The $2 billion ingredient that clinical trials say 'doesn't work' because they test the wrong compounds

Cochrane reviews on echinacea for colds show mixed results. But most clinical trials used products standardized on polysaccharides or caffeic acid derivatives NOT alkamides. The alkamide-CB2 mechanism is the most pharmacologically compelling, the best-absorbed (lipophilic), and the least-studied in humans. We might be dismissing a $2B ingredient based on trials that tested the wrong fraction.Publications of interest:https://pubmed.ncbi.nlm.nih.gov/24554461/https://pmc.ncbi.nlm.nih.gov/articles/PMC4068831/https://pubmed.ncbi.nlm.nih.gov/15921096/