Syphilis in Pregnancy: Clinical Manifestations and Management Guidelines

This podcast addresses the alarming resurgence of syphilis and congenital syphilis in the United States. The text outlines the pathophysiology and clinical stages of the infection, highlighting its devastating impact on pregnancy, including risks of stillbirth and neonatal death. It provides a comprehensive guide for obstetrician–gynecologists on modern diagnostic methods, comparing traditional and reverse screening algorithms. Furthermore, the source emphasizes the necessity of penicillin G as the primary treatment and discusses the management of the Jarisch-Herxheimer reaction. Finally, it underscores the importance of public health reporting and addressing socioeconomic barriers to care to mitigate this growing crisis.