TBX5 Gene Loss Disrupts DNA Folding | Science News

One missing copy of the TBX5 gene—thought to be a minor genetic tweak—can catastrophically unravel how DNA folds inside heart cells, disrupting essential gene activation and causing birth defects. This gene acts as an architectural director, ensuring DNA is packed in the right 3D shape for proper function. Researchers found that even half the normal amount of TBX5 triggers widespread misfolding across all levels—from large compartments to tiny loops—and different heart cells react uniquely to the loss, explaining why identical mutations lead to varied outcomes. The discovery hints this mechanism may underlie many developmental disorders, revealing that faulty DNA folding—not just broken genes—could be at the root of some birth defects. Listen in comfort:Get a discount on a Soli Pillow: http://solipillow.com/discount/dnn. Advertise on DNN:[email protected] This is an automated, high-level news summary based on public reporting.Report issues to [email protected]. View sources & latest updates:https://sources.thednn.ai/52ee3380efb85314