TFS#90 - Jacob George On Drug Research & Development, Hepatitis Cures, Blue Zone Diet w/ Renowned Hepatologist & Liver Research Scientist Prof.

Professor Jacob George is a renowned hepatologist and liver research scientist who studies the causes of and mechanisms for the development of liver disease and liver cancer.  Professor George’s work has made significant contributions to clinical practice. His team first identified the role of interferon lambda 3 gene polymorphisms for predicting treatment response in chronic hepatitis C, and a second gene polymorphism that interacts with interferon lambda 3. These discoveries are considered major advances in the field and the finest examples of ‘personalized medicine'.  Professor George was an author of the groundbreaking study of combination telaprevir, pegylated interferon, and ribavirin therapy for hepatitis C, which changed the landscape of hepatitis C treatments, heralding the era of direct-acting antivirals. His work identifying insulin resistance as the universal underlying pathophysiological abnormality in fatty liver disease underpins the majority of research on this condition and is the cornerstone of current therapy (lifestyle intervention; exercise; insulin-sensitizing agents). He also first described the association between hepatitis C and insulin resistance.  Professor George is an advisor to Hepatitis Australia, the Transfusion Related AIDS and Infectious Diseases Service, and at state and national levels, on viral hepatitis. He oversees research for the Asian Pacific Association for the Study of Liver. He is a Fellow of the American Association for the Study of Liver Disease.  Professor Jacob George MBBS, FRACP, Ph.D., FAASLD CHAPTERS: 00:00 Intro 00:20 Meet Prof. Jacob George 01:00 Professors In The Hospital 02:30 KPIs For Delivering Clinical Care 03:40 Research & Academic KPIs 05:00 Medical Research Method 06:10 Mice Lab Testing 08:30 How Washing Hands Saved Lives 09:40 Pathophysiology Cycle 11:40 Curing Hepatitis C 12:30 Designing Drugs 14:40 Growing Virus In The Lab 16:00 Hepatitis B Breakthroughs 18:40 Virus Reservoir Forms 20:40 Eliminating Dormant Virus 22:00 Early Phase Human Studies 24:30 Long Term Side Effects 24:50 Thalidomide Scandal 26:00 Clinical Trials 27:00 Post Marketing Research 29:05 Cost vs Benefit 29:45 Independent Experts 31:55 The Covid Vaccines 33:15 Do Masks Work? 35:30 Does Vaccine Works? 37:20 Personal Risk Factors 37:55 The Old Man’s Friend 39:05 The Immune Response 41:30 The Immune System 43:05 Natural Immunity 44:30 Immune System Memory 46:15 Average Human Lifespan 47:00 Healthy Aging 48:20 Cancer Development 50:50 The Blue Zone Diet 53:35 Social Constructs On Food Behavior 55:20 The Agricultural Age 57:30 Nutritional Ecology 59:25 Child Rearing Experiment 01:02:15 Knowledge Dissemination 01:04:10 Just A Speck 01:04:35 Outro