The 120 Year Diet

How Long Can Humans Live?The crossroads of food, science, and longevity are pushing the forefront of current thinking.  The science of Epigenetics and Nutrigenomics deals with how what we put in our bodies impacts our DNA, the chance of disease and the likelihood of living a long life.This week's podcast dives into the flavors around the art and science of food as medicine.Let me know what you think after listening.  I’ve posted the show notes/ outline below for further contemplation.Show Notes:Intermittent FastingNutrient denseVital and essential nutritional cofactors The 120 year diet Not new – 80yrs + of dataDr. Walford – 1950s pioneer of conceptUnder-nutrition without malnutritionRestrict calories to 40% of 2,000 cal dietOur daily intake has ballooned along with waistlineVitaminsMineralsPhytonutrients**Notice I didn’t say anything about eating a cow sandwhich Experiements showing benefit of up to 70% reduction in calorie intake  Beneficial Mechanisms of Caloric Restriction CV effectsDecrease HR, BP, LDL & triglyceridesImproved insulin sensitivity – normalization of glucose levelsIncrease protein synthesiselimination of abnormal proteinsEnhanced actions of chaperone moleculesSynthesis & maintenance of essentialproteinsModulation of apoptosis (orderly cell death)Improvement in repair & maintenance of DNA integrityBenefits transcriptionReduce oxidative stressQualitative and quantitative decrease in free radicalsDecrease body temperatureReduction in body fat massDecrease visceral fat massIncrease muscle massBeneficial effects on age related decreases in hormone secretionDHEAGrowth hormoneImproved brain functionMemoryCognitionMoodEnhanced engagement in physical activityGrowth factor stimulationBrain derived neurotrophic factor (BDNF)Weight loss  Calorie Restriction MimeticsMetforminResveratrolCarnosineAvocadoGymnema2-deoxyglucoseAminoguanidineHydroxycitrateAdiponectinThiazolidinodionesIodoacetateModulators of NPYExandinPYY3-36LeptinAlpha Lipoic AcidCinnamonAcetyl-L-CarnitineMixed AntioxidantsOxaloacetate (not approved for supplement use)  Positive lifestyle change and multiple interventions promote longevity in a synergistic manner.Welcome to ReCharge, the show where ancient wisdom meets modern science. Each episode delivers practical, high-impact tools you can use immediately. This is your place to reset, reframe, and rebuild a life with more clarity, energy, and purpose. Hosted on Acast. See acast.com/privacy for more information.