EPISODE · May 21, 2026 · 16 MIN
The Brain's Self-Balancing Oscillations
from OsciPod · host sk
How does the brain stay stable through aging, learning, and injury? This episode explores a computational model showing that inhibitory synaptic plasticity — a self-adjusting rule that strengthens local braking whenever excitation runs too high — can dynamically balance excitation and inhibition across a 68-region cortical network. With this mechanism in place, the model simultaneously matches multiple measures of MEG functional connectivity over a far wider range of parameters than any unbalanced model, achieving performance statistically indistinguishable from real individual human brains. Reference: Abeysuriya et al. (2018) "A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks" PLoS Computational Biology. https://doi.org/10.1371/journal.pcbi.1006007
What this episode covers
How does the brain stay stable through aging, learning, and injury? This episode explores a computational model showing that inhibitory synaptic plasticity — a self-adjusting rule that strengthens local braking whenever excitation runs too high — can dynamically balance excitation and inhibition across a 68-region cortical network. With this mechanism in place, the model simultaneously matches multiple measures of MEG functional connectivity over a far wider range of parameters than any unbalanced model, achieving performance statistically indistinguishable from real individual human brains. Reference: Abeysuriya et al. (2018) "A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks" PLoS Computational Biology. https://doi.org/10.1371/journal.pcbi.1006007
NOW PLAYING
The Brain's Self-Balancing Oscillations
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
No similar podcasts found.