Sunday Science Week 3 Klotho Gene and Enzyme

The Go UnPro Podcast Sunday Science Week 3 Klotho Gene And Enzyme  Speaker-Organized Summary: Key Points, Decisions, and Next Steps Dr. Brent Laartz Summary of Key Points and Decisions The discussion focuses on a gene and gene product called Klotho, which was discovered in 1997 and is named after the Greek god of fate and destiny. Knockout mice with Klotho upregulation showed a 15-30% longer lifespan and improved cardiovascular, renal, and brain health, as well as lower rates of cognitive decline. However, a recent study published in the Journals of Gerontology in 2025 found a U-shaped relationship between Klotho levels and all-cause mortality. The study showed that both high and low levels of Klotho were associated with increased mortality, and this was linked to increased liver fibrosis. Next Steps Further research is needed to fully understand the relationship between Klotho levels and health outcomes. Multiple studies on Klotho have been published in the past year, and more are expected in the next one to two years. The speaker encourages the audience to follow the podcast on various platforms to stay updated on the latest developments in longevity and science.