EPISODE · Apr 20, 2026 · 5 MIN
The 3% curcuminoid that outperforms the other 97%
from NutraSift: The nutraceutical innovation podcast · host Siftlink SA
Bisdemethoxycurcumin makes up only ~3% of the curcuminoid complex, yet it's the most potent NF-kB inhibitor of the three curcuminoids. The dominant compound, curcumin itself (~77%), is actually the weakest at nuclear translocation inhibition. The industry standardizes on "95% total curcuminoids", treating three molecules with different mechanisms as one. The company that fractionates and standardizes on bisdemethoxycurcumin specifically could own a new IP category.Publications of interest:https://pmc.ncbi.nlm.nih.gov/articles/PMC8406555/, https://pubmed.ncbi.nlm.nih.gov/17522064/, https://pubmed.ncbi.nlm.nih.gov/18449507/
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The 3% curcuminoid that outperforms the other 97%
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