Viability in a Porcine DCD and DBD Heart Transplant Model. The study found that 24-hour hypothermic oxygenated perfusion (H. O. P. E.) successfully preserved graft viability in a porcine heart transplant model. This innovative approach extended preservation time up to 24 hours for both donation after circulatory death (D. C. D.) and donation after brain death (D. B. D.) donor hearts. H. O. P. E. demonstrated efficacy in mitigating organ injury, which is a known risk associated with prolonged standard static cold storage exceeding 4 to 5 hours. Article number three. Long term effects of medical therapy pre- and post- pulmonary endarterectomy – insights from the UK CURATE registry. The U. K. CURATE registry revealed limited and conflicting evidence regarding the use of pulmonary hypertension (P. H.) medical therapy as a bridge to pulmonary endarterectomy (P. E. A.) for chronic thromboembolic pulmonary hypertension (C. T. E. P. H.). The study also demonstrated an absence of consensus on criteria for continuing or restarting P. H. medical therapy post-operatively. The registry provided crucial data on the characteristics and long-term outcomes of patients receiving P. H. bridging therapy, along with identifying characteristics of residual P. H. post-P. E. A. Article number four. Association of Pre-Transplant Torque Teno Virus Load With Early Post-Transplant Outcomes in Lung Transplant Recipients: A Multicenter Cohort Study. A multicenter cohort study involving 334 adult first-time lung transplant recipients established that pre-transplant Torque teno virus (T. T. V.) load is a significant factor in early post-transplant outcomes. This study demonstrated the relevance of T. T. V. levels, recognized as a surrogate marker of net immunosuppression, for lung transplantation patient care. The primary endpoint investigated was infection within 3 months, with plasma samples systematically collected immediately prior to transplantation. Article number five. Residual left atrial v wave predicts clinical outcome of transcatheter edge-to-edge mitral valve repair. The study found that a residual left atrial (L. A.) v wave predicts the clinical outcome following transcatheter edge-to-edge mitral valve repair (M-TEER). This investigation, involving 299 patients, demonstrated that monitoring L. A. pressure intraprocedurally effectively complements echocardiographic assessments of residual mitral regurgitation. The presence of a residual L. A. v wave provides crucial prognostic information for M-TEER success and patient outcomes. Thank you for listening. Don’t forget to subscribe. Keywords residual pulmonary hypertension, heart transplantation, graft viability, post-transplant infection, multivessel disease, chronic thromboembolic pulmonary hypertension, Left atrial pressure, fractional flow reserve, transcatheter edge-to-edge mitral valve repair, cold ischemic time, mitral regurgitation, ST-segment elevation myocardial infarction, Hypothermic oxygenated perfusion, lung transplantation, v wave, prognostic indicator, pulmonary hypertension medical therapy, bridging therapy, Pulmonary endarterectomy, immunosuppression, complete revascularization, donation after circulatory death, Torque teno virus, heart failure, cohort study. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post H. O. P. E. Extends Heart Transplant Window 03/24/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded March 23, 2026. This episode summarizes 5 key cardiology studies on topics like adverse pregnancy outcomes and sleep apnea. Key takeaway: Adverse Pregnancy Outcomes Predict Heart Risk. Article Links: Article 1: Initial Pediatric Experience of Preserving Cardiac Allografts in a 10°C Cooler. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Temporary Mechanical Circulatory Support in LVAD Candidates with Right Ventricular Dysfunction: Acuity Without Long-Term Futility. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Natural History of Tricuspid Regurgitation Following Transcatheter-Edge-to – Edge Repair; Insights from Clinical Trials and Multi-Center Registries. (The Canadian journal of cardiology) Article 4: Win Ratio Analysis for Peak-flow Adaptive Servo-ventilation in Treating Sleep Apnea in Heart Failure with Reduced Ejection Fraction. (The Canadian journal of cardiology) Article 5: Lifetime Adverse Pregnancy Outcome History and Cardiovascular Risk. (Hypertension (Dallas, Tex. : 1979)) Full episode page: https://podcast.explainheart.com/podcast/adverse-pregnancy-outcomes-predict-heart-risk-03-23-26/ Featured Articles Article 1: Initial Pediatric Experience of Preserving Cardiac Allografts in a 10°C Cooler. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41865850 Summary: This study reported the initial pediatric experience of preserving cardiac allografts using a 10 degree Celsius cooler, a method with established favorable results in adult cardiac transplants. The single-center retrospective review documented recipient characteristics, intraoperative courses, and postoperative outcomes associated with this preservation technique. This investigation represents the first clinical application and evaluation of 10 degree Celsius allograft preservation in pediatric patients. Article 2: Temporary Mechanical Circulatory Support in LVAD Candidates with Right Ventricular Dysfunction: Acuity Without Long-Term Futility. