The Best Women’s Health Tips on the Planet with Dr. Jennifer Pearlman

What if menopause is one of the most important longevity events in human biology, and we've been ignoring it?Dr. Matt Kaeberlein sits down with Dr. Jennifer Pearlman, founder of PearlMD and pioneer in female-centric longevity medicine, to unpack why women's health has been systemically underfunded, undertreated, and misunderstood and what a proactive approach actually looks like.From the flawed science behind the Women's Health Initiative to the nuts and bolts of hormone optimization, testosterone for women, and the emerging field of ovarian tissue cryopreservation, Dr. Pearlman brings 20+ years of clinical expertise and a framework she calls FemSpan: harnessing the unique biology of female longevity while mitigating the risks most medicine ignores.Timestamps:00:00 — Cold open00:47 — Welcome & Dr. Pearlman's origin story02:33 — Why the medical system fails women08:37 — How the women's health landscape has shifted over 20 years09:26 — The Women's Health Initiative: what went wrong13:07 — What drove the reemergence of menopause medicine14:38 — Big Pharma, funding, and the micronized progesterone question17:13 — "Medicine progresses one funeral at a time"18:01 — From functional medicine to precision medicine20:35 — Rebranding aging: from anti-aging to longevity23:50 — Navigating the gray zone between frontier and fringe27:46 — How to identify credible practitioners33:32 — What every woman should know about the menopause transition36:41 — Why take a proactive approach? Symptoms, disease risk, and aging38:19 — The two simultaneous biology processes of menopause41:46 — The role of FSH and hormone optimization43:28 — Estradiol as the body's regenerative signal47:24 — What to test and when50:38 — The metabolic theory of menopause55:08 — Visceral fat as an evolutionary adaptation57:26 — How to navigate hormone therapy01:00:24 — Bioidentical hormones: reclaiming the term01:06:45 — Why route of administration matters01:11:35 — Progesterone: the unsung hero of menopause management01:23:19 — Testosterone for women: what the science actually says01:34:25 — Introducing FemSpan: the female longevity framework01:37:55 — The biological aging advantages women carry01:46:46 — Can we close the healthspan gap?01:53:05 — Could reversing menopause extend female lifespan?02:00:29 — Regenerative medicine and the future of female longevity02:03:10 — Ovarian tissue cryopreservation explained02:10:39 — AI in women's precision medicine02:15:50 — Medicine at scale: opportunity and risk02:21:41 — Advanced cardiovascular diagnostics and the female gap02:24:22 — Closing thoughts: your aging trajectory is more in your control than you think