The 229 Podcast: Breach Simulations and the CISO Burnout Epidemic with Anahi Santiago

October 16, 2025: How do you build a cybersecurity program that lasts over a decade? Anahi Santiago, CISO at ChristianaCare, shares what separates healthcare organizations that prioritize security from those where CISOs burn out in 18 months. She reveals why bringing state agencies and the National Guard into tabletop exercises transformed her team's preparedness, how she aligned security with patient safety from day one, and why healthcare's open environments create unique challenges that other industries never face. From managing 70,000 medical devices to building operational resilience across multiple states, Anahi offers hard-won insights on creating a culture where cybersecurity thrives—not just survives. Key Points: 01:04 The Role and Longevity of a CISO04:58 Unique Challenge of Healthcare Cyber13:41 Tabletop Exercises and Preparedness19:33 Creating a Culture of Security27:36 Sports Analogies and Leadership in Healthcare X: This Week Health LinkedIn: This Week Health Donate: Alex’s Lemonade Stand: Foundation for Childhood Cancer