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41865849 Summary: V. A. D. Candidates with Right Ventricular Dysfunction: Acuity Without Long-Term Futility. This study found that temporary mechanical circulatory support, utilized as a bridge to durable Left Ventricular Assist Device implantation in advanced heart failure patients with right ventricular dysfunction, indicates acuity without leading to long-term futility. While right ventricular dysfunction at Left Ventricular Assist Device implantation predicts early morbidity and mortality, the data demonstrated that temporary mechanical circulatory support does not independently contribute to long-term risk. This redefines the prognostic implications of preoperative temporary mechanical circulatory support in this vulnerable patient population. Article 3: Natural History of Tricuspid Regurgitation Following Transcatheter-Edge-to – Edge Repair; Insights from Clinical Trials and Multi-Center Registries. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41865992 Summary: This study found that transcatheter edge-to-edge repair for significant tricuspid regurgitation achieved sustained improvement in most patients at one-year follow-up, based on contemporary registries. The data showed that early reduction in tricuspid regurgitation was influenced by factors such as anatomic complexity, leaflet coaptation mechanics, and device-related characteristics. Furthermore, results demonstrated that late tricuspid regurgitation recurrence was primarily driven by ongoing right-sided chamber remodeling and interactions between the leaflets and the device clip. Article 4: Win Ratio Analysis for Peak-flow Adaptive Servo-ventilation in Treating Sleep Apnea in Heart Failure with Reduced Ejection Fraction. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41865991 Summary: This study employed a win ratio analysis to evaluate the effects of peak flow triggered adaptive servo-ventilation for sleep apnea in patients with Heart Failure with Reduced Ejection Fraction. The win ratio approach expanded the assessment of intervention effects beyond conventional morbid and mortal events, incorporating endpoints related to symptom relief and quality of life. This analysis provided a more comprehensive understanding of adaptive servo-ventilation’s impact on overall patient well-being in this specific cardiology population. Article 5: Lifetime Adverse Pregnancy Outcome History and Cardiovascular Risk. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41859799 Summary: This study established a relationship between a lifetime history of adverse pregnancy outcomes and long-term cardiovascular disease risk in 59154 parous participants from the Nurses’ Health Study two. The investigation identified cardiovascular events, including myocardial infarction, stroke, and coronary revascularization, in women with self-reported histories of gestational diabetes, gestational hypertension, preeclampsia, preterm delivery, and low birthweight. This comprehensive analysis confirmed the cumulative impact of various adverse pregnancy outcomes on future cardiovascular health. Transcript Today’s date is March 23, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Initial Pediatric Experience of Preserving Cardiac Allografts in a 10°C Cooler. This study reported the initial pediatric experience of preserving cardiac allografts using a 10 degree Celsius cooler, a method with established favorable results in adult cardiac transplants. The single-center retrospective review documented recipient characteristics, intraoperative courses, and postoperative outcomes associated with this preservation technique. This investigation represents the first clinical application and evaluation of 10 degree Celsius allograft preservation in pediatric patients. Article number two. Temporary Mechanical Circulatory Support in L. V. A. D. Candidates with Right Ventricular Dysfunction: Acuity Without Long-Term Futility. This study found that temporary mechanical circulatory support, utilized as a bridge to durable Left Ventricular Assist Device implantation in advanced heart failure patients with right ventricular dysfunction, indicates acuity without leading to long-term futility. While right ventricular dysfunction at Left Ventricular Assist Device implantation predicts early morbidity and mortality, the data demonstrated that temporary mechanical circulatory support does not independently contribute to long-term risk. This redefines the prognostic implications of preoperative temporary mechanical circulatory support in this vulnerable patient population. Article number three. Natural History of Tricuspid Regurgitation Following Transcatheter-Edge-to-Edge Repair; Insights from Clinical Trials and Multi-Center Registries. This study found that transcatheter edge-to-edge repair for significant tricuspid regurgitation achieved sustained improvement