The Biological Variation Data Critical Appraisal Checklist: A Standard for Evaluating Studies on Biological Variation

Data on biological variation can be used in many ways, most notably for the diagnosis and monitoring of disease and also for setting analytical performance specifications.  In 2014, after the first strategic conference of the European Federation of Clinical Chemistry and Laboratory Medicine, a task force was established to develop criteria for evaluation of the literature on biological variation. A report from this group appears in the March 2018 issue of Clinical Chemistry.