Test may help identify people at risk of coeliac disease

A study into the behaviour of immune cells in coeliac disease patients showed surprising results. Instead of being overactive, T cells in coeliac disease were subdued, and didn't survive as long as T cells from healthy people. Researchers say this effect isn’t simply driven by inflammation or diet, but suggests an underlying difference linked to genetic risk, and the test could one day help clinicians identify people at risk of developing coeliac disease and other auto-immune disorders.Guest/sProfessor Jason Tye-Din, Coeliac Research Lab Head, Walter and Eliza Hall Institute; Director, Snow Centre for Immune HealthDr Vanessa Bryant, Bryant Lab Head, Walter and Eliza Hall Institute; Scientific Engagement and Collaboration Lead, Snow Centre for Immune Health ReferencesFunctional immune profiling reveals CD4+ T cell dysregulation in coeliac disease (Immunology and Cell Biology, 2026)