in most patients at one-year follow-up, based on contemporary registries. The data showed that early reduction in tricuspid regurgitation was influenced by factors such as anatomic complexity, leaflet coaptation mechanics, and device-related characteristics. Furthermore, results demonstrated that late tricuspid regurgitation recurrence was primarily driven by ongoing right-sided chamber remodeling and interactions between the leaflets and the device clip. Article number four. Win Ratio Analysis for Peak-flow Adaptive Servo-ventilation in Treating Sleep Apnea in Heart Failure with Reduced Ejection Fraction. This study employed a win ratio analysis to evaluate the effects of peak flow triggered adaptive servo-ventilation for sleep apnea in patients with Heart Failure with Reduced Ejection Fraction. The win ratio approach expanded the assessment of intervention effects beyond conventional morbid and mortal events, incorporating endpoints related to symptom relief and quality of life. This analysis provided a more comprehensive understanding of adaptive servo-ventilation’s impact on overall patient well-being in this specific cardiology population. Article number five. Lifetime Adverse Pregnancy Outcome History and Cardiovascular Risk. This study established a relationship between a lifetime history of adverse pregnancy outcomes and long-term cardiovascular disease risk in 59154 parous participants from the Nurses’ Health Study two. The investigation identified cardiovascular events, including myocardial infarction, stroke, and coronary revascularization, in women with self-reported histories of gestational diabetes, gestational hypertension, preeclampsia, preterm delivery, and low birthweight. This comprehensive analysis confirmed the cumulative impact of various adverse pregnancy outcomes on future cardiovascular health. Thank you for listening. Don’t forget to subscribe. Keywords adverse pregnancy outcomes, sleep apnea, temporary mechanical circulatory support, tricuspid regurgitation, preterm delivery, quality of life, transcatheter edge-to-edge repair, leaflet coaptation, cardiovascular risk, right ventricular remodeling, 10 degree Celsius cooler, cardiac allograft, pediatric heart transplantation, win ratio analysis, Heart Failure with Reduced Ejection Fraction, adaptive servo-ventilation, Left Ventricular Assist Device, bridge to transplant, advanced heart failure, preeclampsia, gestational diabetes, device-related factors, right ventricular dysfunction, organ preservation. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Adverse Pregnancy Outcomes Predict Heart Risk 03/23/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded March 22, 2026. This episode summarizes 5 key cardiology studies on topics like cardiac surgery and sex-based differences. Key takeaway: Suv39h1 Deficiency Rescues Heart Failure. Article Links: Article 1: Sex-Based Differences in Outcomes Following Mitral Valve Surgery: A Contemporary Analysis From 2 Institutions. (Journal of the American Heart Association) Article 2: The impact of environmental pollution and climate change on hypertension: a position paper by the European Society of Hypertension (ESH) Working Group on Environment in Hypertension. (Cardiovascular research) Article 3: Suppressor of variegation 3-9 homolog 1 deficiency attenuates cardiac fibrosis and rescues heart failure through TACC2. (Cardiovascular research) Article 4: Nuclear export by COPS5/CSN5/JAB1 mediates vascular smooth muscle cell dedifferentiation in neointimal hyperplasia. (Cardiovascular research) Article 5: Lgi3-4 proteins modulate the KV1.5 channelosome and are potential therapeutic targets for atrial fibrillation. (Cardiovascular research) Full episode page: https://podcast.explainheart.com/podcast/suv39h1-deficiency-rescues-heart-failure-03-22-26/ Featured Articles Article 1: Sex-Based Differences in Outcomes Following Mitral Valve Surgery: A Contemporary Analysis From 2 Institutions. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41859896 Summary: A comprehensive retrospective cohort study involving 3313 adult patients who underwent mitral valve surgery provided data to investigate sex as an independent risk factor for perioperative mortality. The analysis focused on operative mortality as the primary outcome, stratified by patient sex. This research established a foundational dataset to clarify the influence of sex on surgical outcomes in mitral valve disease. Article 2: The impact of environmental pollution and climate change on hypertension: a position paper by the European Society of Hypertension (ESH) Working Group on Environment in Hypertension. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41861066 Summary: S. H.) Working Group on Environment in Hypertension. A position paper by the European Society of Hypertension Working Group found that environmental pollution and climate change contribute to over 9 million premature deaths annually worldwide. Air and noise pollution demonstrate the strongest epidemiological links to hypertension and cardiovascular disease. Furthermore, emerging evidence connects light pollution, toxic metal exposure, and climate-related factors to these health burdens. This comprehensive analysis highlights the significant impact of environmental factors on global hypertension rates. Article 3: Suppressor of variegation 3-9 homolog 1 deficiency attenuates cardiac fibrosis and rescues heart failure through TACC2. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41861065 Summary: This study found that a deficiency in suppressor of variegation 3-9 homolog 1, or Suv39h1, attenuates cardiac fibrosis and rescues heart failure. The research demonstrated that Suv39h1 expression increased in cardiac fibroblasts during fibrosis. This mechanism was identified to operate through TACC2, suggesting a critical role for Suv39h1 in regulating cardiac extracellular matrix production. These findings reveal a novel therapeutic target for heart failure. Article 4: Nuclear export by COPS5/CSN5/JAB1 mediates vascular smooth muscle cell dedifferentiation in neointimal hyperplasia. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41861053 Summary: This study found that nuclear export mediated by COPS5/CSN5/JAB1 facilitates vascular smooth muscle cell dedifferentiation, contributing to neointimal hyperplasia. The research showed increased COPS5/CSN5 levels in human idiopathic pulmonary hypertension (I. P. A. H.) neointima, atherosclerotic lesions, and rabbit vein grafts. This suggests a direct involvement of COPS5 in vascular remodeling following injury. Understanding this mechanism offers a potential therapeutic target for conditions involving neointimal hyperplasia. Article 5: Lgi3-4 proteins modulate the KV1.5 channelosome and are potential therapeutic targets for atrial fibrillation. Journal: Cardiovascular research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41854369 Summary: This study found that Lgi3 and Lgi4 proteins interact directly with K. V. 1.5 channels in human atrial tissue and heterologous cells. In a mouse model with A. A. V. 9-mediated cardiac-specific Lgi4 expression, the research observed impaired sinoatrial and atrioventricular conduction, leading to a prolonged Q. R. S. interval. The data showed delayed action potential repolarization in atria, indicating Lgi3-4 proteins modulate cardiac electrophysiology. These findings suggest Lgi3-4 proteins are potential therapeutic targets for atrial fibrillation. Transcript Today’s date is March 22, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Sex-Based Differences in Outcomes Following Mitral Valve Surgery: A Contemporary Analysis From 2 Institutions. A comprehensive retrospective cohort study involving 3313 adult patients who underwent mitral valve surgery provided data to investigate sex as an independent risk factor for perioperative mortality. The analysis focused on operative mortality as the primary outcome, stratified by patient sex. This research established a foundational dataset to clarify the influence of sex on surgical outcomes in mitral valve disease. Article number two. The impact of environmental pollution and climate change on hypertension: a position paper by the European Society of Hypertension (E. S. H.) Working Group on Environment in Hypertension. A position paper by the European Society of Hypertension Working Group found that environmental pollution and climate change contribute to over 9 million premature deaths annually worldwide. Air and noise pollution demonstrate the strongest epidemiological links to hypertension and cardiovascular disease. Furthermore, emerging evidence connects light pollution, toxic metal exposure, and climate-related factors to these health burdens. This comprehensive analysis highlights the significant impact of environmental factors on global hypertension rates. Article number three. Suppressor of variegation 3-9 homolog 1 deficiency attenuates cardiac fibrosis and rescues heart failure through TACC2. This study found that a deficiency in suppressor of variegation 3-9 homolog 1, or Suv39h1, attenuates cardiac fibrosis and rescues heart failure. The research demonstrated that Suv39h1 expression increased in cardiac fibroblasts during fibrosis. This mechanism was identified to operate through TACC2, suggesting a critical role for Suv39h1 in regulating cardiac extracellular matrix production. These findings reveal a novel therapeutic target for heart failure. Article number four. Nuclear export by COPS5/CSN5/JAB1 mediates vascular smooth muscle cell dedifferentiation in neointimal hyperplasia. This study found that nuclear export mediated by COPS5/CSN5/JAB1 facilitates vascular smooth muscle cell dedifferentiation, contributing to neointimal hyperplasia. The research showed increased COPS5/CSN5 levels in human idiopathic pulmonary hypertension (I. P. A. H.) neointima, atherosclerotic lesions, and rabbit vein grafts. This suggests a direct involvement of COPS5 in vascular remodeling following injury. Understanding this mechanism offers a potential therapeutic target for conditions involving neointimal hyperplasia. Article number five. Lgi3-4 proteins modulate the KV1.5 channelosome and are potential therapeutic targets for atrial fibrillation. This study found that Lgi3 and Lgi4 proteins interact directly with K. V. 1.5 channels in human atrial tissue and heterologous cells. In a mouse model with A. A. V. 9-mediated cardiac-specific Lgi4 expression, the research observed impaired sinoatrial and atrioventricular conduction, leading to a prolonged Q. R. S. interval. The data showed delayed action potential repolarization in atria, indicating Lgi3-4 proteins modulate cardiac electrophysiology. These findings suggest Lgi3-4 proteins are potential therapeutic targets for atrial fibrillation. Thank you for listening. Don’t forget to subscribe. Keywords cardiac surgery, sex-based differences, Lgi3-4 proteins, K. V. 1.5 channels, mitral valve surgery, Q. R. S. interval, cardiovascular disease, COPS5, dedifferentiation, cardiac electrophysiology, operative mortality, Suv39h1, vascular smooth muscle cell, air pollution, therapeutic target, noise pollution, TACC2, patient outcomes, environmental pollution, climate change, atrial fibrillation, hypertension, vascular injury, neointimal hyperplasia, heart failure, cardiac fibrosis. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Suv39h1 Deficiency Rescues Heart Failure 03/22/26 first appeared on Cardiology Today.

Welcome to Cardiology Today – Recorded March 21, 2026. This episode summarizes 5 key cardiology studies on topics like coronary artery disease and Time-restricted eating. Key takeaway: Apixaban Safe for Kids’ Heart Thromboprophylaxis. Article Links: Article 1: Effect of 2 Weeks of Time-Restricted Eating on Innate Immunity and Systemic Inflammation in Patients With a History of Myocardial Infarction: A Randomized-Controlled Crossover Study. (Journal of the American Heart Association) Article 2: Association of Multiple Plasma Metals With Cerebral Microbleeds: A Brain Magnetic Resonance Imaging-Based Study. (Journal of the American Heart Association) Article 3: Prior Antiplatelet Exposure and Clinical Outcomes Among Korean Patients With Acute Myocardial Infarction. (Journal of the American Heart Association) Article 4: Ex Vivo Effect of Apixaban on Hemostatic Biomarkers in Children With Heart Disease: A SAXOPHONE Trial Substudy. (Journal of the American Heart Association) Article 5: Prognostic Impact of Elevated Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension: Insights From a Japanese Multicenter Registry. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/apixaban-safe-for-kids-heart-thromboprophylaxis-03-21-26/ Featured Articles Article 1: Effect of 2 Weeks of Time-Restricted Eating on Innate Immunity and Systemic Inflammation in Patients With a History of Myocardial Infarction: A Randomized-Controlled Crossover Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41859904 Summary: A randomized-controlled crossover study investigated a two-week time-restricted eating intervention, allowing eating only between 8 a.m. and 2 p.m., in patients with a history of myocardial infarction. The research explored the intervention’s effects on metabolomic parameters and innate immune cell function. This study provided a structured assessment of time-restricted eating as a potential modulator of inflammation and immune cell function in established coronary artery disease. Article 2: Association of Multiple Plasma Metals With Cerebral Microbleeds: A Brain Magnetic Resonance Imaging-Based Study. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41859900 Summary: This cross-sectional study found an association between multiple plasma metals and cerebral microbleeds, with detection performed using brain magnetic resonance imaging. The research identified that environmental metal exposure and systemic metal circulation are factors related to cerebrovascular health. This study provided direct data on the connections between various plasma metals and the presence of cerebral microbleeds. Article 3: Prior Antiplatelet Exposure and Clinical Outcomes Among Korean Patients With Acute Myocardial Infarction. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41859899 Summary: A retrospective cohort study of 29281 Korean patients with acute myocardial infarction found that prior antiplatelet exposure was a factor influencing clinical outcomes. The study identified patient cohorts that specifically excluded individuals with pre-existing atrial fibrillation, coronary artery disease, heart failure, cerebrovascular accident, or prior thrombolysis. This research provided concrete findings on how antiplatelet medication history impacts prognosis in an East Asian population, which is characterized by distinct antithrombotic response profiles. Article 4: Ex Vivo Effect of Apixaban on Hemostatic Biomarkers in Children With Heart Disease: A SAXOPHONE Trial Substudy. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41859898 Summary: The SAXOPHONE (Safety of Apixaban on Pediatric Heart Disease on the Prevention of Embolism) trial definitively demonstrated the safety of apixaban for thromboprophylaxis in children with heart disease. An exploratory substudy assessed apixaban’s ex vivo effects on surrogate biomarkers of efficacy, including D-dimer, thrombin generation assay parameters, Factor eight, fibrinogen, and protein C. This research provided specific data on apixaban’s impact on coagulation factors and hemostatic proteins in this pediatric patient group. Article 5: Prognostic Impact of Elevated Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension: Insights From a Japanese Multicenter Registry. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41859897 Summary: This study evaluated the real-world relationship between pulmonary vascular resistance and prognosis in Group two pulmonary hypertension, which is defined as pulmonary hypertension caused by left heart disease. Researchers analyzed data from 563 patients across two prospective Japanese multicenter registries, thus establishing specific patient cohorts for this analysis. The investigation assessed the efficacy of emerging therapies within this challenging condition, providing concrete data on therapeutic approaches for patients with left heart disease and pulmonary hypertension. Transcript Today’s date is March 21, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Effect of 2 Weeks of Time-Restricted Eating on Innate Immunity and Systemic Inflammation in Patients With a History of Myocardial Infarction: A Randomized-Controlled Crossover Study. A randomized-controlled crossover study investigated a two-week time-restricted eating intervention, allowing eating only between 8 a.m. and 2 p.m., in patients with a history of myocardial infarction. The research explored the intervention’s effects on metabolomic parameters and innate immune cell function. This study provided a structured assessment of time-restricted eating as a potential modulator of inflammation and immune cell function in established coronary artery disease. Article number two. Association of Multiple Plasma Metals With Cerebral Microbleeds: A Brain Magnetic Resonance Imaging-Based Study. This cross-sectional study found an association between multiple plasma metals and cerebral microbleeds, with detection performed using brain magnetic resonance imaging. The research identified that environmental metal exposure and systemic metal circulation are factors related to cerebrovascular health. This study provided direct data on the connections between various plasma metals and the presence of cerebral microbleeds. Article number three. Prior Antiplatelet Exposure and Clinical Outcomes Among Korean Patients With Acute Myocardial Infarction. A retrospective cohort study of 29281 Korean patients with acute myocardial infarction found that prior antiplatelet exposure was a factor influencing clinical outcomes. The study identified patient cohorts that specifically excluded individuals with pre-existing atrial fibrillation, coronary artery disease, heart failure, cerebrovascular accident, or prior thrombolysis. This research provided concrete findings on how antiplatelet medication history impacts prognosis in an East Asian population, which is characterized by distinct antithrombotic response profiles. Article number four. Ex Vivo Effect of Apixaban on Hemostatic Biomarkers in Children With Heart Disease: A SAXOPHONE Trial Substudy. The SAXOPHONE (Safety of Apixaban on Pediatric Heart Disease on the Prevention of Embolism) trial definitively demonstrated the safety of apixaban for thromboprophylaxis in children with heart disease. An exploratory substudy assessed apixaban’s ex vivo effects on surrogate biomarkers of efficacy, including D-dimer, thrombin generation assay parameters, Factor eight, fibrinogen, and protein C. This research provided specific data on apixaban’s impact on coagulation factors and hemostatic proteins in this pediatric patient group. Article number five. Prognostic Impact of Elevated Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension: Insights From a Japanese Multicenter Registry. This study evaluated the real-world relationship between pulmonary vascular resistance and prognosis in Group two pulmonary hypertension, which is defined as pulmonary hypertension caused by left heart disease. Researchers analyzed data from 563 patients across two prospective Japanese multicenter registries, thus establishing specific patient cohorts for this analysis. The investigation assessed the efficacy of emerging therapies within this challenging condition, providing concrete data on therapeutic approaches for patients with left heart disease and pulmonary hypertension. Thank you for listening. Don’t forget to subscribe. Keywords coronary artery disease, Time-restricted eating, pediatric heart disease, clinical outcomes, Korean patients, prognosis, magnetic resonance imaging, pulmonary hypertension, Antiplatelet exposure, D-dimer, emerging therapies, Pulmonary vascular resistance, thromboprophylaxis, cerebral microbleeds, antithrombotic response, environmental exposure, left heart disease, Apixaban, cerebrovascular health, myocardial infarction, acute myocardial infarction, hemostatic biomarkers, innate immunity, Plasma metals, systemic inflammation. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Apixaban Safe for Kids’ Heart Thromboprophylaxis 03/21/26 first appeared on Cardiology Today.